Category: 5034-06-0

Auguste, Sandra P. published the artcileSynthesis of uridine derivatives containing strategically placed radical traps as potential inhibitors of ribonucleotide reductase, Product Details of C3H9ClOS, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1995), 395-404, database is CAplus.

A series of uridine derivatives, e.g. I, have been prepared with a view to inhibiting the enzyme ribonucleotide reductase by trapping the radical responsible for initiating the reduction These have an oxime ether on the beta face at C-3 or C-2 of the ribose moiety. Compounds I were tested with ribonucleotide reductase, HSV-1, and cytomegalovirus but showed no activity.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Product Details of C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Alghamdi, Reem D. published the artcilePolyethylene grafted silica nanoparticles via surface-initiated polyhomologation: A novel filler for polyolefin nanocomposite, Application In Synthesis of 5034-06-0, the publication is Polymer (2022), 125029, database is CAplus.

Silica nanoparticles (SiO₂ NPs) were prepared and functionalized with polyethylene (PE@SiO₂ NPs) using the surface-initiated polyhomologation (SI-polyhomologation) technique. Polyolefin nanocomposites were fabricated later by melt mixing of different ratios of the as-prepared SiO₂ NPs and PE@SiO₂ NPs with linear low-d. polyethylene (LLDPE) and low-d. polyethylene (LDPE) matrixes. Firstly, SiO₂ NPs were modified with different alkoxysilane ligands, dichloro(divinyl)silane (DCDVS), allyl trimethoxysilane (ATMS), and vinyl triethoxylsilane (VTES). Subsequently, thexylborane, an initiator for SI-polyhomologation, was immobilized to the modified surface of SiO₂NPs through hydroboration reactions. Polyhomologation was then allowed to proceed by adding monomer solution to form polyethylene brushes covalently bonded to the surface of the NPs. Physiochem. characterizations had confirmed the morphol., chem. structure, and thermal stability for each step of modification reactions. LLDPE and LDPE nanocomposites were prepared by extrusion with SiO₂ NPs and PE@SiO₂ NPs as nanofillers. Finally, tensile tests and morphol. SEM-based analyses are presented to discuss the influence of the grafted PE on both the dispersion of the fillers and the mech. properties of the filler/matrix interphase.

Polymer published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Application In Synthesis of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sone, Toshihiko published the artcileEnantioselective synthesis of 2,2-disubstituted terminal epoxides via catalytic asymmetric Corey-Chaykovsky epoxidation of ketones, Recommanded Product: trimethyloxosulphonium chloride, the publication is Molecules (2012), 1617-1634, database is CAplus and MEDLINE.

Catalytic asym. Corey-Chaykovsky epoxidation of various ketones RCOR¹ (R = Ph, 1-naphthyl, n-octyl, etc., R¹ = Me; R = Ph, 4-ClC₆H₄, 3-pyridyl, etc., R¹ = ET, n-Pr, CHMe₂) with dimethyloxosulfonium methylide using a heterobimetallic La-Li₃-BINOL complex (LLB) is described. The reaction proceeded smoothly at room temperature in the presence of achiral phosphine oxide additives, and 2,2-disubstituted terminal epoxides I were obtained in high enantioselectivity (97%-91% ee) and yield (>99%-88%) from a broad range of Me ketones with 1-5 mol% catalyst loading. Enantioselectivity was strongly dependent on the steric hindrance, and other ketones, such as Et ketones and Pr ketones resulted in slightly lower enantioselectivity (88%-67% ee).

Molecules published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C6H8N2, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sone, Toshihiko published the artcileCatalytic Asymmetric Synthesis of 2,2-Disubstituted Terminal Epoxides via Dimethyloxosulfonium Methylide Addition to Ketones, Formula: C3H9ClOS, the publication is Journal of the American Chemical Society (2008), 130(31), 10078-10079, database is CAplus and MEDLINE.

Catalytic asym. Corey-Chaykovsky epoxidation of ketones with dimethyloxosulfonium methylide using an La-Li₃-tris(binaphthoxide) + Ar₃P:O (Ar = 2,4,6-trimethoxyphenyl) complex proceeded smoothly at room temperature, and 2,2-disubstituted terminal epoxides were obtained with high enantioselectivity (91-97%) and yield (>88-99%) from a broad range of Me ketones with 1-5 mol% catalyst loading. The use of achiral additive Ar₃P:O was important to achieve high enantioselectivity.

Journal of the American Chemical Society published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C19H14O2, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lai, J. S. published the artcilePreparation of sulfur ylide complexes of platinum by phase transfer catalysis, Application of trimethyloxosulphonium chloride, the publication is Journal of Organometallic Chemistry (1990), 393(3), 431-40, database is CAplus.

Various sulfur ylide complexes of Pt were prepared by the phase transfer catalysis (PTC). Thus, reaction of Pt(PR₃)₂Cl₂ (R = Me, Ph) in CH₂Cl₂ with [S(O)(CH₃)₃]I under PTC/OH^– conditions give complexes {Pt(PR₃)₂[(CH₂)₂S(O)(CH₃)]}I, which contain a bidentate double sulfur ylide. With Pt(dppe)Cl₂ [dppe = Ph₂P(CH₂)₂PPh₂] as starting material, a similar product was obtained. But when Pt(dppm)Cl₂ [dppm = Ph₂PCH₂PPh₂] was treated with [S(O)(CH₃)₃]Cl under PTC/OH^– conditions, an unexpected product {Pt(PPh₂CH₃)(PPh₂OH)[(CH₂)₂S(O)(CH₃)]}Cl was obtained. This compound contains a bidentate double sulfur ylide and two unsym. phosphines resulting from the base hydrolysis of dppm. Compound {Pt(PPh₃)₂[(CH₂)₂S(O)(CH₃)]}I, was subjected to an x-ray diffraction study.

Journal of Organometallic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Application of trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Apgar, James M. published the artcileIbrexafungerp: An orally active β-1,3-glucan synthesis inhibitor, SDS of cas: 5034-06-0, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127661, database is CAplus and MEDLINE.

We previously reported medicinal chem. efforts that identified MK-5204 (I), an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identified 4-pyridyl as the preferred replacement for the carboxamide of MK-5204, leading to improvements in antifungal activity in the presence of serum, and increased oral exposure. Reoptimizing the aminoether at C3 in the presence of this newly discovered C2 substituent, confirmed that the (R) t-Bu, Me aminoether of MK-5204 provided the best balance of these two key parameters, culminating in the discovery of ibrexafungerp (II), which is currently in phase III clin. trials. Ibrexafungerp displayed significantly improved oral efficacy in murine infection models, making it a superior candidate for clin. development as an oral treatment for Candida and Aspergillus infections.

Bioorganic & Medicinal Chemistry Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, SDS of cas: 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Szeto, Judy published the artcileMulti-step continuous flow synthesis of fluconazole, Related Products of chlorides-buliding-blocks, the publication is Journal of Flow Chemistry (2019), 9(1), 35-42, database is CAplus.

The development of a flow chem. approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification The synthesis has been successfully demonstrated on a Vaportec com. flow chem. system.

Journal of Flow Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C10H16O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nadir, Upender K. published the artcileReaction of dimethyloxosulfonium methylide with oxaziridines – transformation to azetidines, Computed Properties of 5034-06-0, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1989), 28B(8), 685-6, database is CAplus.

Reaction of N-arylsufonyloxaziridines I (R = SO₂C₆H₄H₄Me-4, SO₂Ph) with Me₂S(O):CH₂ yields azetidines whereas reaction with I (R = Me₃C) leads to the corresponding azomethine PhCH:NCMe₃.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Computed Properties of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Norris, Peter published the artcileDevelopment of reactions of 6- and 5-substituted 1,3-dimethyluracils with dimethylsulfoxonium methylide, Application In Synthesis of 5034-06-0, the publication is Journal of Organic Chemistry (1999), 64(20), 7290-7298, database is CAplus.

6-Chloro-1,3-dimethyluracil reacts with dimethylsulfoxonium methylide, MeS(:O):CH₂, to give sulfoxonium ylide I in 51% yield. The structure of I was established spectroscopically and by its reactions with various electrophiles and electron-deficient olefins. Thus, I is converted by HCl to a sulfoxonium chloride which then yields 6-(chloromethyl)-1,3-dimethyluracil (II) by heating in MeCN. I undergoes deuterium exchange at the 5-position, at its methine carbon, and into its Me groups attached to sulfur. Reaction of I with BzCl gives the highly substituted ylide III or the nucleophilic substitution products II and (α-chlorophenacyl)uracil IV, depending on reaction conditions. Treatment of I with electron-deficient olefins yields 6-cyclopropyluracils, e.g. V. Many of the cyclopropyluracils were converted to trans-1-(1,3-dimethyluracilyl)-2-vinylcyclopropanes and cycloheptenyluracils. Reaction 5-(phenylsulfinyl)-1,3-dimethyluracil with MeS(:O):CH₂ yields cyclothymine VI, whereas reaction of 5-phenylseleninyl-1,3-dimethyluracil with MeS(:O):CH₂ gave I as the major product.

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Application In Synthesis of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Jing published the artcileMichael acceptor in gambogic acid-Its role and application for potent antitumor agents, Recommanded Product: trimethyloxosulphonium chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(14), 2844-2848, database is CAplus and MEDLINE.

Gambogic acid (GA), a natural product with unique structure, was reported to have broad antiproliferation activities against cancer cell lines. As a reactive Michael acceptor, the 10-position of GA is susceptible to nucleophiles, thus limiting its clin. application as an anticancer agent. Moreover, the 6-OH forms an intramol. hydrogen bond with 8-C=O, which can make the 9, 10 double bond more reactive to nucleophiles. In this essay, two strategies (A and B) were applied to solve the above-mentioned problems. Strategy A was to increase the steric hindrance of C-10 to reduce the activity of GA towards nucleophiles. Strategy B was to replace the hydroxyl of C-6 with other substituents based on the assumption that the intra-mol. hydrogen bond could increase the electrophilicity of C-10. Results showed the electrophilicity of C-10 disappeared as well as the antiproliferation activity against cancer cell lines by introducing a Me group at C-10. Strategy B showed that the electrophilicity of C-10 was reduced dramatically while maintained the activity by replacement of the hydroxyl of C-6 with neutral or basic groups.

Bioorganic & Medicinal Chemistry Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C17H18N3NaO3S, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics