Category: 5781-53-3

Liu, Jianrong; Ma, Ling; Song, Chang; Xing, Hui; Cen, Shan; Lin, Wenhan published their research in ACS Chemical Biology in 2021. The article was titled 《Anti-HIV Effects of Baculiferins Are Regulated by the Potential Target Protein DARS》.HPLC of Formula: 5781-53-3 The article contains the following contents:

Baculiferins are a group of marine sponge-derived polycyclic alkaloids with anti-HIV (human immunodeficiency virus) activities. To identify addnl. baculiferin-based congeners for SAR anal. and to investigate the mode of action, a total of 18 new baculiferin-type derivatives were synthesized. The inhibitory activities of the congeners against the HIV-1 virus were evaluated in vitro, and the relevant SAR was discussed. Compound 18 exerted the most potent activity toward VSV-G-pseudotyped HIV-1 (IC50 of 3.44μM) and HIV-1 strain SF33 (IC50 of 2.80μM) in vitro. To identify the cellular targets, three photoaffinity baculiferin probes were simultaneously synthesized. Photoaffinity labeling experiments together with LC-MS/MS data identified aspartate-tRNA ligase (DARS) as a putative target protein of 18. The overexpression and knockdown of DARS in HEK293T cells provided addnl. data to demonstrate that DARS is a potential target protein in the regulation of HIV virus infection. The modes of antiviral baculiferins 13 and 18 binding to DARS were determined by a mol. docking simulation. Thus, baculiferin 18 is considered a promising lead as a new mol. target for the development of anti-HIV agents. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C3H3ClO3In 2019 ,《Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay》 appeared in ACS Infectious Diseases. The author of the article were Lee, Minhee; Zhao, Jinshi; Kwak, Seung-Hwa; Cho, Jae; Lee, Myungju; Gillespie, Robert A.; Kwon, Do-Yeon; Lee, Hyunji; Park, Hyun-Ju; Wu, Qinglin; Zhou, Pei; Hong, Jiyong. The article conveys some information:

The UDP-2,3-diacylglucosamine pyrophosphatase LpxH in the Raetz pathway of lipid A biosynthesis is an essential enzyme in the vast majority of Gram-neg. pathogens and an excellent novel antibiotic target. The 32P-radioautog. thin-layer chromatog. assay has been widely used for anal. of LpxH activity, but it is inconvenient for evaluation of a large number of LpxH inhibitors over an extended time period. Here, we report a coupled, nonradioactive LpxH assay that utilizes the recently discovered Aquifex aeolicus lipid A 1-phosphatase LpxE for quant. removal of the 1-phosphate from lipid X, the product of the LpxH catalysis; the released inorganic phosphate is subsequently quantified by the colorimetric malachite green assay, allowing the monitoring of the LpxH catalysis. Using such a coupled enzymic assay, we report the biochem. characterization of a series of sulfonyl piperazine LpxH inhibitors. Our anal. establishes a preliminary structure-activity relationship for this class of compounds and reveals a pharmacophore of two aromatic rings, two hydrophobic groups, and one hydrogen-bond acceptor. We expect that our findings will facilitate the development of more effective LpxH inhibitors as potential antibacterial agents. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schirmer, Tobias E.; Rolka, Alessa B.; Karl, Tobias A.; Holzhausen, Ferdinand; Koenig, Burkhard published their research in Organic Letters in 2021. The article was titled 《Photocatalytic C-H Trifluoromethylthiolation by the Decatungstate Anion》.Application of 5781-53-3 The article contains the following contents:

A broadly applicable method for the trifluoromethylthiolation of methylene C(sp3)-H, methine C(sp3)-H, α-oxygen C(sp3)-H, and formyl C(sp2)-H bonds is presented using the decatungstate anion as the sole catalyst. By adjusting the substrate ratio and reaction concentration, this method was applied to 40 examples in good regioselectivities, including the derivatization of natural products. Furthermore, SCF3-drug analogs were synthesized by subsequent functionalization of the SCF3 products, highlighting the importance of this photocatalyzed C-H functionalization. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe》 were Ding, Lele; Tian, Zhenhao; Hou, Jie; Dou, Tongyi; Jin, Qiang; Wang, Dandan; Zou, Liwei; Zhu, Yadi; Song, Yunqing; Cui, Jingnan; Ge, Guangbo. And the article was published in Chinese Chemical Letters in 2019. Application of 5781-53-3 The author mentioned the following in the article:

Carboxylesterase 1 (CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiol. processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biol. systems, a practical and isoform-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity, sensitivity, enzymic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CES1 activities in several biol. systems including tissue preparations, living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biol. systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clin. practice and fundamental research. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Bai, Junping; Zhou, Junliang; Ji, Xin; Wang, Nannan; Dong, Xiaochun; Wu, Wei; Zhao, Weili published an article in Chinese Chemical Letters. The title of the article was 《Development of environment-insensitive and highly emissive BODIPYs via installation of N,N’-dialkylsubstituted amide at meso position》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

Fluorescent dyes play a crucial role in fluorescence imaging and sensing technol. However, there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane permeability. Fluorescent dyes with strong fluorescence emission in both nonpolar and polar solvents are highly desirable. In this manuscript, we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N’-dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-Light-Enabled Paterno-Buchi Reaction via Triplet Energy Transfer for the Synthesis of Oxetanes》 was written by Rykaczewski, Katie A.; Schindler, Corinna S.. Reference of Methyl 2-chloro-2-oxoacetate And the article was included in Organic Letters in 2020. The article conveys some information:

One of the most efficient ways to synthesize oxetanes is the light-enabled [2+2] cycloaddition reaction of carbonyls and alkenes, referred to as the Paterno-Buchi reaction. The reaction conditions for this transformation typically require the use of high energy UV light to excite the carbonyl, limiting the applications, safety, and scalability. We herein report the development of a visible-light-mediated Paterno-Buchi reaction protocol that relies on triplet energy transfer from an iridium-based photocatalyst to the carbonyl substrates. This mode of activation is demonstrated for a variety of aryl glyoxylates and negates the need for both visible-light-absorbing carbonyl starting materials and UV light to enable access to a variety of functionalized oxetanes in up to 99% yield. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Reference of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Reference of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jian-Qiang; Tu, Xiaodong; Tang, Qi; Li, Ke; Xu, Liang; Wang, Siyu; Ji, Mingjuan; Li, Zhiming; Wu, Jie published an article in 2021. The article was titled 《Efficient access to aliphatic esters by photocatalyzed alkoxycarbonylation of alkenes with alkyloxalyl chlorides》, and you may find the article in Nature Communications.Related Products of 5781-53-3 The information in the text is summarized as follows:

A strategy to access aliphatic esters RC(O)OR1 (R = 2-chloro-2-(4-methylphenyl)ethyl, 2-chloroheptyl, 2-chloro-2-cyclohexylethyl, 2-chloro-3-(2,3-dihydro-1H-indol-1-yl)-2-methyl-3-oxopropyl, etc.; R1 = Et, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl, 4-phenylbutyl, etc.) from olefins RH through a photocatalyzed alkoxycarbonylation reaction was reported. Alkyloxalyl chlorides R1C(O)2C(O)Cl, generated in situ from the corresponding alcs. R1OH and oxalyl chloride, are engaged as alkoxycarbonyl radical fragments under photoredox catalysis. This transformation tolerates a broad scope of electron-rich and electron-deficient olefins and provides the corresponding β-chloro esters in good yields. Addnl., a formal β-selective alkene alkoxycarbonylation is developed. Moreover, a variety of oxindole-3-acetates I (R2 = H, t-Bu, CN, me, etc.; R3 = Me, Bn; R4 = Me, Et, Bn, i-Pr), Et 2-(1-methyl-2-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)acetate, Et 2-(7-methyl-6-oxo-1,2,3,4,6,7-hexahydroazepino[3,2,1-hi]indol-7-yl)acetate, Et 2-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[g]indol-3-yl)acetate and furoindolines II are prepared in good to excellent yields. A more concise formal synthesis of (±)-physovenine is accomplished as well. With these strategies, a wide range of natural-product-derived olefins and alkyloxalyl chlorides are also successfully employed. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Related Products of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Related Products of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Chen, Ying; Wang, Fei; Liu, Bo-Xi; Rao, Wei-Dong; Wang, Shun-Yi published an article in Organic Chemistry Frontiers. The title of the article was 《A Ni(II)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates》.Product Details of 5781-53-3 The author mentioned the following in the article:

A Ni(II)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates to synthesize benzylic sulfides/selenides under mild conditions is developed. The oxalates prepared from the corresponding alcs. are used as carbon radical precursors to participate in the reaction. This strategy has the advantages of easy substrate availability and mild conditions, and provides a new method for the preparation of unsym. sulfides/selenides with good functional group tolerance. In the part of experimental materials, we found many familiar compounds, such as Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Ying; Sheng, Daopeng; Wang, Fei; Rao, Weidong; Shen, Shu-Su; Wang, Shun-Yi published an article in 2022. The article was titled 《Nickel(II)/TPMPP catalyzed reductive coupling of oxalates and tetrasulfides: synthesis of unsymmetric disulfides》, and you may find the article in Organic Chemistry Frontiers.Application In Synthesis of Methyl 2-chloro-2-oxoacetate The information in the text is summarized as follows:

A Ni(II)/tris(para-methoxyphenyl)phosphine (TPMPP)-catalyzed reductive cross-coupling reaction of benzyl oxalates and tetrasulfides to synthesize unsym. disulfides was reported. The benzyl oxalate works as the carbon radical precursor in this reaction. This catalytic strategy has the advantages of mild reaction conditions, wide substrate range and easy operation and provided a new approach for the preparation of unsym. disulfides with good functional group tolerance. Also, this method successfully achieved the synthesis of disulfides at the gram-scale, making it highly valuable. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application In Synthesis of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application In Synthesis of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Ishida, Toshiaki; Watanabe, Bunta; Mashiguchi, Kiyoshi; Yamaguchi, Shinjiro published an article in Phytochemistry Letters. The title of the article was 《Synthesis and structure-activity relationship of 16,17-modified gibberellin derivatives》.Related Products of 5781-53-3 The author mentioned the following in the article:

Gibberellins (GAs) are a group of diterpenoid plant hormones that control plant growth and development at various stages. Biol. active GAs share the common structures of a 3β-hydroxy group, a carboxy group at C-6, and a γ-lactone between C-4 and C-10. Hydroxylation at C-2β is a major deactivation step in many plant species, and hydroxylation at C-13 has been shown to weaken the binding affinity of GAs to their receptor proteins. In rice, bioactive GA4 has also been shown to be deactivated through 16α,17-epoxidation Moreover, 16,17-dihydro-16α,17-dihydroxy GA4 has been identified as an aglycon of its glucoside from rice. However, our knowledge on the biol. activity of 16,17-epoxidized GAs is currently limited to 16,17-dihydro-16α,17-epoxy GA4. Moreover, the bioactivity of 16,17-dihydro-16α,17-dihydroxy GA4 remains unknown. Here, we synthesized 16,17-epoxidized or dihydroxylated GA derivatives and performed a structure-activity relationship study using rice seedlings. 16,17-Epoxidation of bioactive GA1 and GA4 reduced their activity to promote elongation of rice leaf sheaths. Moreover, 16,17-dihydroxylation significantly decreased the activities of 16,17-dihydro-16α,17-epoxy GAs. These results suggest that GAs are deactivated in a stepwise manner via 16,17-epoxidation and hydrolysis of these epoxy groups. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Related Products of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Related Products of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics