Category: 452-75-5

On December 15, 2021, Nair, K. P. Rajappan; Herbers, Sven; Grabow, Jens-Uwe; Nguyen, Ha Vinh Lam published an article.Electric Literature of 452-75-5 The title of the article was Neighborhood matters: Steric effects on methyl internal rotation and chlorine nuclear quadrupole coupling in 2-fluoro-4-chlorotoluene. And the article contained the following:

The rotational spectrum of 2-fluoro-4-chlorotoluene was studied in the frequency range 4 to 24 GHz by Fourier transform microwave spectroscopy. Fine torsional splittings into doublets were found for all rotational transitions due to Me internal rotation hindered with a barrier of about 230 cm-1. In combination with the quadrupole coupling hyperfine splittings on the same order of magnitude originating from the chlorine nucleus, rich spectral features were observed Rotational and quadrupole coupling constants for the 35Cl and 37Cl isotopologues studied in natural abundance were precisely determined Results from the experiment were supported by quantum chem. calculations at several levels of theory for the rotational constants and by Bailey’s semi-exptl. method for the quadrupole coupling constants The χcc quadrupole coupling tensor element and the barrier to Me internal rotation were compared with those of other halogen-substituted toluene derivatives The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to fluoro chlorotoluene internal rotation nuclear quadrupole coupling, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 20, 2013, Chae, Sang Youl; Yoon, Young Wook; Lee, Sang Kuk published an article.Synthetic Route of 452-75-5 The title of the article was Vibronic spectroscopy of jet-cooled benzyl-type radicals produced from 2-fluoro-4-chlorotoluene by corona discharge. And the article contained the following:

A home-made pinhole-type glass nozzle was employed to generate vibronically excited but jet-cooled benzyl-type radicals from precursor 2-fluoro-4-chlorotoluene with a large amount of carrier gas He, from which the visible vibronic emission spectrum was recorded with a long-path monochromator. From an anal. of the spectrum observed, it was found that two benzyl-type radicals, 2-fluorobenzyl and 2-fluoro-4-chlorobenzyl radicals, were formed from the precursor in corona discharge. The possible pathway for the production of benzyl-type radicals that can explain the spectroscopic observation is herein proposed. In addition, the electronic energy of the D1 → D0 transition and the vibrational mode frequencies in the D0 state of the 2-fluoro-4-chlorobenzyl radical were determined for the first time. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Synthetic Route of 452-75-5

The Article related to benzyl type radical corona discharge reaction mechanism, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Synthetic Route of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 1, 1987, Fukuoka, Shinsuke published a patent.Product Details of 452-75-5 The title of the patent was Preparation of aryl fluoro-substituted aromatic carboxylates as intermediates for agrochemicals, pharmaceuticals, and monomers. And the patent contained the following:

The title esters, useful as intermediates for agrochems., pharmaceuticals, and monomers, are prepared by aryloxycarbonylation. Heating a mixture of 22.2 g p-FC6H4I, 11.3 g PhOH, 22.2 g Bu3N, and 40 mg PdCl2 at 200° and 30 kg/cm2 CO gave 98% p-FC6H4CO2Ph. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5

The Article related to fluoroarenecarboxylate intermediate agrochem pharmaceutical monomer, aryl fluoroarenecarboxylate intermediate agrochem pharmaceutical monomer, aryloxycarbonylation fluoroaryl halide and other aspects.Product Details of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 20, 1995, Miyamoto, Yoshiko; Kohno, Hitoshi; Pfleiderer, Wolfgang; Boeger, Peter; Wakabayashi, Ko published an article.Application of 452-75-5 The title of the article was Synthesis of 1,2,4-triazolo[1,5-a]-1,3,5-triazine derivatives for phytotoxic activity. And the article contained the following:

Treatment of benzylideneaminoguanidines (I) with Et N-cyanoformimidate (II) in MeCN at room temperature gave 1-benzylideneamino-2-cyanoiminomethylguanidines (III). I (R1 = 2-F and 4-Cl, R2 = H, R3 = Me) and I (R1 = 4-Cl, R2 = H, R3 = Me) were treated with II directly to give 7-methylamino-2-halophenyl-1,2,4-triazolo[1,5-a]-1,3,5-triazines V (R1 = 2-F and 4-Cl, R2 = H, R3 = Me) and V (R1 = 4-Cl, R2 = H, R3 = Me) under similar conditions. III were readily cyclized to the corresponding 1,2-dihydro-1,2,4-triazolo[1,5-a]-1,3,5-triazines (IV) by brief heating in MeOH. IV were oxidized with iodine in EtOH to give the corresponding V. Phytotoxic activities of III, IV, and V were assayed using green microalgae, Scenedesmus acutus. V (R1 = 2-F and 4-Cl, R2 = R3 = H) and some other compounds were found to suppress the cell growth and chlorophyll formation of Scenedesmus, but those activities were still not good enough to be utilized as a herbicide or plant growth regulator. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application of 452-75-5

The Article related to triazolotriazine synthesis phytotoxicity, condensation benzylideneaminoguanidine cyanoformimidate, cyclization benzylideneaminocyanoiminomethylguanidine, oxidation hydrotriazolotriazine and other aspects.Application of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 31, 1996, Al-Darwich, M. J.; Plenevaux, A.; Lemaire, C.; Fiore, G. D.; Christiaens, L.; Comar, D.; Luxen, A. published an article.Quality Control of 4-Chloro-2-fluorotoluene The title of the article was Enantioselective syntheses of no-carrier-added (n.c.a.) (S)-4-chloro-2-[18F] fluorophenylalanine and (S)-(α-methyl)-4-chloro-2-[18f] fluorophenylalanine. And the article contained the following:

Title compounds I (R = H, Me) were prepared and labeled with no carrier added 18F through a radiochem. synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F]fluorobenzyl iodide and the lithium enolate of 1,3-imidazolidinones II. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatog. (HPLC) purification, with a radiochem. yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F] fluoride. The enantiomeric excesses were ≥97% for both mols. without chiral separation and the radiochem. and chem. purities were ≥98%. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene

The Article related to asym preparation fluorine 18 chlorofluorophenylalanine, phenylalanine chlorofluoromethyl fluorine 18 asym preparation, stereoselective alkylation imidazolidinone chlorofluorobenzyl iodide and other aspects.Quality Control of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 24, 2012, Lundgren, Rylan J.; Stradiotto, Mark published a patent.Product Details of 452-75-5 The title of the patent was Preparation of amines, hydrazones, hydrazines, and indazoles by hydroamination or cross-coupling reactions catalyzed by palladium or gold in the presence of a phosphine ligand. And the patent contained the following:

The invention provides compounds and ligands of formula I that are useful in transition metal catalyzed cross-coupling reactions. Compounds of formula I wherein R1 and R2 are independently t-Bu, cyclohexyl, 2-tolyl, 1-adamantyl; R3 and R4 are independently C1-5 alkyl; R3R4 taken together to form a 4- to 10-membered heterocyclyl; each X is independently N and CR5; each X1 is independently N and CR6; R5 is H, Me, OME, halo, and CF3; R6 is H, Me, OMe, NMe2, halo and CF3; vicinal R5R6 may be taken together to form a 5- to 7-membered heterocyclic or carbocyclic ring; provided that no more than one of each X and X1 is N; are claimed. For example, the compounds and ligands of the invention are useful in palladium or gold catalyzed cross-coupling reactions. Ligand II was used in the palladium-catalyzed cross-coupling of chlorobenzene with hydrazine followed by condensation to give diphenylhhydrazone. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5

The Article related to aryl halide amine cross coupling palladium phosphine, arylamine preparation, indazole preparation, hydrazone preparation, hydrazine preparation, palladium phosphine cross coupling catalyst and other aspects.Product Details of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 9, 2016, Park, Chan Hee; Lee, Sang Hwi; Im, Junhwan; Lee, Soon Ok; Kim, Jongmin; Ko, Kwang Seok; Kim, Byungho; Kong, Minjung; Kim, Mi Sun; Moon, Hyung Jo published a patent.Name: 4-Chloro-2-fluorotoluene The title of the patent was Preparation of heterocyclic derivatives for preventing or treating diseases associated with the activation of STAT3 protein. And the patent contained the following:

The title compounds I [one of X1-X4 = C(Rx1), and the others = (independently) C(Rx2) or N; one of Y and Z = S or NH, and the other = CH or N; Rx1 = L1S(:O)(:Xs)Rs (wherein Xs = O or NH; L1 = (un)subsitituted CH2 or NH; Rs = alkyl, haloalkyl, alkoxyalkyl, etc.); Rx2 = H, halo, NO2, etc.; A and B = (independently) a monocyclic- or bicyclic-saturated or unsaturated C3-10 carbocycle or 5-12 membered heterocycle; R1 = H, halo, CN, etc.; R2 = H, halo, OH, etc.; R3 = O, NH, N(alkyl), N(OH); R4 = H, alkyl; or R4 is linked to R1 to form a chain; L2 = (un)substituted (CH2)m, (CH2)nO, O, etc. (m = 0-3; n = 1-3); p = 0-4, and, when p is 2 or higher, R1 moieties are the same as or different from each other; q = 0-4, and, when q is 2 or higher, R2 moieties are the same as or different from each other] which have an inhibitory effect on the activation of STAT3 protein, and are useful for the prevention or treatment of diseases associated with the activation of STAT3 protein, were prepared E.g., a multi-step synthesis of N-(3-chloro-5-(2-(3-ethoxy-5-(trifluoromethoxy)phenyl)propan-2-yl)phenyl)-5-(2-(methylsulfonyl)propan-2-yl)benzo[b]thiophene-2-carboxamide, starting from 3-chloro-5-nitrobenzoic acid, was described. Exemplified compounds I were evaluated on their inhibitory effect on the dimerization of STAT3 and STAT1 (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Name: 4-Chloro-2-fluorotoluene

The Article related to heterocyclic amide preparation stat3 protein activation inhibitor antitumor antiinflammatory, benzothiophenecaboxamide preparation stat3 protein activation inhibitor antitumor antiinflammatory and other aspects.Name: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 21, 2012, Yu, Juntian; Zhang, Ling; Sun, Zhiguo; Luan, Xiuli published a patent.Quality Control of 4-Chloro-2-fluorotoluene The title of the patent was Method for preparing 4-chloro-2-fluorotoluene. And the patent contained the following:

The invention relates to the method for preparation of 4-chloro-2-fluorotoluene. 4-Chloro-2-fluorotoluene was prepared via salt formation of 5-chloro-2-methylaniline with hydrofluoric acid; the resulting 5-chloro-2-methylaniline hydrofluoric acid salt underwent diazotization to give 5-chloro-2-methylphenyldiazonium fluoride, which underwent denitrogenation to give the title compound The method has few steps, high yield and high product purity. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene

The Article related to chloro methyl aniline salt formation, hydrofluoric acid salt chloro methyl aniline preparation diazotization, phenyl diazonium fluoride preparation denitrogenation, fluoro methyl toluene preparation and other aspects.Quality Control of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 22, 1986, Fukuoka, Shinsuke published a patent.Recommanded Product: 4-Chloro-2-fluorotoluene The title of the patent was Aryl fluorobenzoates. And the patent contained the following:

The title esters, useful as intermediates for agrochems., polymers, and pharmaceuticals (no data), are prepared by reaction of fluorinated aromatic halides with CO and aromatic hydroxy compounds over Pd compounds and phosphine catalysts in the presence of bases. Thus, CO was pressurized into a mixture of p-FC6H4Br 17.5, PhOH 11.3, Bu3N 22.2, Ph3P 0.4, and PdCl2 0.04 g at 30 kg/cm2 and heated at 200° to give 98% p-FC6H4CO2Ph with 99% conversion. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Recommanded Product: 4-Chloro-2-fluorotoluene

The Article related to aryl fluorobenzoate preparation intermediate agrochem, fluorobenzene aryloxycarbonylation catalyst, pharmaceutical intermediate aryl fluorobenzoate preparation, polymer intermediate aryl fluorobenzoate preparation and other aspects.Recommanded Product: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Moselage, Marc; Li, Jie; Kramm, Frederik; Ackermann, Lutz published an article in 2017, the title of the article was Ruthenium(II)-Catalyzed C-C Arylations and Alkylations: Decarbamoylative C-C Functionalizations.Computed Properties of 452-75-5 And the article contains the following content:

Ruthenium(II)biscarboxylate catalysis enabled selective C-C functionalizations by means of decarbamoylative C-C arylations. The versatility of the ruthenium(II) catalysis was reflected by widely applicable C-C arylations and C-C alkylations of aryl amides, as well as acids with modifiable pyrazoles, through facile organometallic C-C activation. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Computed Properties of 452-75-5

The Article related to arylindazole decarbamoylative arylation alkylation ruthenium, arylpyrazole decarbamoylative arylation alkylation, ruthenium decarbamoylative arylation alkylation catalyst, c−c activation, amides, arylation, reaction mechanisms, ruthenium and other aspects.Computed Properties of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics