Category: 50-84-0

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Escaping from Flatland: Antimalarial Activity of sp(3)-Rich Bridged Pyrrolidine Derivatives published in 2020. HPLC of Formula: C7H4Cl2O2, Reprint Addresses Cox, B (corresponding author), Univ Sussex, Photodivers Ltd, Sch Life Sci, Brighton BN1 9QJ, E Sussex, England.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

We utilized synthetic photochemistry to generate novel sp 3 -rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-azabicyclo[2.1.1]hexane scaffold. Preliminary antimalarial screening of the library provided promising compounds with activity in the 1-5 mu M range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Cox, B; Duffy, J; Zdorichenko, V; Bellanger, C; Hurcum, J; Laleu, B; Booker-Milburn, KI; Elliott, LD; Robertson-Ralph, M; Swain, CJ; Bishop, SJ; Hallyburton, I; Anderson, M or concate me.. HPLC of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Copper (II) immobilized on magnetically separable L-arginine-beta-cyclodextrin ligand system as a robust and green catalyst for direct oxidation of primary alcohols and benzyl halides to acids in neat conditions WOS:000517798600004 published article about EFFICIENT HETEROGENEOUS CATALYST; SCHIFF-BASE COMPLEX; SELECTIVE OXIDATION; AEROBIC OXIDATION; CARBOXYLIC-ACID; PYRIDINIUM CHLOROCHROMATE; RECYCLABLE CATALYST; SECONDARY ALCOHOLS; DIMETHYL-SULFOXIDE; MANGANESE-DIOXIDE in [Nejad, Masoumeh Jadidi; Salamatmanesh, Arefe; Heydari, Akbar] Tarbiat Modares Univ, Chem Dept, POB 14155-4838, Tehran, Iran in 2020, Cited 61. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Category: chlorides-buliding-blocks

Copper (II) immobilized on L-arginine-beta-cyclodextrin-functionalized magnetite nanoparticles (nano-Fe3O4@L-arginine-CD-Cu(II)) were successfully synthesized and fully characterized using FT-IR, XRD, SEM, EDX, ICP, TGA and VSM techniques. The catalytic activity of these magnetically retrievable nanoparticles was evaluated in the direct oxidation of primary alcohols and benzyl halides to acids in neat conditions that was observed to proceed well and products were obtained in good yields. In addition to showing good catalytic activity, the magnetic catalyst is easy to synthesize and can be recycled at least five times with little loss in activity. (C) 2020 Elsevier B.V. All rights reserved.

Category: chlorides-buliding-blocks. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Nejad, MJ; Salamatmanesh, A; Heydari, A or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about CYCLOOXYGENASE-2; ANALOGS; ANTICANCER; MECHANISMS; ENZYMES; SAFROLE, Saw an article supported by the Dean of Scientific Research, An-Najah National University [ANNU-1920-Sc013]. Product Details of 50-84-0. Published in BMC in LONDON ,Authors: Hawash, M; Jaradat, N; Hameedi, S; Mousa, A. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Non-steroidal anti-inflammatory drugs are among the most used drugs. They are competitive inhibitors of cyclooxygenase (COX). Twelve novel compounds (aryl acetate and aryl acetic acid groups) were synthesized in this work in order to identify which one was the most potent and which group was most selective towards COX1 and COX2 by using an in vitro COX inhibition assay kit. The cytotoxicity was evaluated for these compounds utilizing MTS assay against cervical carcinoma cells line (HeLa). The synthesized compounds were identified using FTIR, HRMS,H-1-NMR, and(13)C-NMR techniques. The results showed that the most potent compound against the COX1 enzyme was 4f with IC50 = 0.725 mu M. The compound 3b showed potent activity against both COX1 and COX2 with IC50 = 1.12 and 1.3 mu M, respectively, and its selectivity ratio (0.862) was found to be better than Ketoprofen (0.196). In contrast, compound 4d was the most selective with a COX1/COX2 ratio value of 1.809 in comparison with the Ketoprofen ratio. All compounds showed cytotoxic activity against the HeLa Cervical cancer cell line at a higher concentration ranges (0.219-1.94 mM), and the most cytotoxic compound was 3e with a CC(50)value of 219 mu M. This was tenfold more than its IC(50)values of 2.36 and 2.73 mu M against COX1 and COX2, respectively. In general, the synthesized library has moderate activity against both enzymes (i.e., COX1 and COX2) and ortho halogenated compounds were more potent than the meta ones.

Product Details of 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Hawash, M; Jaradat, N; Hameedi, S; Mousa, A or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Authors Szafranski, K; Slawinski, J; Tomorowicz, L; Kawiak, A in MDPI published article about SULFONAMIDE HYBRIDS; DERIVATIVES; QSAR; AGENTS in [Szafranski, Krzysztof; Slawinski, Jaroslaw; Tomorowicz, Lukasz] Med Univ Gdansk, Fac Pharm, Dept Organ Chem, Al Gen J Hallera 107, Gdansk 80416, Poland; [Kawiak, Anna] Univ Gdansk, Intercollegiate Fac Biotechnol, Dept Biotechnol, Ul Abrahama 58, Gdansk 80307, Poland; [Kawiak, Anna] Med Univ Gdansk, Ul Abrahama 58, Gdansk 80307, Poland in 2020, Cited 28. Application In Synthesis of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

To learn more about the structure-activity relationships of (E)-3-(5-styryl-1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives, which in our previous research displayed promising in vitro anticancer activity, we have synthesized a group of novel (E)-5-[(5-(2-arylvinyl)-1,3,4-oxadiazol-2-yl)]-4-chloro-2-R-1-benzenesulfonamides 7-36 as well as (E)-4-[5-styryl1,3,4-oxadiazol-2-yl]benzenesulfonamides 47-50 and (E)-2-(2,4-dichlorophenyl)-5-(2-arylvinyl)-1,3,4-oxadiazols 51-55. All target derivatives were evaluated for their anticancer activity on HeLa, HCT-116, and MCF-7 human tumor cell lines. The obtained results were analyzed in order to explain the influence of a structure of the 2-aryl-vinyl substituent and benzenesulfonamide scaffold on the anti-tumor activity. Compound 31, bearing 5-nitrothiophene moiety, exhibited the most potent anticancer activity against the HCT-116, MCF-7, and HeLa cell lines, with IC50 values of 0.5, 4, and 4.5 mu M, respectively. Analysis of structure-activity relationship showed significant differences in activity depending on the substituent in position 3 of the benzenesulfonamide ring and indicated as the optimal meta position of the sulfonamide moiety relative to the oxadizole ring. In the next stage, chemometric analysis was performed basing on a set of computed molecular descriptors. Hierarchical cluster analysis was used to examine the internal structure of the obtained data and the quantitative structure-activity relationship (QSAR) analysis with multiple linear regression (MLR) method allowed for finding statistically significant models for predicting activity towards all three cancer cell lines.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Szafranski, K; Slawinski, J; Tomorowicz, L; Kawiak, A or concate me.. Application In Synthesis of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about BACTERIAL LEAF-BLIGHT; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; 1,4-PENTADIEN-3-ONE DERIVATIVES; MOSAIC-VIRUS; DESIGN; INHIBITORS; 3D-QSAR; BETA, Saw an article supported by the National Key Research and Development Program of China [2017YFD0200506]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21867003]; Major Program of Innovation Research Team of Educational Commission of Guizhou Province [2016113]; Science and Technology Platform for Talent of Guizhou Province [20165608]; Science and Technology Project of Guizhou Province [20172956]. SDS of cas: 50-84-0. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Tang, X; Wang, ZB; Zhong, XM; Wang, XB; Chen, LJ; He, M; Xue, W. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal and antiviral activities. The bioassay results indicated that most of target compounds showed good antiviral activities against tobacco mosaic virus (TMV) and antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (Rs). Especially, the anti-Xoo effect of title compounds 5k (N-(5-methoxybenzo[d]thiazol-2-yl)-2-((5-(2-tolyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) and the anti-Rs effect of title compounds 5a (N-(5-nitrobenzo[d]thiazol-2-yl)-2-((5-(4-(trifluorom ethyl)phenyl)-1,3,4-thiadiazol-2-yl)thio)acetmide) respectively reached 52.4% and 71.6% at 100 mu g/mL, which are superior to that of bismerthiazol (32.0% and 52.3%). In addition, the protective and inactivation activities of title compound 5i (N-(5-methoxybenzo [d]thiazol-2-yl)-2-((5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) against TMV were 79.5% and 88.3%, respectively, which are better than that of ningnanmycin (76.4% and 86.8%). The above research showed that benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety may be used as potential molecular templates in searching for highly-efficient antiviral and antibacterial agents.

SDS of cas: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Tang, X; Wang, ZB; Zhong, XM; Wang, XB; Chen, LJ; He, M; Xue, W or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Quality Control of 2,4-Dichlorobenzoic acid. In 2019 TETRAHEDRON LETT published article about ARYL HALIDES; COUPLING REACTIONS; AMINO-ACIDS; COPPER; INHIBITION; AMINATION; EFFICIENT; ANALOGS; KINASE; MYOINOSITOL in [Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Chen, Guoliang] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 53. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Myo-inositol is originally applied as a cardiovascular medicine in clinic, which can be multi-ton manufactured via extraction from the byproducts in agricultural product processing such as defatted rice bran and corn-soaking water. Herein, the application of myo-inositol (MI) as a novel versatile tridentate O-donor ligand has been first described for promoting Cu-catalyzed amination reaction in aqueous medium. (C) 2019 Published by Elsevier Ltd.

Quality Control of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, QF; Du, FY; Chen, YG; Fu, Y; Chen, GL or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about THERMAL-DECOMPOSITION KINETICS; ORGANIC FRAMEWORKS; CRYSTAL-STRUCTURE; BUILDING UNITS; COMPLEXES; IONS; ACID; 3D; EUROPIUM(III); TERBIUM(III), Saw an article supported by the Education Baureau of Liaoning Province [LQ2017011]; Natural Science Foundation of Liaoning ProvinceNatural Science Foundation of Liaoning Province [2019-ZD-0495]. Computed Properties of C7H4Cl2O2. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Zhang, JW; Wang, CR; Liu, WH; Xu, S; Liu, BQ. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Ln(NO3)(3)center dot nH(2)O reacted with 2,4-dichlorobenzoic acid (2,4-HDCB) and NaOH under solvothermal conditions of water and ethanol to yield four lanthanide-organic coordination polymers (CPs) [Eu(2,4-DCB)(3)(CH3CH2OH)(2)] (1) and [Ln(2,4-DCB)(3)(H2O)] [Ln = Gd (2), Tb (3), Dy (4)]. The second ligand 4,4′-bipyridine (4,4′-bpy) was introduced into the above reaction systems to provide four new lanthanide-organic CPs [Ln(2)(2,4-DCB)(6)(4,4′-bpy)(H2O)(2)] [Ln = Eu (5), Gd (6), Tb (7), Dy (8)]. Single-crystal and powder X-ray diffraction analyses reveal that CPs 1 and 2 possess similar one-dimensional (1D) structures, and CPs 2-4 and 5-8 are isostructural, respectively. In 1-4, the 2,4-DCB anions bridge the Ln(III) ions to form a 1D chain. In 5-8, six 2,4-DCB anions link two Ln(III) ions into a binuclear Ln(2)(2,4-DCB)(6) unit, and the Ln(2)(2,4-DCB)(6) units are further connected by the 4,4′-bpy co-ligands to generate a 1D chain. The photoluminescent and magnetic properties of 1-8 were investigated.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhang, JW; Wang, CR; Liu, WH; Xu, S; Liu, BQ or concate me.. Computed Properties of C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Degradation of 2,4-Dichlorobenzoic Acid by Coupled Electrocatalytic Reduction and Anodic Oxidation WOS:000551697600028 published article about ELECTROCHEMICAL DEGRADATION; PALLADIUM NANOPARTICLES; OXYGEN REDUCTION; FOAM ELECTRODES; HYDRODECHLORINATION; CARBON; CATHODE; MECHANISM; 2,4-DICHLOROPHENOL; DECHLORINATION in [Li, Ning; Song, Xiaozhe; Wang, Hui] Beijing Forestry Univ, Coll Environm Sci & Engn, Beijing 100083, Peoples R China in 2020, Cited 35. Product Details of 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Dual effects of cathodic dechlorination and oxidative decomposition of 2,4-dichlorobenzoic acid (2,4-DCBA) can be achieved using electrochemical reduction-oxidation technology. The removal efficiency was improved by optimizing the experimental conditions affecting electrode activity and contaminant degradation. The 2,4-DCBA removal efficiency reached 90.8% at a current density at 50 mA.cm(-2), initial pH of 5, and sodium sulfate concentration of 0.05 mol.L-1, with a 2,4-DCBA concentration of 20 mg.L-1. Furthermore, a good total organic carbon removal efficiency of 81.6% was achieved in the electrocatalytic reduction and oxidation process, with the present system retaining high stability after many experiment cycles. The reaction mechanism under different conditions is discussed, which provides new approaches to the degradation of chlorinated organic compounds.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Li, N; Song, XZ; Wang, H or concate me.. Product Details of 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocks. I found the field of Chemistry very interesting. Saw the article Characterization of luminescent hydroxyapatite@terbium complex core-shell composites using chlorobenzoic acid as ligands published in 2020, Reprint Addresses Jiang, GP; Tao, DL (corresponding author), Fuyang Normal Univ, Coll Chem & Mat Engn, Fuyang 236037, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

Three kinds of novel hydroxyapatite@terbium complex core-shell composites were synthesized with 2-chlorobenzoic acid, 4-chlorobenzoic acid, and 2,4-dichlorobenzoic acid as the ligand, respectively. The XRD, UV/vis absorption and FT-IR results show that terbium ions are coordinated with ligands and the corresponding complexes are successfully included into composites. SEM and EDS results reveal that Tb complexes are fully and homogenously coated on the surface of hydroxyapatite (HAP) microspheres consisting of a large number of nanosized crystals. The strongest luminescence properties are obtained when 2,4-dichlorobenzoic acid is used as ligand. The study on fluorescence lifetime of composites shows that the lifetime is inversely related to emission intensity. TGA-DSC results indicate that the core-shell composites have an excellent thermal stability. Therefore, the current core-shell structure provides a cost-effective route to manufacture of biocompatible and heat-resistant highly luminescent materials. (C) 2020 Chinese Society of Rare Earths. Published by Elsevier B.V. All rights reserved.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Jiang, GP; Song, LL; Tao, DL; Jin, F or concate me.. Category: chlorides-buliding-blocks

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 2,4-Dichlorobenzoic acid. In 2021 INT J MOL SCI published article about IN-VITRO; BIOLOGICAL PROPERTIES; DERIVATIVES; ASSAY; PHOTOSTABILITY; MANGIFERIN; EXPRESSION; LIPOPHILICITY; MUTAGENICITY; PROTECTION in [Popiol, Justyna; Sloczynska, Karolina; Koczurkiewicz-Adamczyk, Paulina; Piska, Kamil; Wojcik-Pszczola, Katarzyna; Pekala, Elzbieta] Jagiellonian Univ Med Coll, Fac Pharm, Dept Pharmaceut Biochem, Med 9, PL-30688 Krakow, Poland; [Gunia-Krzyzak, Agnieszka; Zelaszczyk, Dorota; Marona, Henryk] Jagiellonian Univ Med Coll, Fac Pharm, Chair Organ Chem, Dept Bioorgan Chem, Med 9, PL-30688 Krakow, Poland; [Krupa, Anna] Jagiellonian Univ Med Coll, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, Med 9, PL-30688 Krakow, Poland; [Zmudzki, Pawel] Jagiellonian Univ Med Coll, Fac Pharm, Dept Med Chem, Med 9, PL-30688 Krakow, Poland in 2021, Cited 58. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety. The ultraviolet spectroscopic properties of the tested compounds were confirmed in chloroform solutions. They acted as UVB or UVA/UVB absorbers. The most promising compound 9 (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate) absorbed UV radiation in the range 290-369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound 9 possessed very beneficial UV protection parameters (SPFin vitro of 19.69 +/- 0.46 and UVA PF of 12.64 +/- 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Additionally, compound 9 was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 mu M when tested on five cell lines, and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Additionally, its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application.

Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Popiol, J; Gunia-Krzyzak, A; Sloczynska, K; Koczurkiewicz-Adamczyk, P; Piska, K; Wojcik-Pszczola, K; Zelaszczyk, D; Krupa, A; Zmudzki, P; Marona, H; Pekala, E or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics