Category: 452-75-5

On October 19, 2017, Kumoi, Hirofumi; Tanaka, Masato published a patent.Formula: C7H6ClF The title of the patent was Production method of phthalocyanine crystals and process for producing electrophotographic photoreceptor using the same. And the patent contained the following:

Title production method of phthalocyanine crystal includes mixing of phthalocyanine compound obtained by the acid pasting method with an organic compound and subjecting it to crystal transformation to obtain phthalocyanine crystal, which comprises a rotatable rotor and a jacket covering the rotor, at least the rotor has a flow path of a coolant or a heat medium therein and a gap between the rotor and the inner wall of the jacket has a portion forming an annular space, the rotor and the inner wall of the jacket both have a smooth surface and a crystal transformation is performed using a disperser having a structure in which a mixture of the phthalocyanine compound and the organic compound passes through the space filled with media particles. Thus, 0.3 parts of hydroxygallium phthalocyanine pigment powder (prepared by reacting chlorogallium phthalocyanine pigment with sulfuric acid), 9.7 parts of N,N-dimethylformamide were mixed in stainless steel container and then the mixed solution was subjected to dispersion treatment using glass beads as media particles and then the mixture was dispersed by using a dispersion machine to obtain hydroxygallium phthalocyanine crystals. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Formula: C7H6ClF

The Article related to phthalocyanine crystal organic compound electrophotog photoreceptor, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Phthalocyanines and other aspects.Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 19, 1987, Fukuoka, Shinsuke published a patent.Quality Control of 4-Chloro-2-fluorotoluene The title of the patent was Preparation of aryl fluoroarenecarboxylates as intermediates for agrochemicals, pharmaceuticals, and polymers. And the patent contained the following:

The title esters, useful as intermediates for agrochems., pharmaceuticals, and heat-stable polymers, are prepared Heating a mixture of p-FC6H4Br 50, PhONa 60, and Ni(acac)2 2.5 mmol in MePh at 250° and 50 kg/cm2 CO gave 82% p-FC6H4CO2Ph. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene

The Article related to aryl arenecarboxylate intermediate agrochem pharmaceutical, polymer intermediate aryl arenecarboxylate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Quality Control of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2021, Zhang, Guoxiang; Zhang, Zongnan; Zeng, Rong published an article.Name: 4-Chloro-2-fluorotoluene The title of the article was Photoinduced FeCl3-Catalyzed Alkyl Aromatics Oxidation toward Degradation of Polystyrene at Room Temperature. And the article contained the following:

Main observation and conclusion : While polystyrene is widely used in daily life as a synthetic plastic, the subsequently selective degradation is still very challenging and highly required. Herein, we disclose a highly practical and selective reaction for the catalytically efficient oxidation of alkyl aromatics (including 1°, 2°, and 3° alkyl aromatics) to carboxylic acids. While dioxygen was used as the sole terminal oxidant, this protocol was catalyzed by the inexpensive and readily available ferric compound (FeCl3) with irradiation of visible light (blue LEDs) under only 1 atm of O2 at room temperature This system could further facilitate the selective degradation of polystyrene to benzoic acid, providing an important and practical tool to generate high-value chem. from abundant polystyrene wastes. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Name: 4-Chloro-2-fluorotoluene

The Article related to polystyrene aromatic oxidation degradation iron chloride catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 11, 1999, Wingert, Horst; Gotz, Norbert; Keil, Michael; Muller, Bernd published a patent.Electric Literature of 452-75-5 The title of the patent was Manufacture of substituted benzyl bromides. And the patent contained the following:

Benzyl bromides ring-substituted with ≥1 electron-withdrawing group and optionally with ≥1 Me group are prepared by bromination of correspondingly substituted toluenes with a brominating agent at 20-95° in the presence of an oxidizing agent and either an azodinitrile or an azodicarboxylate ester. Thus, (1) a solution of 26.2 g AIBN in 548 g o-MeC6H4NO2 and (2) 725 g 15% aqueous H2O2 were sep. added simultaneously over 2-2.5 h to a mixture of AIBN 6.6, PhCl 1350, and 47% HBr 620 g at 75° and the mixture was stirred 2 h addnl. at 75° to give an organic phase containing (excluding solvent) o-BrCH2C6H4NO2 60.4, o-MeC6H4NO2 21.5, and o-Br2CHC6H4NO2 18.2%, corresponding to a 58.1% yield of the desired product. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to bromination methylbenzene derivative oxidizing agent, radical generator bromination methylbenzene derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 5, 2014, Grammenos, Wassilios; Craig, Ian Robert; Boudet, Nadege; Mueller, Bernd; Dietz, Jochen; Lauterwasser, Erica May Wilson; Lohmann, Jan Klaas; Grote, Thomas; Haden, Egon; Escribano Cuesta, Ana published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of triazole derivatives for use as agrochemical fungicides. And the patent contained the following:

Title compounds I [R1 = (un)substituted alkyl, alkenyl, cycloalkyl, etc.; R2 = H, (un)substituted alkyl, Ph, cycloalkyl, etc.; R3 = halo; each R4 independently = halo, CN, NO2, OH, etc.; each R5 independently = halo, CN, OH, (un)substituted alkyl, etc.; m = 1 to 3; n = 0 to 5], and their N-oxides and agriculturally acceptable salts, are prepared and disclosed as fungicides. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated for combating phytopathogenic fungi (no data). The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks

The Article related to triazole preparation fungicide, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 31, 2020, Zhang, Yingying; Han, Fangwai; Zhang, Mengyao; Zhang, Huixin; Li, Ying; Wang, Ru; Zeng, Yongfei; Liu, Guiyan published an article.Application of 452-75-5 The title of the article was Highly Active Pd-PEPPSI Complexes for Suzuki-Miyaura Cross-coupling of Aryl Chlorides: an Investigation on the Effect of Electronic Properties. And the article contained the following:

Three new Pd-pyridine enhanced precatalyst preparation, stabilization and initiation (PEPPSI) complexes with halogen groups on the N-heterocyclic carbene and pyridine were prepared Their structures was clearly characterized by NMR spectroscopy and X-ray single-crystal diffraction. The effects of the electronic properties of halogen groups on the catalytic activity in the Suzuki-Miyaura cross-coupling of aryl chlorides were investigated. These Pd-PEPPSI complexes catalyzed the cross-coupling reaction efficiently with a low catalyst loading(0.05%, molar ratio) at room temperature and the products were obtained in high yields. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application of 452-75-5

The Article related to palladium peppsi complex diastereoselective preparation crystal structure, arylboronic acid aryl chloride palladium catalyst suzuki coupling, biaryl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 31, 2017, Liu, Li; Wang, Ting; Huang, Zhuyan; Li, Qin published a patent.Safety of 4-Chloro-2-fluorotoluene The title of the patent was Method for preparing 4-chloro-2-fluoro-phenylpropionic acid. And the patent contained the following:

The invention relates to the tech. field of chem. synthesis, especially a method for preparing 4-chloro-2-fluoro-phenylpropionic acid. The method uses low-cost and easily available 4-chloro-2-fluorotoluene as raw material to prepare the target product 4-chloro-2-fluoro-phenylpropionic acid through halogenation, nucleophilic substitution and hydrolytic decarboxylation, and the total yield of the target product can reach 74%. During the treatment process, the intermediate and the final product can be purified by the steps such as extraction, vacuum evaporation, vacuum filtration and recrystallization, which are easy to perform, and easily accomplish industrial production, compared with the column purification treatment. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Safety of 4-Chloro-2-fluorotoluene

The Article related to chlorofluorophenylpropionic acid preparation, Aliphatic Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 13, 2011, Hesp, Kevin D.; Lundgren, Rylan J.; Stradiotto, Mark published an article.Recommanded Product: 4-Chloro-2-fluorotoluene The title of the article was Palladium-Catalyzed Mono-α-arylation of Acetone with Aryl Halides and Tosylates. And the article contained the following:

The first example of selective Pd-catalyzed mono-α-arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates is reported. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of functional groups at modest Pd loadings using Cs2CO3 as the base and employing acetone as both a reagent and the solvent. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Recommanded Product: 4-Chloro-2-fluorotoluene

The Article related to aryl methyl ketone preparation, arylhalide acetone monoarylation palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Recommanded Product: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 30, 1996, Bomben, Andrea; Marques, Carlos A.; Selva, Maurizio; Tundo, Pietro published an article.Category: chlorides-buliding-blocks The title of the article was Synthesis of substituted phenyl ketones via Pd-catalyzed hydrodechlorination of their polychlorinated derivatives. And the article contained the following:

2- And 3-methylacetophenone, 2- and 3-methylbenzophenone, and 2,2′-, 2,3′- and 3,3′-dimethylbenzophenone were prepared through a Pd-catalyzed hydrodechlorination of the corresponding dichlorinated derivatives The reaction was carried out under multiphase conditions at 30-50°, by bubbling H2 at atm. pressure into a biphasic system constituted by isooctane and 50% aq KOH, in the presence of Pd/C and Aliquat 336. Likewise, fluorinated aceto- and benzophenones were prepared starting from the corresponding chlorinated methylfluoro- and dimethylfluoro ketones. The presence of the onium salt allows the reaction to proceed with a high chemoselectivity. Cl is moved while both the reduction of the carbonyl group and/or fluorine removal are prevented. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks

The Article related to phenyl ketone preparation, palladium catalyzed hydrodechlorination chlorophenyl ketone, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alsabeh, Pamela G.; Lundgren, Rylan J.; McDonald, Robert; Johansson Seechurn, Carin C. C.; Colacot, Thomas J.; Stradiotto, Mark published an article in 2013, the title of the article was An Examination of the Palladium/Mor-DalPhos Catalyst System in the Context of Selective Ammonia Monoarylation at Room Temperature.Application In Synthesis of 4-Chloro-2-fluorotoluene And the article contains the following content:

An examination of the [{Pd(cinnamyl)Cl}2]/Mor-DalPhos (Mor-DalPhos=di(1-adamantyl)-2-morpholinophenylphosphine) catalyst system in Buchwald-Hartwig aminations employing ammonia was conducted to better understand the catalyst formation process and to guide the development of precatalysts for otherwise challenging room-temperature ammonia monoarylations. The combination of [{Pd(cinnamyl)Cl}2] and Mor-DalPhos afforded [(κ2-P,N-Mor-DalPhos)Pd(η1-cinnamyl)Cl] (2), which, in the presence of a base and chlorobenzene, generated [(κ2-P,N-Mor-DalPhos)Pd(Ph)Cl] (1 a). Halide abstraction from 1 a afforded [(κ3-P,N,O-Mor-DalPhos)Pd(Ph)]OTf (5), bringing to light a potential stabilizing interaction that is offered by Mor-DalPhos. An examination of [(κ2-P,N-Mor-DalPhos)Pd(aryl)Cl] and related precatalysts for the coupling of ammonia and chlorobenzene at room temperature established the suitability of 1 a in such challenging applications. The scope of reactivity for the use of 1 a (5 mol %) encompassed a range of (hetero)aryl (pseudo)halides (X=Cl, Br, I, OTs) with diverse substituents (alkyl, aryl, ether, thioether, ketone, amine, fluoro, trifluoromethyl, and nitrile), including chemoselective arylations. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application In Synthesis of 4-Chloro-2-fluorotoluene

The Article related to palladium mor dalphos catalyst ammonia monoarylation room temperature, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Application In Synthesis of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics