Category: 5034-06-0

Nagao, Yoshimitsu published the artcileUtilization of sulfur-containing leaving group. 7. Highly selective nonenzymic chiral induction into 3-methylglutaric acid and cis-4-cyclohexen-1,2-ylenebis(acetic acid) utilizing a functional five-membered heterocycle 4(R)-MCTT, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (1985), 50(21), 4072-80, database is CAplus.

Diamide I, prepared by treatment of 3-methylglutaric acid with 4(R)-(methoxycarbonyl)-1,3-thiazolidine-2-thione [4(R)-MCTT] in the presence of DCC in pyridine, was subjected to aminolysis with 1 equiv of piperidine in CH₂Cl₂ at -30° to give a mixture of diastereomers II [R₂N = piperidino, R¹₂N = MCTT moiety (III)] and II (R₂N = MCTT moiety, R¹₂N = piperidino) in a 88:12 ratio. III was separated by silica gel column chromatog. and treated with various nucleophiles to give optically pure bifunctional synthons (II; R₂N and R¹₂N = nucleophilic group) in high yields. Highly selective chiral induction into cis-4-cyclohexen-1,2-ylenebis(acetic acid) was also performed. Aminolysis of IV (R₂N and R¹₂N = MCTT moiety) (V) with 1 equiv of piperidine gave 94% diastereomer IV (R₂N = piperidino, R¹₂N = MCTT moiety). Similar chiral induction into cis-cyclohexan-1,2-xylenebis(acetic acid) and aminolysis of its 4(R)-MCTT diamide (VI) with piperidine were also carried out; opposite selectivity was obtained. The conformations of V and VI in a solvent, the relationship between the susceptibility of their conformations and environmental temperature, and the diastereoselectivity of the reaction are discussed on the basis of the 400-MHz ¹H NMR spectra.

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Elkik, Elias published the artcileα-Fluoro-α-ethylenic ketones: preparation and reaction with dimethylsulfoxonium methylide, SDS of cas: 5034-06-0, the publication is Tetrahedron Letters (1985), 26(33), 3977-80, database is CAplus.

RCH:CFCOR¹ (R = Ph, R¹ = Ph, Bu, Me; R = Me₂CH, R¹ = Bu; R = Me₃C, R¹ = Ph), prepared from RCH:CFCO₂Et and R¹Li, underwent cyclization with Me₂S(O):CH₂ to give the epoxides I in 6-90% yield.

Tetrahedron Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, SDS of cas: 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagao, Yoshimitsu published the artcileA new nonenzymatic chiral induction into prochiral meso compounds, Related Products of chlorides-buliding-blocks, the publication is Tetrahedron (1984), 40(8), 1215-23, database is CAplus.

A highly selective asym. induction into prochiral meso compounds used the chiral methoxycarbonyl-1,3-thiazolidine-2-thione I. Thus, condensation of I with the dimethylglutaric anhydride II in CH₂Cl₂-pyridine containing DCC gave 64.1% diamide III which underwent aminolysis with piperidine to give piperidide IV. Nucleophilic substitution reactions of IV gave the chiral meso compounds V [R = Me₂S⁺(O)C^–H, EtO₂CCH₂, 4-BrC₆H₄S, PhCHMeNH] in 79.1-98.7% yields. The mol. structure of IV was confirmed by x-ray crystal structure anal.

Tetrahedron published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gerstenberger, Ina published the artcileRegioselective and stereoselective transformations of enantiopure para-benzoquinone equivalents, Synthetic Route of 5034-06-0, the publication is European Journal of Organic Chemistry (1998), 643-650, database is CAplus.

The selectivities of typical transformations of the 1,4-benzoquinone Diels-Alder adduct I (RR¹ = bond) and its dihydro derivative I (R, R¹ = H) are highly dependent on the mechanistic path followed. To avoid ambiguities and to make sure of clearly defined regioselectivity, 1,4-benzoquinone monoethylene ketal was examined and proven not only to be an excellent dienophile but, of course, also to lead to reliable regioselectivity in subsequent transformations. This led to the correction of an earlier provisional assignment of alkylation products.

European Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Alkayal, Nazeeha published the artcileWell-defined polymethylene-based block co/terpolymers by combining anthracene/maleimide Diels-Alder reaction with polyhomologation, Category: chlorides-buliding-blocks, the publication is Polymer Chemistry (2015), 6(27), 4921-4926, database is CAplus.

A novel strategy towards well-defined polymethylene-based co/terpolymers, by combining the anthracene/maleimide Diels-Alder reaction with polyhomologation, is presented. For the synthesis of diblock copolymers the following approach was applied: (a) synthesis of α-anthracene-ω-hydroxy-polymethylene by polyhomologation using tri(9-anthracene-Me Pr ether)borane as the initiator, (b) synthesis of furan-protected-maleimide-terminated poly(ε-caprolactone) or polyethylene glycol and (c) the Diels-Alder reaction between the anthracene and maleimide-terminated polymers. In the case of triblock terpolymers the α-anthracene-ω-hydroxy-polymethylene was used as a macroinitiator for the ring-opening polymerization of D, L – lactide to afford an anthracene-terminated PM-b-PLA copolymer, followed by the Diels-Alder reaction with furan-protected maleimide-terminated poly (ε-caprolactone) or polyethylene glycol to give the triblock terpolymers. All the intermediates and final products were characterized by SEC, ¹H NMR, UV-VIS spectroscopy and DSC.

Polymer Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Creighton, John A. published the artcileVibrational spectra of some trimethylsulfoxonium salts, -h9 and -d9, COA of Formula: C3H9ClOS, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (1969), 25(7), 1314-18, database is CAplus.

The ir (3650-40 cm.-1) and Raman spectra of (CD3)3,SOI as a solid, Raman data for Me3SOCl and Me3SOI as salts and for the former in aqueous solution have been obtained, and the ir spectra recorded to 50 cm.-1 For the cations there are 36 fundamentals which for C3v geometry divide by Γ = 8 a1 + 4a2 + 12e. The previous interpretation of Me3SOI (C., et al., 1967) is largely confirmed by the new results. The frequencies 1339 and 1318 cm.-1 are now taken as a1 and e, resp., rather than as the reverse of this since, for the corresponding Raman lines of the chloride in solution, that at 1348 cm.-1 appears polarized while that at 1313 cm.-1 is depolarized. The ν (C-S) modes are observed in the Raman spectra. A feature of particular note in the Raman spectrum of solid Me3SOI is the prominent line at 1371 cm.-1 which appears to have its counterpart for (CD3)3SOI at 990 cm.-1 The corresponding ir bands are very weak. Comparison is made with the fundamental frequencies for the isoelectronic mol. (CH3)3PO, with small changes in the assignment.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, COA of Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hahn, Elliot F. published the artcileNarcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (1975), 18(3), 259-62, database is CAplus and MEDLINE.

A series of 11 title compounds was prepared from naloxone [465-65-6] and naltrexone [16590-41-3] by the Wittig reaction, or by reaction with sulfur ylides or alkyllithium reagents. Most of the derivatives had oral potencies superior to the parent compounds in hot plate and tail clip tests in mice. 6-Desoxy-6-methylenenaloxone (I) [42971-34-6] and 6-desoxy-6-methylenenaltrexone (II) [55096-26-9] had the greatest increase in potency over parent compounds Structure-activity relations were discussed.

Journal of Medicinal Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Herscovici, Jean published the artcileSynthesis of spiroepoxynucleosides, Recommanded Product: trimethyloxosulphonium chloride, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1986), 1297-301, database is CAplus.

The first syntheses of spiroepoxyhexopyranosylpurines and -pyrimidines, e.g., I (R = theophyllinyl, thyminyl), are reported. The spiro epoxy group was introduced at C-2′ by treatment of 2′-keto-β-L-nucleosides with dimethylsulfoxonium methylide. Addition of the sulfur ylide generated from Me₃SOCl and NaH afforded β-L–talo– and β-L–galacto-spironucleosides. Interestingly, when trimethylsulfoxonium chloride was activated with BuLi, an inversion took place at C-1′ leading exclusively to an α-L–galacto-spironucleoside.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Alkayal, Nazeeha published the artcileWell-defined polyethylene-based graft terpolymers by combining nitroxide-mediated radical polymerization, polyhomologation and azide/alkyne “click” chemistry, Quality Control of 5034-06-0, the publication is Polymer Chemistry (2016), 7(17), 2986-2991, database is CAplus.

Novel well-defined polyethylene-based graft terpolymers were synthesized via the “grafting onto” strategy by combining nitroxide-mediated radical polymerization (NMP), polyhomologation and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chem. Three steps were involved in this approach: (i) synthesis of alkyne-terminated polyethylene-b-poly(ε-caprolactone) (PE-b-PCL-alkyne) block copolymers (branches) by esterification of PE-b-PCL-OH with 4-pentynoic acid; the PE-b-PCL-OH was obtained by polyhomologation of dimethylsulfoxonium methylide to afford PE-OH, followed by ring opening polymerization of ε-caprolactone using PE-OH as a macroinitiator, (ii) synthesis of random copolymers of styrene (St) and 4-chloromethylstyrene (4-CMS) with various CMS contents, by nitroxide-mediated radical copolymerization (NMP), and conversion of chloride to azide groups by reaction with sodium azide (NaN₃) (backbone) and (iii) “click” linking reaction to afford the PE-based graft terpolymers. All intermediates and final products were characterized by high-temperature size exclusion chromatog. (HT-SEC), Fourier transform IR spectroscopy (FTIR), proton NMR spectroscopy (¹H NMR) and differential scanning calorimetry (DSC).

Polymer Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Quality Control of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Leggio, Antonella published the artcileUnusual Reactivity of Dimethylsulfoxonium Methylide with Esters, HPLC of Formula: 5034-06-0, the publication is European Journal of Organic Chemistry (2012), 2012(1), 114-118, database is CAplus.

Dimethylsulfoxonium methylide was treated with esters under mild conditions to rapidly afford the corresponding carboxylic acids at room temperature Moreover, by performing the procedure on enantiopure substrates, it was demonstrated that the reaction occurs without racemization. ¹⁸O-labeled reagents showed that the reaction does not proceed through an ester hydrolysis mechanism. The reactions are characterized by an unusual reactivity of the dimethylsulfoxonium methylide. This methodol. is general and can be considered a valid alternate route for ester cleavage when a substrate is sensitive to hydrolysis conditions.

European Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, HPLC of Formula: 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics