Category: 42074-68-0

Liang, Jun published the artcileChemical synthesis of Ub-AMC via ligation of peptide hydrazides, SDS of cas: 42074-68-0, the publication is Science China: Chemistry (2013), 56(9), 1301-1306, database is CAplus.

The C-terminal conjugate of ubiquitin with 7-amino-4-methylcoumarin (Ub-AMC) is an important probe for fluorescence-based anal. of deubiquitinating enzyme (DUB) activity. It is important to develop more efficient methods for the preparation of Ub-AMC because the currently available technol. is still expensive for scaled-up production In the present work we report an efficient strategy for total chem. synthesis of Ub-AMC through ligation of peptide hydrazides. Three peptide segments are assembled via N-to-C sequential ligation and the resulting product is converted to Ub-AMC via TCEP-mediated desulfurization. The synthetic Ub-AMC is shown to have expected biol. functions through the measurement of its DUB activity.

Science China: Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Liyun published the artcile“Orange alert”: A fluorescent detector for bisphenol A in water environments, Computed Properties of 42074-68-0, the publication is Analytica Chimica Acta (2014), 51-56, database is CAplus and MEDLINE.

Due to the prevalent use of polycarbonate plastics and epoxy resins in packaging materials and paints for ships, there has been a widespread global contamination of environmental water sources with bisphenol A (BPA). BPA, an endocrine disruptor, has been found to cause tremendous health problems. Therefore, there is an urgent need for detecting BPA in a convenient and sensitive manner to ensure water safety. Herein, we develop a fluorescent turn-on BPA probe, named Bisphenol Orange (BPO), which could conveniently detect BPA in a wide variety of real water samples including sea water, drain water and drinking water. BPO shows superior selectivity toward BPA and up to 70-fold increase in fluorescence emission at 580 nm when mixed with BPA in water. Mechanistic studies suggest a plausible water-dependent formation of hydrophobic BPA clusters which favorably trap and restrict the rotation of BPO and recover its inherent fluorescence.

Analytica Chimica Acta published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H4BrClO2, Computed Properties of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Subiros-Funosas, Ramon published the artcileUse of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin, Category: chlorides-buliding-blocks, the publication is Biopolymers (2012), 98(2), 89-97, database is CAplus and MEDLINE.

The presence of low pKa N-hydroxylamines is beneficial in peptide chem. as they reduce some base-mediated side reactions. Here we evaluated the applicability and buffering capacity of Et 2-cyano-2-(hydroxyimino)acetate (Oxyma) in the prevention of aspartimide/piperidide formation and Pro-based overcoupling and compared it with the performance of HOBt and HOAt. In addition, the compatibility of these additives with the highly acid-labile 2-chlorotrityl chloride resin is examined © 2011 Wiley Periodicals, Inc. Biopolymers, 2011.

Biopolymers published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C4H6N2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Al Musaimi, Othman published the artcileBypassing osmotic shock dilemma in a polystyrene resin using the green solvent cyclopentyl methyl ether (CPME): a morphological perspective, Quality Control of 42074-68-0, the publication is Polymers (Basel, Switzerland) (2019), 11(5), 874, database is CAplus and MEDLINE.

The “osmotic shock” phenomenon is the main thing that is responsible for morphol. structure alteration, which can jeopardize the use of a polymer in a chem. process. This is extremely important in solid-phase peptide synthesis (SPPS), which is the method of choice for the preparation of these important biol. active compounds Herein, we have used Hildebrand solubility parameters (d) to investigate the influence of different ethers that are used in the precipitation step of the SPPS using a polystyrene resin. The green cyclopentyl Me ether (CPME) has shown to be slightly superior to 2-methyltetrahydrofurane, which is also a green ether and clearly better than the hazardous di-Et ether and tert-Bu Me ether. These results have been corroborated by scanning electron microscope (SEM) anal. and computational studies. All together, these confirm the adequacy of CPME for being the ether of choice to be used in SPPS.

Polymers (Basel, Switzerland) published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Quality Control of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Xiao-Gang published the artcileA multifunctional metal-organic framework based tumor targeting drug delivery system for cancer therapy, COA of Formula: C19H14Cl2, the publication is Nanoscale (2015), 7(38), 16061-16070, database is CAplus and MEDLINE.

Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free “green” post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.

Nanoscale published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C10H9NO, COA of Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sanchez, Laura M. published the artcileVersatile Method for the Detection of Covalently Bound Substrates on Solid Supports by DART Mass Spectrometry, Recommanded Product: 2-Chlorotrityl chloride, the publication is Organic Letters (2011), 13(15), 3770-3773, database is CAplus and MEDLINE.

Anal. of substrates directly on solid phase resins without the need for sep. cleavage conditions remains an outstanding challenge in the field of solid phase synthesis. The authors now present the 1st example of simultaneous cleavage and mass spectrometric anal. of peptides from solid supports using direct anal. in real time (DART) mass spectrometry. This method is compatible with a diverse array of solid phase resins and is suitable for anal. of both peptides and organic substrates.

Organic Letters published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Recommanded Product: 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wen, Gesi published the artcileStabilizing amyloid-β peptide by the N-terminus capture is capable of preventing and eliminating amyloid-β oligomers, Product Details of C19H14Cl2, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(54), 7673-7676, database is CAplus and MEDLINE.

Elimination of amyloid-β (Aβ) oligomers remains challenging. We describe here a novel strategy to prevent and eliminate the Aβ oligomers from either the early aggregation or the fibril dissolution pathway by targeting the flexible N-terminus, but not the widely investigated hydrophobic segment, with a rationally designed cyclopeptide.

Chemical Communications (Cambridge, United Kingdom) published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C24H29N5O3, Product Details of C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics