Category: 50-84-0

Recommanded Product: 50-84-0. In 2019 CHEM ENG J published article about ZERO-VALENT IRON; ELECTROCHEMICAL REDUCTIVE DECHLORINATION; NICKEL COMPOSITE ELECTRODE; AQUEOUS-SOLUTION; 2,4-DICHLOROPHENOXYACETIC ACID; FOAM ELECTRODE; HALOACETIC ACIDS; PD/FE NANOPARTICLES; CHLOROACETIC ACIDS; WASTE-WATER in [Zhou, Jiasheng; Lou, Zimo; Zhou, Xiaoxin; Yang, Kunlun; Xu, Xinhua] Zhejiang Univ, Dept Environm Engn, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China; [Xu, Jiang; Gao, Xiaoyu; Zhang, Yilin] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA; [Xu, Jiang; Gao, Xiaoyu; Zhang, Yilin] Ctr Environm Implicat Nanotechnol CEINT, Durham, NC USA in 2019, Cited 67. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this study, a novel approach was developed for the dechlorination of 2,4-dichlorobenzoic acid (2,4-DCBA) via the combination of the moveable activated carbon (AC) supported palladium (Pd) nanoparticles and nickel (Ni) foam electrode. The morphology and chemical structure of Pd/AC catalyst was investigated by various characterization techniques, including SEM, TEM, EXS-mapping, XRD, and XPS. Pd nanoparticles was successfully loaded and dispersed on the AC, accompanied with the significantly enhanced reactivity. The removal rate of 2,4-DCBA by Ni electrode with moveable Pd/AC catalyst was 222, 25, and 5 folds higher than dispersed AC and Ni electrode system, chemical deposited Pd/Ni electrode, and electrodeposited Pd/Ni electrode, respectively. Compared with the conventional electrocatalytic reductive approach which deposited Pd on the Ni foam electrode, moveable Pd/AC catalyst possesses higher surface area, more atomic H* production and more active sites, favored mass transfer, and enhanced reactivity, without the consideration of catalyst loss and deactivation. The effects of Pd:AC mass ratio, constant current, initial solution pH, and electrolyte concentration on the dechlorination of 2,4-DCBA were studied. Generally, high Pd loading, constant current, and acidity favored the dechlorination of 2,4-DCBA, while excessive electrolyte would inhibit the dechlorination of 2,4-DCBA. Good longevity and recyclability of moveable Pd/AC catalyst was confirmed via consecutive experiments. The findings of the present study show that making the catalyst moveable is a promising strategy for electrocatalytic remediation technology.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, JS; Lou, Z; Xu, J; Zhou, XX; Yang, KL; Gao, XY; Zhang, YL; Xu, XH or concate me.. Recommanded Product: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 2,4-Dichlorobenzoic acid. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Escaping from Flatland: Antimalarial Activity of sp(3)-Rich Bridged Pyrrolidine Derivatives published in 2020, Reprint Addresses Cox, B (corresponding author), Univ Sussex, Photodivers Ltd, Sch Life Sci, Brighton BN1 9QJ, E Sussex, England.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

We utilized synthetic photochemistry to generate novel sp 3 -rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-azabicyclo[2.1.1]hexane scaffold. Preliminary antimalarial screening of the library provided promising compounds with activity in the 1-5 mu M range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Cox, B; Duffy, J; Zdorichenko, V; Bellanger, C; Hurcum, J; Laleu, B; Booker-Milburn, KI; Elliott, LD; Robertson-Ralph, M; Swain, CJ; Bishop, SJ; Hallyburton, I; Anderson, M or concate me.. Recommanded Product: 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2020 WORLD J CLIN CASES published article about GENOTYPE-PHENOTYPE CORRELATION; GENE; FAMILY; SH2 in [Hu, Xiao-Mei; Yuan, Ke; Chen, Hong; Chen, Chun; Fang, Yan-Lan; Zhu, Jian-Fang; Liang, Li; Wang, Chun-Lin] Zhejiang Univ, Affiliated Hosp 1, Dept Pediat, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China in 2020, Cited 14. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Application In Synthesis of 2,4-Dichlorobenzoic acid

BACKGROUND X-linked agammaglobulinemia is a primary immunodeficiency disease caused by gene mutations of Bruton’s tyrosine kinase (BTK). We found a new mutation point and summarized the correlation analysis and performed a literature review. CASE SUMMARY The proband was a 5-year-old boy. He was admitted to our hospital due to a recurrent cough and a fever that had persisted for a month. He had a history of multiple respiratory infections and sinusitis. There was no immunodeficiency or recurrent infection history among his family members. Agammaglobulinemia was characterized as follows: Immunoglobulin (Ig) A, 90.0 mg/dL (90-450 mg/dL); IgG, 20.0 mg/dL (800-1800 mg/dL); and IgM, 18.0 mg/dL (60-280 mg/dL). Notably, the assessment of IgG subtypes revealed the following very low levels: Subtype 1, 0.26 g/L (3.62-12.28 g/L); subtype 2, 0.10 g/L (0.57-2.9 g/L); subtype 3, 0.009 g/L (0.129-0.789 g/L); and subtype 4, 0.003 g/L (0.013-1.446 g/L). Cellular immunological test results were as follows: CD3, 74.6% (50%-84.0%); CD4, 47.3% (27.0%-51.0%); and CD8, 24.9% (15.0%-44.0%). Ade novohemizygous deletion inBTKwas detected: c.902_c.904delAAG/p.E301del. Transcript levels of the mutantBTKwere similar to those of the wild-type gene, though overexpression resulted in markedly reduced levels of mutantBTK(9.49% +/- 1.58%), relative to the wild-typeBTK(75.8% +/- 2.98%, P < 0.01). CONCLUSION This case of X-linked agammaglobulinemia was attributed to ade novohemizygous deletion mutation inBTK(c.902_c.904delAAG/p.E301del). The mutation resulted in markedly reducedBTKprotein stabilityin vitro. Application In Synthesis of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Hu, XM; Yuan, K; Chen, H; Chen, C; Fang, YL; Zhu, JF; Liang, L; Wang, CL or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article On Water promoted N-arylation reactions using Cu (0)/myo-inositol catalytic system WOS:000475998200015 published article about ARYL HALIDES; COUPLING REACTIONS; AMINO-ACIDS; COPPER; INHIBITION; AMINATION; EFFICIENT; ANALOGS; KINASE; MYOINOSITOL in [Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Chen, Guoliang] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 53. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Category: chlorides-buliding-blocks

Myo-inositol is originally applied as a cardiovascular medicine in clinic, which can be multi-ton manufactured via extraction from the byproducts in agricultural product processing such as defatted rice bran and corn-soaking water. Herein, the application of myo-inositol (MI) as a novel versatile tridentate O-donor ligand has been first described for promoting Cu-catalyzed amination reaction in aqueous medium. (C) 2019 Published by Elsevier Ltd.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, QF; Du, FY; Chen, YG; Fu, Y; Chen, GL or concate me.. Category: chlorides-buliding-blocks

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Quality Control of 2,4-Dichlorobenzoic acid. In 2021 GREEN CHEM published article about ONE-POT SYNTHESIS; GREEN CHEMISTRY; BOND FORMATION; GOLD(I)-CATALYZED PROTODECARBOXYLATION; SELECTIVE DEUTERATION; FUNCTIONALIZATION; TRANSFORMATIONS; MICROREACTORS; NANOPARTICLES; EXCHANGE in [Meszaros, Rebeka; Fulop, Ferenc] Univ Szeged, Inst Pharmaceut Chem, Eotvos U 6, H-6720 Szeged, Hungary; [Marton, Andras; Szabados, Marton; Palinko, Istvan] Univ Szeged, Dept Organ Chem, Dom Ter 8, H-6720 Szeged, Hungary; [Szabados, Marton; Varga, Gabor; Palinko, Istvan] Univ Szeged, Mat & Solut Struct Res Grp, Aradi Vertanuk Tere 1, H-6720 Szeged, Hungary; [Szabados, Marton; Varga, Gabor; Palinko, Istvan] Univ Szeged, Interdisciplinary Excellence Ctr, Inst Chem, Aradi Vertanuk Tere 1, H-6720 Szeged, Hungary; [Varga, Gabor] Univ Szeged, Dept Phys Chem & Mat Sci, Rerrich Bela Ter 1, H-6720 Szeged, Hungary; [Konya, Zoltan; Kukovecz, Akos] Univ Szeged, Dept Appl & Environm Chem, Rerrich Bela Ter 1, H-6720 Szeged, Hungary; [Konya, Zoltan] Hungarian Acad Sci, MTA SZTE React Kinet & Surface Chem Res Grp, Rerrich Bela Ter 1, H-6720 Szeged, Hungary; [Fulop, Ferenc; Otvos, Sandor B.] Hungarian Acad Sci, MTA SZTE Stereochem Res Grp, Eotvos U 6, H-6720 Szeged, Hungary; [Otvos, Sandor B.] Karl Franzens Univ Graz, NAWI Graz, Inst Chem, Heinrichstr 28, A-8010 Graz, Austria in 2021, Cited 99. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Herein, we report novel catalytic methodologies for protodecarboxylations and decarboxylative deuterations of carboxylic acids utilizing a silver-containing hybrid material as a heterogeneous noble metal catalyst. After an initial batch method development, a chemically intensified continuous flow process was established in a simple packed-bed system which enabled gram-scale protodecarboxlyations without detectable structural degradation of the catalyst. The scope and applicability of the batch and flow processes were demonstrated through decarboxylations of a diverse set of aromatic carboxylic acids. Catalytic decarboxylative deuterations were achieved on the basis of the reaction conditions developed for the protodecarboxylations using D2O as a readily available deuterium source.

Quality Control of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Meszaros, R; Marton, A; Szabados, M; Varga, G; Konya, Z; Kukovecz, A; Fulop, F; Palinko, I; Otvos, SB or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Copper (II) immobilized on magnetically separable L-arginine-beta-cyclodextrin ligand system as a robust and green catalyst for direct oxidation of primary alcohols and benzyl halides to acids in neat conditions WOS:000517798600004 published article about EFFICIENT HETEROGENEOUS CATALYST; SCHIFF-BASE COMPLEX; SELECTIVE OXIDATION; AEROBIC OXIDATION; CARBOXYLIC-ACID; PYRIDINIUM CHLOROCHROMATE; RECYCLABLE CATALYST; SECONDARY ALCOHOLS; DIMETHYL-SULFOXIDE; MANGANESE-DIOXIDE in [Nejad, Masoumeh Jadidi; Salamatmanesh, Arefe; Heydari, Akbar] Tarbiat Modares Univ, Chem Dept, POB 14155-4838, Tehran, Iran in 2020, Cited 61. Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Copper (II) immobilized on L-arginine-beta-cyclodextrin-functionalized magnetite nanoparticles (nano-Fe3O4@L-arginine-CD-Cu(II)) were successfully synthesized and fully characterized using FT-IR, XRD, SEM, EDX, ICP, TGA and VSM techniques. The catalytic activity of these magnetically retrievable nanoparticles was evaluated in the direct oxidation of primary alcohols and benzyl halides to acids in neat conditions that was observed to proceed well and products were obtained in good yields. In addition to showing good catalytic activity, the magnetic catalyst is easy to synthesize and can be recycled at least five times with little loss in activity. (C) 2020 Elsevier B.V. All rights reserved.

Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Nejad, MJ; Salamatmanesh, A; Heydari, A or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article 5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma WOS:000467781700006 published article about MYOFIBROBLAST DIFFERENTIATION; MURINE MODEL; FIBROSIS; PATHWAY; TISSUE; CYTOSKELETON; CONTRACTION; DERIVATIVES; MECHANISMS; BLEOMYCIN in [Kahl, Dylan J.; Hutchings, Kim M.; Larsen, Scott D.] Univ Michigan, Coll Pharm, Vahlteich Med Chem Core, Ann Arbor, MI 48109 USA; [Wen, Bo; Sun, Duxin] Univ Michigan, Coll Pharm, UM Pharmcokinet Core, Ann Arbor, MI 48109 USA; [Khanna, Dinesh; Tsou, Pei-Suen; Campbell, Phillip L.; Fox, David A.] Univ Michigan, Med Ctr, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA; [Khanna, Dinesh; Tsou, Pei-Suen; Campbell, Phillip L.; Fox, David A.] Univ Michigan, Med Ctr, Clin Autoimmun Ctr Excellence, Ann Arbor, MI 48109 USA; [Lisabeth, Erika Mathes; Haak, Andrew J.; Leipprandt, Jeffrey R.; Dexheimer, Thomas; Neubig, Richard R.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA; [Bailie, Marc] Michigan State Univ, Vivo Facil, E Lansing, MI 48824 USA in 2019, Cited 47. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Product Details of 50-84-0

Through a phenotypic high-throughput screen using a serum response element luciferase promoter, we identified a novel 5-aryl-1,3,4-oxadiazol-2-ylthiopropionic acid lead inhibitor of Rho/myocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription with good potency (IC50 = 180 nM). We were able to rapidly improve the cellular potency by 5 orders of magnitude guided by sharply defined and synergistic SAR. The remarkable potency and depth of the SAR, as well as the relatively low molecular weight of the series, suggests, but does not prove, that binding to the unknown molecular target may be occurring through a covalent mechanism. The series nevertheless has no observable cytotoxicity up to 100 mu M. Ensuing pharmacokinetic optimization resulted in the development of two potent and orally bioavailable anti-fibrotic agents that were capable of dose-dependently reducing connective tissue growth factor gene expression in vitro as well as significantly reducing the development of bleomycin-induced dermal fibrosis in mice in vivo.

Product Details of 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Kahl, DJ; Hutchings, KM; Lisabeth, EM; Haak, AJ; Leipprandt, JR; Dexheimer, T; Khanna, D; Tsou, PS; Campbell, PL; Fox, DA; Wen, B; Sun, DX; Bailie, M; Neubig, RR; Larsen, SD or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Electrocatalytic dechlorination of 2,4-dichlorobenzoic acid using different carbon-supported palladium moveable catalysts: Adsorption and dechlorination activity WOS:000457952600022 published article about 2,4-DICHLOROPHENOXYACETIC ACID; REDUCTIVE DECHLORINATION; ELECTROCHEMICAL PROCESS; WASTE-WATER; HYDRODECHLORINATION; REMOVAL; PARTICLES; EFFICIENT; IRON; PERFORMANCE in [Zhou, Jiasheng; Lou, Zimo; Yang, Kunlun; Li, Yizhou; Liu, Yuanli; Xu, Xinhua] Zhejiang Univ, Dept Environm Engn, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China; [Lou, Zimo; Xu, Jiang] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA; [Baig, Shams Ali] Abdul Wali Khan Univ, Dept Environm Sci, Mardan 23200, Pakistan in 2019, Cited 52. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Recommanded Product: 2,4-Dichlorobenzoic acid

In the present study, carbon black (CB), multi walled carbon nanotubes (MWCNTs), and granular activated carbon (GAC) were employed to support palladium (Pd) catalyst. The prepared Pd/CB, Pd/MWCNTs and Pd/GAC moveable catalysts were aimed to address the common issues (easy loss of catalyst and poor long-term performance) of normal fixed catalysts. The results of various characterizations (e.g., TEM, XRD, and XPS) clearly show that the Pd nanopartides were successfully loaded onto the carbon-supports, especially CB and MWCNTs. And more importantly, the morphologies, Pd distribution, and chemical structure of these moveable catalysts were almost not changed after 3 h reaction. The moveable Pd/CB, Pd/MWCNTs, and Pd/GAC catalysts had good reactivity for 2,4-dichlorobenzoic acid (2,4-DCBA) dechlorination, and Pd/CB exhibited the best performance. The Pd/CB also shows the best adsorption capacity of 2,4-DCBA and dechlorination product (benzoic acid, BA), and the adsorption of BA was significantly inhibited in the presence of current due to the repulsion between the both negatively charged compounds and adsorbents. The removal of 2,4-DCBA and the generation rate of BA was improved with a pre-adsorption process, which was a promising strategy with higher dechlorination rate and shortened electrolysis time. Moreover, the loss of Pd catalyst was negligible during the 10 consecutive cycles experiment, and the improved longevity could be expected. These results suggested the good reactivity, stability, and reusability of moveable Pd/CB catalyst.

Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, JS; Lou, ZM; Yang, KL; Xu, J; Li, YZ; Liu, YL; Baig, SA; Xu, XH or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Zhou, ZJ; Tan, YQ; Shen, X; Ivlev, S; Meggers, E in [Zhou, Zijun; Tan, Yuqi; Shen, Xiang; Ivlev, Sergei; Meggers, Eric] Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35043 Marburg, Germany published Catalytic enantioselective synthesis of beta-amino alcohols by nitrene insertion in 2021, Cited 49. HPLC of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Chiral beta-amino alcohols are important building blocks for the synthesis of drugs, natural products, chiral auxiliaries, chiral ligands and chiral organocatalysts. The catalytic asymmetric beta-amination of alcohols offers a direct strategy to access this class of molecules. Herein, we report a general intramolecular C(sp(3))-H nitrene insertion method for the synthesis of chiral oxazolidin-2-ones as precursors of chiral beta-amino alcohols. Specifically, the ring-closing C(sp(3))-H amination of N-benzoyloxycarbamates with 2 mol% of a chiral ruthenium catalyst provides cyclic carbamates in up to 99% yield and with up to 99% ee. The method is applicable to benzylic, allylic, and propargylic C-H bonds and can even be applied to completely non-activated C (sp(3))-H bonds, although with somewhat reduced yields and stereoselectivities. The obtained cyclic carbamates can subsequently be hydrolyzed to obtain chiral beta-amino alcohols. The method is very practical as the catalyst can be easily synthesized on a gram scale and can be recycled after the reaction for further use. The synthetic value of the new method is demonstrated with the asymmetric synthesis of a chiral oxazolidin-2-one as intermediate for the synthesis of the natural product aurantioclavine and chiral beta-amino alcohols that are intermediates for the synthesis of chiral amino acids, indane-derived chiral Box-ligands, and the natural products dihydrohamacanthin A and dragmacidin A.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, ZJ; Tan, YQ; Shen, X; Ivlev, S; Meggers, E or concate me.. HPLC of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. In 2019 J MED CHEM published article about 20S PROTEASOMES; CRYSTAL-STRUCTURE; IMMUNOPROTEASOME; SITES; YEAST; GENERATION; BORTEZOMIB; MECHANISM; SUBSTRATE; KNOWLEDGE in [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Leiden Inst Chem, Gorlaeus Labs, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Netherlands Prote Ctr, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Huber, Eva M.; Heinemeyer, Wolfgang; Groll, Michael] Tech Univ Munich, Lehrstuhl Biochem, Dept Chem, Ctr Integrated Prot Sci, D-85748 Garching, Germany; [Driessen, Christoph] Kantonsspital St Gallen, Dept Hematol & Oncol, CH-9007 St Gallen, Switzerland; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Kisselev, Alexei F.] Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA in 2019, Cited 43. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the beta 1c, beta 1i, beta 5c, and beta 5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting beta 2c or beta 2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the beta 2c- and beta 2i-selective-compounds LU-002c (4; IC50 beta 2c: 8 nM, IC50 beta 2i/beta 2c: 40-fold) and LU-002i (5; IC50 beta 2i: 220 nM, IC50 beta 2c/beta 2i: 45-fold), respectively. Co-crystal structures with beta 2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of beta 2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, YM; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics