Category: 50-84-0

Authors Zhou, JS; Lou, ZM; Yang, KL; Xu, J; Li, YZ; Liu, YL; Baig, SA; Xu, XH in ELSEVIER published article about 2,4-DICHLOROPHENOXYACETIC ACID; REDUCTIVE DECHLORINATION; ELECTROCHEMICAL PROCESS; WASTE-WATER; HYDRODECHLORINATION; REMOVAL; PARTICLES; EFFICIENT; IRON; PERFORMANCE in [Zhou, Jiasheng; Lou, Zimo; Yang, Kunlun; Li, Yizhou; Liu, Yuanli; Xu, Xinhua] Zhejiang Univ, Dept Environm Engn, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China; [Lou, Zimo; Xu, Jiang] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA; [Baig, Shams Ali] Abdul Wali Khan Univ, Dept Environm Sci, Mardan 23200, Pakistan in 2019, Cited 52. Application In Synthesis of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

In the present study, carbon black (CB), multi walled carbon nanotubes (MWCNTs), and granular activated carbon (GAC) were employed to support palladium (Pd) catalyst. The prepared Pd/CB, Pd/MWCNTs and Pd/GAC moveable catalysts were aimed to address the common issues (easy loss of catalyst and poor long-term performance) of normal fixed catalysts. The results of various characterizations (e.g., TEM, XRD, and XPS) clearly show that the Pd nanopartides were successfully loaded onto the carbon-supports, especially CB and MWCNTs. And more importantly, the morphologies, Pd distribution, and chemical structure of these moveable catalysts were almost not changed after 3 h reaction. The moveable Pd/CB, Pd/MWCNTs, and Pd/GAC catalysts had good reactivity for 2,4-dichlorobenzoic acid (2,4-DCBA) dechlorination, and Pd/CB exhibited the best performance. The Pd/CB also shows the best adsorption capacity of 2,4-DCBA and dechlorination product (benzoic acid, BA), and the adsorption of BA was significantly inhibited in the presence of current due to the repulsion between the both negatively charged compounds and adsorbents. The removal of 2,4-DCBA and the generation rate of BA was improved with a pre-adsorption process, which was a promising strategy with higher dechlorination rate and shortened electrolysis time. Moreover, the loss of Pd catalyst was negligible during the 10 consecutive cycles experiment, and the improved longevity could be expected. These results suggested the good reactivity, stability, and reusability of moveable Pd/CB catalyst.

Application In Synthesis of 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 50-84-0. Chu, Y; Reddy, BRS; Gajulapalli, VPR; Babu, KS; Kim, E; Lee, S in [Chu, Yeonjeong; Lee, Sanghee] Korea Inst Sci & Technol, Brain Sci Inst, Seoul, South Korea; [Chu, Yeonjeong; Gajulapalli, V. Pratap Reddy; Kim, Eunha] Ajou Univ, Dept Mol Sci & Technol, Suwon, South Korea; [Reddy, B. Raja Sekhara; Babu, K. Sudhakar] Sri Krishnadevaraya Univ, Dept Chem, Anantapur, Andhra Pradesh, India; [Lee, Sanghee] Hanyang Univ, Dept HY KIST Bioconvergence, Seoul, South Korea published Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers in 2020, Cited 25. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-molecule IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. In this study, we assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To investigate structure-activity relationship, we designed and synthesized a series of ARP analogues and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 5i was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. Our results suggested a beneficial therapeutic potential of 5i as an anti-viral agent.

Recommanded Product: 50-84-0. Welcome to talk about 50-84-0, If you have any questions, you can contact Chu, Y; Reddy, BRS; Gajulapalli, VPR; Babu, KS; Kim, E; Lee, S or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Chi, YH; Yeh, TK; Ke, YY; Lin, WH; Tsai, CH; Wang, WP; Chen, YT; Su, YC; Wang, PC; Chen, YF; Wu, ZW; Yeh, JY; Hung, MC; Wu, MH; Wang, JY; Chen, CP; Song, JS; Shih, C; Chen, CT; Chang, CP in [Chi, Ya-Hui; Yeh, Teng-Kuang; Ke, Yi-Yu; Lin, Wen-Hsing; Tsai, Chia-Hua; Wang, Wan-Ping; Chen, Yen-Ting; Su, Yu-Chieh; Wang, Pei-Chen; Chen, Yan-Fu; Wu, Zhong-Wei; Yeh, Jen-Yu; Hung, Ming-Chun; Wu, Mine-Hsine; Wang, Jing-Ya; Chen, Ching-Ping; Song, Jen-Shin; Shih, Chuan; Chen, Chiung-Tong; Chang, Chun-Ping] Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Taiwan; [Chi, Ya-Hui] China Med Univ, Grad Inst Biomed Sci, Taichung 40402, Taiwan; [Chang, Chun-Ping] Chung Yuan Christian Univ, Dept Chem, Taoyuan 320314, Taiwan published Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins in 2021, Cited 45. Application In Synthesis of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

The A-type Aurora kinase is upregulated in many human cancers, and it stabilizes MYC-family oncoproteins, which have long been considered an undruggable target. Here, we describe the design and synthesis of a series of pyrimidine-based derivatives able to inhibit Aurora A kinase activity and reduce levels of cMYC and MYCN. Through structure-based drug design of a small molecule that induces the DFG-out conformation of Aurora A kinase, lead compound 13 was identified, which potently (IC50 < 200 nM) inhibited the proliferation of high-MYC expressing small-cell lung cancer (SCLC) cell lines. Pharmacokinetic optimization of 13 by prodrug strategies resulted in orally bioavailable 25, which demonstrated an 8-fold higher oral AUC (F = 62.3%). Pharmacodynamic studies of 25 showed it to effectively reduce cMYC protein levels, leading to >80% tumor regression of NCI-H446 SCLC xenograft tumors in mice. These results support the potential of 25 for the treatment of MYC-amplified cancers including SCLC.

Application In Synthesis of 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxa-diazole as multitargeted hybrids for the treatment of Alzheimer’s disease published in 2021. Recommanded Product: 50-84-0, Reprint Addresses Shrivastava, SK (corresponding author), Banaras Hindu Univ, Dept Pharmaceut Engn & Technol, Pharmaceut Chem Res Lab, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Novel N-Benzylpyrrolidine hybrids were designed, synthesized, and tested against multiple in-vitro and in-vivo parameters. Among all the synthesized molecules, 8f and 12f showed extensive inhibition against beta-secretase1 (hBACE-1), human acetylcholinesterase (hAChE) & human butyrylcholinesterase (hBuChE). These molecules are also endowed with significant AChE-peripheral anionic site (PAS) binding capability, blood-brain barrier permeability, potential disassembly of A beta aggregates along with neuroprotection ability on SHSY-5Y cell lines. Results of the Y-Maze and Morris water maze test concluded that compounds 8f and 12f ameliorated cognitive dysfunction induced by scopolamine and A beta. The ex-vivo activity was executed on rat’s brain homogenate indicating a reduction in AChE level and oxidative stress. The pharmacokinetic investigation ascertained considerable oral absorption profile of the lead 12f. The results of the in silico docking studies and molecular dynamics simulations demonstrated stable interactions of compounds 8f and 12f with the target residues of hAChE, hBuChE and hBACE-1.

Welcome to talk about 50-84-0, If you have any questions, you can contact Choubey, PK; Tripathi, A; Tripathi, MK; Seth, A; Shrivastava, SK or send Email.. Recommanded Product: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Zhou, JS; Lou, Z; Xu, J; Zhou, XX; Yang, KL; Gao, XY; Zhang, YL; Xu, XH in [Zhou, Jiasheng; Lou, Zimo; Zhou, Xiaoxin; Yang, Kunlun; Xu, Xinhua] Zhejiang Univ, Dept Environm Engn, Coll Environm & Resource Sci, Hangzhou 310058, Zhejiang, Peoples R China; [Xu, Jiang; Gao, Xiaoyu; Zhang, Yilin] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA; [Xu, Jiang; Gao, Xiaoyu; Zhang, Yilin] Ctr Environm Implicat Nanotechnol CEINT, Durham, NC USA published Enhanced electrocatalytic dechlorination by dispersed and moveable activated carbon supported palladium catalyst in 2019, Cited 67. Computed Properties of C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this study, a novel approach was developed for the dechlorination of 2,4-dichlorobenzoic acid (2,4-DCBA) via the combination of the moveable activated carbon (AC) supported palladium (Pd) nanoparticles and nickel (Ni) foam electrode. The morphology and chemical structure of Pd/AC catalyst was investigated by various characterization techniques, including SEM, TEM, EXS-mapping, XRD, and XPS. Pd nanoparticles was successfully loaded and dispersed on the AC, accompanied with the significantly enhanced reactivity. The removal rate of 2,4-DCBA by Ni electrode with moveable Pd/AC catalyst was 222, 25, and 5 folds higher than dispersed AC and Ni electrode system, chemical deposited Pd/Ni electrode, and electrodeposited Pd/Ni electrode, respectively. Compared with the conventional electrocatalytic reductive approach which deposited Pd on the Ni foam electrode, moveable Pd/AC catalyst possesses higher surface area, more atomic H* production and more active sites, favored mass transfer, and enhanced reactivity, without the consideration of catalyst loss and deactivation. The effects of Pd:AC mass ratio, constant current, initial solution pH, and electrolyte concentration on the dechlorination of 2,4-DCBA were studied. Generally, high Pd loading, constant current, and acidity favored the dechlorination of 2,4-DCBA, while excessive electrolyte would inhibit the dechlorination of 2,4-DCBA. Good longevity and recyclability of moveable Pd/AC catalyst was confirmed via consecutive experiments. The findings of the present study show that making the catalyst moveable is a promising strategy for electrocatalytic remediation technology.

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Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits WOS:000459223600034 published article about 20S PROTEASOMES; CRYSTAL-STRUCTURE; IMMUNOPROTEASOME; SITES; YEAST; GENERATION; BORTEZOMIB; MECHANISM; SUBSTRATE; KNOWLEDGE in [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Leiden Inst Chem, Gorlaeus Labs, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Espinal, Christofer; Du, Yimeng; Janssens, Marissa; Florea, Bogdan I.; van der Marel, Gijsbert A.; Overkleeft, Herman S.] Netherlands Prote Ctr, Einsteinweg 55, NL-2333 CC Leiden, Netherlands; [Huber, Eva M.; Heinemeyer, Wolfgang; Groll, Michael] Tech Univ Munich, Lehrstuhl Biochem, Dept Chem, Ctr Integrated Prot Sci, D-85748 Garching, Germany; [Driessen, Christoph] Kantonsspital St Gallen, Dept Hematol & Oncol, CH-9007 St Gallen, Switzerland; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Weyburne, Emily S.; Kisselev, Alexei F.] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, 1 Med Ctr Dr HB7936, Lebanon, NH 03756 USA; [Kisselev, Alexei F.] Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA in 2019, Cited 43. Name: 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the beta 1c, beta 1i, beta 5c, and beta 5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting beta 2c or beta 2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the beta 2c- and beta 2i-selective-compounds LU-002c (4; IC50 beta 2c: 8 nM, IC50 beta 2i/beta 2c: 40-fold) and LU-002i (5; IC50 beta 2i: 220 nM, IC50 beta 2c/beta 2i: 45-fold), respectively. Co-crystal structures with beta 2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of beta 2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.

Name: 2,4-Dichlorobenzoic acid. Welcome to talk about 50-84-0, If you have any questions, you can contact Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, YM; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about DNA-BINDING; ACRIDONE DERIVATIVES; ANTICANCER; INHIBITORS, Saw an article supported by the National Key Research and Development Program of China [2018YFC0310900]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81850410553, 41776168]; Natural Science Foundation of Ningbo City [2018A610410]; Foundation of Ningbo University [XYL18004]; National 111 Project of ChinaMinistry of Education, China – 111 Project [D16013]; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund; K.C. Wong Magna Fund in Ningbo University. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Zhang, B; Dou, ZD; Xiong, Z; Wang, N; He, S; Yan, XJ; Jin, HX. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Name: 2,4-Dichlorobenzoic acid

A series of novel N-phenylbenzamide-4-methylamine acridine derivatives were designed and synthesized based initially on the structure of amsacrine (m-AMSA). Molecular docking suggested that the representative compound 9a had affinity for binding DNA topoisomerase (Topo) II, which was comparable with that of m-AMSA, and furthermore that 9a could have preferential interactions with Topo I. After synthesis of 9a and analogues 9b-9f, these were all tested in vitro and the synthesized compounds displayed potent antiproliferative activity against three different cancer cell lines (K562, CCRF-CEM and U937). Among them, compounds 9b, 9c and 9d exhibiting the highest activity with IC50 value ranging from 0.82 to 0.91 mu M against CCRF-CEM cells. In addition, 9b and 9d also showed high antiproliferative activity against U937 cells, with IC50 values of 0.33 and 0.23 mu M, respectively. The pharmacological mechanistic studies of these compounds were evaluated by Topo I/II inhibition, western blot assay and cell apoptosis detection. In summary, 9b effectively inhibited the activity of Topo I/II and induced DNA damage in CCRF-CEM cells and, moreover, significantly induced cell apoptosis in a concentration-dependent manner. These observations provide new information and guidance for the structural optimization of more novel acridine derivatives.

Name: 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocks. Recently I am researching about ORYZAE PV. ORYZAE; FUNGICIDAL ACTIVITY; BIOLOGICAL EVALUATION; DERIVATIVES; VIRULENCE; DESIGN; SALTS, Saw an article supported by the Key Technologies RD ProgramNational Key Technology R&D Program [2014BAD23B01]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372052, 21662009, 21702037, 31860516]; Ministry of Education of ChinaMinistry of Education, China [20135201110005, 213033A]; Guizhou Provincial ST Program [[2012]6012, LH [2017]7259, [2017]5788]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wang, PY; Wang, MW; Zeng, D; Xiang, M; Rao, JR; Liu, QQ; Liu, LW; Wu, ZB; Li, Z; Song, BA; Yang, S. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

The emergence and widespread occurrence of plant bacterial diseases that cause global production constraints have become major challenges to agriculture worldwide. To promote the discovery and development of new bactericides, imidazole-labeled 1,3,4-oxadiazole thioethers were first fabricated by integrating the crucially bioactive scaffolds of the imidazole motif and 1,3,4-oxadiazole skeleton in a single molecular architecture. Subsequently, a superior antibacterial compound A(6) was gradually discovered possessing excellent competence against plant pathogens Xanthomonas oryzae pv oryzae and Xanthomonas axonopodis pv citri with EC50 values of 0.734 and 1.79 mu g/mL, respectively. These values were better than those of commercial agents bismerthiazol (92.6 mu g/mL) and thiodiazole copper (77.0 mu g/mL). Further modifying the imidazole moiety into the imidazolium scaffold led to the discovery of an array of potent antibacterial compounds providing the corresponding minimum EC50 values of 0.295 and 0.607 mu g/mL against the two strains. Moreover, a plausible action mechanism for attacking pathogens was proposed based on the concentration dependence of scanning electron microscopy, transmission electron microscopy, and fluorescence microscopy images. Given the simple molecular structures, easy synthetic procedure, and highly efficient bioactivity, imidazole (or imidazolium)-labeled 1,3,4-oxadiazole thioethers can be further explored and developed as promising indicators for the development of commercial drugs.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

SDS of cas: 50-84-0. Zeynizadeh, B; Sepehraddin, F; Mousavi, H in [Zeynizadeh, Behzad; Sepehraddin, Farhad; Mousavi, Hossein] Urmia Univ, Fac Chem, Dept Organ Chem, Orumiyeh, Iran published Green and Highly Efficient Strategies for the Straightforward Reduction of Carboxylic Acids to Alcohols Using Four Different and Affordable Types of Hydrogen Donors in 2019, Cited 87. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Green, simple, and highly efficient various strategies for the straightforward reduction of carboxylic acids to corresponding alcohols have been developed by employing four different types of cost-effective hydrogen donors, namely sodium borohydride (NaBH4), ammonium formate (HCO2NH4), glycerol, and isopropanol (i-PrOH) in the presence of Fe3O4@APTMS@ZrCp2Clx ((x = 0, 1, 2)) as a robust and durable nanocatalyst under neat conditions. Also, the mentioned magnetically separable nanocatalyst was recovered and reused at least five times without significant loss in catalytic activity. In comparison with the known protocols for the direct reduction of carboxylic acids to corresponding alcohols, our current methods offer several benefits such as being straightforward (without isolation of aldehyde intermediates), mild reaction conditions, eco-friendly, short reaction times, good to excellent yields of the products, use of inexpensive hydrogen donors, recoverability, and reusability of the catalyst and so on.

Welcome to talk about 50-84-0, If you have any questions, you can contact Zeynizadeh, B; Sepehraddin, F; Mousavi, H or send Email.. SDS of cas: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. Xiao, SN; Lin, Z; Wang, XD; Lu, JC; Zhao, YQ in [Xiao, Shengnan; Lin, Zhe; Wang, Xude; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Funct Food & Red Wine, Shenyang 110016, Liaoning, Peoples R China; [Lu, Jincai] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China; [Zhao, Yuqing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China published Synthesis and Cytotoxicity Evaluation of Panaxadiol Derivatives in 2020, Cited 24. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this study, 13 panaxadiol (PD) derivatives were synthesized via reactions with aromatic compounds and amino acids. Following this, the cytotoxicity of these compounds was evaluated against four cancer cell lines (human hepatoma cells HepG-2, human lung cancer cells A549, human breast cancer cells MCF-7, and human colon cancer cells HCT-116) and one normal cell lines (human gastric epithelial cells GES-1). The results showed that the panaxadiol derivatives 3, 12, and 13 showed significant inhibition of cellular proliferation against cancer cells compared with PD, and the panaxadiol derivative 12 had the lowest IC50 value for A549 (IC50=18.91 +/- 1.03 mu m). For MCF-7 cells, most compounds exhibited good inhibition of cellular proliferation, and the panaxadiol derivative 13 showed the strongest inhibitory effect (IC50=8.62 +/- 0.23 mu m), which significantly increased the cytotoxicity of PD and was stronger than the positive control (mitomycin). For normal cells, all compounds exhibited low or no toxic effects; thus, these derivatives can be used to develop novel antiproliferative agents.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics