Category: 5034-06-0

Collins, Nathan published the artcileFully Automated Chemical Synthesis: Toward the Universal Synthesizer, HPLC of Formula: 5034-06-0, the publication is Organic Process Research & Development (2020), 24(10), 2064-2077, database is CAplus.

Automated peptide and oligonucleotide synthesizers enabled a revolution in mol. biol. and helped pave the way to modern synthetic biol. Similarly, fully automated synthetic chem. could herald a new wave of innovation in biol. and materials sciences by greatly facilitating access to known and novel mols. Here, we report on an automated multistep chem. synthesizer, AutoSyn, that makes milligram-to-gram-scale amounts of virtually any drug-like small mol. in a matter of hours and demonstrate its versatility with the synthesis of ten known drugs. Of the FDA-approved small-mol. drugs for which we were able to compute a synthetic route, 87% are predicted to be synthesized on AutoSyn. Moreover, AutoSyn enables digital synthesis protocols that ensure the reproducibility and transferability of synthesis protocols from one lab to another. If this follows the same evolution as automated peptide and DNA syntheses, it will lead to an exponential increase in chem. innovation across biol. and material sciences.

Organic Process Research & Development published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, HPLC of Formula: 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kakei, Hiroyuki published the artcileCatalytic Asymmetric Cyclopropanation of Enones with Dimethyloxosulfonium Methylide Promoted by a La-Li₃-(Biphenyldiolate)₃ + NaI Complex, Recommanded Product: trimethyloxosulphonium chloride, the publication is Journal of the American Chemical Society (2007), 129(44), 13410-13411, database is CAplus and MEDLINE.

Catalytic asym. cyclopropanation of enones with dimethyloxosulfonium methylide using a La-Li₃-(biphenyldiolate)₃ + NaI complex is described. The present method is complementary to the previously reported catalytic enantioselective methods in terms of ylides used, and trans products, e.g., I, were exclusively obtained in good yield (96-73%) and high enantioselectivity (99-84% ee). Use of biphenyldiol and NaI additive was essential to achieve high enantioselectivity.

Journal of the American Chemical Society published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Juhl, Martin published the artcilerac-(1S,6S)-Methyl 6-methyl-2-oxobicyclo[4.1.0]heptane-1-carboxylate, Related Products of chlorides-buliding-blocks, the publication is Acta Crystallographica, Section E: Structure Reports Online (2007), 63(2), o838-o839, database is CAplus.

The crystal structure of the title compound, C₁₀H₁₄O₃, was studied as part of a study of the chem. of nucleophilic 1,4-additions to highly electrophilic C=C double bonds. Crystallog. data are given. The cyclohexane ring adopts a half-chair conformation. The crystal packing is stabilized by van der Waals forces.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Man published the artcileEffect of trimethylsulphoxonium halide surfactants on consolute solutions of immiscible solvents, COA of Formula: C3H9ClOS, the publication is Physics and Chemistry of Liquids (2011), 49(3), 302-308, database is CAplus.

Consolute solution temperatures (CST) ± 0.01 K and corresponding solubilities of phenol-water mixtures with 0.35 millimol kg-1 trimethylsulfoxonium chloride (TMSOC), trimethylsulfoxonium bromide (TMSOB), and trimethylsulfoxonium iodide (TMSOI) cationic surfactants are reported. The halide surfactants (TMSOX, X = Cl-, Br-, I-) decreased the CST by about 1.73-2.18° with 3-5% less mutual mixing as compared to phenol-water mixtures Three -CH3 (methyl) and the chloride (Cl-), bromide (Br-) and iodide (I-) halide ions of surfactants had developed hydrophobic and hydrophilic interactions, resp. The CST data are as TMSOI > TMSOB > TMSOC with corresponding mutual solubilities as TMSOC > TMSOB > TMSOI, with slightly stronger I–water interaction due to induced potential of a large-sized iodide ion. The hydrophobic interactions mildly dominated with smaller sized Cl- anion with slightly higher mutual solubility Comparatively, consolute solutions with surfactants are obtained at slightly lower temperatures with higher mutual mixing.

Physics and Chemistry of Liquids published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is 0, COA of Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Weber, Lothar published the artcileBis(dimethyl sulfoxoniummethylide) tetracarbonyl complexes of chromium, molybdenum and tungsten, Recommanded Product: trimethyloxosulphonium chloride, the publication is Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie (1976), 31B(6), 780-5, database is CAplus.

From the photochem. reaction of M(CO)6 (M = Cr, Mo, W) and Me2S(O):CH2 in ether, yellow solids of [Me2S(O)CH2]2M(CO)4 are obtained in good yields. [Me2S(O)CH2]2M(CO)4 (M = Cr, Mo) are also accessible by the displacement of olefin from LM(CO)4 (L = norbornadiene) by excess ylide in ether. Pale insoluble [Me2S(O)CH2]3Mo(CO)3 is the sole product from the reaction of L1Mo(CO)3 (L1 = cycloheptatriene) and excess ylide in ether.

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C23H43NP2, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Izzo, Patrick T. published the artcilePreparation of 1-aryl-1,2-cyclopropanedicarboximides. An application of dimethylsulfoxonium methylide, Formula: C3H9ClOS, the publication is Journal of Organic Chemistry (1963), 1713-15, database is CAplus.

1-Aryl-1,2-cyclopropanedicarboximides (I) were prepared in the presence of dimethylsulfoxonium methylide (II). Trimethylsulfoxonium chloride (III) was prepared by the method of Kuhn and Trischmann (CA 52, 14523g),m. 215-16°. III(1.5g.) added to a suspension of 0.29 g. NaH in 150 ml. tetrahydrofuran (THF), the mixture refluxed with evolution of H, stirred under reflux 45-60 min., and 0.012 mole N-methyl-2-arylmaleimide added to the solution (containing II), the mixture refluxed 2 hrs., cooled, alc. added, solvent removed in vacuo, the residue taken up in CH₂Cl₂, and the solution washed, dried, and evaporated gave I (R, R¹, m.p., % yield given): Ph, H, 55-7°, 21; Ph, Et, 113-146deg;, 81; 3,4,5-trimethoxyphenyl, H, 136-86°, 21. The structure of I was supported by infrared and ultraviolet spectra, elementary analyses, and unsaturation tests. N-Methyl-2-phenylsuccinimide (37.8 g.), 39.2 g. N-bromosuccinimide, 0.4 g. Bz₂O₂, and 800 ml. CCl₄ refluxed 24 hrs., stored 16 hrs. at room temperature, the succinimide removed, and the filtrate evaporated gave 49.2 g. 2-bromo-N-methyl2-phenylsuccinimide (IV), m. 110.5-12°. IV (7.5 g.) in 75 ml. C₆H₆ and 3 g. NEt₃ kept 1 hr. at room temperature and the product separated gave 3.7 g. N-methyl-2-phenylmaleimide (V), m. 147-8°. Arylation of maleimide with 3,4,5-trimethoxyphenyldiazonium chloride gave 27% 2-chloro-3-(3,4,5-trimethoxyphenyl)succinimide (VI), m. 207-8° (decomposition). VI (2 g.) heated 0.5 hr. with 8 ml. 2,6-lutidine gave 1.5 g. 2-(3,4,5-trimethoxyphenyl)maleimide (VII), m. 211-13°. VII (2.8 g.) in 75 ml. THF brought to reflux with 0.24 g. NaH, then treated in 45 min. under reflux with 7 g. MeI in 10 ml. THF, the mixture refluxed 1.75 hrs., evaporated, and the residue taken up in CHCl₈ gave 2 g. N-methyl-2-(3,4,5-trimethoxyphenyl)maleimide, m. 155-66deg;. V (8.9 g.) in 150 ml. CH₂Cl₂ treated in one lot with 0.054 mole MeCHN₂ in Et₂O gave 11.6 g. N,5-dimethyl-3-phenyl-1-pyrazoline-3,4-dicarboximide (VIII), m. 106-76deg; (decomposition). VIII (5.1 g.) in 50 ml. alc. was heated 0.5 hr., evapd, in vacuo, and the 4.4 g. of oil subjected to partition chromatography. Evaporation of material from the first peak gave 5% N-methyl-2-ethyl-3phenylmaleimide, m. 69-70°. The 2nd and slower moving component was obtained as the chief yield, 4 g., of N,3-dimethyl-1-phenyl-1,2-cyclopropanedicarboximide.

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jurga, Stefan published the artcileNuclear magnetic relaxation studies in solids, COA of Formula: C3H9ClOS, the publication is Ser. Fiz. (Uniw. im. Adama Mickiewicza Poznaniu) (1980), 58 pp., database is CAplus.

Spin-lattice relaxation times in the laboratory and in the rotating frame are reported for trimethyloxosulfonium fluoride, chloride, bromide and iodide as well as for Me₂SO and Me₂SO₂ over a wide temperature range. A model was developed that makes it possible to analyze the exptl. data on the basis of 4 independent reorientations around 3 3-fold axis and around center of gravity . The following conclusions consistent with the 2nd moment and spin-lattice relaxation results are drawn about reorientational state of cations and mols. The Me group is reorienting about its 3-fold axis at random between 3 equilibrium positions separated by 120° in all the compounds A 3-fold reorientation of all cations around the C₃ axis (designed by S → O bond) occurs. There is dynamical inequivalence of Me groups within the Me₂SO mol. and trimethyloxosulfonium chloride with 1:2 ratio. There is observed translational diffusion in Me₂SO₂. The activation energies for C₃ and C‘₃ reorientations decrease with an increase of an anion ionic radius (with exception of the iodide salt for the last motion).

Ser. Fiz. (Uniw. im. Adama Mickiewicza Poznaniu) published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, COA of Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baez, Jose E. published the artcileSynthesis of Poly(methylene-b-ε-caprolactone) and Poly(ε-caprolactone) with Linear Alkyl End Groups: Synthesis, Characterization, Phase Behavior, and Compatibilization Efficacy, Computed Properties of 5034-06-0, the publication is Industrial & Engineering Chemistry Research (2017), 56(37), 10366-10383, database is CAplus.

Diblock copolymers of poly(methylene-b-ε-caprolactone) (PM-b-PCL) were synthesized in two steps: (a) polyhomologation, to obtain following oxidative cleavage of the carbon-boron, (PM, block1), an α-hydroxyl-ω-Me polymethylene (PMOH, CH3-[CH2]m-OH). Following transfer reaction to the ring-opening polymerization catalyst and (b) ring-opening polymerization (ROP) of ε-caprolactone (CL) (PCL, block2). In addition, a series of homopolymers derived from poly(ε-caprolactone) (PCL) oligoesters containing an end group of docosyl (CH3-[CH2]21- or C22) (C22-PCL) were obtained as a model to compare their phys. properties by DSC with those of PM-b-PCL. The oligomers derived from PM-b-PCL and C22-PCL were characterized by 1H and 13C NMR, AFM, DSC, GPC and MALDI-TOF. PM-b-PCL and C22-PCL were evaluated as compatibilizers for PE/PCL polymer blends. Identification and anal. of optimized blocks of PM-b-PCL by POM and SEM showed improved mixing of PE/PCL blends.

Industrial & Engineering Chemistry Research published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Computed Properties of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ladelta, Viko published the artcileA new tricrystalline triblock terpolymer by combining polyhomologation and ring-opening polymerization. synthesis and thermal properties, Application In Synthesis of 5034-06-0, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2019), 57(24), 2450-2456, database is CAplus.

New tricryst. triblock terpolymers, polyethylene-block-poly(ε-caprolactone)-block-poly(L-lactide) (PE-b-PCL-b-PLLA), were synthesized by ROP of ε-caprolactone (CL) and L-lactide (LLA) from linear ω-hydroxyl polyethylene (PE-OH) macroinitiators. The linear PE-OH macroinitiators were prepared by C1 polymerization of Me sulfoxonium methylide (polyhomologation). Tin(II) 2-ethylhexanoate was used as the catalyst for the sequential ROP of CL and LLA in one-pot polymerization at 85 °C in toluene (PE-OH macroinitiators are soluble in toluene at 80 °C). ¹H NMR spectra confirmed the formation of PE-b-PCL-b-PLLA triblock terpolymers through the appearance of the characteristic proton peaks of each block. GPC traces showed the increase in the number average mol. weight from PE-OH macroinitiator to PE-b-PCL, and PE-b-PCL-b-PLLA corroborating the successful synthesis. The existence of three crystalline blocks was proved by DSC and XRD spectroscopy.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Application In Synthesis of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ladelta, Viko published the artcileTetracrystalline Tetrablock Quarterpolymers: Four Different Crystallites under the Same Roof, Synthetic Route of 5034-06-0, the publication is Angewandte Chemie, International Edition (2019), 58(45), 16267-16274, database is CAplus and MEDLINE.

Multicrystalline block polymers having three or more crystalline segments are essential materials for the advancement of physics in the field of crystallinity. The challenging synthesis of multicrystalline polymers has resulted in only a limited number of tricryst. terpolymers having been reported to date. We report, for the first time, the synthesis of polyethylene-b-poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(L-lactide) (PE-b-PEO-b-PCL-b-PLLA), a tetracryst. tetrablock quarterpolymer, by combining polyhomologation, ring-opening polymerization, and an organic/metal “catalyst switch” strategy. ¹H NMR spectroscopy and gel-permeation chromatog. confirmed the formation of the tetrablock quarterpolymer, while differential scanning calorimetry, X-ray diffraction, and wide-line separation solid-state NMR spectroscopy revealed the existence of four different crystalline domains.

Angewandte Chemie, International Edition published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics