Khajehzadeh, Mostafa’s team published research in Inorganica Chimica Acta in 2019-01-24 | 611-19-8

Inorganica Chimica Acta published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Khajehzadeh, Mostafa; Moghadam, Majid; Jamehbozorgi, Saeed published the artcile< Synthesis and characterization of a new poly(N-heterocyclic carbene Cu complex) immobilized on nano-silica, (CuII-NHCs)n@nSiO2, and its application as an efficient and reusable catalyst in the synthesis of benzimidazoles, benzothiazoles, 1,2,3-triazoles, bis-triazoles and Sonogashira-Hagihara reactions>, COA of Formula: C7H6Cl2, the main research area is benzimidazole benzothiazole triazole preparation; aryl benzyl halide aldehyde acetylene Sonogashira Hagihara reaction; poly heterocyclic carbene copper complex catalyst preparation.

The present study describes the synthesis and characterization of a new poly(N-heterocyclic carbene Cu complex) immobilized on nano silica, (CuII-NHCs)n@nSiO2. The (CuII-NHCs)n@nSiO2 dendritic polymer was characterized by FT-IR, TGA, UV-vis, FE-SEM, TEM and ICP-OES techniques. The catalytic activity of this new catalyst was studied in the synthesis of benzimidazoles I (Ar = 2-MeC6H4, 3-BrC6H4, 4-ClC6H4, etc.), benzothiazoles II, 1,2,3-triazoles III (R1 = H, 2-Br, 4-Cl, etc.), bis-triazoles and Sonogashira-Hagihara cross-coupling reactions. The (CuII-NHCs)n@nSiO2 heterogeneous catalyst showed the advantages such as high efficiency, good to excellent yield, short reaction times, easy separation and high reusability of the catalyst.

Inorganica Chimica Acta published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Jun’s team published research in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2021-01-31 | 611-19-8

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Azabicyclic compounds Role: AGR (Agricultural Use), BSU (Biological Study, Unclassified), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Xu, Jun; Yang, Tianjiao; Wang, Jiayi; Song, Gonghua published the artcile< Multistep Synthesis and Nematicidal Activity of 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-One Derivatives>, Computed Properties of 611-19-8, the main research area is azabicyclooctanyl iminoisoindolone preparation nematicidal SAR.

Novel 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-ones I [R = H, 5-F, 6-MeO, 5-Cl; R1 = Me, benzyl, 4-chlorobenzyl, etc.; R2 = tert-Bu, cyclohexyl, 2-MeOC6H4, etc.] which derived from 5-HT3 receptor antagonists hexahydroazepinylbenzamides were designed and synthesized through isocyanide insertion reaction. All target compounds I were evaluated against pinewood nematodes B. xylophilus and root-knot nematodes M. incognita. Good lethal rate (75%) for I [R = 5-Cl, R1= Me, R2 = tert-butyl] and serious nervous curl effect against pinewood nematodes B. xylophilus for I [R = H, R1= Me, R2 = tert-butyl] were observed at 10 mg/l. The inhibition activities of I [R = H, R1= Me, R2 = 2-MeOC6H4, etc.] against root-knot nematodes M. incognita were 84% at 160 mg/l and 60% at 20 mg/l for in-vitro test and test tube test, resp.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Azabicyclic compounds Role: AGR (Agricultural Use), BSU (Biological Study, Unclassified), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, He’s team published research in Journal of Chemical Research in 2019-11-30 | 611-19-8

Journal of Chemical Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Related Products of 611-19-8.

Li, He; Zhang, Yijun; Liu, Dinghua; Liu, Xiaoqin published the artcile< An improved method for the synthesis of phenylacetic acid derivatives via carbonylation>, Related Products of 611-19-8, the main research area is phenylacetic acid preparation; benzyl chloride carbonylation palladium catalyst.

A series of phenylacetic acid derivatives RCH2CO2H [R = 2-ClC6H4, 4-MeC6H4, 2,4-Cl2C6H3, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80°C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system.

Journal of Chemical Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Related Products of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Raju, D Suryanarayana’s team published research in International Journal of Life Science and Pharma Research in 2020 | 611-19-8

International Journal of Life Science and Pharma Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, HPLC of Formula: 611-19-8.

Raju, D. Suryanarayana; Sasidhar, R. L. C.; Vidyadhara, S. published the artcile< Synthesis and characterization of some novel 5-chloro benzimidazole-2-one derivatives with specific docking studies against PPAR-γ>, HPLC of Formula: 611-19-8, the main research area is piperidinyl benzimidazolone preparation mol docking; peroxisome proliferator activated receptor gamma; benzyl halide acyl chloride alkylation acylation.

A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives I (Ar = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and II have been synthesized. The compounds were docked against peroxisome proliferator activated receptor-γ (PPAR-γ) by using MCULE software. It was found that the synthesized mols. were active against PPAR-γ by their comparative docking scores with that of standard marketed drugs i.e. Rosiglitazone and Pioglitazone. In particular compounds II (Ar = 2-MeC6H4) and I (Ar = 2-MeC6H4, 4-MeC6H4) showed more binding capacity. The synthesized mols. were identified to have good binding capacity with PPAR- γ according to their docking data.

International Journal of Life Science and Pharma Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, HPLC of Formula: 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Hang’s team published research in European Journal of Medicinal Chemistry in 2021-04-15 | 611-19-8

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Xu, Hang; Yan, Zhong-zuo; Guo, Meng-bi; An, Ran; Wang, Xin; Zhang, Rui; Mou, Yan-hua; Hou, Zhuang; Guo, Chun published the artcile< Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is benzylselanyl dichlorophenylethyltriazole preparation antifungal antitumor SAR pharmacokinetics docking; dichlorophenyl phenylselanylethylimidazole preparation antifungal antitumor SAR pharmacokinetics docking; Antifungal; CYP51; Miconazole; Selenium; Superior pharmacological profile.

A series of selenium-containing miconazoles. compounds I, II [R = H, 3-F, 2-Me, etc. ; X= F, Cl], III [R = H, 3-F, 2-Me, etc.; X= F, C] were identified as potent antifungal drugs in our previous study. Representative compound I (MIC = 0.01μg/mL against C.alb. 5314) proved efficacious in inhibiting the growth of fungal pathogens. However, further study showed lead compound I exhibited potential hemolysis, significant cytotoxic effect and unfavorable metabolic stability and was therefore modified to overcome these drawbacks. In this article, the further optimization of selenium-containing miconazole derivatives resulted in the discovery of similarly potent compound II [R = 4-F ; X= F] (MIC = 0.02μg/mL against C.alb. 5314), exhibiting a superior pharmacol. profile with decreased rate of metabolism, cytotoxic effect and hemolysis. Furthermore, compound II [R = 4-F ; X= F] showed fungicidal activity against Candida albicans and significant effects on the treatment of resistant Candida albicans infections. Meanwhile, compound II [R = 4-F ; X= F] not only could reduce the ergosterol biosynthesis pathway by inhibiting CYP51, but also inhibited biofilm formation. More importantly, compound II [R = 4-F ; X= F] also shows promising in vivo efficacy after i.p. injection and the PK study of compound II [R = 4-F ; X= F] was evaluated. In addition, mol. docking studies provide a model for the interaction between the compound II [R = 4-F ; X= F] and the CYP51 protein. Overall, it was believed that these selenium-containing miconazole compounds can be further developed for the potential treatment of fungal infections.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Cui-Tian’s team published research in Organic Letters in 2021-02-05 | 611-19-8

Organic Letters published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Quality Control of 611-19-8.

Wang, Cui-Tian; Li, Ming; Ding, Ya-Nan; Wei, Wan-Xu; Zhang, Zhe; Gou, Xue-Ya; Jiao, Rui-Qiang; Wen, Ya-Ting; Liang, Yong-Min published the artcile< Alkylation-Terminated Catellani Reactions by Cyclobutanol C-C Cleavage>, Quality Control of 611-19-8, the main research area is aromatic hydrocarbon preparation; cyclobutanol aryl iodide benzoyloxyamine Catellani reaction; alkyl iodide aryl cyclobutanol Catellani reaction; iodide aryl bromide cyclobutanol Catellani reaction; benzyl chloride aryl iodide cyclobutanol Catellani reaction.

This report describes the first application of a cyclobutanol ring-opening procedure in the Catellani termination reaction, which includes two β-carbon elimination processes. This tandem reaction features mild conditions, high yields, good functional group tolerance, and a broad substrate scope. Meanwhile, four types of electrophiles (N-benzoyloxyamines, e.g., 4-benzoyloxymorpholine, alkyl iodides RR1CHI [R = CH3, (CH2)3CH3, (CH2)4CH3, (CH2)4C(O)2CH3, (CH2)7CH3; R1 = H, CH3], aryl bromides R2C6H4Br [R2 = 2-C(O)2Me, 4-CF3, 4-C(O)2Me], and benzyl chlorides R3C6H4CH2Cl = H, 2-Me, 2-Cl, 3-Me, 4-F, 4-OMe) are quite compatible with this termination reaction for the construction of various types of polysubstituted aromatic hydrocarbons, e.g., I.

Organic Letters published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Quality Control of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Han-Ying’s team published research in European Journal of Organic Chemistry in 2019 | 611-19-8

European Journal of Organic Chemistry published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Peng, Han-Ying; Dong, Zhi-Bing published the artcile< Transition-Metal-Free C(sp3)-S Coupling in Water: Synthesis of Benzyl Dithiocarbamates Using Thiuram Disulfides as an Organosulfur Source>, COA of Formula: C7H6Cl2, the main research area is dithiocarbamate benzyl green synthesis; benzyl halide nucleophilic substitution tetraalkylthiuram disulfide water.

A simple, highly efficient and environmentally benign method for the synthesis of benzyl dithiocarbamates was reported. Without addition of metal catalyst, a series of 34 benzyl dithiocarbamates were obtained in good to excellent yields by treating benzyl halides with tetraalkylthiuram disulfides in water. The protocol allows easy access to C(sp3)-S bond formation, features the advantages of easy performance, environmental friendliness, good to excellent yields, and good functional tolerance, showing potential value for the preparation of some biol. active compounds

European Journal of Organic Chemistry published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rajabi, Mahboobeh’s team published research in Research on Chemical Intermediates in 2020-08-31 | 611-19-8

Research on Chemical Intermediates published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Electric Literature of 611-19-8.

Rajabi, Mahboobeh; Albadi, Jalal; Momeni, Ahmadreza published the artcile< Click synthesis of 1,4-disubstituted-1,2,3-triazoles catalyzed by melamine-supported CuO nanoparticles as an efficient recyclable catalyst in water>, Electric Literature of 611-19-8, the main research area is triazole preparation regioselective; benzyl chloride alkylchloride ethynylbenzene click reaction copper nanocatalyst.

Melamine-supported CuO nanoparticles (M-CuO nanocatalyst) are prepared as a new and efficient recyclable nanocatalyst for the regioselective synthesis of 1,2,3-triazoles I (R = Me, Ph, 4-methylphenyl, etc.; R1 = H, OMe) in water. This new nanocatalyst was prepared by co-precipitation method and characterized by FT-IR spectral study, TGA, DSC, XRF, ICP-OES, XRD, SEM, EDS and BET anal. A wide range of 1,4-disubstituted-1,2,3-triazoles I was synthesized from reaction of benzyl halides or alkyl halides RCH2Cl with Ph acetylene and sodium azide in high yields. M-CuO nanocatalyst could be reused more than 6 times without considerable loss of its initial activity.

Research on Chemical Intermediates published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Electric Literature of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Xi’s team published research in European Journal of Organic Chemistry in 2020-10-26 | 611-19-8

European Journal of Organic Chemistry published new progress about Allylic halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Name: 1-Chloro-2-(chloromethyl)benzene.

Wang, Xi; Wu, Chun-Yan; Li, Yue-Sheng; Dong, Zhi-Bing published the artcile< Three-Component Synthesis of 2-Substituted Thiobenzoazoles Using Tetramethyl Thiuram Monosulfide (TMTM) as Thiocarbonyl Surrogate>, Name: 1-Chloro-2-(chloromethyl)benzene, the main research area is thiobenzoazole preparation tetramethyl thiuram monosulfide thiocarbonyl.

A metal-free synthesis of 2-benzyl/allyl-substituted thiobenzoazoles was developed starting from tetra-Me thiuram monosulfide (TMTM) which served as thiocarbonyl surrogate. By using 2-aminophenols (or 2-aminothiophenols, or 1,2-phenylenediamines) and TMTM as starting materials, 2-mercaptobenzoazoles could be synthesized efficiently. The subsequent C-S bond formation with benzyl/allyl halides gave the final products (2-benzyl/allyl-substituted thiobenzoazoles) with good to excellent yields. The metal-free conditions, inexpensive and easily available starting materials, and broad substrate scope are the advantageous features of this protocol.

European Journal of Organic Chemistry published new progress about Allylic halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Name: 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acharya, Badri Narayan’s team published research in Monatshefte fuer Chemie in 2021-03-31 | 611-19-8

Monatshefte fuer Chemie published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Synthetic Route of 611-19-8.

Acharya, Badri Narayan; Ghorpade, RamaRao; Singh, Kshetra Pal; Kumar, Deo; Nayak, Sabita published the artcile< Synthesis and muscarinic acetylcholine receptor (mAChR) antagonist activity of substituted piperazine-triazoles>, Synthetic Route of 611-19-8, the main research area is dibenzyltriazolyl methyl piperazine preparation muscarinic acetylcholine receptor antagonist SAR; benzyltriazolyl methylpiperazinylchlorobenzonitrile preparation muscarinic acetylcholine receptor antagonist SAR docking.

This study described synthesis of a series of piperazine-triazole derivatives and their ex vivo evaluation for preliminary muscarinic acetylcholine receptor (mAChR) blocking activity on rat ileum model. A mol. based on benzonitrile piperazine triazole scaffold showed good tissue relaxation and blocking of neurotransmitter ACh in the ex vivo experiment

Monatshefte fuer Chemie published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Synthetic Route of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics