Category: 50-84-0

Hu, ZY; Belitz, F; Zhang, GD; Papp, F; Goossen, LJ in [Hu, Zhiyong; Belitz, Florian; Zhang, Guodong; Papp, Florian; Goossen, Lukas J.] Ruhr Univ Bochum, Evonik Chair Organ Chem, D-44801 Bochum, Germany published Ru-Catalyzed (E)-Specific ortho-C-H Alkenylation of Arenecarboxylic Acids by Coupling with Alkenyl Bromides in 2021, Cited 68. Category: chlorides-buliding-blocks. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In the presence of [p-cymene)RuCl2](2), (E)-configured alkenyl bromides couple with aromatic carboxylates to form orthovinylbenzoic acids. This C-H vinylation proceeds in high yields without any activating phosphine ligands and has an excellent functional group tolerance. Starting from commonly available (E/Z)-mixtures of alkenyl bromides, (E)-configured vinyl arenes or dienes are formed exclusively. Mechanistic studies show that this selectivity is achieved because the (E)configured alkenyl bromides undergo a smooth coupling, whereas the (Z)-isomers are rapidly eliminated with the formation of alkynes.

Category: chlorides-buliding-blocks. Welcome to talk about 50-84-0, If you have any questions, you can contact Hu, ZY; Belitz, F; Zhang, GD; Papp, F; Goossen, LJ or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2019 SYNLETT published article about C-N; NITROGEN NUCLEOPHILES; COUPLING REACTIONS; H HETEROCYCLES; ARYL HALIDES; EFFICIENT; BOND; DERIVATIVES; IMIDAZOLES; PYRAZOLES in [Yuan, Chunling; Zhao, Yingdai; Zheng, Li] Jinzhou Med Univ, Pharm Sch, Dept Med Chem, Jinzhou 121001, Liaoning, Peoples R China in 2019, Cited 57. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. HPLC of Formula: C7H4Cl2O2

The first application of alpha-D-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C-N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional group tolerance with characters of selectivity. These N-arylazoles allow rapid access to several pharmaceutical intermediates and can be easily transformed into a variety of other interesting scaffolds as well.

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Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H4Cl2O2. In 2021 GREEN CHEM published article about ONE-POT SYNTHESIS; GREEN CHEMISTRY; BOND FORMATION; GOLD(I)-CATALYZED PROTODECARBOXYLATION; SELECTIVE DEUTERATION; FUNCTIONALIZATION; TRANSFORMATIONS; MICROREACTORS; NANOPARTICLES; EXCHANGE in [Meszaros, Rebeka; Fulop, Ferenc] Univ Szeged, Inst Pharmaceut Chem, Eotvos U 6, H-6720 Szeged, Hungary; [Marton, Andras; Szabados, Marton; Palinko, Istvan] Univ Szeged, Dept Organ Chem, Dom Ter 8, H-6720 Szeged, Hungary; [Szabados, Marton; Varga, Gabor; Palinko, Istvan] Univ Szeged, Mat & Solut Struct Res Grp, Aradi Vertanuk Tere 1, H-6720 Szeged, Hungary; [Szabados, Marton; Varga, Gabor; Palinko, Istvan] Univ Szeged, Interdisciplinary Excellence Ctr, Inst Chem, Aradi Vertanuk Tere 1, H-6720 Szeged, Hungary; [Varga, Gabor] Univ Szeged, Dept Phys Chem & Mat Sci, Rerrich Bela Ter 1, H-6720 Szeged, Hungary; [Konya, Zoltan; Kukovecz, Akos] Univ Szeged, Dept Appl & Environm Chem, Rerrich Bela Ter 1, H-6720 Szeged, Hungary; [Konya, Zoltan] Hungarian Acad Sci, MTA SZTE React Kinet & Surface Chem Res Grp, Rerrich Bela Ter 1, H-6720 Szeged, Hungary; [Fulop, Ferenc; Otvos, Sandor B.] Hungarian Acad Sci, MTA SZTE Stereochem Res Grp, Eotvos U 6, H-6720 Szeged, Hungary; [Otvos, Sandor B.] Karl Franzens Univ Graz, NAWI Graz, Inst Chem, Heinrichstr 28, A-8010 Graz, Austria in 2021, Cited 99. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Herein, we report novel catalytic methodologies for protodecarboxylations and decarboxylative deuterations of carboxylic acids utilizing a silver-containing hybrid material as a heterogeneous noble metal catalyst. After an initial batch method development, a chemically intensified continuous flow process was established in a simple packed-bed system which enabled gram-scale protodecarboxlyations without detectable structural degradation of the catalyst. The scope and applicability of the batch and flow processes were demonstrated through decarboxylations of a diverse set of aromatic carboxylic acids. Catalytic decarboxylative deuterations were achieved on the basis of the reaction conditions developed for the protodecarboxylations using D2O as a readily available deuterium source.

Welcome to talk about 50-84-0, If you have any questions, you can contact Meszaros, R; Marton, A; Szabados, M; Varga, G; Konya, Z; Kukovecz, A; Fulop, F; Palinko, I; Otvos, SB or send Email.. HPLC of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. In 2020 INT J BIOL MACROMOL published article about IN-VITRO EVALUATION; ALPHA-GLUCOSIDASE INHIBITION; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; SCHIFF-BASES; DERIVATIVES; ACETYLCHOLINESTERASE; THIOSEMICARBAZIDES; CHILDREN; ANALOGS in [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Uddin, Nizam] Univ Karachi, Dept Chem, Karachi 75270, Pakistan; [Ali, Muhammad] Univ Nizwa, Nat & Med Sci Res Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman; [Anouar, El Hassane] Prince Sattam bin Abdulaziz Univ, Coll Sci & Humanities Al Kharj, Dept Chem, Al Kharj 11942, Saudi Arabia; [Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Gulraiz] Imam Abdulrahman Bin Faisal Univ, Environm Engn Dept, Coll Engn Bldg A13,POB 1982, Dammam 31441, Saudi Arabia; [Farooq, Rai Khalid] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Neurosci Res, POB 1982, Dammam 31441, Saudi Arabia; [Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, Coll Comp Sci & Informat Technol CCSIT, Dept Comp Informat Syst, POB 1982, Dammam 31441, Saudi Arabia; [Iqbal, Naveed] Univ Poonch Rawalakot AJK, Dept Chem, Rawalakot, Pakistan; [Farooq, Muhammad] Hazara Univ, Dept Phys, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan in 2020, Cited 54. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

beta-Glucuronidase is responsible for the catalytic deconjugation of beta-D-glucuronides. beta-Glucuronidase has evolved to be a viable molecular target for numerous therapeutic treatments. It plays a pivotal role in the metabolism of drugs and endogenous substances. Herein, we report the inhibitory potentials of newly developed and modular benzimidazole-triazolothiadiazole hybrids spaced through a phenyl linker (1-26) and their interactions with the beta-glucuronidase. All analogues showed IC50 values in the range of 1.30 +/- 0.10 to 44.10 +/- 0.80 mu M, and hence were found to have outstanding inhibitory potential as compare to the standard D-saccharic acid 1,4-lactone (IC50 = 48.4 +/- 1.25 mu M). These modular hybrids were successfully synthesized, rigorously characterized through various spectroscopic techniques. Molecular docking studies further revealed the potential interactions between the inhibitor and active amino acid site in beta-glucuronidase. These findings helped in identifying the potential for new drug candidates. A Plausible structure activity relationship (SAR) were established which suggested that variation in the inhibitory potential was mainly based upon the substituents attached to the phenyl ring. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 2,4-Dichlorobenzoic acid. Authors Anastassiadou, M; Bernasconi, G; Brancato, A; Cabrera, LC; Ferreira, L; Greco, L; Jarrah, S; Kazocina, A; Leuschner, R; Magrans, JO; Miron, I; Nave, S; Pedersen, R; Reich, H; Rojas, A; Sacchi, A; Santos, M; Scarlato, AP; Theobald, A; Vagenende, B; Verani, A in EUROPEAN FOOD SAFETY AUTHORITY-EFSA published article about in [Anastassiadou, Maria; Bernasconi, Giovanni; Brancato, Alba; Cabrera, Luis Carrasco; Ferreira, Lucien; Greco, Luna; Jarrah, Samira; Kazocina, Aija; Leuschner, Renata; Magrans, Jose Oriol; Miron, Ileana; Nave, Stefanie; Pedersen, Ragnor; Reich, Hermine; Rojas, Alejandro; Sacchi, Angela; Santos, Miguel; Scarlato, Alessia Pia; Theobald, Anne; Vagenende, Benedicte; Verani, Alessia] European Food Safety Author EFSA, Parma, Italy in 2021, Cited 4. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

The applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Finland to evaluate the confirmatory data that were identified for propiconazole in the framework of the MRL review under Article 12 of Regulation (EC) No 396/2005 as not available. Following the decision on the non-renewal of the approval of propiconazole and the decision to lower the maximum residue levels (MRLs) for propiconazole to the limit of quantification (LOQ) for all commodities, the data gaps identified in the MRL review are no longer relevant. EFSA summarised some new studies on the toxicological profile of propiconazole metabolites CGA91305, SYN547889 and NOA436613, which were assessed by the rapporteur Member State. Overall, the available information is not sufficient to characterise the toxicological profile of metabolites convertible to 2,4-dichlorobenzoic acid as data gaps still exist for SYN547889, NOA436613, CGA118244, CGA118245, CGA91304 and CGA91305. (C) 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer’s Disease WOS:000491219000019 published article about BETA-AMYLOID AGGREGATION; ACETYLCHOLINESTERASE INHIBITOR; ACID-DERIVATIVES; DIRECTED LIGANDS; DESIGN; PEPTIDE; ASSAY; SITE; BUTYRYLCHOLINESTERASE; NEUROTOXICITY in [Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Shrivastava, Sushant Kumar] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Sen Singh, Saumitra; Singh, Surya Pratap] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India in 2019, Cited 80. Recommanded Product: 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer’s disease (AD). Tested compounds exhibited moderate to excellent inhibition against human acetylcholinesterase (hAChE), butyrylcholinesterase (hBChE), and beta-secretase-1 (hBACE-1). The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Hybrids 6g and 10f also elicited favorable permeation across the blood -brain barrier and were devoid of neurotoxic liability toward SH-SYSY neuroblastoma cells. Both leads remarkably disassembled A beta aggregation in thioflavin T-based selfand AChE-induced experiments. Compounds 6g and 10f ameliorated scopolamine gamma-induced cognitive dysfunctions in the Ymaze test. The ex vivo studies of rat brain homogenates established the reduced AChE levels and antioxidant activity of both compounds. Compound 6g also elicited noteworthy improvement in A beta-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of A beta and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis. The pharmacokinetic study showed excellent oral absorption characteristics of compound 6g. The in silica molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.

Recommanded Product: 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents WOS:000571118800001 published article about CYCLOOXYGENASE-2; ANALOGS; ANTICANCER; MECHANISMS; ENZYMES; SAFROLE in [Hawash, Mohammed; Jaradat, Nidal; Hameedi, Saba] An Najah Natl Univ, Fac Med & Hlth Sci, Dept Pharm, POB 7, Nablus 00970, Palestine; [Mousa, Ahmed] An Najah Natl Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Nablus 00970, Palestine in 2020, Cited 37. HPLC of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Non-steroidal anti-inflammatory drugs are among the most used drugs. They are competitive inhibitors of cyclooxygenase (COX). Twelve novel compounds (aryl acetate and aryl acetic acid groups) were synthesized in this work in order to identify which one was the most potent and which group was most selective towards COX1 and COX2 by using an in vitro COX inhibition assay kit. The cytotoxicity was evaluated for these compounds utilizing MTS assay against cervical carcinoma cells line (HeLa). The synthesized compounds were identified using FTIR, HRMS,H-1-NMR, and(13)C-NMR techniques. The results showed that the most potent compound against the COX1 enzyme was 4f with IC50 = 0.725 mu M. The compound 3b showed potent activity against both COX1 and COX2 with IC50 = 1.12 and 1.3 mu M, respectively, and its selectivity ratio (0.862) was found to be better than Ketoprofen (0.196). In contrast, compound 4d was the most selective with a COX1/COX2 ratio value of 1.809 in comparison with the Ketoprofen ratio. All compounds showed cytotoxic activity against the HeLa Cervical cancer cell line at a higher concentration ranges (0.219-1.94 mM), and the most cytotoxic compound was 3e with a CC(50)value of 219 mu M. This was tenfold more than its IC(50)values of 2.36 and 2.73 mu M against COX1 and COX2, respectively. In general, the synthesized library has moderate activity against both enzymes (i.e., COX1 and COX2) and ortho halogenated compounds were more potent than the meta ones.

Welcome to talk about 50-84-0, If you have any questions, you can contact Hawash, M; Jaradat, N; Hameedi, S; Mousa, A or send Email.. HPLC of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. Recently I am researching about 3-ISOTHIOCYANATO OXINDOLES; SPIROOXINDOLES; CYCLOADDITIONS; CONSTRUCTION; CYCLIZATION; MALEIMIDES; BENZAMIDES; ALKALOIDS; SCAFFOLDS; DISCOVERY, Saw an article supported by the Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN201801321, KJZD M201801301]; Natural Science Foundation Project of CQ CSTSC [cstc2020jcyj-msxmX0733, cstc2018jszx-cyzdX0023]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Lei, J; He, LJ; Tang, DY; Wen, JY; Yan, W; Li, HY; Chen, ZZ; Xu, ZG. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Chemoselective approaches were developed for derivatizing diastereoselective chromanone spiro-gamma-lactams through the Michael-type addition by using amide as a weak nucleophile to construct the spiro-carbon center under basic conditions. To expand the scope of this post-Ugi cascade reaction, a new series of oxidized chromone derivatives was synthesized by altering solvent from EtOH to DMF. Compounds 7 a and 7 b which could be synthesized in one day, demonstrated comparable anticancer activities with legendary anticancer drug paclitaxel in the PANC and U87 cell lines. This methodology offers a new approach to construct spiro-carbon centers with functionalized chromanones or chromones under mild reaction conditions.

Welcome to talk about 50-84-0, If you have any questions, you can contact Lei, J; He, LJ; Tang, DY; Wen, JY; Yan, W; Li, HY; Chen, ZZ; Xu, ZG or send Email.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Formula: C7H4Cl2O2. Zhang, JW; Wang, CR; Liu, WH; Xu, S; Liu, BQ in [Zhang, Ju-Wen; Wang, Cen-Ru; Liu, Wen-Hua; Xu, Shuang; Liu, Bin-Qiu] Bohai Univ, Dept Chem, Jinzhou 121013, Peoples R China; [Zhang, Ju-Wen] Bohai Univ, Coll Chem & Chem Engn, Profess Technol Innovat Ctr Liaoning Prov Convers, Jinzhou 121013, Peoples R China published Two kinds of 2,4-dichlorobenzoate-based lanthanide coordination polymers tuned by 4,4 ‘-bipyridine: Syntheses, structures, photoluminescence, and magnetism in 2020, Cited 57. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Ln(NO3)(3)center dot nH(2)O reacted with 2,4-dichlorobenzoic acid (2,4-HDCB) and NaOH under solvothermal conditions of water and ethanol to yield four lanthanide-organic coordination polymers (CPs) [Eu(2,4-DCB)(3)(CH3CH2OH)(2)] (1) and [Ln(2,4-DCB)(3)(H2O)] [Ln = Gd (2), Tb (3), Dy (4)]. The second ligand 4,4′-bipyridine (4,4′-bpy) was introduced into the above reaction systems to provide four new lanthanide-organic CPs [Ln(2)(2,4-DCB)(6)(4,4′-bpy)(H2O)(2)] [Ln = Eu (5), Gd (6), Tb (7), Dy (8)]. Single-crystal and powder X-ray diffraction analyses reveal that CPs 1 and 2 possess similar one-dimensional (1D) structures, and CPs 2-4 and 5-8 are isostructural, respectively. In 1-4, the 2,4-DCB anions bridge the Ln(III) ions to form a 1D chain. In 5-8, six 2,4-DCB anions link two Ln(III) ions into a binuclear Ln(2)(2,4-DCB)(6) unit, and the Ln(2)(2,4-DCB)(6) units are further connected by the 4,4’-bpy co-ligands to generate a 1D chain. The photoluminescent and magnetic properties of 1-8 were investigated.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Synthesis of Thiazolium-Labeled 1,3,4-Oxadiazole Thioethers as Prospective Antimicrobials: In Vitro and in Vivo Bioactivity and Mechanism of Action WOS:000499743400011 published article about BIOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITY; SULFONE DERIVATIVES; FUNGICIDAL ACTIVITY; ANTIFUNGAL ACTIVITY; NATURAL-PRODUCTS; DESIGN; COMBINATION; RESISTANCE; INHIBITION in [Wang, Ming-Wei; Zhu, Huai-He; Wang, Pei-Yi; Zeng, Dan; Wu, Yuan-Yuan; Liu, Li-Wei; Wu, Zhi-Bing; Yang, Song] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Ctr R&D Fine Chem,Minist Educ, Guiyang 550025, Guizhou, Peoples R China; [Li, Zhong; Yang, Song] East China Univ Sci & Technol, Coll Pharm, Shanghai 200237, Peoples R China in 2019, Cited 58. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Recommanded Product: 2,4-Dichlorobenzoic acid

In this study, a type of thiazolium-labeled 1,3,4-oxadiazole thioether bridged by diverse alkyl chain lengths was constructed. The antimicrobial activity of the fabricated thioether toward plant pathogenic bacteria and fungi was then screened. Antibacterial evaluation indicated that title compounds possess specific characteristics that enable them to severely attack three phytopathogens, namely, Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri with minimal EC50 values of 0.10, 3.27, and 3.50 mu g/mL, respectively. Three-dimensional quantitative structure-activity relationship models were established to direct the following excogitation for exploring higher active drugs. The in vivo study against plant bacterial diseases further identified the prospective application of title compounds as alternative antibacterial agents. The proteomic technique, scanning electron microscopy patterns, and fluorescence spectrometry were exploited to investigate the antibacterial mechanism. Additionally, some target compounds performed superior inhibitory actions against three tested fungal strains. In view of their simple molecular architecture and highly efficient bioactivity, these substrates could be further explored as promising surrogates for fighting against plant microbial infections.

Welcome to talk about 50-84-0, If you have any questions, you can contact Wang, MW; Zhu, HH; Wang, PY; Zeng, D; Wu, YY; Liu, LW; Wu, ZB; Li, Z; Yang, S or send Email.. Recommanded Product: 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics