Category: 42074-68-0

Liu, Danni published the artcileCellular membrane-anchored fluorescent probe with aggregation-induced emission characteristics for selective detection of Cu²⁺ ions, Formula: C19H14Cl2, the publication is Faraday Discussions (2017), 377-393, database is CAplus and MEDLINE.

The exploration of advanced fluorescent probes that can detect divalent copper (Cu²⁺) in aqueous environments and even in live organisms is particularly valuable for understanding the occurrence and development of Cu²⁺-related diseases. In this work, we report the design and synthesis of an aggregation-induced emission luminogen (AIEgen)-based probe (TPE-Py-EEGTIGYG) by integrating an AIEgen, TPE-Py, with a peptide, EEGTIGYG, which can selectively detect Cu²⁺ in both aqueous solution and live cells. Peptide EEGTIGYG has dual functionality in the probe design, namely improving water solubility and providing specific cell membrane-binding ability. TPE-Py-EEGTIGYG can self-assemble into nanoaggregates at high concentration in aqueous solution (e.g., 25 μM), which possess large fluorescence output due to the restriction of intramol. rotation of the Ph rings on TPE-Py. The fluorescence of the TPE-Py-EEGTIGYG nanoaggregates can be significantly quenched by Cu²⁺ but not by other metal ions, achieving the selective detection of Cu²⁺ in aqueous media. Furthermore, TPE-Py-EEGTIGYG can exist as a mol. species and is very weakly fluorescent in dilute aqueous solution (e.g., 5 μM), but can however largely switch on its fluorescence upon specifically anchoring onto the cell membrane. The emissive probes on the cell membrane can be used for the detection of Cu²⁺ ions that move in and out of cells with a fluorescence “turn-off” mode.

Faraday Discussions published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Gi Won published the artcileSensitive ratiometric detection of Al(III) ions in a 100% aqueous buffered solution using a fluorescent probe based on a peptide receptor, Formula: C19H14Cl2, the publication is New Journal of Chemistry (2018), 42(2), 1437-1445, database is CAplus.

Ratiometric detection of Al(III) ions in aqueous buffered solutions is still a significant challenge. Herein, a fluorescent probe [1-pyrenyl]-CH₂CO-L-Ser-L-Asp-OH (I) based on a dipeptide receptor bearing a pyrene fluorophore was synthesized by solid phase synthesis for the ratiometric detection of Al(III) ions in aqueous solutions The peptidyl bioprobe detected Al(III) ions sensitively in a 100% aqueous buffered solution through ratiometric response. Upon the addition of Al(III) ions, the excimer emission at 476 nm increased significantly, and the monomer emission at 395 nm decreased considerably. Approx. 3.5 equiv of Al(III) was required for the complete ratiometric response of I. Also, I showed linear responses to nanomolar concentrations (0-500 nM) of Al(III) by change in the intensity ratio of the excimer and monomer emissions. The detection limit of I for Al(III) was 138.1 nM (R² = 0.980) in 100% aqueous solutions The probe showed highly selective response to Al(III) in the presence of 16 metal ions. The fluorescent peptidyl probe was suitable for the ratiometric detection of Al(III) ions in ground water, tap water, and urine.

New Journal of Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pola, R. published the artcileThe pH-dependent and enzymatic release of cytarabine from hydrophilic polymer conjugates, HPLC of Formula: 42074-68-0, the publication is Physiological Research (Prague, Czech Republic) (2016), 65(Suppl. 2), S225-S232, database is CAplus.

Cytarabine is one of the most efficient drugs in the treatment of hematol. malignancies. In this work, we describe the synthesis and characterization of two different polymer conjugates of cytarabine that were designed for the controlled release of cytarabine within the leukemia cells. Reactive copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) and 3-(3-methacrylamidopropa-noyl)thiazolidine-2-thione) or 3-(N-methacryloylglycyl-phenylalanylleucylglycyl)thiazolidine-2-thione were used in the study as reactive polymer precursors for reaction with cytarabine. The enzymic release of cytarabine from the conjugate containing a GFLG spacer utilizing cathepsin B was verified. In addition to enzymolysis, the pH-dependent hydrolysis of cytarabine from both copolymers was also confirmed. Approx. 40 % and 20 % of the drug was released by spontaneous hydrolysis at pH 7.4 within 72 h from the polymer conjugates with the GFLG and beta-Ala spacers, resp. At pH 6.0, the spontaneous hydrolysis slowed down, and less than 10 % of the drug was liberated within 72 h. The results of the cytotoxicity evaluation of the polymer conjugates in vitro against various cell lines showed that the cytotoxicity of the polymer conjugates is approx. three times lower in comparison to free cytarabine.

Physiological Research (Prague, Czech Republic) published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hsu, Ling-Huang published the artcileNanofibrous hydrogels self-assembled from naphthalene diimide (NDI)/amino acid conjugates, HPLC of Formula: 42074-68-0, the publication is RSC Advances (2015), 5(26), 20410-20413, database is CAplus.

The combination of a naphthalene diimide (NDI) group and a single amino-acid of serine (Ser) or lysine (Lys) can be used to promote the formation of a supramol. hydrogel, which indicates the aromatic amino acid is not necessary to be used in the structural design of NDI-capped small mol. hydrogelators. An equimolar ratio of NDI-Ser and NDI-Lys can form a stable hydrogel under neutral conditions and its gel-to-sol transition temperature is higher than 37 °C. This work, as the first example of NDI-containing hydrogelators without aromatic rings in the side chains of amino acids, illustrates a new approach to design NDI-capped supramol. hydrogels.

RSC Advances published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haney, Conor M. published the artcileDynamic covalent side-chain cross-links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers, SDS of cas: 42074-68-0, the publication is Journal of Peptide Science (2014), 20(2), 108-114, database is CAplus and MEDLINE.

Peptide cyclization via chemoselective reactions between side chains has proven a useful strategy to control folded structure. We report here a method for the synthesis of side-chain to side-chain cyclic peptides based on the intermol. reaction between a linear peptide functionalized with two aminooxy or hydrazide side chains and an organic dialdehyde linker. A family of oxime-based and hydrazone-based cyclic products is prepared in a modular and convergent fashion by combination of unprotected linear peptide precursors and various small mol. linkers in neutral aqueous buffer. The side-chain to side-chain linkages that result can alter peptide folding behavior. The dynamic covalent nature of the Schiff bases in the cyclic products can be utilized to create mixtures where product composition changes in response to exptl. conditions. Thus, a linear peptide precursor can select one organic linker from a mixture, and a cyclic product can dynamically exchange the small mol. component of the macrocycle. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.

Journal of Peptide Science published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kikuchi, Haruhisa published the artcileIsolation of a Cyclic Depsipeptide, Aspergillicin F, and Synthesis of Aspergillicins with Innate Immune-Modulating Activity, Safety of 2-Chlorotrityl chloride, the publication is Journal of Natural Products (2015), 78(8), 1949-1956, database is CAplus and MEDLINE.

Innate immunity is the front line of self-defense against microbial infection. After searching for natural compounds that regulate innate immunity using an ex vivo Drosophila culture system, we identified a new cyclic depsipeptide, aspergillicin F, from the fungus Aspergillus sp., as an innate immune suppressor. The total synthesis and biol. evaluation of the aspergillicin family, including aspergillicin F, were performed, revealing that slight structural differences in the side chains of amino acid residues alter innate immunity-regulating activity.

Journal of Natural Products published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Safety of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Linhai published the artcileElaborate Supramolecular Architectures Formed by Co-Assembly of Metal Species and Peptoid Macrocycles, HPLC of Formula: 42074-68-0, the publication is Crystal Growth & Design (2021), 21(7), 3889-3901, database is CAplus.

Peptoids are a family of sequence-specific oligomers capable of mimicking the structure and function of polypeptides. The innate folding and self-assembly capabilities of peptoid oligomers can be enhanced by the presence of coordinated metal ions. The authors explore the co-assembly of water-soluble hexameric and tetrameric peptoid macrocycles with Na⁺ and K⁺ ions. Solid-state structures were solved for six cyclopeptoid-metal coassemblies by x-ray diffraction using single crystals grown from fully aqueous solutions Subtle variations in the peptoid oligomer composition give rise to dramatic alterations in the supramol. assemblies. Some structures feature extensively hydrated porous architectures that include unusual metal ion clusters. The ability to study the metallopeptoid structure at an at. resolution in crystals obtained from an aqueous solution is an important advancement, as most previous peptoid crystal structures were obtained from nonaqueous or cosolvent solutions These results will facilitate the design of peptoids and other foldamers for the assembly of supramol. frameworks.

Crystal Growth & Design published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mei, Leixia published the artcileSupramolecular self-assembly of fluorescent peptide amphiphiles for accurate and reversible pH measurement, Quality Control of 42074-68-0, the publication is Organic & Biomolecular Chemistry (2019), 17(4), 939-944, database is CAplus and MEDLINE.

We report the synthesis and self-assembly of fluorescent peptide amphiphiles (NBD-PA) composed of a fluorescent NBD probe and a peptide derivative VVAADD with a C₁₂-alkyl-chain as the linker (NBD-C₁₂-VVAADD). The self-assembly of NBD-PA formed beta-sheet structures at neutral pH in aqueous solution, contributed to an âˆ?0-fold increase in the fluorescence and quantum yield of NBD mols., and conferred a supramol. hydrogel with excellent viscoelastic properties, while gel-to-sol transition of NBD-PA occurred rapidly when the pH value was adjusted to strongly alk. (e.g. pH 11). Through the pH-responsive self-assembly behavior, we further explored the relation between fluorescence of NBD-PA and pH values. Interestingly, the fluorescence of the NBD-PA system exhibited an excellent sigmoidal function relation (R² = 0.9999) with the alk. pH values, which enabled accurate pH measurement regardless of salt types and ionic strength of solvents. Furthermore, the fluorescence of NBD-PA was fully reversible upon cycles of pH shifts, with the chem. structure of NBD-PA well-maintained throughout the process. These features of NBD-PA would facilitate the design of in situ pH detection systems as well as pH-responsive actuators for various applications in future.

Organic & Biomolecular Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Quality Control of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghiani, S. published the artcileSynthesis, radiolabeling, and pre-clinical evaluation of [⁴⁴Sc]Sc138995-P-AAZTA conjugate PSMA inhibitor, a new tracer for high-efficiency imaging of prostate cancer, SDS of cas: 42074-68-0, the publication is European Journal of Nuclear Medicine and Molecular Imaging (2021), 48(8), 2351-2362, database is CAplus and MEDLINE.

The aim of this work was to demonstrate the suitability of AAZTA conjugated to PSMA inhibitor (B28110) labeled with scandium-44 as a new PET tracer for diagnostic imaging of prostate cancer. Nowadays, scandium-44 has received significant attention as a potential radionuclide with favorable characteristics for PET applications. A polyaminopolycarboxylate heptadentate ligand based on a 1,4-diazepine scaffold (AAZTA) has been thoroughly studied as chelator for Gd3+ ions for MRI applications. The excellent results of the equilibrium, kinetic, and labeling studies led to a preliminary assessment of the in vitro and in vivo behavior of [44Sc][Sc-(AAZTA)]- and two derivatives, i.e., [44Sc][Sc (CNAAZTA-BSA)] and [44Sc][Sc (CNAAZTA-cRGDfK)]. Results: B28110 was synthesized by hybrid approach, combining solid-phase peptide synthesis (SPPS) and solution chem. to obtain high purity (97%) product with an overall yield of 9%. Subsequently, the radioactive labeling was performed with scandium-44 produced from natural calcium target in cyclotron, in good radiochem. yields (RCY) under mild condition (pH 4, 298 K). Stability study in human plasma showed good RCP% of [44Sc]Sc-B28110 up to 24 h (94.32%). In vivo PET/MRI imaging on LNCaP tumor-bearing mice showed high tracer accumulation in the tumor regions as early as 20 min post-injection. Ex vivo biodistribution studies confirmed that the accumulation of 44Sc-PSMA-617 was two-fold lower than that of the radiolabeled B28110 probes. This work demonstrated the suitability of B28110 for the complexation with scandium-44 at room temperature and the high performance of the resulting new tracer based on AAZTA chelator for the diagnosis of prostate cancer using PET.

European Journal of Nuclear Medicine and Molecular Imaging published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brueckner, Alexander C. published the artcileVisible-light-mediated, nitrogen-centered radical amination of tertiary alkyl halides under metal-free conditions to form α-tertiary amines, Application of 2-Chlorotrityl chloride, the publication is Organic & Biomolecular Chemistry (2016), 14(19), 4387-4392, database is CAplus and MEDLINE.

A mild and operationally convenient amino-functionalization of a range of tertiary alkyl halides by reaction with iminoiodinanes (PhI=NNs) and I₂ was developed. According to the mechanistic experiments described within the reaction was speculated to proceed through a light-promoted, N-centered radical pathway involving a N,N-diiodosulfonamide reactive species. This method of direct N-incorporation offers an attractive alternative to the production of α-tertiary amines, a synthetically challenging structural class found in a variety of bioactive mols.

Organic & Biomolecular Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics