Category: 50-84-0

Recently I am researching about BOND ACTIVATIONS; FUNCTIONALIZATION; DIMERIZATION, Saw an article supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence StrategyGerman Research Foundation (DFG) [EXC-2033-390677874, SFB TRR88, FOR 982/1]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zeng, ZY; Goebel, JF; Liu, XM; Goossen, LJ. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Computed Properties of C7H4Cl2O2

2,2′-Biaryldicarboxylates are important functionalities in bioactive compounds, functional materials, and chiral catalysts. These compounds have been found to be conveniently accessible from benzoic acids via Rh-catalyzed electrooxidative C-H/C-H couplings, giving valuable dihydrogen as the byproduct. In an undivided cell with Pt electrodes, RhCl3 center dot 3H(2)O catalyzes the oxidative carboxylate-directed ortho-homocoupling of various aromatic acids with a current efficiency of 67%. The protocol is operationally simple, tolerates a wide variety of functional groups, and does not require the exclusion of air and moisture. Heterodimerizations via cross-dehydrogenative couplings of naphthyl-1-carboxylic acids with acrylic or benzoic acids were also shown to work.

Welcome to talk about 50-84-0, If you have any questions, you can contact Zeng, ZY; Goebel, JF; Liu, XM; Goossen, LJ or send Email.. Computed Properties of C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about ELECTROCHEMICAL REDUCTIVE DECHLORINATION; ZERO-VALENT IRON; 2,4-DICHLOROPHENOXYACETIC ACID; PALLADIUM NANOPARTICLES; THERMAL CATALYSIS; FOAM ELECTRODES; WASTE-WATER; DEGRADATION; CATHODE; TRICHLOROETHYLENE, Saw an article supported by the Science and Technology Project of Zhejiang Province, China [LGF18B070001]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41877463]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Lou, ZM; Wang, ZN; Zhou, JS; Zhou, CC; Xu, J; Xu, XH. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Category: chlorides-buliding-blocks

Electrocatalytic hydrodechlorination (ECH) has been proposed as a potential technology for the effective degradation of organochlorine contaminants. In this study, a nanoscale Pd/TiC catalyst with low resistance was dip-coated onto Ti, aiming to fabricate a stable Pd/TiC/Ti electrode with enhanced ECH reactivity for efficient dechlorination. Electrochemical techniques indicated that the Pd/TiC/Ti electrode had a larger electrochemically active surface area and more rapid interfacial charge transfer than the conventional Pd/C/Ti electrode. In a batch experiment, the dechlorination rate for ECH of 2,4-dichlorobenzoic acid (2,4-DCBA, a model pollutant) by Pd/TiC/Ti was 1.3-14.5 times higher than those by Pd/C/Ti, Pd/MWCNTs/Ti, and Pd/MoS2/Ti, respectively. Scavenger experiments, ESR spin-trapping spectroscopy, and cyclic voltammetry clarified the intensified atomic H* generation by Pd/TiC/Ti. DFT calculations revealed that Pd/TiC/Ti had stronger binding ability with atomic H* (E-ads: -2.89 eV vs. -2.44 eV) and 2,4-DCBA (E-ads: -3.62 eV vs. -2.15 eV), respectively, when compared with Pd/C/Ti. As a result, enhanced generation of atomic H*, together with strengthened adsorption of atomic H* and 2,4-DCBA, would contribute to a faster ECH reaction. The Pd/TiC/Ti electrode retained its reactivity after 10 successive batch experiments (80 h), and showed high tolerance to the constituents in actual water matrices including lake water and river water. This study proposed a promising ECH electrode for the treatment of chlorinated organics in water matrices.

Welcome to talk about 50-84-0, If you have any questions, you can contact Lou, ZM; Wang, ZN; Zhou, JS; Zhou, CC; Xu, J; Xu, XH or send Email.. Category: chlorides-buliding-blocks

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents WOS:000526839700017 published article about MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL EVALUATION; IN-VITRO; DOCKING; ANALOGS in [Srinivasarao, Singireddi; Nandikolla, Adinarayana; Suresh, Amaroju; Aggarwal, Himanshu; Sekhar, Kondapalli Venkata Gowri Chandra] Birla Inst Technol & Sci, Dept Chem, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Calster, Kevin Van; De Voogt, Linda; Cappoen, Davie] Univ Ghent, Fac Biosci Engn, Dept Green Chem & Technol, Coupure Links 653, B-9000 Ghent, Belgium; [Ghosh, Balaram] Birla Inst Technol & Sci, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Murugesan, Sankaranarayanan] Birla Inst Technol & Sci, Dept Pharm, Med Chem Res Lab, Pilani 333031, Rajasthan, India in 2020, Cited 34. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Application In Synthesis of 2,4-Dichlorobenzoic acid

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among the tested compounds, five compounds (6a, 6e, 6h, 6j and 6k) from Series-I and one compound (7e) from Series-II exhibited significant activity against Mycobacterium tuberculosis H37Ra with 50% inhibitory concentrations (IC50) ranging from 1.35 to 2.18 mu M. To evaluate the efficacy of these compounds, we examined their IC90 values. Five of the most active compounds were found to be more active with IC(90)s ranging from 3.73 to 4.00 mu M and one compound (6e) showed an IC90 of 40.32 mu M. Moreover, single crystals were developed for 6d, 6f and 6n. In addition, most active compounds were evaluated for their cytotoxicity on HEK-293 (human embryonic kidney) cells. Our results indicate that the compounds are nontoxic to human cells. The molecular interactions of the derivatised conjugates in docking studies reveal their suitability for further development.

Application In Synthesis of 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2019 SYNLETT published article about AROMATIC-SUBSTITUTION; (HETERO)ARYL HALIDES; COPPER; LIGANDS; TAMIBAROTENE; AMIDATION; AMINATION; TACRINE; ANALOGS in [Du, Fangyu; Zhou, Qifan; Fu, Yang; Chen, Yuanguang; Chen, Guoliang] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China; [Wu, Ying] Yunnan Inst Trop Crops, Jinghong 666100, Peoples R China in 2019, Cited 47. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Formula: C7H4Cl2O2

Herein, we report the natural ligand quebrachitol (QCT) as a promoter for a Cu(II) catalyst, which is highly effective for N-arylation of various amines and related aryl halides. A series of diarylamine derivatives were obtained in high yields by using diethylene glycol (DEG) as both ligand and solvent. The C-N coupling reactions proceed under mild conditions and exhibit good functional group tolerance.

Formula: C7H4Cl2O2. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Tian, K; Li, XQ; Zhang, L; Gan, YY; Meng, J; Wu, SQ; Wan, JL; Xu, Y; Cai, CT; Ouyang, GP; Wang, ZC in [Tian, Kun; Li, Xiao-Qin; Zhang, Li; Wu, Shou-Qun; Wan, Jin-Lin; Ouyang, Gui-Ping] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang 550025, Guizhou, Peoples R China; [Gan, Yi-Yuan; Meng, Jiao; Xu, Yang; Cai, Chao-Ting; Ouyang, Gui-Ping; Wang, Zhen-Chao] Guizhou Univ, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China; [Ouyang, Gui-Ping; Wang, Zhen-Chao] Drug Synthet Engn Lab Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China published Synthesis of novel indole derivatives containing double 1,3,4-oxadiazole moiety as efficient bactericides against phytopathogenic bacterium Xanthomonas oryzae in 2019, Cited 37. COA of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

A series of novel indole derivatives containing double 1,3,4-oxadiazole moiety was designed, synthesized and evaluated for their antibacterial activities in vitro. These compounds were fully characterized by H-1 NMR, C-13 NMR, and HRMS. Bioassay results indicated that most of title compounds exhibited excellent antibacterial activities against rice bacterial pathogen Xanthomonas oryzae (Xoo). For example, compounds 7d, 7h, 7i, 7j, 7k, 7l and 7m had the half-maximal effective concentration (EC50) values of 52.31, 54.12, 40.65, 38.80, 51.13, 52.75 and 50.66 mu g/mL, respectively, which was better than that of commercial product bismerthiazol (BMT) (85.18 mu g/mL). The experimental results proved that indole derivatives bearing double 1,3,4-oxadiazole unit are promising candidates for the development of new agricultural bactericides against pathogenic bacterium Xoo. [GRAPHICS] .

Welcome to talk about 50-84-0, If you have any questions, you can contact Tian, K; Li, XQ; Zhang, L; Gan, YY; Meng, J; Wu, SQ; Wan, JL; Xu, Y; Cai, CT; Ouyang, GP; Wang, ZC or send Email.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 2,4-Dichlorobenzoic acid. Tao, DY; Wang, R; Shi, S; Yun, LF; Tong, R; Peng, YE; Guo, W; Liu, YF; Hu, SH in [Tao, Danyang; Tong, Rui; Peng, Yue’e; Guo, Wei; Hu, Shenghong] China Univ Geosci, State Key Lab Biogeol & Environm Geol, Wuhan 430074, Peoples R China; [Wang, Rong; Shi, Si; Peng, Yue’e] China Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Peoples R China; [Yun, Lifen] BGI Genom BGI Shenzhen, Shenzhen 518083, Peoples R China; [Liu, Yanfeng] China Univ Geosci, Sch Environm Studies, Wuhan, Peoples R China published The identification of halogenated disinfection by-products in tap water using liquid chromatography-high resolution mass spectrometry in 2020, Cited 48. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this paper, a comprehensive method for the identification of the unknown halogenated DBPs (X-DBPs, X = CI, Br, and I) in the tap water of Wuhan, China via liquid chromatography-high resolution mass spectrometry (LC-HRMS) was developed. 123 X-DBPs were identified through the stepwise procedure, 94 of them were newly identified, and 3 of them were confirmed by standards. Most X-DBPs were aliphatic compounds and highly unsaturated and phenolic compounds, some X-DBPs contained multiple halogen atoms and rich in carboxyl groups, such as C2H2O2BrCl, C2H2O2Br2, and C2H2O2ClI. It was worth noting that the concentration of some X-DBPs had the same trend with time. Most CI-DBPs remained stable and I-DBPs were detected occasionally by monitoring the change of concentration of these X-DPBs with the time during three consecutive months. The results demonstrate that the proposed method could provide valuable molecular formula and structure information on unknown multiple halogenated DBPs, or be used for the identification of other multiple halogenated organic compounds in different media. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Agriculture very interesting. Saw the article Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2-yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach published in 2020. COA of Formula: C7H4Cl2O2, Reprint Addresses Guo, Y; Jin, CY; Yang, RG (corresponding author), Zhengzhou Univ, Sch Pharmaceut Sci, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Henan, Peoples R China.; Jin, CY (corresponding author), Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

(+)-Nootkatone, a non-food bioactive natural bicyclic sesquiterpene ketone, is isolated from Chamaecyparis nootkatensis [D. Don] Spach as a renewable forest resource. In continuation of our effort to develop synthetic natural derived insecticides from non-food bioactive products, a small library of thirty N-(1,3- thiazol-2-yl) carboxamides fused (+)-nootkatone was prepared by molecular hybridization and characterized by H-1/C-13 NMR, HR-MS, and IR spectroscopy. Their insecticidal activities against Mythimna separata Walker and Plutella xylostella Linnaeus were evaluated. Compounds B6, B7, B9, B19-21 and B24 showed better insecticidal activity against M. separata than the botanical insecticide azadirachtin, and their LC50 values ranged from 0.55 -0.68 mg/mL. Particularly, compound B9 exhibited 1.87-fold more pronounced insecticidal activity against M. separata than azadirachtin. The insecticidal activity of B21 against P. xylostella was 1.37-fold of that of azadirachtin. Through acetylcholinesterase (AChE) inhibitory activity and molecular docking studies, AChE may be the insecticidal target of B9 against M. separata. In addition, three pronounced compounds B9, B21 and B24 exhibited low hemolytic and cytotoxic activities on normal mammalian cells. These findings will give insights into the further development of (+)-nootkatone derivatives as potentially synthetic natural derived insecticides for pest management.

Welcome to talk about 50-84-0, If you have any questions, you can contact Guo, Y; Liu, ZY; Hou, EH; Ma, NN; Fan, JP; Jin, CY; Yang, RG or send Email.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 2,4-Dichlorobenzoic acid. In 2019 J MED CHEM published article about 20S PROTEASOMES; CRYSTAL-STRUCTURE; IMMUNOPROTEASOME; SITES; YEAST; GENERATION; BORTEZOMIB; MECHANISM; SUBSTRATE; KNOWLEDGE in [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Leiden Inst Chem, Gorlaeus Labs, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Netherlands Prote Ctr, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Huber, Eva M.; Heinemeyer, Wolfgang; Groll, Michael] Tech Univ Munich, Lehrstuhl Biochem, Dept Chem, Ctr Integrated Prot Sci, D-85748 Garching, Germany; [Driessen, Christoph] Kantonsspital St Gallen, Dept Hematol & Oncol, CH-9007 St Gallen, Switzerland; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Kisselev, Alexei F.] Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA in 2019, Cited 43. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the beta 1c, beta 1i, beta 5c, and beta 5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting beta 2c or beta 2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the beta 2c- and beta 2i-selective-compounds LU-002c (4; IC50 beta 2c: 8 nM, IC50 beta 2i/beta 2c: 40-fold) and LU-002i (5; IC50 beta 2i: 220 nM, IC50 beta 2c/beta 2i: 45-fold), respectively. Co-crystal structures with beta 2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of beta 2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.

Application In Synthesis of 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Alcohol Oxidations by Schiff Base Manganese(III) Complexes WOS:000508211300001 published article about RECOVERABLE CATALYSTS; MOLECULAR-STRUCTURE; OXOCHROMIUM(V) CATIONS; SALEN COMPLEXES; EPOXIDATION; LIGANDS; OLEFINS; COORDINATION; CRYSTAL; DONOR in [Neshat, Abdollah; Kakavand, Meysam; Osanlou, Farzane] IASBS, Dept Chem, Zanjan 4513766731, Iran; [Mastrorilli, Piero; Todisco, Stefano] Politecn Bari, DICATECh Dept, Via Orabona 4, I-70125 Bari, Italy; [Schingaro, Emanuela; Mesto, Ernesto] Univ Bari Aldo Moro Bari, Dipartimento Sci Terra & Geoambientali, Via Orabona 4, I-70125 Bari, Italy in 2020, Cited 68. Computed Properties of C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Asymmetric Schiff base manganese(III) complexes involving salen ligands, N,N’-bis(salicylidene)2,3-diaminopyridine, N,N’-bis(3-methoxysalicylidene)2,3-diaminopyridine, N,N’-bis(3,5-di-tert-butylsalicylidene)2,3-diaminopyridine and N,N’-bis(3,5-di-chloro-salicylidene)2,3-diaminopyridine were prepared and their catalytic activity was investigated in the oxidation of some primary and secondary alcohols. During optimization of oxidation reactions, Mn-4, bearing electron withdrawing N,N’-Bis(3,5-di-chloro-salicylidene)2,3-diaminopyridine ligand, showed higher activity than other catalysts tested. The catalytic reactions were carried out in the presence of various oxidants such as oxygen, hydrogen peroxide or tert-butyl hydroperoxide (TBHP) and additives such as acetic acid and imidazole. The oxidant/additive combination of TBHP and imidazole was shown to be effective for the oxidation process and the degree of their impact on oxidation reaction was found highly dependent on a balanced ratio between them. Mn-4 was selected as the most effective catalyst under optimized reaction conditions and revealed efficient for the oxidation of secondary alcohols.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. Recently I am researching about DONOR-ACCEPTOR CYCLOPROPANES; ASYMMETRIC ALPHA-AMINOXYLATION; DIELS-ALDER; CYCLOADDITION REACTIONS; ANNULATION REACTION; EFFICIENT APPROACH; CARBONYL-COMPOUNDS; ALDOL SYNTHESIS; ENE REACTION; ONE-POT, Saw an article supported by the Science and Engineering Research Board (SERB). Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Purkait, A; Jana, CK. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Unlike other alkylamines, benzylamines upon reaction with a nitrosoarene undergo oxidation to the corresponding imines. A direct amination of benzylamines, which was difficult to achieve due to its facile oxidation, to the corresponding hydrazones is reported. A wide variety of benzylamines and N-heterocycles were reacted with nitrosoarenes to provide structurally diverse hydrazones and hydrazides, respectively. Moreover, the direct N-amination reaction was applied to the one-pot synthesis of triazoles.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Purkait, A; Jana, CK or concate me.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics