Category: 50-84-0

Authors Sharma, P; Tripathi, A; Tripathi, PN; Sen Singh, S; Singh, SP; Shrivastava, SK in AMER CHEMICAL SOC published article about BETA-AMYLOID AGGREGATION; ACETYLCHOLINESTERASE INHIBITOR; ACID-DERIVATIVES; DIRECTED LIGANDS; DESIGN; PEPTIDE; ASSAY; SITE; BUTYRYLCHOLINESTERASE; NEUROTOXICITY in [Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Shrivastava, Sushant Kumar] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Sen Singh, Saumitra; Singh, Surya Pratap] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India in 2019, Cited 80. Recommanded Product: 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer’s disease (AD). Tested compounds exhibited moderate to excellent inhibition against human acetylcholinesterase (hAChE), butyrylcholinesterase (hBChE), and beta-secretase-1 (hBACE-1). The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Hybrids 6g and 10f also elicited favorable permeation across the blood -brain barrier and were devoid of neurotoxic liability toward SH-SYSY neuroblastoma cells. Both leads remarkably disassembled A beta aggregation in thioflavin T-based selfand AChE-induced experiments. Compounds 6g and 10f ameliorated scopolamine gamma-induced cognitive dysfunctions in the Ymaze test. The ex vivo studies of rat brain homogenates established the reduced AChE levels and antioxidant activity of both compounds. Compound 6g also elicited noteworthy improvement in A beta-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of A beta and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis. The pharmacokinetic study showed excellent oral absorption characteristics of compound 6g. The in silica molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.

Welcome to talk about 50-84-0, If you have any questions, you can contact Sharma, P; Tripathi, A; Tripathi, PN; Sen Singh, S; Singh, SP; Shrivastava, SK or send Email.. Recommanded Product: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Diastereoselective and Reversed Regioselective Annulations of N-Alkyl Anilines to Julolidines and Lilolidines published in 2020. SDS of cas: 50-84-0, Reprint Addresses Jana, CK (corresponding author), Indian Inst Technol Guwahati, Dept Chem, Gauhati 780139, Assam, India.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

A three-component annulation reaction of N-alkyl anilines, cyclic 1,3-dicarbonyl compounds, and aryl aldehydes to julolidines and lilolidines is reported. The 6 pi-electrocyclization enabled the annulation to proceed with reversed regioselectivity as compared with the annulation that occurs in the Povarov reaction. Both cyclic and acyclic N-alkyl anilines participated in the reaction to provide a wide range of julolidines and lilolidines as the single regio- and diastereoisomers in good to excellent yields.

SDS of cas: 50-84-0. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Nine Supramolecular Adducts of 4-dimethylaminopyridine and Carboxylic acids Assembled by Classical Hydrogen Bonds and Other Noncovalent Intermolecular Interactions WOS:000663587500014 published article about PROTON-TRANSFER COMPOUNDS; SOLID-STATE LANDSCAPE; CRYSTAL-STRUCTURE; STRUCTURAL-CHARACTERIZATION; PHARMACEUTICAL COCRYSTALS; MOLECULAR-STRUCTURE; ORGANIC SALTS; SOLUBILITY; SYNTHON; ARCHITECTURES in [Chen, Bin; Wu, Ronghui; Jin, Shouwen; Bai, Liqun] Zhejiang A&F Univ, Linan 311300, Peoples R China; [Chen, Bin; Lin, Zhihao; Jin, Shouwen; Dong, Lingfeng; Xu, Weiqiang] Zhejiang A&F Univ, Jiyang Coll, Zhuji 311800, Zhejiang, Peoples R China; [Wang, Daqi] Liaocheng Univ, Dept Chem Engn, Liaocheng 252059, Shandong, Peoples R China in 2021, Cited 86. Product Details of 50-84-0. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Cocrystallization of the widely available 4-dimethylaminopyridine, with a series of carboxylic acids gave nine molecular adducts 4-dimethylaminopyridinium trifluoroacetate (1) , 4-dimethylaminopyridinium glycolate glycolic acid (2) , 4-dimethylaminopyridinium 2-furoate dihydrate (3) , tri(4-dimethylaminopyridinium) tri(o-chlorobenzoate) tetrahydrate (4) , 4-dimethylaminopyridinium 4-bromobenzoate 4-bromobenzoic acid (5) , 4-dimethylaminopyridinium 4-formylbenzoate 4-formylbenzoic acid (6) , 4-dimethylaminopyridinium 2,4-dichlorobenzoate (7) , 4-dimethylaminopyridinium 2-aminobenzoate 2-aminobenzoic acid (8) and bis(4-dimethylaminopyridinium) 5-nitroisophthalate 5-nitroisophthalic acid methanol solvate (9) . The nine adducts have been characterised by X-ray diffraction, IR and elemental analysis, the melting points were also reported. Their structural and supramolecular aspects are fully analyzed. The result reveals that among the nine investigated crystals only the ring Ns in the 4-dimethylaminopyridine moieties are protonated when the carboxylic acids are deprotonated. The crystal packing is interpreted by the strong charge-assisted N-H center dot center dot center dot O hydrogen bond between the NH+ and the deprotonated acidic groups. Except the N-H center dot center dot center dot O hydrogen bonds, the charge assisted or neutral O-H center dot center dot center dot O hydrogen bonds were also found at 2-6, 8 and 9 . The COOH center dot center dot center dot COO- synthon has been at 2, 5-6 and 8-9. Further analysis of the crystal packing indicated that a different family of additional CH-O/CH2-O/CH3-O, F-F, Br-Br, CH-Cl, CH3-Cl, CH-pi/CH3-pi, C-H center dot center dot center dot C-pi, C-pi, Cl-O, O-C, O-pi and pi-pi contacts contribute to the stabilization and expansion of the total high-dimensional (2D-3D) framework structures. For the synergism of the various nonbonding contacts there created homo/hetero supramolecular synthons or both. (C) 2021 Elsevier B.V. All rights reserved.

Welcome to talk about 50-84-0, If you have any questions, you can contact Chen, B; Lin, ZH; Wu, RH; Jin, SW; Dong, LF; Bai, LQ; Xu, WQ; Wang, DQ or send Email.. Product Details of 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples WOS:000488136700013 published article about NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PERFORMANCE LIQUID-CHROMATOGRAPHY; SENSITIVE FLUORESCENCE DETERMINATION; COLUMN-SWITCHING TECHNIQUE; TANDEM MASS-SPECTROMETRY; METAL-ORGANIC FRAMEWORK; SOLID-PHASE EXTRACTION; ION CHROMATOGRAPHY; HUMAN SERUM; HPLC in [Muhammad, Nadeem; Cui, Hairong] Wuchang Univ Technol, Dept Environm Engn, Wuhan, Hubei, Peoples R China; [Muhammad, Nadeem; Guo, Dandan; Zhang, Yun; Subhani, Qamar] Zhejiang Univ, Dept Chem, Xixi Campus, Hangzhou 310028, Zhejiang, Peoples R China; [Guo, Dandan] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China; [Intisar, Azeem; Qadir, Muhammad Abdul] Univ Punjab, Inst Chem, Lahore, Pakistan; [Subhani, Qamar] Higher Educ Dept, Lahore, Punjab, Pakistan in 2019, Cited 46. Recommanded Product: 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Analysis of acidic pharmaceuticals in complex biological samples is a challenging and formidable task due to the existence of interfering constituents within the sample matrices. Therefore, in order to avoid analytical column clogging and suppression/enhancement of signals of the analyte of interest, herein a simple, cost-effective and quick online ion chromatography based clean-up setup was introduced. This system was further coupled with a cost-effective homemade photochemically induced fluorimetric (PIF) setup for direct online conversion of non fluorescent acidic pharmaceutical drugs into their respective fluorescent species. This advantageous system was favorably applied for the determination of four non-fluorescent acidic compounds in two complex biological samples (human serum and oral fluid) with minimum labor and organic solvent consumption. At optimized conditions, the developed method has shown good sensitivity, selectivity, satisfactory recoveries (88.68-102.14%) and low limits of detection (0.35-8.10 mu g/L) with minimum or zero matrix effect.

Recommanded Product: 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2020 J NEUROSURG-PEDIATR published article about FRONTO-ORBITAL ADVANCEMENT; POSTOPERATIVE HELMET THERAPY; SAGITTAL SYNOSTOSIS; CORONAL SYNOSTOSIS; RIGID FIXATION; OPEN REPAIR; CRANIOSYNOSTOSIS; CRANIECTOMY; OUTCOMES; CARE in [Zubovic, Ema; Skolnick, Gary B.; Naidoo, Sybill D.; Patel, Kamlesh B.] Washington Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, St Louis, MO 63110 USA; [Lapidus, Jodi B.] Univ Calif San Francisco, Dept Surg, Div Plast & Reconstruct Surg, San Francisco, CA USA; [Smyth, Matthew D.] Washington Univ, Sch Med, Dept Neurosurg, St Louis, MO USA in 2020, Cited 41. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Product Details of 50-84-0

OBJECTIVE Management of craniosynostosis at an early age is important for mitigating the risk of abnormal cranial development, but treatment can result in significant expenses. Previous research has shown that endoscope-assisted craniectomy (EAC) is less costly than open cranial vault remodeling (CVR) for patients with sagittal synostosis. The aim of this study was to strengthen the existing body of healthcare cost research by elucidating the charges associated with open and endoscopic treatment for patients with nonsagittal synostosis. METHODS The authors performed a retrospective analysis of data obtained in 41 patients who underwent open CVR and 38 who underwent EAC with postoperative helmet therapy for nonsagittal, single-suture craniosynostosis (metopic, coronal, and lambdoid) between 2008 and 2018. All patients were < 1 year of age at the time of surgery and had a minimum 1 year of follow-up. Inpatient charges, physician fees, helmet charges, and outpatient clinic visits in the 1st year were analyzed. RESULTS The mean ages of the children treated with EAC and open CVR were 3.5 months and 8.7 months, respectively. Patients undergoing EAC with postoperative helmet therapy required more outpatient clinic visits in the 1st year than patients undergoing CVR (4 vs 2; p < 0.001). Overall, 13% of patients in the EAC group required 1 helmet, 30% required 2 helmets, 40% required 3 helmets, and 13% required 4 or more helmets; the mean total helmeting charges were $10,072. The total charges of treatment, including inpatient charges, physician fees, outpatient clinic visit costs, and helmet charges, were significantly lower for the EAC group than they were for the open CVR group ($50,840 vs $95,588; p < 0.001). CONCLUSIONS Despite the additional charges for postoperative helmet therapy and the more frequent outpatient visits, EAC is significantly less expensive than open CVR for patients with metopic, coronal, and lambdoid craniosynostosis. In conjunction with the existing literature on clinical outcomes and perioperative resource utilization, these data support EAC as a cost-minimizing treatment for eligible patients with nonsagittal synostosis. Product Details of 50-84-0. Welcome to talk about 50-84-0, If you have any questions, you can contact Zubovic, E; Lapidus, JB; Skolnick, GB; Naidoo, SD; Smyth, MD; Patel, KB or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2019 CHEM PAP published article about ANTIBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; LEAF-BLIGHT; ANALOGS; DESIGN; POTENT; WILT; GENOME in [Tian, Kun; Li, Xiao-Qin; Zhang, Li; Wu, Shou-Qun; Wan, Jin-Lin; Ouyang, Gui-Ping] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang 550025, Guizhou, Peoples R China; [Gan, Yi-Yuan; Meng, Jiao; Xu, Yang; Cai, Chao-Ting; Ouyang, Gui-Ping; Wang, Zhen-Chao] Guizhou Univ, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China; [Ouyang, Gui-Ping; Wang, Zhen-Chao] Drug Synthet Engn Lab Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China in 2019, Cited 37. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Quality Control of 2,4-Dichlorobenzoic acid

A series of novel indole derivatives containing double 1,3,4-oxadiazole moiety was designed, synthesized and evaluated for their antibacterial activities in vitro. These compounds were fully characterized by H-1 NMR, C-13 NMR, and HRMS. Bioassay results indicated that most of title compounds exhibited excellent antibacterial activities against rice bacterial pathogen Xanthomonas oryzae (Xoo). For example, compounds 7d, 7h, 7i, 7j, 7k, 7l and 7m had the half-maximal effective concentration (EC50) values of 52.31, 54.12, 40.65, 38.80, 51.13, 52.75 and 50.66 mu g/mL, respectively, which was better than that of commercial product bismerthiazol (BMT) (85.18 mu g/mL). The experimental results proved that indole derivatives bearing double 1,3,4-oxadiazole unit are promising candidates for the development of new agricultural bactericides against pathogenic bacterium Xoo. [GRAPHICS] .

Welcome to talk about 50-84-0, If you have any questions, you can contact Tian, K; Li, XQ; Zhang, L; Gan, YY; Meng, J; Wu, SQ; Wan, JL; Xu, Y; Cai, CT; Ouyang, GP; Wang, ZC or send Email.. Quality Control of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Formula: C7H4Cl2O2. I found the field of Chemistry very interesting. Saw the article Synthesis of novel indole derivatives containing double 1,3,4-oxadiazole moiety as efficient bactericides against phytopathogenic bacterium Xanthomonas oryzae published in 2019, Reprint Addresses Ouyang, GP (corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang 550025, Guizhou, Peoples R China.; Ouyang, GP; Wang, ZC (corresponding author), Guizhou Univ, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China.; Ouyang, GP; Wang, ZC (corresponding author), Drug Synthet Engn Lab Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

A series of novel indole derivatives containing double 1,3,4-oxadiazole moiety was designed, synthesized and evaluated for their antibacterial activities in vitro. These compounds were fully characterized by H-1 NMR, C-13 NMR, and HRMS. Bioassay results indicated that most of title compounds exhibited excellent antibacterial activities against rice bacterial pathogen Xanthomonas oryzae (Xoo). For example, compounds 7d, 7h, 7i, 7j, 7k, 7l and 7m had the half-maximal effective concentration (EC50) values of 52.31, 54.12, 40.65, 38.80, 51.13, 52.75 and 50.66 mu g/mL, respectively, which was better than that of commercial product bismerthiazol (BMT) (85.18 mu g/mL). The experimental results proved that indole derivatives bearing double 1,3,4-oxadiazole unit are promising candidates for the development of new agricultural bactericides against pathogenic bacterium Xoo. [GRAPHICS] .

Formula: C7H4Cl2O2. Welcome to talk about 50-84-0, If you have any questions, you can contact Tian, K; Li, XQ; Zhang, L; Gan, YY; Meng, J; Wu, SQ; Wan, JL; Xu, Y; Cai, CT; Ouyang, GP; Wang, ZC or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 2,4-Dichlorobenzoic acid. Yao, Y; Kadam, RU; Lee, CCD; Woehl, JL; Wu, NC; Zhu, XY; Kitamura, S; Wilson, IA; Wolan, DW in [Yao, Yao; Woehl, Jordan L.; Kitamura, Seiya; Wolan, Dennis W.] Scripps Res Inst, Dept Mol Med, La Jolla, CA 92037 USA; [Kadam, Rameshwar U.; Lee, Chang-Chun David; Wu, Nicholas C.; Zhu, Xueyong; Wilson, Ian A.; Wolan, Dennis W.] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA; [Wilson, Ian A.] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA published An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen in 2020, Cited 45. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and is a validated target for drug discovery. However, to date, only a very few bona fide small molecules have been reported against the HA. To identity new antiviral lead candidates against the highly conserved fusion machinery in the HA stem, we synthesized a fluorescence-polarization probe based on a recently described neutralizing cyclic peptide P7 derived from the complementarity-determining region loops of human bnAbs FI6v3 and CR9114 against the HA stem. We then designed a robust binding assay compatible with high-throughput screening to identify molecules with low micromolar to nanomolar affinity to influenza A group 1 HAs. Our simple, low-cost, and efficient in vitro assay was used to screen H1/Puerto Rico/8/1934 (H1/PR8) HA trimer against similar to 72,000 compounds. The crystal structure of H1/PR8 HA in complex with our best hit compound F0045(S) confirmed that it binds to pockets in the HA stem similar to bnAbs FI6v3 and CR9114, cyclic peptide P7, and small-molecule inhibitor JNJ4796. F0045 is enantioselective against a panel of group 1 HAs and F0045(S) exhibits in vitro neutralization activity against multiple H1N1 and H5N1 strains. Our assay, compound characterization, and small-molecule candidate should further stimulate the discovery and development of new compounds with unique chemical scaffolds and enhanced influenza antiviral capabilities.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Yao, Y; Kadam, RU; Lee, CCD; Woehl, JL; Wu, NC; Zhu, XY; Kitamura, S; Wilson, IA; Wolan, DW or concate me.. Recommanded Product: 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 2,4-Dichlorobenzoic acid. In 2020 ACS APPL MATER INTER published article about NITROGEN-DOPED CARBON; HYDROGEN-PEROXIDE; ELECTROCHEMICAL OXIDATION; POROUS CARBON; WASTE-WATER; GRAPHENE; MECHANISM; ELECTROSYNTHESIS; IDENTIFICATION; COORDINATION in [Li, Ning; Song, Xiaozhe; Wang, Li; Geng, Xinle; Wang, Hui] Beijing Forestry Univ, Coll Environm Sci & Engn, Beijing 00083, Peoples R China; [Tang, Hanyu; Bian, Zhaoyong] Beijing Normal Univ, Coll Water Sci, Beijing 100875, Peoples R China in 2020, Cited 55. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Electrochemical reduction-oxidation processes with the aid of cathode catalysts are promising technologies for the decomposition of organic compounds. High-efficiency and low-cost catalysts for electrochemical reductive dechlorination and two-electron oxygen reduction reaction (ORR) are vital to the overall degradation of chlorinated organic compounds. This study reports electrochemical dechlorination using a single-atom Co-loaded sulfide graphene (Co-SG) catalyst via atomic hydrogen generated from the electrochemical reduction of H2O and electrolysis of hydrogen. The Co-SG electrocatalyst exhibited a remarkable performance for H2O2 synthesis with a half-wave potential of 0.70 V (vs RHE) and selectivity over 90%. The high electrochemical performance was achieved for bifunctional electrocatalysis with regard to the smaller overpotentials, faster kinetics, and higher cycling stability compared to the noble metal-based electrocatalysts. In this study, 2,4-dichlorobenzoic acid was well degraded and the TOC concentration was effectively reduced. This work introduces the preparation of a new active site for high-performance single-atom catalysts and also promotes its application in the electrochemical degradation of chlorinated organic pollutants.

Application In Synthesis of 2,4-Dichlorobenzoic acid. Welcome to talk about 50-84-0, If you have any questions, you can contact Li, N; Song, XZ; Wang, L; Geng, XL; Wang, H; Tang, HY; Bian, ZY or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Synthesis and biological activities of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety WOS:000465007200008 published article about BACTERIAL LEAF-BLIGHT; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; 1,4-PENTADIEN-3-ONE DERIVATIVES; MOSAIC-VIRUS; DESIGN; INHIBITORS; 3D-QSAR; BETA in [Tang, Xu; Wang, Zhongbo; Zhong, Xinmin; Chen, Lijuan; He, Ming; Xue, Wei] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang, Guizhou, Peoples R China; [Wang, Xiaobin] Nanjing Agr Univ, Coll Sci, Nanjing, Jiangsu, Peoples R China in 2019, Cited 37. Name: 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal and antiviral activities. The bioassay results indicated that most of target compounds showed good antiviral activities against tobacco mosaic virus (TMV) and antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (Rs). Especially, the anti-Xoo effect of title compounds 5k (N-(5-methoxybenzo[d]thiazol-2-yl)-2-((5-(2-tolyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) and the anti-Rs effect of title compounds 5a (N-(5-nitrobenzo[d]thiazol-2-yl)-2-((5-(4-(trifluorom ethyl)phenyl)-1,3,4-thiadiazol-2-yl)thio)acetmide) respectively reached 52.4% and 71.6% at 100 mu g/mL, which are superior to that of bismerthiazol (32.0% and 52.3%). In addition, the protective and inactivation activities of title compound 5i (N-(5-methoxybenzo [d]thiazol-2-yl)-2-((5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) against TMV were 79.5% and 88.3%, respectively, which are better than that of ningnanmycin (76.4% and 86.8%). The above research showed that benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety may be used as potential molecular templates in searching for highly-efficient antiviral and antibacterial agents.

Name: 2,4-Dichlorobenzoic acid. Welcome to talk about 50-84-0, If you have any questions, you can contact Tang, X; Wang, ZB; Zhong, XM; Wang, XB; Chen, LJ; He, M; Xue, W or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics