Category: 5034-06-0

Hahn, Elliot F.; Fishman, Jack; Heilman, Richard D. published an article in 1975, the title of the article was Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists.Application of 5034-06-0 And the article contains the following content:

A series of 11 title compounds was prepared from naloxone [465-65-6] and naltrexone [16590-41-3] by the Wittig reaction, or by reaction with sulfur ylides or alkyllithium reagents. Most of the derivatives had oral potencies superior to the parent compounds in hot plate and tail clip tests in mice. 6-Desoxy-6-methylenenaloxone (I) [42971-34-6] and 6-desoxy-6-methylenenaltrexone (II) [55096-26-9] had the greatest increase in potency over parent compounds Structure-activity relations were discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application of 5034-06-0

The Article related to morphine antagonist noroxymorphone, naloxone analog morphine antagonist, naltrexone analog morphine antagonist, Pharmacodynamics: Structure-Activity and other aspects.Application of 5034-06-0

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On October 10, 2019, Hobbs, Heather; Bravi, Gianpaolo; Campbell, Ian; Convery, Maire; Davies, Hannah; Inglis, Graham; Pal, Sandeep; Peace, Simon; Redmond, Joanna; Summers, Declan published an article.Safety of trimethyloxosulphonium chloride The title of the article was Correction to Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway [Erratum to document cited in CA171:311735]. And the article contained the following:

There are errors in Figures 4 and 5 as well as the corresponding article and Supporting Information text; the corrections are provided here. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Safety of trimethyloxosulphonium chloride

The Article related to morpholine isostere pi3k akt mtor pathway inhibitor conformation erratum, Placeholder for records without volume info and other aspects.Safety of trimethyloxosulphonium chloride

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Leggio, Antonella; De Marco, Rosaria; Perri, Francesca; Spinella, Mariagiovanna; Liguori, Angelo published an article in 2012, the title of the article was Unusual Reactivity of Dimethylsulfoxonium Methylide with Esters.Name: trimethyloxosulphonium chloride And the article contains the following content:

Dimethylsulfoxonium methylide was treated with esters under mild conditions to rapidly afford the corresponding carboxylic acids at room temperature Moreover, by performing the procedure on enantiopure substrates, it was demonstrated that the reaction occurs without racemization. 18O-labeled reagents showed that the reaction does not proceed through an ester hydrolysis mechanism. The reactions are characterized by an unusual reactivity of the dimethylsulfoxonium methylide. This methodol. is general and can be considered a valid alternate route for ester cleavage when a substrate is sensitive to hydrolysis conditions. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Name: trimethyloxosulphonium chloride

The Article related to dimethylsulfoxonium methylide ester cleavage, carboxylic acid preparation mechanism, General Organic Chemistry: Synthetic Methods and other aspects.Name: trimethyloxosulphonium chloride

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On August 20, 2009, Mangion, Ian K.; Nwamba, Ikenna K.; Shevlin, Michael; Huffman, Mark A. published an article.Category: chlorides-buliding-blocks The title of the article was Iridium-Catalyzed X-H Insertions of Sulfoxonium Ylides. And the article contained the following:

The unique reactivity of sulfoxonium ylides as a carbene source is described for a variety of X-H bond insertions, taking advantage of a simple, com. available iridium catalyst. This method has applications in both intra- and intermol. reactivity, including a practical ring-expansion strategy for lactams. The safety and stability of sulfoxonium ylides recommend them as preferable surrogates to traditional diazo ketones and esters. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Category: chlorides-buliding-blocks

The Article related to sulfoxonium ylide iridium catalyst insertion reaction, General Organic Chemistry: Synthetic Methods and other aspects.Category: chlorides-buliding-blocks

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Braendstroem, Arne; Lamm, Bo published an article in 1974, the title of the article was Trimethyloxosulfonium chloride from the iodide through ion pair extraction.Product Details of 5034-06-0 And the article contains the following content:

Trimethyloxosulfonium chloride (I) was prepared from the iodide (II) by extraction with Ph-CH2N+Bu3Cl- (III) between CH2Cl2 and H2O. Thus, III in H2O was shaken with II in CH2Cl2 and the aqueous phase washed with CH2Cl2 and then evaporated to give I. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Product Details of 5034-06-0

The Article related to sulfonium trimethyloxo, Aliphatic Compounds: Sulfoxides and Sulfones and other aspects.Product Details of 5034-06-0

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On May 20, 2009, Schrittwieser, Joerg H.; Lavandera, Ivan; Seisser, Birgit; Mautner, Barbara; Kroutil, Wolfgang published an article.HPLC of Formula: 5034-06-0 The title of the article was Biocatalytic Cascade for the Synthesis of Enantiopure β-Azidoalcohols and β-Hydroxynitriles. And the article contained the following:

A three-step, two-enzyme, one-pot reaction sequence starting from prochiral α-chloroketones leading to enantiopure β-azidoalcs. and β-hydroxynitriles was described. Asym. bioreduction of α-chloroketones by hydrogen transfer catalyzed by an alc. dehydrogenase (ADH) established the stereogenic center in the first step to furnish enantiopure chlorohydrin intermediates. Subsequent biocatalyzed ring closure to the epoxide and nucleophilic ring opening with azide, N3-, or cyanide, CN-, both catalyzed by a nonselective halohydrin dehalogenase (Hhe), proceeded with full retention of configuration to give enantiopure β-azidoalcs. and β-hydroxynitriles, resp. Both enantiomers of various optically pure β-azidoalcs. and β-hydroxynitriles were synthesized. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009). The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).HPLC of Formula: 5034-06-0

The Article related to chloroketones reduction ring closure opening azide cyanide enzyme catalyzed, alc azido nitrile hydroxy asym preparation biocatalytic cascade, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 5034-06-0

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On February 28, 2007, Juhl, Martin; Sotofte, Inger published an article.Quality Control of trimethyloxosulphonium chloride The title of the article was rac-(1S,6S)-Methyl 6-methyl-2-oxobicyclo[4.1.0]heptane-1-carboxylate. And the article contained the following:

The crystal structure of the title compound, C10H14O3, was studied as part of a study of the chem. of nucleophilic 1,4-additions to highly electrophilic C=C double bonds. Crystallog. data are given. The cyclohexane ring adopts a half-chair conformation. The crystal packing is stabilized by van der Waals forces. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Quality Control of trimethyloxosulphonium chloride

The Article related to mol structure methyl oxobicycloheptanecarboxylate, crystal structure methyl oxobicycloheptanecarboxylate, Crystallography and Liquid Crystals: Crystal Structure and other aspects.Quality Control of trimethyloxosulphonium chloride

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Chloride – Wikipedia,
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On March 13, 2014, Lazerwith, Scott E.; Lew, Willard; Zhang, Jennifer; Morganelli, Philip; Liu, Qi; Canales, Eda; Clarke, Michael O.; Doerffler, Edward; Byun, Daniel; Mertzman, Michael; Ye, Hong; Chong, Lee; Xu, Lianhong; Appleby, Todd; Chen, Xiaowu; Fenaux, Martijn; Hashash, Ahmad; Leavitt, Stephanie A.; Mabery, Eric; Matles, Mike; Mwangi, Judy W.; Tian, Yang; Lee, Yu-Jen; Zhang, Jingyu; Zhu, Christine; Murray, Bernard P.; Watkins, William J. published an article.Category: chlorides-buliding-blocks The title of the article was Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection. And the article contained the following:

Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure-activity relationships for intrinsic cellular potency. The pharmacokinetic profile was enhanced through incorporation of heterocyclic ethers on the N-alkyl substituent. Hydroxyl groups were incorporated to modulate protein binding. Intrinsic potency was further improved through enantiospecific introduction of an olefin in the N-acyl motif, resulting in the discovery of the phase 2 clin. candidate GS-9669. The unexpected activity of this compound against the clin. relevant NS5B M423T mutant, relative to the wild type, was shown to arise from both the N-alkyl substituent and the N-acyl group. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Category: chlorides-buliding-blocks

The Article related to gs9669 clin candidate synthesis hepatitis c infection treatment, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Category: chlorides-buliding-blocks

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Sone, Toshihiko; Yamaguchi, Akitake; Matsunaga, Shigeki; Shibasaki, Masakatsu published an article in 2012, the title of the article was Enantioselective synthesis of 2,2-disubstituted terminal epoxides via catalytic asymmetric Corey-Chaykovsky epoxidation of ketones.Related Products of 5034-06-0 And the article contains the following content:

Catalytic asym. Corey-Chaykovsky epoxidation of various ketones RCOR1 (R = Ph, 1-naphthyl, n-octyl, etc., R1 = Me; R = Ph, 4-ClC6H4, 3-pyridyl, etc., R1 = ET, n-Pr, CHMe2) with dimethyloxosulfonium methylide using a heterobimetallic La-Li3-BINOL complex (LLB) is described. The reaction proceeded smoothly at room temperature in the presence of achiral phosphine oxide additives, and 2,2-disubstituted terminal epoxides I were obtained in high enantioselectivity (97%-91% ee) and yield (>99%-88%) from a broad range of Me ketones with 1-5 mol% catalyst loading. Enantioselectivity was strongly dependent on the steric hindrance, and other ketones, such as Et ketones and Pr ketones resulted in slightly lower enantioselectivity (88%-67% ee). The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Related Products of 5034-06-0

The Article related to enantioselective synthesis terminal epoxide asym corey chaykovsky epoxidation ketone, epoxide enantioselective synthesis corey chaykovsky epoxidation ketone, Heterocyclic Compounds (One Hetero Atom): Ethylene Oxides and other aspects.Related Products of 5034-06-0

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Chlorides – an overview | ScienceDirect Topics

Elkik, Elias; Imbeaux-Oudotte, Michele published an article in 1985, the title of the article was α-Fluoro-α-ethylenic ketones: preparation and reaction with dimethylsulfoxonium methylide.Quality Control of trimethyloxosulphonium chloride And the article contains the following content:

RCH:CFCOR1 (R = Ph, R1 = Ph, Bu, Me; R = Me2CH, R1 = Bu; R = Me3C, R1 = Ph), prepared from RCH:CFCO2Et and R1Li, underwent cyclization with Me2S(O):CH2 to give the epoxides I in 6-90% yield. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Quality Control of trimethyloxosulphonium chloride

The Article related to fluoroethenyl ketone cyclization dimethylsulfoxonium methylide, epoxide fluoroethenyl, Heterocyclic Compounds (One Hetero Atom): Ethylene Oxides and other aspects.Quality Control of trimethyloxosulphonium chloride

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics