Category: 50-84-0

Recommanded Product: 50-84-0. Recently I am researching about HIGHLY SELECTIVE OXIDATION; PLATINUM CATALYST; MOLECULAR-OXYGEN; ALLYLIC ALCOHOLS; PORE STRUCTURE; POROUS CARBON; ALDEHYDES; EFFICIENT; NANOPARTICLES; SURFACE, Saw an article supported by the Institute for Advanced Studies in Basic Science (IASBS) Research Council [G2019IASBS31100]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Preparation of an ordered mesoporous polypyrrole/carbon (PPy/OMC) composite has been described through a two-step nanocasting process using KIT-6 as a template. Characterization of the PPy/OMC nanocomposite by various analysis methods such as TEM, XRD, TGA, SEM and N-2 sorption confirmed the preparation of a material with ordered mesoporous structure, uniform pore size distribution, high surface area and high stability. This nanocomposite was then used for the immobilization of palladium nanoparticles. The nanoparticles were almost uniformly distributed on the support with a narrow particle size of 20-25 nm, confirmed by various analysis methods. Performance of the Pd@PPy/OMC catalyst was evaluated in the aerobic oxidation of various primary and secondary alcohols on water as a green solvent, giving the corresponding carboxylic acids and ketones in high yields and excellent selectivity. The catalyst could also be reused for at least 10 reaction runs without losing its catalytic activity and selectivity. High catalytic efficiency of the catalyst can be attributed to a strong synergism between the PPy/OMC and that of supported Pd nanoparticles.

Welcome to talk about 50-84-0, If you have any questions, you can contact Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H or send Email.. Recommanded Product: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article New (mu-oxo)bis(mu-carboxylato)diruthenium(III) complexes containing 1,4,7-trimethyl-1,4,7-triazacyclononane ligands WOS:000652819900005 published article about STRUCTURAL-CHARACTERIZATION; OXIDATION; OXO; RUTHENIUM in [Qian, Bing-Feng; Wang, Jun-Ling; Jia, Ai-Quan; Shi, Hua-Tian; Zhang, Qian-Feng] Anhui Univ Technol, Inst Mol Engn & Appl Chem, Maanshan 243002, Anhui, Peoples R China in 2021, Cited 24. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Formula: C7H4Cl2O2

Treatment of [(Me3tacn)RuCl3 center dot H2O] (Me3tacn = 1,4,7-trimethyl-1,4,7-tri-azacyclononane) with substituted benzoic acid or phenylacetic acid, in water in the presence of potassium hexafluorophosphate gave a series of cationic dinuclear Ru(III)-Ru(III) (mu-oxo)bis(mu-carboxylato) complexes [(Me3tacn)2Ru2(mu-O)(mu-OOCR)2](PF6)2 (R = Ph, 1; -py, 2; -C6H4-2-Cl, 3; -C6H3-2,4-Cl2, 4; -CH2C6H4-2-CH3, 5; -CH2C6H4-4-CH3, 6; -CH2C6H4-4-OCH3, 7; -CH2C6H4-4-Cl, 8). All complexes are well characterized by infrared, UV/Vis and mass spectroscopies, and their electrochemical properties were also investigated. The molecular structures of 1, 2 center dot 2C3H6O, 5 center dot 2C3H6O, 7 and 8 have been also established by single-crystal X-ray diffraction. The photocatalytic properties for H2 evolution by water splitting of complexes 1, 2, 3, 5, and 7 were also investigated in the paper.

Welcome to talk about 50-84-0, If you have any questions, you can contact Qian, BF; Wang, JL; Jia, AQ; Shi, HT; Zhang, QF or send Email.. Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Acylation of 25-hydroxyprotopanaxatriol with aromatic acids increases cytotoxicity WOS:000484878400054 published article about PANAX-GINSENG; IN-VITRO; ANTITUMOR EVALUATION; ANTICANCER ACTIVITY; PROSTATE-CANCER; GINSENOSIDES; DERIVATIVES; PROLIFERATION; SEMISYNTHESIS; APOPTOSIS in [Lv, Liyan; Piao, Huri] Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133002, Peoples R China; [Lv, Liyan; Lu, Jincai] Shenyang Pharmaceut Univ, Dept Med Plant, Shenyang 110016, Liaoning, Peoples R China; [Zhang, Hongyu; Wang, Xude; Su, Guangyue; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Liaoning, Peoples R China; [Zhao, Yuqing] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 36. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Application In Synthesis of 2,4-Dichlorobenzoic acid

20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to search for a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives. Cytotoxicity assay of these derivatives towards MCF-7, A549, U87, HO-8901, Hela cancer cell lines and normal IOSE144 cell lines were tested by MTF assay. Results showed that compared with compound 25-OH-PPD, Compounds 4, 5, 6, 10, 11 showed strong anticancer activity, and all compounds showed low toxicity or no toxicity for normal cells. In particular, compound 6 exhibited the best anti-tumor activity in all cancer cell lines (MCF-7, A549, U87, HO-8901, and Hela) with IC50 values of 5.04 mu M, 1.36 mu M, 3.24 mu M, 3.47 mu M, 4.57 mu M, respectively. Among the five cell lines, all the compounds showed strong inhibition on A549 cells. Further studies showed that Compound 6 significantly inhibited the proliferation of A549 cells by inducing apoptosis. Our results indicate that Compound 6 is a potential anticancer inhibitor and provides a theoretical basis for further research.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

SDS of cas: 50-84-0. Wang, MW; Zhu, HH; Wang, PY; Zeng, D; Wu, YY; Liu, LW; Wu, ZB; Li, Z; Yang, S in [Wang, Ming-Wei; Zhu, Huai-He; Wang, Pei-Yi; Zeng, Dan; Wu, Yuan-Yuan; Liu, Li-Wei; Wu, Zhi-Bing; Yang, Song] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Ctr R&D Fine Chem,Minist Educ, Guiyang 550025, Guizhou, Peoples R China; [Li, Zhong; Yang, Song] East China Univ Sci & Technol, Coll Pharm, Shanghai 200237, Peoples R China published Synthesis of Thiazolium-Labeled 1,3,4-Oxadiazole Thioethers as Prospective Antimicrobials: In Vitro and in Vivo Bioactivity and Mechanism of Action in 2019, Cited 58. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this study, a type of thiazolium-labeled 1,3,4-oxadiazole thioether bridged by diverse alkyl chain lengths was constructed. The antimicrobial activity of the fabricated thioether toward plant pathogenic bacteria and fungi was then screened. Antibacterial evaluation indicated that title compounds possess specific characteristics that enable them to severely attack three phytopathogens, namely, Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri with minimal EC50 values of 0.10, 3.27, and 3.50 mu g/mL, respectively. Three-dimensional quantitative structure-activity relationship models were established to direct the following excogitation for exploring higher active drugs. The in vivo study against plant bacterial diseases further identified the prospective application of title compounds as alternative antibacterial agents. The proteomic technique, scanning electron microscopy patterns, and fluorescence spectrometry were exploited to investigate the antibacterial mechanism. Additionally, some target compounds performed superior inhibitory actions against three tested fungal strains. In view of their simple molecular architecture and highly efficient bioactivity, these substrates could be further explored as promising surrogates for fighting against plant microbial infections.

Welcome to talk about 50-84-0, If you have any questions, you can contact Wang, MW; Zhu, HH; Wang, PY; Zeng, D; Wu, YY; Liu, LW; Wu, ZB; Li, Z; Yang, S or send Email.. SDS of cas: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. Yazdani, E; Heydari, A in [Yazdani, Elahe; Heydari, Akbar] Tarbiat Modares Univ, Chem Dept, POB 14155-4838, Tehran, Iran published Acceptorless dehydrogenative oxidation of primary alcohols to carboxylic acids and reduction of nitroarenes via hydrogen borrowing catalyzed by a novel nanomagnetic silver catalyst in 2020, Cited 46. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

A novel silver nano magnetic catalyst was devised for dehydrogenative oxidation of aromatic and aliphatic alcohols to the corresponding acid with water as the sole oxygen source and hydrogen gas as the only byproduct. The designed catalytic system advantages from easy recovery of magnetic materials i.e. magnetic decantation, being economically viable and environmentally friendly. Furthermore, the catalytic reaction is able to reduce aryl nitro compounds in the absence of any reducing agent. (C) 2020 Elsevier B.V. All rights reserved.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Yazdani, E; Heydari, A or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Concise Synthesis of Isocoumarins through Rh-Catalyzed Direct Vinylene Annulation: Scope and Mechanistic Insight WOS:000551552600081 published article about C-H/O-H; (ELECTRON-DEFICIENT ETA(5)-CYCLOPENTADIENYL)RHODIUM(III) CATALYST; BENZOIC-ACIDS; CARBOXYLIC-ACIDS; OXIDATIVE ANNULATION; NATURAL-PRODUCTS; ACTIVATION/ALKYNE ANNULATION; WEAK COORDINATION; ALPHA-PYRONES; N BOND in [Mihara, Gen; Ghosh, Koushik; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan; [Nishii, Yuji] Osaka Univ, Grad Sch Engn, Frontier Res Base Global Young Researchers, Suita, Osaka 5650871, Japan in 2020, Cited 66. Recommanded Product: 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Transition-metal-catalyzed activation of inert C-H bonds and subsequent C-C bond formation have emerged as powerful synthetic tools for the synthesis of elaborate cyclic molecules. In this report, we introduce an efficient synthetic method of 3,4-unsubstituted isocoumarins adopting an electron-deficient (CpRh)-Rh-E complex as the catalyst. The use of vinylene carbonate as a vinylene transfer reagent enables the direct construction of isocoumarins from readily available benzoic acids, without any external oxidants as well as bases. The reaction mechanism is evaluated by computational analysis to find an unprecedented rhodium shift event within the catalytic cycle.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Mihara, G; Ghosh, K; Nishii, Y; Miura, M or concate me.. Recommanded Product: 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Design, synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents published in 2020. Application In Synthesis of 2,4-Dichlorobenzoic acid, Reprint Addresses Yuan, ZG; Jiang, YY (corresponding author), Tsinghua Univ, Grad Sch Shenzhen, State Key Lab Chem Oncogen, Key Lab Chem Biol, Shenzhen 518055, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTF assays indicated that most of the compounds significantly inhibited multiple cancer cells proliferation. In addition, all the compounds displayed Topo II inhibition activity at 10 mol/L, and also possessed good PARP-1 inhibitory activities. Subsequent mechanistic studies showed that compound 9a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 cells. Our study suggested that 9a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Application In Synthesis of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about HYDROXAMIC ACID-DERIVATIVES; DNA-REPAIR; ANTIPROLIFERATIVE ACTIVITY; KINASE INHIBITORS; CANCER; BINDING; ROLES; DNMT, Saw an article supported by the Shenzhen Development and Reform Committee [20151961, 2019156]; Department of Science and Technology of Guangdong Province [2017B030314083]. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Formula: C7H4Cl2O2

In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTF assays indicated that most of the compounds significantly inhibited multiple cancer cells proliferation. In addition, all the compounds displayed Topo II inhibition activity at 10 mol/L, and also possessed good PARP-1 inhibitory activities. Subsequent mechanistic studies showed that compound 9a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 cells. Our study suggested that 9a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Jiang, GP; Song, LL; Tao, DL; Jin, F in [Jiang, Guangpeng; Song, Lulu; Tao, Dongliang; Jin, Feng] Fuyang Normal Univ, Coll Chem & Mat Engn, Fuyang 236037, Peoples R China published Characterization of luminescent hydroxyapatite@terbium complex core-shell composites using chlorobenzoic acid as ligands in 2020, Cited 29. Recommanded Product: 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Three kinds of novel hydroxyapatite@terbium complex core-shell composites were synthesized with 2-chlorobenzoic acid, 4-chlorobenzoic acid, and 2,4-dichlorobenzoic acid as the ligand, respectively. The XRD, UV/vis absorption and FT-IR results show that terbium ions are coordinated with ligands and the corresponding complexes are successfully included into composites. SEM and EDS results reveal that Tb complexes are fully and homogenously coated on the surface of hydroxyapatite (HAP) microspheres consisting of a large number of nanosized crystals. The strongest luminescence properties are obtained when 2,4-dichlorobenzoic acid is used as ligand. The study on fluorescence lifetime of composites shows that the lifetime is inversely related to emission intensity. TGA-DSC results indicate that the core-shell composites have an excellent thermal stability. Therefore, the current core-shell structure provides a cost-effective route to manufacture of biocompatible and heat-resistant highly luminescent materials. (C) 2020 Chinese Society of Rare Earths. Published by Elsevier B.V. All rights reserved.

Recommanded Product: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Jiang, GP; Song, LL; Tao, DL; Jin, F or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins published in 2021. Product Details of 50-84-0, Reprint Addresses Chi, YH; Chang, CP (corresponding author), Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Taiwan.; Chi, YH (corresponding author), China Med Univ, Grad Inst Biomed Sci, Taichung 40402, Taiwan.; Chang, CP (corresponding author), Chung Yuan Christian Univ, Dept Chem, Taoyuan 320314, Taiwan.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

The A-type Aurora kinase is upregulated in many human cancers, and it stabilizes MYC-family oncoproteins, which have long been considered an undruggable target. Here, we describe the design and synthesis of a series of pyrimidine-based derivatives able to inhibit Aurora A kinase activity and reduce levels of cMYC and MYCN. Through structure-based drug design of a small molecule that induces the DFG-out conformation of Aurora A kinase, lead compound 13 was identified, which potently (IC50 < 200 nM) inhibited the proliferation of high-MYC expressing small-cell lung cancer (SCLC) cell lines. Pharmacokinetic optimization of 13 by prodrug strategies resulted in orally bioavailable 25, which demonstrated an 8-fold higher oral AUC (F = 62.3%). Pharmacodynamic studies of 25 showed it to effectively reduce cMYC protein levels, leading to >80% tumor regression of NCI-H446 SCLC xenograft tumors in mice. These results support the potential of 25 for the treatment of MYC-amplified cancers including SCLC.

Product Details of 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chi, YH; Yeh, TK; Ke, YY; Lin, WH; Tsai, CH; Wang, WP; Chen, YT; Su, YC; Wang, PC; Chen, YF; Wu, ZW; Yeh, JY; Hung, MC; Wu, MH; Wang, JY; Chen, CP; Song, JS; Shih, C; Chen, CT; Chang, CP or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics