Category: 5781-53-3

《Intramolecular Cyclization of 2-Alkynylphenylcarbonyls With a Pendant Double Bond under Copper Catalysis: A General Approach to Norabietane Core Structure》 was written by Kang, Juyeon; Lee, Ju Hui; Lee, Junseong; Oh, Chang Ho. Formula: C3H3ClO3This research focused ontricyclic compound preparation; alkynyl phenylcarbonyl cyclization copper catalyst. The article conveys some information:

Synthetic routes leading to [6,6,6]-tricyclic compounds I [R = H, Me, C(O)OMe; R1 = H, OMe; R2 = H, OMe; R3 = H, CH(CH3)2; R2R3 = -OCH2O-; R4 = H, Me, OMe, Ph, etc.; R5 = H, C(O)OMe, C(O)OEt; R6 = H, Me, C(O)OMe, etc.] and II (R6 = H, Me; R7 = H, C(O)OMe) were reported using metal catalysts from ene-yne aldehydes. Based on this result, the synthesis of various [6,6,6]-tricyclic compounds I and II is reported using transition metal-catalyzed cyclization from enyne-carbonyl substrates. Tricyclic compounds containing the CO2Me group would be the prospective precursors of the natural product Lepenine.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of Methyl 2-chloro-2-oxoacetateIn 2020 ,《Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Atack, Thomas C.; Raymond, Donald D.; Blomquist, Christa A.; Pasaje, Charisse Flerida; McCarren, Patrick R.; Moroco, Jamie; Befekadu, Henock B.; Robinson, Foxy P.; Pal, Debjani; Esherick, Lisl Y.; Ianari, Alessandra; Niles, Jacquin C.; Sellers, William R.. The article conveys some information:

FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured parasites. However, due to the highly conserved nature of the binding pockets of FKBPs and the immunosuppressive properties of these drugs, there is a need for compounds that selectively inhibit FKBP35 and lack the undesired side effects. In contrast to human FKBPs, FKBP35 contains a cysteine, C106, adjacent to the rapamycin binding pocket, providing an opportunity to develop targeted covalent inhibitors of Plasmodium FKBP35. Here, we synthesize inhibitors of FKBP35, show that they directly bind FKBP35 in a model cellular setting, selectively covalently modify C106, and exhibit antiplasmodium activity in blood-stage cultured parasites. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Quality Control of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sun, Yue; Yang, Zi-Hui; Gu, Wen published an article in Chinese Journal of Structural Chemistry. The title of the article was 《Synthesis, crystal structure and antifungal activity of new furan-1,3,4-oxadiazole carboxamide derivatives》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

A series of novel furan-1,3,4-oxadiazole carboxamide derivatives I (R = H, Me, Br, Cl, F) were designed, synthesized and characterized by spectroscopic methods including HR-MS, 1H- and 13C-NMR. The crystal structure of compound I (R = Br) was determined by single-crystal X-ray diffraction. The compound crystallizes in the triclinic system, space group P1 with a = 4.7261(5), b = 10.4672(11), c = 14.5886(13) Å, α = 106.081(4)°, β = 91.043(3)°, γ = 99.456(4)°, Z = 2, V = 682.48(12) Å3, Mr = 348.16, Dc = 1.694 Mg/m3, S = 1.008, μ = 3.025 mm-1, F(000) = 348, the final R = 0.0775 and wR = 0.2080 for 2774 observed reflections (I > 2σ(I)). There are two kinds of hydrogen bonds (N(3)-H(3A)…N(2) and C(8)-H(8A)…O(3)) present in its crystal structure. The preliminary antifungal assay showed that compounds I (R = Cl, F) exhibited significant antifungal activities against several plant pathogenic fungi. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Access to galectin-3 inhibitors from chemoenzymic synthons》 was written by Dussouy, Christophe; Teletchea, Stephane; Lambert, Annie; Charlier, Cathy; Botez, Iuliana; Ceuninck, Frederic De; Grandjean, Cyrille. Quality Control of Methyl 2-chloro-2-oxoacetate And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Chemoenzymic strategies are useful for providing both regio- and stereoselective access to bioactive oligosaccharides. We show herein that a glycosynthase mutant of a Thermus thermophilus α-glycosidase can react with unnatural glycosides such as 6-azido-6-deoxy-D-glucose/glucosamine to lead to β-D-galactopyranosyl-(1→3)-D-glucopyranoside or β-D-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-D-glucopyranoside derivatives bearing a unique azide function. Taking advantage of the orthogonality between the azide and the hydroxyl functional groups, the former was next selectively reacted to give rise to a library of galectin-3 inhibitors. Combining enzyme substrate promiscuity and bioorthogonality thus appears as a powerful strategy to rapidly access to sugar-based ligands. The results came from multiple reactions, including the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Zn-Mediated Fragmentation of Tertiary Alkyl Oxalates Enabling Formation of Alkylated and Arylated Quaternary Carbon Centers》 was written by Ye, Yang; Chen, Haifeng; Sessler, Jonathan L.; Gong, Hegui. Computed Properties of C3H3ClO3This research focused onzinc mediated fragmentation tertiary alkyl oxalate; alkylated arylated quaternary carbon center preparation; activated alkene aryl nickel intermediate preparation reaction. The article conveys some information:

Zn-mediated reduction of readily accessible dialkyl oxalates derived from tertiary alcs. provides an efficient approach to C-O bond fragmentation and alkyl radical formation. With MgCl2 as the indispensable additive and Ni as the promoter, trapping the radical with activated alkenes and aryl-Ni intermediates allows for the generation of alkylated and arylated all-carbon quaternary centers. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Catalytic synthesis of thiazolidines by the reaction of Nef-isocyanide reaction》 was written by Daghlavi, Amneh; Kowsari, Elaheh; Abdouss, Majid; Ghasemi, Mohammad Hadi; Asadi, Elham. HPLC of Formula: 5781-53-3 And the article was included in Research on Chemical Intermediates in 2020. The article conveys some information:

A practical and efficient method for the synthesis of thiazolidine derivatives via Nef-isocyanide three-component reaction using supported phosphoric acid on graphene oxide (GO-H2PO4) is described. A relatively simple method starting with cyclic and acyclic thiourea was employed. The catalyst was characterized using FTIR, SEM, energy-dispersive x-ray spectroscopy, and X-ray diffraction techniques. Using a combination of acetonitrile as solvent and GO-H2PO4 as a catalytic system, the best results were obtained. All products were characterized using m.p., FTIR, MASS, 1H NMR, and 13C NMR techniques. The use of com. available chems., reusability of the catalyst, high yields, decreased environmental hazards, with no need for the separation of stereoisomers, and, consequently, a reduced number of overall steps are the advantages of this approach that make it an appropriate choice at an increased scale. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Exploring the Relationship between BODIPY Structure and Spectroscopic Properties to Design Fluorophores for Bioimaging》 was published in Chemistry – A European Journal in 2020. These research results belong to Donnelly, Joanna L.; Offenbartl-Stiegert, Daniel; Marin-Beloqui, Jose M.; Rizzello, Loris; Battaglia, Guiseppe; Clarke, Tracey M.; Howorka, Stefan; Wilden, Jonathan D.. Product Details of 5781-53-3 The article mentions the following:

Designing chromophores for biol. applications requires a fundamental understanding of how the chem. structure of a chromophore influences its photophys. properties. We here describe the synthesis of a library of BODIPY dyes, exploring diversity at various positions around the BODIPY core. The results show that the nature and position of substituents have a dramatic effect on the spectroscopic properties. Substituting in a heavy atom or adjusting the size and orientation of a conjugated system provides a means of altering the spectroscopic profiles with high precision. The insight from the structure-activity relationship was applied to devise a new BODIPY dye with rationally designed photochem. properties including absorption towards the near-IR region. The dye also exhibited switch-on fluorescence to enable visualization of cells with high signal-to-noise ratio without washing-out of unbound dye. The BODIPY-based probe is non-cytotoxic and compatible with staining procedures including cell fixation and immunofluorescence microscopy. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xian; Feng, Xiaoliang; Chen, Fan; Zhu, Shengqing; Qing, Feng-Ling; Chu, Lingling published an article in 2021. The article was titled 《Divergent Aminocarbonylations of Alkynes Enabled by Photoredox/Nickel Dual Catalysis》, and you may find the article in Angewandte Chemie, International Edition.Application of 5781-53-3 The information in the text is summarized as follows:

A metallaphotoredox-catalyzed strategy for the selective and divergent aminocarbonylation of alkynes with amines and 1 atm of CO was reported. This synergistic protocol not only enables the Markovnikov-selective hydroaminocarbonylation of alkynes to afford α,β-unsaturated amides, but also facilitated a sequential four-component hydroaminocarbonylation/radical alkylation in the presence of tertiary and secondary alkyl boronate esters, which allowed for straightforward conversion of alkynes into corresponding amides. Preliminary mechanistic studied disclose that a photoinduced oxidative insertion of aniline and CO into nickel followed by a migratory insertion of (carbamoyl)nickel species was involved. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Ying; Xu, Lanting; Jiang, Yongwen; Ma, Dawei published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides》.HPLC of Formula: 5781-53-3 The article contains the following contents:

α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and Et cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Addnl., the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted Et cyanoacetates proceeds smoothly at 60°C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls. Thus, e.g., 4-chloroanisole + Et cyanoacetate → 2-(4-methoxyphenyl)acetonitrile (up to 80%). In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Reductive Coupling between C-N and C-O Electrophiles》 were He, Rong-De; Li, Chun-Ling; Pan, Qiu-Quan; Guo, Peng; Liu, Xue-Yuan; Shu, Xing-Zhong. And the article was published in Journal of the American Chemical Society in 2019. Computed Properties of C3H3ClO3 The author mentioned the following in the article:

The cross-electrophile reaction is a promising strategy for C-C bond formation. Recent studies have focused mainly on reactions with organic halides. Here we report a coupling reaction between C-N and C-O electrophiles that demonstrates the possibility of constructing a C-C bond via C-N and C-O cleavage. Several reactions between benzyl/aryl ammonium salts and vinyl/aryl C-O electrophiles have been studied. Preliminary mechanistic studies revealed that the benzyl ammoniums were activated through a radical mechanism. The results came from multiple reactions, including the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics