Category: 5034-06-0

Izzo, Patrick T. published an article in 1963, the title of the article was Preparation of 1-aryl-1,2-cyclopropanedicarboximides. An application of dimethylsulfoxonium methylide.Related Products of 5034-06-0 And the article contains the following content:

1-Aryl-1,2-cyclopropanedicarboximides (I) were prepared in the presence of dimethylsulfoxonium methylide (II). Trimethylsulfoxonium chloride (III) was prepared by the method of Kuhn and Trischmann (CA 52, 14523g),m. 215-16°. III(1.5g.) added to a suspension of 0.29 g. NaH in 150 ml. tetrahydrofuran (THF), the mixture refluxed with evolution of H, stirred under reflux 45-60 min., and 0.012 mole N-methyl-2-arylmaleimide added to the solution (containing II), the mixture refluxed 2 hrs., cooled, alc. added, solvent removed in vacuo, the residue taken up in CH2Cl2, and the solution washed, dried, and evaporated gave I (R, R1, m.p., % yield given): Ph, H, 55-7°, 21; Ph, Et, 113-146deg;, 81; 3,4,5-trimethoxyphenyl, H, 136-86°, 21. The structure of I was supported by infrared and ultraviolet spectra, elementary analyses, and unsaturation tests. N-Methyl-2-phenylsuccinimide (37.8 g.), 39.2 g. N-bromosuccinimide, 0.4 g. Bz2O2, and 800 ml. CCl4 refluxed 24 hrs., stored 16 hrs. at room temperature, the succinimide removed, and the filtrate evaporated gave 49.2 g. 2-bromo-N-methyl2-phenylsuccinimide (IV), m. 110.5-12°. IV (7.5 g.) in 75 ml. C6H6 and 3 g. NEt3 kept 1 hr. at room temperature and the product separated gave 3.7 g. N-methyl-2-phenylmaleimide (V), m. 147-8°. Arylation of maleimide with 3,4,5-trimethoxyphenyldiazonium chloride gave 27% 2-chloro-3-(3,4,5-trimethoxyphenyl)succinimide (VI), m. 207-8° (decomposition). VI (2 g.) heated 0.5 hr. with 8 ml. 2,6-lutidine gave 1.5 g. 2-(3,4,5-trimethoxyphenyl)maleimide (VII), m. 211-13°. VII (2.8 g.) in 75 ml. THF brought to reflux with 0.24 g. NaH, then treated in 45 min. under reflux with 7 g. MeI in 10 ml. THF, the mixture refluxed 1.75 hrs., evaporated, and the residue taken up in CHCl8 gave 2 g. N-methyl-2-(3,4,5-trimethoxyphenyl)maleimide, m. 155-66deg;. V (8.9 g.) in 150 ml. CH2Cl2 treated in one lot with 0.054 mole MeCHN2 in Et2O gave 11.6 g. N,5-dimethyl-3-phenyl-1-pyrazoline-3,4-dicarboximide (VIII), m. 106-76deg; (decomposition). VIII (5.1 g.) in 50 ml. alc. was heated 0.5 hr., evapd, in vacuo, and the 4.4 g. of oil subjected to partition chromatography. Evaporation of material from the first peak gave 5% N-methyl-2-ethyl-3phenylmaleimide, m. 69-70°. The 2nd and slower moving component was obtained as the chief yield, 4 g., of N,3-dimethyl-1-phenyl-1,2-cyclopropanedicarboximide. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Related Products of 5034-06-0

trimethyloxosulphonium chloride(cas:5034-06-0) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Related Products of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kuhn, Richard; Trischmann, Heinrich published an article in 1958, the title of the article was Trimethylsulfoxonium ion.Synthetic Route of 5034-06-0 And the article contains the following content:

Me2SO (I) (16 g.) and 30 ml. MeI refluxed 3 days gave 25 g. octagonal plates of trimethylsulfoxonium iodide, Me3S+OI- (II), m. 200° (H2O), insoluble in C6H6, Et2O, CHCl3, petr. ether, sparingly soluble in MeOH, soluble in H2O (1.5 g. in 100 ml. at 20°). II shaken with an aqueous suspension of AgCl gave the H2O-soluble chloride, long needles, (MeOH-C6H6); picrate, decompose 210° (H2O); tetraphenylborate, m. 195° (aqueous EtOH). The reineckate, phosphomolybdate, and phosphotungstate are very little soluble Thermal decomposition of II gave I. II shaken with aqueous CO2-free Ag2O gave the oily hydroxide, which in the presence of air crystallized to the bicarbonate or carbonate. Reduction of II with HI gave blue-black crystals of the periodide, Me3S+I3-, which on boiling with H2O yielded iodine and Me3S+I-, identical with an authentic specimen. II (1 g.) and 5 ml. pyridine (III), refluxed 15 min., or the chloride and III refluxed 240 min. at 115°, gave quant. yields of III.MeI and III.MeCl, resp. Similarly II and quinoline gave the corresponding MeI derivative, m. 70-2° (monohydrate) (EtOH). II (2.2 g.), 0.7 g. p-O2NC6H4OH, and 10 g. Ag2O in Me2NCHO shaken 2 days at 20°, CHCl3 added, the mixture filtered, washed with 2N NaOH and H2O, dried, and concentrated gave 78% p-O2NC6H4OMe, m. 55°, b0.1 100-5°. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

trimethyloxosulphonium chloride(cas:5034-06-0) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Creighton, John A.; Green, John Henry Spencer; Harrison, David John published an article in 1969, the title of the article was Vibrational spectra of some trimethylsulfoxonium salts, -h9 and -d9.Product Details of 5034-06-0 And the article contains the following content:

The ir (3650-40 cm.-1) and Raman spectra of (CD3)3,SOI as a solid, Raman data for Me3SOCl and Me3SOI as salts and for the former in aqueous solution have been obtained, and the ir spectra recorded to 50 cm.-1 For the cations there are 36 fundamentals which for C3v geometry divide by Γ = 8 a1 + 4a2 + 12e. The previous interpretation of Me3SOI (C., et al., 1967) is largely confirmed by the new results. The frequencies 1339 and 1318 cm.-1 are now taken as a1 and e, resp., rather than as the reverse of this since, for the corresponding Raman lines of the chloride in solution, that at 1348 cm.-1 appears polarized while that at 1313 cm.-1 is depolarized. The ν (C-S) modes are observed in the Raman spectra. A feature of particular note in the Raman spectrum of solid Me3SOI is the prominent line at 1371 cm.-1 which appears to have its counterpart for (CD3)3SOI at 990 cm.-1 The corresponding ir bands are very weak. Comparison is made with the fundamental frequencies for the isoelectronic mol. (CH3)3PO, with small changes in the assignment. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Product Details of 5034-06-0

The Article related to vibrations methylsulfoxoniums, ir methylsulfoxoniums, raman methylsulfoxoniums, methylsulfoxoniums spectra, sulfoxoniums spectra, and other aspects.Product Details of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Blaschette, Armand; Buerger, Hans published an article in 1969, the title of the article was Vibrational spectra of some trimethyl-h9(and d9)-sulfoxonium halides.SDS of cas: 5034-06-0 And the article contains the following content:

The ir and Raman spectra of Me3SO)X (X = Cl, Br, I) and [(CD3)3SO]X1 (X1 = Cl, I) are reported; assignment of the vibrational bands are given. The size of the anions has a definite yet slight influence on the positions of the ir bands. Similarly as with trimethylphosphine oxide and silanolate, the deuteration changes the character of several vibrations. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).SDS of cas: 5034-06-0

The Article related to ir trimethylsulfoxonium halide, raman trimethylsulfoxonium halide, trimethylsulfoxonium halide spectra, and other aspects.SDS of cas: 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 31, 1991, Anchordoguy, Thomas J.; Cecchini, Christine A.; Crowe, John H.; Crowe, Lois M. published an article.Safety of trimethyloxosulphonium chloride The title of the article was Insights into the cryoprotective mechanism of dimethyl sulfoxide for phospholipid bilayers. And the article contained the following:

DMSO is a widely used cryoprotectant for biol. structures such as membranes. Despite hundreds of studies on the effects of this mol., surprisingly little is known about its cryoprotective mechanism. This study investigates the ability of various DMSO analogs to serve as cryoprotectants for liposomes. The data show that an increase in hydrophobicity progressively reduces the cryoprotective effect of sulfoxides. Addnl. experiments using phospholipid vesicles of varying composition demonstrate that DMSO is markedly less effective on liposomes carrying a net neg. charge. In fact, cryoprotection by DMSO was virtually eliminated in vesicles composed of 30% phosphatidylserine (a neg. charged lipid). Based on these results, it is suggested that the polar sulfoxide moiety of DMSO interacts electrostatically with phospholipid membranes and that this interaction is critical for DMSO’s cryoprotective effect for membranes. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Safety of trimethyloxosulphonium chloride

The Article related to phospholipid membrane cryoprotection dmso, General Biochemistry: Membranes and other aspects.Safety of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 16, 1980, Carle, Joergen S.; Christophersen, Carsten published an article.Quality Control of trimethyloxosulphonium chloride The title of the article was Dogger Bank itch. The allergen is (2-hydroxyethyl)dimethylsulfoxonium ion. And the article contained the following:

The causative agent of Dogger Bank Itch, an allergic contact dermatitis caused by exposure to Alcyonidium gelatinosum, was characterized and synthesized. This allergen is (2-hydroxyethyl)dimethylsulfoxonium ion. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Quality Control of trimethyloxosulphonium chloride

The Article related to allergen dimethylhydroxyethylsulfoxonium preparation property, alcyonidium allergen property, Immunochemistry: Chemistry and other aspects.Quality Control of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics