Category: 452-75-5

On May 2, 1996, Signor, Angelo; Guerrato, Alfredo; Signor, Giovanni published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of furosemide. And the patent contained the following:

Furosemide (I), known diuretic and antihypertensive agent (no data), was prepared by photochlorination of 4-chloro-2-fluoro-toluene followed by aminosulfonylation of 4-chloro-2-fluoro-benzotrichloride and condensation of 4-chloro-2-fluoro-5-(aminosulfonyl)benzoic acid with furfurylamine. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks

The Article related to furosemide preparation diuretic antihypertensive, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 26, 2000, Bell, Stanley Charles; De Vivo, Michael; Hopper, Allen; Isaac, Methvin; O’Brien, Anne; Ognyanov, Vassil Ilya; Schumacher, Richard published a patent.Application In Synthesis of 4-Chloro-2-fluorotoluene The title of the patent was Preparation of amino acid derivatives as glycine transport inhibitors. And the patent contained the following:

Compounds Ar1Ar2CR3-X-Y-CH(NR4R5)CO2R6 [Ar1, Ar2 = (un)substituted aryl; R3 = H, (un)substituted aryl; R4, R5 = H, alkyl, alkanoyl, benzoyl and benzyl; R6 = H, alkyl; X = S, SO, SO2, NR, CRR’, where R and R’ = H, alkyl, aryl, aralkyl; Y is a methylene or ethylene linking element, optionally substituted by an alkyl or Ph group (with provisos)] or their salts, solvates or hydrates were prepared as glycine transport inhibitors. Thus, S-(4-ethyl-4′-fluorodiphenyl)methyl-L-cysteine was prepared by reaction of 4-ethyl-4′-fluorodiphenylmethanol with L-cysteine. Compounds of the invention were tested for inhibition of glycine transport and displayed a plC50 of ∼ 4-8.5. Preferred compounds showed selectivity for the inhibition of glycine transport via GlyT-2 vs. GlyT-1. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application In Synthesis of 4-Chloro-2-fluorotoluene

The Article related to amino acid derivative preparation inhibitor glycine transport, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Application In Synthesis of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 6, 1981, Henrick, Clive A.; Garcia, Barbara A. published a patent.Reference of 4-Chloro-2-fluorotoluene The title of the patent was Substituted amino acids. And the patent contained the following:

N-Ph amino acids I (R = C1-4 alkyl, Cl, F, Br, CF3, C1-4 alkylcarbonyl, cyclopropyl, C1-4 alkylthio optionally substituted with halo; R1 = H, CF3, F, Cl, Br, C1-4 alkoxy, C1-3 alkylthio, C1-4 alkyl; R2 = H, Me, Et; R3 = H, F; R4 = H, metal cation) were prepared as pesticides. Thus, Me2CHCHBrCO2H was treated with SOCl2 to give the acid chloride, which was esterified with m-(PhO)C6H4CH2OH to give the ester, which was treated with p-toluidine to give valine II. II gave a LC50 <0.01% when tested as an insecticide against Musca domestica L. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to phenylvaline benzyl ester preparation insecticide, valine phenyl benzyl ester, phenyl amino acid preparation insecticide, pesticide phenylvaline benzyl ester, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 24, 2000, there was a patent about piperidine aryloxymethyl preparation.Related Products of 452-75-5 The title of the patent was 4-[Aryl(aryloxy)methyl]piperidine derivatives and their use as serotonin and/or noradrenaline reuptake inhibitors. And the patent contained the following:

Title compounds I [R1, R2 = unsubstituted aryl or aryl mono- or polysubstituted with halogen (fluorine, chlorine, bromine, iodine), alkyl, alkoxy, cyano, trifluoromethoxy, trifluoromethyl, benzoyl, Ph, nitro, amino, aminoalkyl, aminoaryl and carbonylamino] are prepared Thus, 16.33 mmol tert-Bu 4-[(4-fluorophenyl)hydroxymethyl]-1-piperidinecarboxylate and 1.9 g 4-fluorophenol in 50 mL THF was treated with 5.0 g Ph3P, a DEAD solution (3.45 mL) in 10 mL THF was added, and after 3 h the product (I, R1 = R2 = 4-fluorophenyl) was isolated as the hydrochloride in 70% yield. Several optically active derivatives were also prepared The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Related Products of 452-75-5

The Article related to piperidine aryloxymethyl preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 4, 2003, Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana published an article.Category: chlorides-buliding-blocks The title of the article was Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters. And the article contained the following:

In a wide search program toward new, efficient, and fast-acting antidepressant drugs, series of new compounds having an (aryl)(aryloxy)methyl moiety linked directly or through a methylene chain to different substituted and unsubstituted cycles (isoquinoline, piperazine, piperidine, tetrahydropyran, or cyclopentane) were prepared These compounds have been evaluated for their affinities for serotonin (5-HT) transporter (SERT) and 5-HT1A and 5-HT2A receptors. Racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidines I (R1 = H, Me, MeCO; R2 = H, 3-F, 4-F, 4-Cl, 4-Me; R3 = H, 2-CN, 4-O2N, 4-MeO, 2-Ph, etc.) showed much higher affinity values for SERT than fluoxetine and resulted in lack of affinity for 5-HT1A and 5-HT2A receptors. Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and α2 receptor. Several of these enantiomers, (-)-I (R1 = R2 = H; R3 = 2-F), (-)-I (R1 = R2 = H; R3 = 3-F), (-)-I (R1 = H; R2 = 3-F; R3 = 2-F), (+)-I (R1 = H; R2 = R3 = 3-F), displayed a dual binding profile with affinities for SERT and NET with Ki < 25 nM and a NET/SERT ratio <10. (-)-I (R1 = R2 = H; R3 = 3-F) (coded as F-98214-TA for development studies) showed a dual binding profile with very high affinity values for SERT and NET (Ki = 1.9 and 13.5 nM, resp.), and further pharmacol. characterization is in progress for its evaluation as a antidepressant. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks

The Article related to piperidine aryloxyalkyl preparation antidepressant serotonin norepinephrine transporter affinity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 26, 1980, Schalke, Peter; Kleemann, Axel published a patent.Synthetic Route of 452-75-5 The title of the patent was Substituted acetonitriles. And the patent contained the following:

Aryl- or heteroarylacetonitriles were prepared by the reaction of methylarenes or -heteroarenes with ClCN in the gas phase at 550-850°; the reactants were injected sep. into the reactor at a temperature somewhat below the reaction temperature, and the reaction mixture was cooled immediately after leaving the reactor. Thus, 3-methylpyridine and ClCN were injected sep. into a reactor at 550°, and the mixture was heated to 680°, followed by treatment with aqueous NaOH to give 75% 3-pyridineacetonitrile of 98-9% purity. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Synthetic Route of 452-75-5

The Article related to areneacetonitrile, heteroareneacetonitrile, acetonitrile aryl heteroaryl, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Synthetic Route of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 20, 2019, Tang, Yanfeng; Wang, Chun; Ding, Xinyu; Ge, Ming; Hu, Yulin; Ni, Renjie; Liu, Weiqun; Zhang, Mengke; Shen, Lujie; Xu, Runsheng published a patent.Recommanded Product: 452-75-5 The title of the patent was Preparation of 4-chloro-7-methyl-1H-indazole. And the patent contained the following:

The invention discloses a preparation method of 4-chloro-7-methyl-1H-indazole, which has the advantages of simple operation and high reaction efficiency. The invention compound was prepared via formylation reaction of 4-chloro-2-fluorotoluene with N, N-dimethylformamide in the presence of diisopropylaminolithium and heterocyclization reaction of the product with hydrazine hydrate. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Recommanded Product: 452-75-5

The Article related to preparation chloro methyl indazole formylation heterocycle, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 452-75-5

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 11, 1993, Cantegril, Richard; Croisat, Denis; Desbordes, Philippe; Guigues, Francois; Mortier, Jacques; Peignier, Raymond; Vors, Jean Pierre published a patent.Formula: C7H6ClF The title of the patent was Fungicidal arylpyrazoles and their preparation, compositions, and use. And the patent contained the following:

The invention relates to new derivatives of the family of 3-arylpyrazoles, their methods of preparation, compositions containing them, and their utilization for the protection of plants against fungal diseases. The invention relates more particularly to 3-arylpyrazole derivatives having the formula I [X1-X5 = H, halo, OH, cyano, NO2, alkyl, amino, etc.; or 2 adjacent X may form carbon chain with optional heteroatoms or substituents; Y = H, halo, NO2, cyano, alkoxy, amino, etc.; Z = H, halo, cyano, OH, NO2, alkoxy, alkylthio, amino, C(Z1)Z2, etc.; Z1 = O, S, alkylamino, imino, arylamino; Z2 = H, halo, OH, SH, cyano, amino, alkyl, alkoxy, etc.]. For example, condensation of 3,5-dichloroacetophenone with DMF di-Me acetal gave 77% 3,5-Cl2C6H3COCH:CHNMe2, which was cyclized with hydrazine hydrate in EtOH give 90% 3-(3,5-dichlorophenyl)-1H-pyrazole (II; Y = H). Chlorination of this with N-chlorosuccinimide in CH2Cl2 gave 57% II (Y = Cl), which as a 1-g/L suspension gave good (≥75%) protection of tomato leaves from Botrytis cinerea. Over 330 compounds, including products and/or intermediates, were prepared Addnl. tests and formulations are described. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Formula: C7H6ClF

The Article related to arylpyrazole preparation fungicide, pyrazole aryl preparation fungicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 5, 1978, Henrick, Clive A.; Garcia, Barbara A. published a patent.Product Details of 452-75-5 The title of the patent was Amino acid esters and thiol esters. And the patent contained the following:

RR1NCR2R3COXR4 [R = cycloalkyl, cycloalkenyl, substituted Ph; R1 = H, alkyl, haloalkylcarbonyl, HCO; R2 = C2-5-alkyl, C2-5-alkenyl, C1-4-haloalkyl, C2-4-haloalkenyl, C3-4-cycloalkyl; R3 = H, F; X = O, S; R4 = CHR5R6 [R5 = H, CN, Me, CF3, CCH, CSNH2; R6 = substituted Ph, Q (R8 = H, alkyl; R9 = alkenyl, alkynyl, aralkyl; X1 = O, S)], CH2R10 [R10 = Q1 (R12R13 = alkylene, alkenylene; X2 = O, S), Q2 (R15 = H, alkyl, alkenyl, alkynyl, aralkyl; R16 = H, alkyl)], CH2CR17:CR18CH2R19 (R17 and R18 = H, Cl, F, Me; R17R18 = bond; R19 = Ph, OPh), CH(CCH)CR20:CHR21 (R20 = H, halo, Me, Et; R21 = allyl, propargyl, 3-butenyl, 3-butynyl, Ph, CH2Ph)] and their salts were prepared as pesticides. Thus, Me2CHCHBrCO2H was treated with SOCl2 to give the acid chloride, which was esterified with HOCH2C6H4OPh-m to give Me2CHCHBrCO2CH2C6H4OPh-m, which was aminated with PhNH2 to give PhNHCH(CHMe2)CO2CH2C6H4OPh-m. A great number of other N-substituted valine esters were also prepared Pesticide activity data are given. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5

The Article related to amino acid ester, pesticide amino acid ester, thioester amino acid, valine ester preparation pesticide, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Furuya, Takeru; Kaiser, Hanns Martin; Ritter, Tobias published an article in 2008, the title of the article was Palladium-mediated fluorination of arylboronic acids.Name: 4-Chloro-2-fluorotoluene And the article contains the following content:

Novel palladium complexes allow mild, two-step fluorination of aryl boronic acids. The reaction is regiospecific, functional-group tolerant, has a broad substrate scope, and is ideally suited for the introduction of fluorine substituents at a late stage for aryl fluoride synthesis. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Name: 4-Chloro-2-fluorotoluene

The Article related to aryl boronic acid palladium acetate complex transmetallation, complex aryl palladium preparation electrophilic fluorination, regioselective aryl fluoride preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Name: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics