Category: 452-75-5

Lundgren, Rylan J.; Peters, Brendan D.; Alsabeh, Pamela G.; Stradiotto, Mark published an article in 2010, the title of the article was A P,N-Ligand for Palladium-Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions.Electric Literature of 452-75-5 And the article contains the following content:

An air-stable P,N-ligand (I), that advances the scope and utility of palladium-catalyzed ammonia cross-coupling reactions, was developed. A variety of aryl chloride and aryl tosylate substrates can be coupled efficiently, most notably electron-rich species lacking ortho-substitution under a range of conditions. The unique preference for ammonia coupling when using Pd/I mixtures can be exploited in unprecedented chemoselective arylations, and for the first time, the room temperature palladium-catalyzed cross-coupling of ammonia has been achieved. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to arylamine preparation, palladium catalyst ammonia cross coupling reaction aryl chloride tosylate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lundgren, Rylan J.; Stradiotto, Mark published an article in 2010, the title of the article was Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Tosylates with Hydrazine.Application In Synthesis of 4-Chloro-2-fluorotoluene And the article contains the following content:

The cross-coupling of aryl chlorides and tosylates with hydrazine in presence of cinnamylpalladium chloride dimer and 4-[2-(bis(1-adamantanyl)phosphinyl)phenyl]morpholine proceeds rapidly with excellent chemoselectivity under mild conditions. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application In Synthesis of 4-Chloro-2-fluorotoluene

The Article related to coupling aryl chloride tosylate hydrazine palladium adamantylphosphinylphenylmorpholine catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydroxylamines, Hydrazines, Triazenes, Azides, Azines, and Azo and Diazo Compounds and other aspects.Application In Synthesis of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tripathi, G. N. R.; Tewari, B. N.; Verma, R. M.; Ram, Sita published an article in 1974, the title of the article was Electronic absorption spectrum of 2-chloro-6-fluorotoluene in vapor phase.Electric Literature of 452-75-5 And the article contains the following content:

The near-uv absorption spectrum of 2-chloro-6-fluorotoluene was investigated. The bands were observed at 2553-2722 Å. The (0,0) band was identified at 2700.7 Å. The vibrational anal. of the bands is proposed in terms of the ground state fundamental 262 cm-1 and the excited state fundamentals 352, 600, 755, 982, 1087, 1175, and 1580 cm-1. The fundamentals identified are correlated with the ir and Raman frequencies. A blue shift in the (0,0) band of 2-chloro-6-fluorotoluene with respect to ο-chlorotoluene is noted. The (0,0) bands of chlorofluorotoluenes and a few other related compounds are calculated with the help of Platt’s spectroscopic moments. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to uv chlorofluorotoluene vibrational analysis, fluorochlorotoluene uv, toluene chlorofluoro uv, Spectra by Absorption, Emission, Reflection, or Magnetic Resonance, and Other Optical Properties: Absorption, Emission, Reflection, and Scattering and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 17, 2020, Hong, Hao; Lu, Jiangping; Zhang, Enxuan; Liu, Zhiqing; Li, Chao published a patent.Synthetic Route of 452-75-5 The title of the patent was Continuous synthesis method for substituted benzoate organic matter. And the patent contained the following:

The present invention provides a continuous synthesis method for a substituted benzoate organic matter. Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Synthetic Route of 452-75-5

The Article related to benzoate preparation oxidation carboxylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Synthetic Route of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 10, 2019, Hong, Hao; Zhang, Enxuan; Lu, Jiangping; Liu, Zhiqing; Li, Chao; Tan, Yang published a patent.Recommanded Product: 452-75-5 The title of the patent was Continuous synthesis method of substituted benzoic acid organic matter by oxygen gas oxidation. And the patent contained the following:

The title continuous synthesis method includes reacting compound (such as 2,4-difluoroacetophenone) and oxygen gas under catalysis of catalyst (cobalt acetate, cobalt acetylacetonate, etc.) in presence of metal halide (sodium bromide, lithium chloride, etc.) and initiator (azobisisobutyronitrile, N-hydroxyphthalimide, etc.) in organic solvent (formic acid, glacial acetic acid, etc.) at 130-180°C and 1-2.5 MPa for 90-240 min to obtain the title compounds (such as 2,4-difluorobenzoic acid). The invention has cheap and easily available oxygen gas, no three wastes, improved utilization rate of oxygen gas, simplified operation, and improved reaction safety and product yield. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Recommanded Product: 452-75-5

The Article related to benzoic acid preparation oxidation acetophenone methylbenzene, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 26, 2004, Yang, Fan; Sun, Jing; Zheng, Rui; Qiu, Wenwei; Tang, Jie; He, Mingyuan published an article.Recommanded Product: 4-Chloro-2-fluorotoluene The title of the article was Oxidation of toluenes to benzoic acids by oxygen in non-acidic solvents. And the article contained the following:

Oxidation of substituted toluenes by mol. oxygen to the corresponding benzoic acids has been investigated. Oxidation of halo-, methoxy-, and cyanotoluenes using Co(C18H35O2)2/NH4Br or Co(OAc)2/NaBr/AcOH as catalysts, in the presence of a radical initiator, gave the benzoic acids in good yields. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Recommanded Product: 4-Chloro-2-fluorotoluene

The Article related to substituted toluene oxygen oxidation, benzoic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 20, 2021, Zeng, Rong; Zhang, Guoxiang published a patent.Electric Literature of 452-75-5 The title of the patent was Preparation of aromatic acids by oxidation of alkyl substituted aromatic compounds. And the patent contained the following:

The invention discloses a preparation of aromatic acids by oxidation of alkyl substituted aromatic compounds, which has high safety and low cost. The aromatic acids of the invention were prepared via oxidation of aromatic compounds The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to aromatic acid preparation alkyl substituted aromatic oxidation iron catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 7, 2007, Wada, Mitsuo; Ida, Kazutaka published a patent.COA of Formula: C7H6ClF The title of the patent was Charge-generating phthalocyanine crystals and electrophotographic photoconductors using them. And the patent contained the following:

The crystals having main diffraction peaks at Bragg angle (2θ±0.2°) 27.2° to CuKa x ray (wavelength 1.541 Å) are manufactured by treatment of amorphous or low-crystalline phthalocyanines with fluorinated aromatic compounds bearing substituents with Hammett constant ≤0.48. Electrophotog. photoconductor cartridges and electrophotog. apparatus are also claimed. The electrophotog. photoconductors show high sensitivity to LED or semiconductor lasers, and low dark decay. Thus, low-crystalline oxytitanylphthalocyanine was treated with 2,4-dichlorofluorobenzene. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).COA of Formula: C7H6ClF

The Article related to charge generator phthalocyanine crystal electrophotog photoconductor, fluoroarene crystallization phthalocyanine electrophotog photoconductor, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Electrophotography, Electrography, and Photoelectrophoretic Imaging and other aspects.COA of Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 31, 2011, Ramalingam, S.; Periandy, S.; Elanchezhian, B.; Mohan, S. published an article.Related Products of 452-75-5 The title of the article was FT-IR and FT-Raman spectra and vibrational investigation of 4-chloro-2-fluorotoluene using ab initio HF and DFT (B3LYP/B3PW91) calculations. And the article contained the following:

FT-IR (4000-100 cm-1) and FT-Raman (4000-100 cm-1) spectra of solid sample of 4-chloro-2-fluorotoluene (4Cl2FT) have been recorded using Bruker IFS 66 V spectrometer. Ab initio-HF (HF/6-311++G (d, p)) and DFT (B3LYP/6-311++G and B3PW91/6-311++G (d, p)) calculations have been performed giving energies, optimized structures, harmonic vibrational frequencies, depolarization ratios, IR intensities, Raman activities. The vibrational frequencies are calculated and scaled values are compared with FT-IR and FT-Raman exptl. values. The isotropic HF and DFT analyses showed good agreement with exptl. observations. The differences between the observed and scaled wave number values of most of the fundamentals are very small in B3LYP than HF. Comparison of the simulated spectra provides important information about the ability of the computational method (B3LYP) to describe the vibrational modes. The influences of substitutions on the geometry of mol. and its normal modes of vibrations have also been discussed. The changes made by substitutions on the benzene are much responsible for the non-linearity of the mol. This is an attractive entity for the future studies of non-linear optics. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Related Products of 452-75-5

The Article related to chlorofluorotoluene ir raman spectra hf dft, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Related Products of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 13, 2009, Ritter, Tobias; Furuya, Takeru; Kaiser, Hanns M. published a patent.Reference of 4-Chloro-2-fluorotoluene The title of the patent was System for fluorinating organic compounds using palladium complexes and fluorinating agents. And the patent contained the following:

Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes of formula I. Also described herein are compositions and kits containing compounds and palladium complexes described herein. Palladium complexes of formula I wherein Pd has valence +2; R11 and R12 are independently (un)substituted aliphatic, (un)substituted heteroaliph., (un)substituted aryl, etc.; when W is C and CRd, Z is a bond, O, S, (un)substituted methylene, (un)substituted ethenylene, N- joined via L to R11, etc.; and L is CO, CO2, SO2, etc.; when W is N and NH and derivatives, Z is a bond, (un)substituted methylene, (un)substituted ethenylene, etc.; Rd is H, (un)substituted aliphatic, (un)substituted heteroaliph., etc.; R1, R2, R3 and R4 are independently (un)substituted aliphatic, (un)substituted heteroaliph., (un)substituted aryl; R1R2 R2R3, and R3R4 are independently taken together to form (un)substituted 5- to 7-membered aryl, heteroaryl, heterocyclic and carbocyclic ring; dashed bon is single and double bond; provided that at least one of R11 and R12 is neg. charged moiety or the complex further comprises of a neg. charged counter ion; are claimed. Fluorobenzene was prepared by transmetalation of II with phenylboronic acid, the resulting phenylpalladium sulfamidate complex underwent electrophilic fluorination to give fluorobenzene. The fluorinated organic compounds may be useful as imaging agents. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to arylboronic acid palladium acetate sulfamidate complex transmetalation, arylpalladium sulfamidate preparation electrophilic fluorination, fluoro arene preparation imaging agent and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics