Category: 452-75-5

On January 1, 2016, MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark published an article.HPLC of Formula: 452-75-5 The title of the article was Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. And the article contained the following:

N-Aryl derivatives of edaravone were identified as potentially effective small mol. inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer’s disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochem. assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).HPLC of Formula: 452-75-5

The Article related to edaravone derivative preparation palladium catalyzed protein misfolding beta amyloid, alzheimers treatment edaravone derivative beta amyloid tau aggregation inhibitor, alzheimer’s disease, beta-amyloid, hydrazine, palladium-catalyzed aminations and other aspects.HPLC of Formula: 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 2, 1987, Fukuoka, Shinsuke published a patent.Reference of 4-Chloro-2-fluorotoluene The title of the patent was A process for preparation of aryl fluorinated aromatic carboxylates by carbonylation of fluorinated aryl halides in the presence of phenols. And the patent contained the following:

The title compounds, useful as intermediates for heat-resistant polymers, agrochems., and pharmaceuticals, are prepared A mixture of p-IC6H4F 22.2, PhOH 11.3, Bu3N 22.2, and Ni(acac)2 0.77 g was autoclaved under CO at 50 kg/cm2 and 200-220° for 2 h to give 95% p-FC6H4CO2Ph. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to fluoroarom carboxylate aryl ester preparation, fluorobenzoate phenyl ester preparation, pharmaceutical agrochem intermediate aryl fluoroarom carboxylate, heat resistant polymer intermediate fluoroarycarboxylate ester, carbonylation fluoroaryl halide and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 8, 2019, Liu, Guiyan; Han, Fangwai; Liu, Chengxin; Wu, Hongli; Zeng, Yongfei; Zhu, Rongjiao; Yu, Xia; Rao, Shuang; Huang, Genping; Wang, Jianhui published an article.Category: chlorides-buliding-blocks The title of the article was A Highly Active Catalyst System for Suzuki-Miyaura Coupling of Aryl Chlorides. And the article contained the following:

New Pd(II) complexes with simple structures were designed and synthesized for Suzuki-Miyaura coupling reactions of aryl chlorides. The new Pd(II) complexes contain bidentate amine ligands, and their structures were characterized by single-crystal x-ray diffraction. They are highly efficient for Suzuki-Miyaura coupling reactions of aryl chlorides with low catalyst loadings (0.01 mol %) in aqueous media at room temperature Two possible reaction pathways involving a Pd(II)/(0)/(II) and a Pd(II)/(IV)/(II) catalytic cycle are proposed, and the mechanism was further studied using d. functional theory (DFT) calculations The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks

The Article related to mesitylethanediamine palladium bromide chloride iodide preparation catalyst suzuki coupling, crystal structure mesitylethanediamine palladium bromide chloride iodide, mol structure mesitylethanediamine palladium bromide chloride iodide, potential energy surface suzuki coupling mesitylethanediamine palladium bromide catalyst and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 31, 1991, Shepard, Kenneth L.; Graham, Samuel L.; Hudcosky, Ronald J.; Michelson, Stuart R.; Scholz, Thomas H.; Schwam, Harvey; Smith, Anthony M.; Sondey, John M.; Strohmaier, Kim M. published an article.Reference of 4-Chloro-2-fluorotoluene The title of the article was Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides. And the article contained the following:

For several decades a goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. (Hydroxyalkyl)sulfonyl-substituted benzene- and thiophenesulfonamides I [R = (CH2)nOH, CH2CH(OH)CH2OH, CH2CH2CMe2OH, etc., n = 2-5; R1 = H, Cl, F, NO2, CO2H, CO2Me, NH2; X = S, SO2] and II [R2 = (CH2)nOH, (CH2)mCO2Me, (CH2)3O2CCH2OMe, (CH2)3O2CCH2CHMe2, (CH2)3NHCH2CHMe2, X = S, SO2, n = 2-4, m = 2, 3] were prepared and examined for carbonic anhydrase inhibitory activity. Thus, condensation of 2-mercaptoethanol with (bromophenylsulfonyl)formamidine III gave I [R = (CH2)2OH, R1 = H, X = S]. These compounds exhibit inhibition of carbonic anhydrase II in the nanomolar range and lower intraocular pressure in the α-chymotrypsinized rabbit model of ocular hypertension after topical instillation. The inhibitory potency could be increased by converting a sulfide to the sulfone. Adding an extra methylene into the 4-substituent of benzene derivatives increases the inhibitory potency slightly more than oxidation of the sulfide. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to hydroxyalkylsulfonylbenzenesulfonamide preparation carbonic anhydrase inhibitor, hydroxyalkylsulfonylthiophenesulfonamide preparation carbonic anhydrase inhibitor, carbonic anhydrase inhibitor hydroxyalkylsulfonylbenzenesulfonamide hydroxyalkylsulfonylthiophenesulfonamide, glaucoma treatment alkylsulfonylbenzenesulfonamide thiophenesulfonamide and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 8, 2019, Liu, Guiyan; Han, Fangwai; Liu, Chengxin; Wu, Hongli; Zeng, Yongfei; Zhu, Rongjiao; Yu, Xia; Rao, Shuang; Huang, Genping; Wang, Jianhui published an article.Category: chlorides-buliding-blocks The title of the article was A Highly Active Catalyst System for Suzuki-Miyaura Coupling of Aryl Chlorides. And the article contained the following:

New Pd(II) complexes with simple structures were designed and synthesized for Suzuki-Miyaura coupling reactions of aryl chlorides. The new Pd(II) complexes contain bidentate amine ligands, and their structures were characterized by single-crystal x-ray diffraction. They are highly efficient for Suzuki-Miyaura coupling reactions of aryl chlorides with low catalyst loadings (0.01 mol %) in aqueous media at room temperature Two possible reaction pathways involving a Pd(II)/(0)/(II) and a Pd(II)/(IV)/(II) catalytic cycle are proposed, and the mechanism was further studied using d. functional theory (DFT) calculations The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks

The Article related to mesitylethanediamine palladium bromide chloride iodide preparation catalyst suzuki coupling, crystal structure mesitylethanediamine palladium bromide chloride iodide, mol structure mesitylethanediamine palladium bromide chloride iodide, potential energy surface suzuki coupling mesitylethanediamine palladium bromide catalyst and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 31, 1991, Shepard, Kenneth L.; Graham, Samuel L.; Hudcosky, Ronald J.; Michelson, Stuart R.; Scholz, Thomas H.; Schwam, Harvey; Smith, Anthony M.; Sondey, John M.; Strohmaier, Kim M. published an article.Reference of 4-Chloro-2-fluorotoluene The title of the article was Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides. And the article contained the following:

For several decades a goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. (Hydroxyalkyl)sulfonyl-substituted benzene- and thiophenesulfonamides I [R = (CH2)nOH, CH2CH(OH)CH2OH, CH2CH2CMe2OH, etc., n = 2-5; R1 = H, Cl, F, NO2, CO2H, CO2Me, NH2; X = S, SO2] and II [R2 = (CH2)nOH, (CH2)mCO2Me, (CH2)3O2CCH2OMe, (CH2)3O2CCH2CHMe2, (CH2)3NHCH2CHMe2, X = S, SO2, n = 2-4, m = 2, 3] were prepared and examined for carbonic anhydrase inhibitory activity. Thus, condensation of 2-mercaptoethanol with (bromophenylsulfonyl)formamidine III gave I [R = (CH2)2OH, R1 = H, X = S]. These compounds exhibit inhibition of carbonic anhydrase II in the nanomolar range and lower intraocular pressure in the α-chymotrypsinized rabbit model of ocular hypertension after topical instillation. The inhibitory potency could be increased by converting a sulfide to the sulfone. Adding an extra methylene into the 4-substituent of benzene derivatives increases the inhibitory potency slightly more than oxidation of the sulfide. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to hydroxyalkylsulfonylbenzenesulfonamide preparation carbonic anhydrase inhibitor, hydroxyalkylsulfonylthiophenesulfonamide preparation carbonic anhydrase inhibitor, carbonic anhydrase inhibitor hydroxyalkylsulfonylbenzenesulfonamide hydroxyalkylsulfonylthiophenesulfonamide, glaucoma treatment alkylsulfonylbenzenesulfonamide thiophenesulfonamide and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics