Category: 4569-86-2

On February 2, 2006, Baeyens Cabrera, Jose Manuel published a patent.Synthetic Route of 4569-86-2 The title of the patent was Use of compounds active on the sigma receptor for the treatment of mechanical allodynia. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the treatment of mech. allodynia. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Synthetic Route of 4569-86-2

The Article related to mech allodynia treatment sigma receptor modulator, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 23, 2007, Buschman, Helmut Heinrich published a patent.Electric Literature of 4569-86-2 The title of the patent was Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Electric Literature of 4569-86-2

The Article related to diabetes pain analgesic sigma receptor ligand, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Electric Literature of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 12, 2021, Wang, Kai; Jia, Fang; Song, Shihao; Zhao, Fang; Pan, Jie; Zhao, Yimei; Jiang, Jun; Ye, Wenjing published a patent.Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride The title of the patent was Preparation of methylene violet derivatives as fluorescent probes for sulfide ion detection. And the patent contained the following:

The title compounds with general formula I•Cl- [wherein R1 = -NHCOCH2-R3, -NH(CH2O)n-R3, –NH(CH2NH)n-R3, -NH(CH2)n-R3, -N=N-(p-phenyl)-R3 or R3, where R3 is 7-nitro-4-(1-piperazinyl-4-yl)-2,1,3-benzoxadiazole; R2 = NH2 or N(Et)2; n = independently 1-12] were prepared as fluorescent probes. For example, compound II•Cl- was prepared in a multi-step synthesis. The fluorescent probe can be used for sulfide ion detection or preparing photodynamic therapy probe. The invention has good water solubility, high detection sensitivity, simple synthesis, mild condition, and low cost. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to preparation methylene violet derivative fluorescent probes sulfide ion detection, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 1998, Proevska, L. I.; Pojarlieff, I. G. published an article.Computed Properties of 4569-86-2 The title of the article was 1H NMR spectra and structure of safranines. Hindered rotation of the 3-dialkylamino group in 7-azo derivatives. And the article contained the following:

The 1H NMR spectra of safranine derivatives are reported. Semiempirical calculations indicate that the high shielding of the 4- and 6-proton adjacent to an amino or hydroxyl group (resonating between 5.5 and 6.0 ppm) is due to accumulation of neg. charge on the 4-and 6-C atoms, augmented by the magnetic anisotropy effect of the orthogonal 5-Ph ring. The ortho protons of the latter resonate up field to the meta and para protons. Hindered rotation of dialkylamino groups, altogether unexpected in view of the rather low barriers in similar anilines, is observed only in the azo derivatives AM1 suggests that this is due to destabilization of the transition state when an amino group is substituted for an azo group. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Computed Properties of 4569-86-2

The Article related to azo derivative safranine hindered rotation, alkylamino hindered rotation safranine derivative, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Computed Properties of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2003, Jonnalagadda, S. B.; Shezi, M.; Pare, B. published an article.Synthetic Route of 4569-86-2 The title of the article was Uncatalyzed and ruthenium(III)-catalyzed reaction of acidic chlorite with methylene violet. And the article contained the following:

The kinetics and mechanism of the uncatalyzed and Ru(III)-catalyzed oxidation of methylene violet [3-amino-7-(diethylamino)-5-phenylphenazinium chloride] (MV) by acidic chlorite is reported. With excess concentrations of other reactants, both uncatalyzed and catalyzed reactions had pseudo-first-order kinetics with respect to MV. The uncatalyzed reaction had first-order dependence on chlorite and H+ concentrations, but the catalyzed reaction had first-order dependence on both chlorite and catalyst, and a fractional order with respect to [H+]. The rate coefficient of the uncatalyzed reaction is (5.72 ± 0.19) M-2 s-1, while the catalytic constant for the catalyzed reaction is (22.4 ± 0.3) × 103 M-1 s-1. Stoichiometry is dependent on the initial concentration of chlorite present. Consistent with the exptl. results, pertinent mechanisms are proposed. The proposed 15-step mechanism is simulated using literature; exptl. and estimated rate coefficients and the simulated plots agreed well with the exptl. curves. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Synthetic Route of 4569-86-2

The Article related to chlorite oxidation kinetics methylene violet dye ruthenium catalyst, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Synthetic Route of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 1, 2012, Wang, Kai; Jin, Qi; Yu, Faquan; Zhang, Heng; Chi, Ruan; Huang, Ting; Zhang, Xiulan; Wan, Chunjie published a patent.Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride The title of the patent was Process for synthesizing janus green b. And the patent contained the following:

The process comprises the following steps: dissolving p-phenylenediamine and N,N-diethylbenzene in acid water, controlling pH of 4-7 in the presence of inorganic oxidant, reacting at (-5)-50 °C, stirring for 0.5-5 h, then adding aniline, increasing temperature to 0-100 °C, reacting for 1-10 h, filtering, concentrating, salting out, filtering, drying filter cake, obtaining methylene violet 3RAX, adding said methylene violet 3RAX into acid water, slowly dripping sodium nitrite aqueous solution, reacting at (-5)-25 °C for 1-5 h, adding N,N-dimethylaniline, reacting for 1-10 h, reducing pressure to dryness, dispersing residue in saturated saline, filtering, and drying filter cake. This process has the advantages of easily obtained raw materials and simple procedures. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to synthesis janus green b oxidation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 1, 2012, Wang, Kai; Song, Lvhua; Chen, Yunfeng; Yu, Faquan; Chi, Ruan; Huang, Ting published a patent.Application In Synthesis of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride The title of the patent was Synthesis of janus green B. And the patent contained the following:

The method comprises dissolving 4-amino-N,N-diethyl aniline in an aqueous acid , mixing with aniline at molar ratio of 1: 1-2 in the presence of inorganic oxidants (chromate, permanganate, or peroxo acid salt), stirring at pH 4-7, -5 to 50°C for 0.5-5 h, reacting with 1-2 M fold aniline, reacting at 0-100°C for 1-10 h, filtering, vacuum concentrating, precipitating, filtering, drying cake to obtain methylene purple 3RAX, adding into acid water at -5°C, slowly dripping sodium nitrite aqueous solution, reacting at -5 to 25°C for 1-5 h, reacting with 1-2 M fold N,N-didimethylaniline for 1-10 h, vacuum distilling, dispersing residue in saturated saline, filtering, and drying cake. This invention has easy-obtained raw materials, simple process, and certain industrialization value. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Application In Synthesis of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to janus green b dye synthesis, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Application In Synthesis of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 11, 2022, Knocke, Frank published a patent.Application In Synthesis of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride The title of the patent was Two component system for holographic recording material mixing photopolymerizable compositions for improved storage time and other properties. And the patent contained the following:

This invention discloses a two-component system for holog. recording material mixing photopolymerizable compositions to enable a longer, improved storage time or period of use, simple and very rapid processing as well as allowing holog. elements to be produced from the recording material that have the highest possible refractive index modulation and high stability and are particularly transparent, clear and not hazy. The present invention relates to a two-component system for mixing photopolymerizable compositions and elements produced therefrom and their use. The photopolymerizable compositions are particularly useful as a recording material for optical elements with refractive index modulation, especially holograms. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Application In Synthesis of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to two component system holog recording material mixing photopolymerizable composition, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Holography and other aspects.Application In Synthesis of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wyrebska, Lucja; Szuster, Lucjan; Stawska, Halina published an article in 2012, the title of the article was Synthesis and characterization of new polisher agent used in electroplating.COA of Formula: C22H23ClN4 And the article contains the following content:

The paper presents results of research on the preparation of polisher agent used in copper electroplating (electropolisher) and intermediate required for the synthesis of N,N-diethylphenosafranine (I). The multi-step synthesis of the intermediate I comprises the nitrosation of N,N-diethylaniline, reduction of p-nitroso-N,N-diethylaniline, oxidation of the resulting N,N-diethyl-p-phenylenediamine and its condensation with aniline. The polisher agent was obtained by diazotization of N,N-diethylphenosafranine and by reacting the resulting diazo compound with N,N-dimethylaniline, to obtain the product with absorption maximum λmax = 584 (300) nm. The usage tests of the newly developed product have shown very good application properties. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).COA of Formula: C22H23ClN4

The Article related to electropolisher electroplating copper preparation intermediate diethylphenosafranine, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.COA of Formula: C22H23ClN4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gradecka, Lucja published an article in 1983, the title of the article was Qualitative and quantitative studies of technical diethylsafranine.Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride And the article contains the following content:

The purity of samples of tech. diethylsafranine (I) [4569-86-2] (used as an inhibitor in electrorefining of Cu) was determined by chromatog. on a silica gel-filled column using 9:1:1:1 BuOH-EtOH-AcOH-H2O mixture as solvent and eluent, and spectrophotometric determination of the concentration of eluted, pure I at wavelength 560 nm utilizing the calibration curve. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to diethylsafranine chromatog spectrophotometric determination, safranine diethyl chromatog spectrophotometric determination, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics