Category: 50-84-0

An article Nine Supramolecular Adducts of 4-dimethylaminopyridine and Carboxylic acids Assembled by Classical Hydrogen Bonds and Other Noncovalent Intermolecular Interactions WOS:000663587500014 published article about PROTON-TRANSFER COMPOUNDS; SOLID-STATE LANDSCAPE; CRYSTAL-STRUCTURE; STRUCTURAL-CHARACTERIZATION; PHARMACEUTICAL COCRYSTALS; MOLECULAR-STRUCTURE; ORGANIC SALTS; SOLUBILITY; SYNTHON; ARCHITECTURES in [Chen, Bin; Wu, Ronghui; Jin, Shouwen; Bai, Liqun] Zhejiang A&F Univ, Linan 311300, Peoples R China; [Chen, Bin; Lin, Zhihao; Jin, Shouwen; Dong, Lingfeng; Xu, Weiqiang] Zhejiang A&F Univ, Jiyang Coll, Zhuji 311800, Zhejiang, Peoples R China; [Wang, Daqi] Liaocheng Univ, Dept Chem Engn, Liaocheng 252059, Shandong, Peoples R China in 2021, Cited 86. SDS of cas: 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Cocrystallization of the widely available 4-dimethylaminopyridine, with a series of carboxylic acids gave nine molecular adducts 4-dimethylaminopyridinium trifluoroacetate (1) , 4-dimethylaminopyridinium glycolate glycolic acid (2) , 4-dimethylaminopyridinium 2-furoate dihydrate (3) , tri(4-dimethylaminopyridinium) tri(o-chlorobenzoate) tetrahydrate (4) , 4-dimethylaminopyridinium 4-bromobenzoate 4-bromobenzoic acid (5) , 4-dimethylaminopyridinium 4-formylbenzoate 4-formylbenzoic acid (6) , 4-dimethylaminopyridinium 2,4-dichlorobenzoate (7) , 4-dimethylaminopyridinium 2-aminobenzoate 2-aminobenzoic acid (8) and bis(4-dimethylaminopyridinium) 5-nitroisophthalate 5-nitroisophthalic acid methanol solvate (9) . The nine adducts have been characterised by X-ray diffraction, IR and elemental analysis, the melting points were also reported. Their structural and supramolecular aspects are fully analyzed. The result reveals that among the nine investigated crystals only the ring Ns in the 4-dimethylaminopyridine moieties are protonated when the carboxylic acids are deprotonated. The crystal packing is interpreted by the strong charge-assisted N-H center dot center dot center dot O hydrogen bond between the NH+ and the deprotonated acidic groups. Except the N-H center dot center dot center dot O hydrogen bonds, the charge assisted or neutral O-H center dot center dot center dot O hydrogen bonds were also found at 2-6, 8 and 9 . The COOH center dot center dot center dot COO- synthon has been at 2, 5-6 and 8-9. Further analysis of the crystal packing indicated that a different family of additional CH-O/CH2-O/CH3-O, F-F, Br-Br, CH-Cl, CH3-Cl, CH-pi/CH3-pi, C-H center dot center dot center dot C-pi, C-pi, Cl-O, O-C, O-pi and pi-pi contacts contribute to the stabilization and expansion of the total high-dimensional (2D-3D) framework structures. For the synergism of the various nonbonding contacts there created homo/hetero supramolecular synthons or both. (C) 2021 Elsevier B.V. All rights reserved.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chen, B; Lin, ZH; Wu, RH; Jin, SW; Dong, LF; Bai, LQ; Xu, WQ; Wang, DQ or concate me.. SDS of cas: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about SYNERGIST, Saw an article supported by the BASF CanadaBASF; Natural Sciences and Engineering Research Council of Canada CRD programNatural Sciences and Engineering Research Council of Canada (NSERC) [CRDPJ417954-1]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Carballo-Arce, AF; Raina, V; Liu, SQ; Liu, R; Jackiewicz, V; Carranza, D; Arnason, JT; Durst, T. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Name: 2,4-Dichlorobenzoic acid

Synthesis of 50 analogues of the natural insecticide synergists, dillapiol and sesamol, is reported. These were evaluated as potential insecticide synergists based on their inhibition of human CYP3A4. The most potent inhibitors have a relatively large hydrophobic substituent at either position 5 or 6 of these molecules. For example, 5-(benzyloxy)-6-(3-phenylsulfonyl)propyl)benzo[d] [1,3]dioxole (18) and the diphenyl acetate of (6,7-dimethoxybenzo[d] [1,3]dioxol-5-yl)propan-1-ol (5n) show inhibitory concentrations for 50% activity IC50 values of 0.086 and 0.2 mu M, respectively. These compounds are 106 and 46 times more potent than dillapiol whose IC50 for the inhibition of CYP3A4 is 9.2 mu M. The ortho-chloro analogue (8f), whose activity is 86 times the activity of dillapiol, is the most potent of the fourteen 5-(benzyloxy-6-(2-propenyl)benzo[d][1,3]dioxoles prepared for this study.

Name: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Carballo-Arce, AF; Raina, V; Liu, SQ; Liu, R; Jackiewicz, V; Carranza, D; Arnason, JT; Durst, T or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Authors Wang, MF; Mi, Y; Hu, FL; Niu, Z; Yin, XH; Huang, Q; Wang, HF; Lang, JP in AMER CHEMICAL SOC published article about 2+2 PHOTODIMERIZATION; PHOTOCHEMISTRY; CHEMISTRY; CYCLOBUTANE; DERIVATIVES; INCREASES; CATALYSIS; POLYMER; CO2 in [Wang, Meng-Fan; Hu, Fei-Long; Niu, Zheng; Wang, Hui-Fang; Lang, Jian-Ping] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China; [Wang, Meng-Fan; Mi, Yan; Hu, Fei-Long; Yin, Xian-Hong; Huang, Qin] Guangxi Univ Nationalities, Guangxi Key Lab Chem & Engn Forest Prod, Nanning 530006, Peoples R China in 2020, Cited 49. Product Details of 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

To obtain a pure product without the isomer byproducts is a goal that many chemists are pursuing. As one kind of very important synthesis method, the photochemical reaction is simple and straightforward yet low-selective. In this work, a coordination interaction based oriented synthesis strategy has been proposed to realize the precise stereochemical control of the isomeric cyclic compounds in the photocycloaddition reaction. Through fixing the reactants via coordination interactions, the arrangements and configurations of the reactants can be adjusted, thereby successfully producing all of the related photocycloaddition products without isomer byproducts for the first time. This work not only provides a new route to synthesize the pure cyclic compounds but also expands the application of the photocycloaddition reaction.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Wang, MF; Mi, Y; Hu, FL; Niu, Z; Yin, XH; Huang, Q; Wang, HF; Lang, JP or concate me.. Product Details of 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Synthesis, characterization, antimicrobial, antioxidant and computational evaluation of N-acyl-morpholine-4-carbothioamides WOS:000515930400001 published article about THIOUREA DERIVATIVES; MOLECULAR DOCKING; CRYSTAL-STRUCTURE; ACYL THIOUREA; ANTIBACTERIAL; DISCOVERY; 3D-QSAR; SERIES; L. in [Aziz, Hamid; Saeed, Aamer] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Khan, Muhammad Aslam; Afridi, Shakeeb] Quaid I Azam Univ, Dept Biotechnol, Islamabad 45320, Pakistan; [Jabeen, Farukh] Laurentian Univ, Dept Biol, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada; [Jabeen, Farukh] Computat Sci Res & Dev Org, 1401,2485 Hurontario St, Mississauga, ON L5A 2G6, Canada in 2021, Cited 42. Application In Synthesis of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

The present research paper reports the convenient synthesis, successful characterization, in vitro antibacterial, antifungal, antioxidant potency and biocompatibility of N-acyl-morpholine-4-carbothioamides (5a-5j). The biocompatible derivatives were found to be highly active against the tested bacterial and fungal strains. Moreover, some of the screened N-acyl-morpholine-4-carbothioamides exhibited excellent antioxidant potential. Docking simulation provided additional information about possibilities of their inhibitory potential against RNA. It has been predicted by in silico investigation of the binding pattern that compounds 5a and 5j can serve as the potential surrogate for design of novel and potent antibacterial agents. The results for the in vitro bioassays were promising with the identification of compounds 5a and 5j as the lead and selective candidate for RNA inhibition. Results of the docking computations further ascertained the inhibitory potential of compound 5a. Based on the in silico studies, it can be suggested that compounds 5a and 5j can serve as a structural model for the design of antibacterial agents with better inhibitory potential. [GRAPHICS] .

Application In Synthesis of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Aziz, H; Saeed, A; Khan, MA; Afridi, S; Jabeen, F or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 50-84-0. Bagal, SK; Omoto, K; Blakemore, DC; Bungay, PJ; Bilsland, JG; Clarke, PJ; Corbett, MS; Cronin, CN; Cui, JJ; Dias, R; Flanagan, NJ; Greasley, SE; Grimley, R; Johnson, E; Fengas, D; Kitching, L; Kraus, ML; McAlpine, I; Nagata, A; Waldron, GJ; Warmus, JS in [Bagal, Sharan K.; Omoto, Kiyoyuki; Blakemore, David C.] Pfizer Global R&D UK, Worldwide Med Chem, Portway Bldg,Granta Pk, Cambridge CB21 6GS, England; [Bungay, Peter J.] Pfizer Global R&D UK, Pharmacokinet Dynam & Metab, Portway Bldg,Granta Pk, Cambridge CB21 6GS, England; [Bilsland, James G.; Dias, Rebecca; Flanagan, Neil J.; Grimley, Rachel; Kitching, Linda; Waldron, Gareth J.] Pfizer Global R&D UK, Portway Bldg,Granta Pk, Cambridge CB21 6GS, England; [Corbett, Matthew S.; Warmus, Joseph S.] Pfizer Global R&D, Groton Labs, Eastern Point Rd, Groton, CT 06340 USA; [Cronin, Ciaran N.; Cui, J. Jean; Greasley, Samantha E.; Johnson, Eric; Kraus, Michelle L.; McAlpine, Indrawan; Nagata, Asako] Pfizer Global R&D, La Jolla Labs, 10770 Sci Ctr Dr, San Diego, CA 92121 USA; [Clarke, Philip J.; Fengas, David] Peakdale Mol, Discovery Pk House,Ramsgate Rd, Sandwich CT13 9ND, Kent, England published Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors in 2019, Cited 61. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are activated by hormones of the neurotrophin family: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4). Moreover, the NGF antibody tanezumab has provided clinical proof of concept for inhibition of the TrkA kinase pathway in pain leading to significant interest in the development of small molecule inhibitors of TrkA. However, achieving TrkA subtype selectivity over TrkB and TrkC via a Type I and Type II inhibitor binding mode has proven challenging and Type III or Type IV allosteric inhibitors may present a more promising selectivity design approach. Furthermore, TrkA inhibitors with minimal brain availability are required to deliver an appropriate safety profile. Herein, we describe the discovery of a highly potent, subtype selective, peripherally restricted, efficacious, and well-tolerated series of allosteric TrkA inhibitors that culminated in the delivery of candidate quality compound 23.

Recommanded Product: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Bagal, SK; Omoto, K; Blakemore, DC; Bungay, PJ; Bilsland, JG; Clarke, PJ; Corbett, MS; Cronin, CN; Cui, JJ; Dias, R; Flanagan, NJ; Greasley, SE; Grimley, R; Johnson, E; Fengas, D; Kitching, L; Kraus, ML; McAlpine, I; Nagata, A; Waldron, GJ; Warmus, JS or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples published in 2019. Recommanded Product: 2,4-Dichlorobenzoic acid, Reprint Addresses Muhammad, N (corresponding author), Wuchang Univ Technol, Dept Environm Engn, Wuhan, Hubei, Peoples R China.; Muhammad, N; Guo, DD (corresponding author), Zhejiang Univ, Dept Chem, Xixi Campus, Hangzhou 310028, Zhejiang, Peoples R China.; Guo, DD (corresponding author), Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Analysis of acidic pharmaceuticals in complex biological samples is a challenging and formidable task due to the existence of interfering constituents within the sample matrices. Therefore, in order to avoid analytical column clogging and suppression/enhancement of signals of the analyte of interest, herein a simple, cost-effective and quick online ion chromatography based clean-up setup was introduced. This system was further coupled with a cost-effective homemade photochemically induced fluorimetric (PIF) setup for direct online conversion of non fluorescent acidic pharmaceutical drugs into their respective fluorescent species. This advantageous system was favorably applied for the determination of four non-fluorescent acidic compounds in two complex biological samples (human serum and oral fluid) with minimum labor and organic solvent consumption. At optimized conditions, the developed method has shown good sensitivity, selectivity, satisfactory recoveries (88.68-102.14%) and low limits of detection (0.35-8.10 mu g/L) with minimum or zero matrix effect.

Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Muhammad, N; Guo, DD; Zhang, Y; Intisar, A; Subhani, Q; Qadir, MA; Cui, HR or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

SDS of cas: 50-84-0. In 2020 J ORG CHEM published article about KINETIC DIASTEREOSELECTIVE ACYLATION; ALKYLATING-AGENTS; GLYCOSYL DONORS; IN-VITRO; GLUCURONIDES; DERIVATIVES; OXIDATION; GLUCOSIDES; DELIVERY; ESTERS in [Bennai, Nedjwa; Chabrier, Amelie; Fatthalla, Maha, I; Tran, Christine; Yen-Pon, Expedite; Alami, Mouad; Messaoudi, Samir] Univ Paris Saclay, CNRS, BioCIS, F-92290 Chatenay Malabry, France; [Bennai, Nedjwa; Belkadi, Mohamed] Univ Sci & Technol Oran Mohamed Boudiaf, Bir El Djir 31000, Algeria; [Fatthalla, Maha, I] Helwan Univ, Fac Sci, Dept Chem, Ain Helwan 11795, Egypt; [Grimaud, Laurence] Sorbonne Univ, Lab Biomol LBM, Ecole Normale Super, CNRS, F-75005 Paris, France in 2020, Cited 55. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

We have discovered a new mode of reactivity of 1-thiosugars in the presence of Cu(II) or Co(II) for a stereoselective O-glycosylation reaction. The process involves the use of a catalytic amount of Cu(acac)(2) or Co(acac)(2) and Ag2CO3 as an oxidant in alpha,alpha,alpha-trifluorotoluene. Moreover, this protocol turned out to have a broad scope, allowing the preparation of a wide range of complex substituted O-glycoside esters in good to excellent yields with an exclusive 1,2-trans-selectivity. The late-stage modification of pharmaceuticals by this method was also demonstrated. To obtain a closer insight into the reaction mechanism, cyclic voltammetry was performed.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Bennai, N; Chabrier, A; Fatthalla, MI; Tran, C; Yen-Pon, E; Belkadi, M; Alami, M; Grimaud, L; Messaoudi, S or concate me.. SDS of cas: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Gu, YC; Sun, XL; Wan, B; Lu, ZE; Zhang, YH in [Gu, Yichao; Sun, Xueliang; Wan, Bin; Lu, Zhuoer; Zhang, Yanghui] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Sustainabil, 1239 Siping Rd, Shanghai 200092, Peoples R China published C(sp(3))-H activation-enabled cross-coupling of two aryl halides: an approach to 9,10-dihydrophenanthrenes in 2020, Cited 63. Computed Properties of C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

A palladium-catalyzed cross-coupling reaction of aryl halides with 2-chlorobenzoic acids has been developed. The reaction forms C(sp(3)), C(sp(2))-palladacycles through C(sp(3))-H activation. The palladacycles react with 2-chlorobenzoic acids through two successive C-C cross-couplings, and two C-C bonds are formed with high chemoselectivity. The reaction provides an innovative method for the synthesis of 9,10-dihydrophenanthrenes.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Gu, YC; Sun, XL; Wan, B; Lu, ZE; Zhang, YH or concate me.. Computed Properties of C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 50-84-0. Zhou, JS; Lou, Z; Xu, J; Zhou, XX; Yang, KL; Gao, XY; Zhang, YL; Xu, XH in [Zhou, Jiasheng; Lou, Zimo; Zhou, Xiaoxin; Yang, Kunlun; Xu, Xinhua] Zhejiang Univ, Dept Environm Engn, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China; [Xu, Jiang; Gao, Xiaoyu; Zhang, Yilin] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA; [Xu, Jiang; Gao, Xiaoyu; Zhang, Yilin] Ctr Environm Implicat Nanotechnol CEINT, Durham, NC USA published Enhanced electrocatalytic dechlorination by dispersed and moveable activated carbon supported palladium catalyst in 2019, Cited 67. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this study, a novel approach was developed for the dechlorination of 2,4-dichlorobenzoic acid (2,4-DCBA) via the combination of the moveable activated carbon (AC) supported palladium (Pd) nanoparticles and nickel (Ni) foam electrode. The morphology and chemical structure of Pd/AC catalyst was investigated by various characterization techniques, including SEM, TEM, EXS-mapping, XRD, and XPS. Pd nanoparticles was successfully loaded and dispersed on the AC, accompanied with the significantly enhanced reactivity. The removal rate of 2,4-DCBA by Ni electrode with moveable Pd/AC catalyst was 222, 25, and 5 folds higher than dispersed AC and Ni electrode system, chemical deposited Pd/Ni electrode, and electrodeposited Pd/Ni electrode, respectively. Compared with the conventional electrocatalytic reductive approach which deposited Pd on the Ni foam electrode, moveable Pd/AC catalyst possesses higher surface area, more atomic H* production and more active sites, favored mass transfer, and enhanced reactivity, without the consideration of catalyst loss and deactivation. The effects of Pd:AC mass ratio, constant current, initial solution pH, and electrolyte concentration on the dechlorination of 2,4-DCBA were studied. Generally, high Pd loading, constant current, and acidity favored the dechlorination of 2,4-DCBA, while excessive electrolyte would inhibit the dechlorination of 2,4-DCBA. Good longevity and recyclability of moveable Pd/AC catalyst was confirmed via consecutive experiments. The findings of the present study show that making the catalyst moveable is a promising strategy for electrocatalytic remediation technology.

Recommanded Product: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, JS; Lou, Z; Xu, J; Zhou, XX; Yang, KL; Gao, XY; Zhang, YL; Xu, XH or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 50-84-0. In 2019 ACS OMEGA published article about SYNERGIST in [Francis Carballo-Arce, Ana; Carranza, David] Univ Nacl, Escuela Quim, Heredia 863000, Costa Rica; [Francis Carballo-Arce, Ana; Raina, Vikrant; Jackiewicz, Victoria; Carranza, David; Durst, Tony] Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON K1N 6N5, Canada; [Liu, Suqi; Liu, Rui; Arnason, John Thor] Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada in 2019, Cited 19. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Synthesis of 50 analogues of the natural insecticide synergists, dillapiol and sesamol, is reported. These were evaluated as potential insecticide synergists based on their inhibition of human CYP3A4. The most potent inhibitors have a relatively large hydrophobic substituent at either position 5 or 6 of these molecules. For example, 5-(benzyloxy)-6-(3-phenylsulfonyl)propyl)benzo[d] [1,3]dioxole (18) and the diphenyl acetate of (6,7-dimethoxybenzo[d] [1,3]dioxol-5-yl)propan-1-ol (5n) show inhibitory concentrations for 50% activity IC50 values of 0.086 and 0.2 mu M, respectively. These compounds are 106 and 46 times more potent than dillapiol whose IC50 for the inhibition of CYP3A4 is 9.2 mu M. The ortho-chloro analogue (8f), whose activity is 86 times the activity of dillapiol, is the most potent of the fourteen 5-(benzyloxy-6-(2-propenyl)benzo[d][1,3]dioxoles prepared for this study.

Recommanded Product: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Carballo-Arce, AF; Raina, V; Liu, SQ; Liu, R; Jackiewicz, V; Carranza, D; Arnason, JT; Durst, T or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics