Category: 5034-06-0

Wang, Dengjin; Nugent, William A. published an article in 2007, the title of the article was Synthesis of an anti-α-amino epoxide by one-carbon homologation of an α-amino ester: (2S,3S)-1,2-epoxy-3-(Boc-amino)-4-phenylbutane.Recommanded Product: trimethyloxosulphonium chloride And the article contains the following content:

The title compound was prepared by homologation of (S)-PhCH2CH(NHBoc)CO2C6H4NO2-4 with Me2S(O):CH2, conversion to (S)-PhCH2CH(NHBoc)CO2CH2Cl with HCl, and cyclization with LiAlH(OCMe3)3. Several other chloro ketones were also prepared The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Recommanded Product: trimethyloxosulphonium chloride

The Article related to aminophenylethyloxirane preparation chloro ketone intermediate, Heterocyclic Compounds (One Hetero Atom): Ethylene Oxides and other aspects.Recommanded Product: trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 1, 2020, Lowe, Robert A.; Taylor, Dale; Chibale, Kelly; Nelson, Adam; Marsden, Stephen P. published an article.Recommanded Product: 5034-06-0 The title of the article was Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds. And the article contained the following:

A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxypyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-related scaffolds were formed by addition of substituents to, cyclization reactions of, and fusion of addnl. ring(s) to the key bicyclic intermediates. A set of 53 screening compounds was designed, synthesized and evaluated in order to determine the biol. relevance of the scaffolds accessible using the synthetic approach. Two inhibitors of Hedgehog signalling, and four compounds with weak activity against the parasite P. falciparum, were discovered. Three of the active compounds may be considered to be indotropane or pyrrotropane pseudo natural products in which a tropane is fused with a fragment from another natural product class. It was concluded that the unified synthetic approach had yielded diverse scaffolds suitable for the design of performance-diverse screening libraries. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Recommanded Product: 5034-06-0

The Article related to tropane library synthesis hedgehog signaling inhibitor antimalarial, alkaloids, antimalarials, hedgehog signalling, molecular diversity, molecular scaffolds, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Recommanded Product: 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 31, 1989, Nadir, Upender K.; Sharma, Raman L.; Koul, Veerinder K. published an article.Safety of trimethyloxosulphonium chloride The title of the article was Reaction of dimethyloxosulfonium methylide with oxaziridines – transformation to azetidines. And the article contained the following:

Reaction of N-arylsufonyloxaziridines I (R = SO2C6H4H4Me-4, SO2Ph) with Me2S(O):CH2 yields azetidines whereas reaction with I (R = Me3C) leads to the corresponding azomethine PhCH:NCMe3. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Safety of trimethyloxosulphonium chloride

The Article related to oxaziridine cyclocondensation sulfonium methylide, azetidine, ylide sulfur cyclocondensation oxaziridine, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Safety of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 8, 2021, Cockerill, G. Stuart; Angell, Richard M.; Bedernjak, Alexandre; Chuckowree, Irina; Fraser, Ian; Gascon-Simorte, Jose; Gilman, Morgan S. A.; Good, James A. D.; Harland, Rachel; Johnson, Sara M.; Ludes-Meyers, John H.; Littler, Edward; Lumley, James; Lunn, Graham; Mathews, Neil; McLellan, Jason S.; Paradowski, Michael; Peeples, Mark E.; Scott, Claire; Tait, Dereck; Taylor, Geraldine; Thom, Michelle; Thomas, Elaine; Villalonga Barber, Carol; Ward, Simon E.; Watterson, Daniel; Williams, Gareth; Young, Paul; Powell, Kenneth published an article.Computed Properties of 5034-06-0 The title of the article was Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. And the article contained the following:

RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits that originated from a phys. property directed hit profiling exercise at Reviral. This exercise encompassed collaborations with a number of contract organizations with collaborative medicinal chem. and virol. during the optimization phase in addition to those utilized as the compound proceeded through preclin. and clin. evaluation. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clin. isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclin. species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers exptl. infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Computed Properties of 5034-06-0

The Article related to sisunatovir analog drug discovery synthesis rsv antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Computed Properties of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Singh, Man published an article in 2011, the title of the article was Effect of trimethylsulphoxonium halide surfactants on consolute solutions of immiscible solvents.Synthetic Route of 5034-06-0 And the article contains the following content:

Consolute solution temperatures (CST) ± 0.01 K and corresponding solubilities of phenol-water mixtures with 0.35 millimol kg-1 trimethylsulfoxonium chloride (TMSOC), trimethylsulfoxonium bromide (TMSOB), and trimethylsulfoxonium iodide (TMSOI) cationic surfactants are reported. The halide surfactants (TMSOX, X = Cl-, Br-, I-) decreased the CST by about 1.73-2.18° with 3-5% less mutual mixing as compared to phenol-water mixtures Three -CH3 (methyl) and the chloride (Cl-), bromide (Br-) and iodide (I-) halide ions of surfactants had developed hydrophobic and hydrophilic interactions, resp. The CST data are as TMSOI > TMSOB > TMSOC with corresponding mutual solubilities as TMSOC > TMSOB > TMSOI, with slightly stronger I–water interaction due to induced potential of a large-sized iodide ion. The hydrophobic interactions mildly dominated with smaller sized Cl- anion with slightly higher mutual solubility Comparatively, consolute solutions with surfactants are obtained at slightly lower temperatures with higher mutual mixing. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to trimethylsulfoxonium halide surfactant immiscible solvent consolute solution, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 13, 2014, Cummings, Maxwell D.; Lin, Tse-I.; Hu, Lili; Tahri, Abdellah; McGowan, David; Amssoms, Katie; Last, Stefaan; Devogelaere, Benoit; Rouan, Marie-Claude; Vijgen, Leen; Berke, Jan Martin; Dehertogh, Pascale; Fransen, Els; Cleiren, Erna; van der Helm, Liesbet; Fanning, Gregory; Nyanguile, Origene; Simmen, Kenny; Van Remoortere, Pieter; Raboisson, Pierre; Vendeville, Sandrine published an article.Application of 5034-06-0 The title of the article was Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase. And the article contained the following:

Structure-based macrocyclization of a 6-carboxylic acid indole chemotype has yielded potent and selective finger-loop inhibitors of the hepatitis C virus (HCV) NS5B polymerase. Lead optimization in conjunction with in vivo evaluation in rats identified several compounds showing (i) nanomolar potency in HCV replicon cells, (ii) limited toxicity and off-target activities, and (iii) encouraging preclin. pharmacokinetic profiles characterized by high liver distribution. This effort culminated in the identification of TMC647055 (I), a nonzwitterionic 17-membered-ring macrocycle characterized by high affinity, long polymerase residence time, and broad genotypic coverage. In vitro results of the combination of I with the HCV protease inhibitor TMC435 (simeprevir) supported an evaluation of this combination in patients with regard to virus suppression and resistance emergence. In a phase 1b trial with HCV genotype 1-infected patients, I was considered to be safe and well-tolerated and demonstrated potent antiviral activity, which was further enhanced in a combination study with TMC435. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application of 5034-06-0

The Article related to tmc647055 macrocyclic hepatitis c virus ns5b polymerase inhibitor preparation, antiviral activity pharmacokinetics biol evaluation tmc647055, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Application of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 4, 1990, Lai, J. S.; Wu, Rey F.; Lin, Ivan J. B.; Cheng, M. C.; Wang, Yu published an article.Product Details of 5034-06-0 The title of the article was Preparation of sulfur ylide complexes of platinum by phase transfer catalysis. And the article contained the following:

Various sulfur ylide complexes of Pt were prepared by the phase transfer catalysis (PTC). Thus, reaction of Pt(PR3)2Cl2 (R = Me, Ph) in CH2Cl2 with [S(O)(CH3)3]I under PTC/OH- conditions give complexes {Pt(PR3)2[(CH2)2S(O)(CH3)]}I, which contain a bidentate double sulfur ylide. With Pt(dppe)Cl2 [dppe = Ph2P(CH2)2PPh2] as starting material, a similar product was obtained. But when Pt(dppm)Cl2 [dppm = Ph2PCH2PPh2] was treated with [S(O)(CH3)3]Cl under PTC/OH- conditions, an unexpected product {Pt(PPh2CH3)(PPh2OH)[(CH2)2S(O)(CH3)]}Cl was obtained. This compound contains a bidentate double sulfur ylide and two unsym. phosphines resulting from the base hydrolysis of dppm. Compound {Pt(PPh3)2[(CH2)2S(O)(CH3)]}I, was subjected to an x-ray diffraction study. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Product Details of 5034-06-0

The Article related to phase transfer catalyzed sulfur ylide platinum, crystal structure platinum sulfur ylide complex, mol structure platinum sulfur ylide complex, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Product Details of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koolpe, Gary A.; Nelson, Wendel L.; Gioannini, T. L.; Angel, Lloyd; Simon, Eric J. published an article in 1984, the title of the article was Diastereomeric 6-desoxy-6-spiro-α-methylene-γ-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted Michael acceptor ligand.Quality Control of trimethyloxosulphonium chloride And the article contains the following content:

The title compounds I and II (R = Me or cyclopropylmethyl) were prepared by sequence reaction starting with direct alkylation of the diacetate ester of the parent ketone by the Reformatskii reagent prepared from Me α-(bromomethyl)acrylate  [4224-69-5], and their affinity for opioid binding sites was determined in crude rat brain membrane preparation by competition against [3H]naltrexone in presence and absence of Na+. 6α-(2-Carboxyallyl)-17-(cyclopropylmethyl)-4,5α-epoxy-3,6β,14-trihydroxymorphinan-γ-lactone (II; R = cyclopropylmethyl) [92398-30-6] was the most potent compound showing a 50% inhibition of binding at 5 nM. The data suggest a receptor nucleophile such as SH is located where it can add to the α,β-unsaturated carbonyl system of the above compound The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Quality Control of trimethyloxosulphonium chloride

The Article related to naltrexone butyrolactone diastereomer preparation, oxymorphone butyrolactone diastereomer preparation, opioid receptor binding morphinanone derivative, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 31, 2019, Szeto, Judy; Vu, Vi-Anh; Malerich, Jeremiah P.; Collins, Nathan published an article.Reference of trimethyloxosulphonium chloride The title of the article was Multi-step continuous flow synthesis of fluconazole. And the article contained the following:

The development of a flow chem. approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification The synthesis has been successfully demonstrated on a Vaportec com. flow chem. system. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Reference of trimethyloxosulphonium chloride

The Article related to fluconazole preparation continuous flow, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Reference of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 18, 2022, Rozema, Michael J.; Bhagavatula, Lakshmi; Christesen, Alan; Dunn, Travis B.; Ickes, Andrew; Kotecki, Brian J.; Marek, James C.; Moschetta, Eric; Morrill, Westin H.; Mulhern, Mathew; Rasmussen, Michael; Reynolds, Troy; Yu, Su published an article.Category: chlorides-buliding-blocks The title of the article was Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib. And the article contained the following:

Process development of a six-stage synthesis of upadacitinib, a JAK1 inhibitor, was described. It was highlighted by an enantioselective and diastereoselective hydrogenation of a tetrasubstituted olefin to set the two pyrrolidine stereocenters. Preparation of the main fragments and strategies to link them together, optimization of the imidazole cyclization and in-depth understanding of the formation of the urea moiety at the final stage were discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Category: chlorides-buliding-blocks

The Article related to upadacitinib preparation enantioselective diastereoselective, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics