Category: 4144-22-3

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Direct Construction of Diverse Polyheterocycles Bearing Pyrrolidinediones via Rh(III)-Catalyzed Cascade C-H Activation/Spirocyclization, published in 2019, which mentions a compound: 4144-22-3, mainly applied to quinazolinone maleimide rhodium catalyst tandem Michael reaction spirocyclization; spiroisoindoloquinazolinepyrrolidine trione preparation; spiropolyheterocycle preparation, COA of Formula: C8H11NO2.

Rh(III)-catalyzed cascade oxidative annulation of 2-arylquinazolinones with various maleimides to afford spiroisoindoloquinazolinones bearing pyrrolidinediones was described. Sequential ortho C-H functionalization and spirocyclization via aza-Michael addition result in the formation of both C-C and C-N bonds in a single operation. This atom- and step-economic strategy provides an efficient and novel approach for the syntheses of diverse polyheterocycles bearing pyrrolidinediones, starting from 2-heteroarylquinazolinones and 5-arylpyrazolopyrimidinones, in good to excellent yields.

Compound(4144-22-3)COA of Formula: C8H11NO2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione), if you are interested, you can check out my other related articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 4144-22-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Studies on the chemistry of isoindoles and isoindolenines. XXIX. Reactions of 2H-isoindole with maleic imides: a simple procedure for the preparation of 7-azabicyclo[2.2.1]heptenes. Author is Kreher, Richard P.; Use, Goetz.

Reaction of 2H-isoindole with N-substituted maleimides gave 90-98% adducts I (R = H, Me, CMe3, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-PhN:NC6H4) with endo-exo ratios varying from 27:73 to 68:32. endo-I were thermally isomerized to exo-I in 65-83% yield. The isomers were also separated chromatog.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Synthetic Route of C8H11NO2.Butler, Richard N.; Farrell, Derval M. published the article 《Steric reversal of the endo-selectivity effect in 1,3-dipolar cycloadditions of phthalazinium-2-ylides with N-substituted maleimides: endo- and exo-1,2-(dicarboxy-N-substituted imido)-1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazines》 about this compound( cas:4144-22-3 ) in Journal of Chemical Research, Synopses. Keywords: imidotetrahydropyrrolophthalazine preparation; pyrrolophthalazine imidotetrahydro preparation; cycloaddition phthalaziniumylide maleimide stereochem. Let’s learn more about this compound (cas:4144-22-3).

N-Methyl- and N-arylmaleimides undergo cycloadditions with phthalazinium-2-dicyanomethanide and -2-unsubstituted methanide 1,3-dipoles to give exclusive or predominant endo-cycloadducts, but with N-tert-butylmaleimide this endo effect is reversed to favor the exo-cycloadducts.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Rhodium-Catalyzed Vinylic C-H Functionalization of Enol Carbamates with Maleimides. Author is Sharma, Satyasheel; Han, Sang Hoon; Jo, Hyeim; Han, Sangil; Mishra, Neeraj Kumar; Choi, Miji; Jeong, Taejoo; Park, Jihye; Kim, In Su.

The rhodium(III)-catalyzed direct C-H functionalization of enol carbamates with a range of maleimides is described. With the assistance of the carbamoyl directing group, this reaction provides biol. relevant succinimide compounds by proceeding through a C-Rh addition and subsequent protonation pathway.

Compound(4144-22-3)Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione), if you are interested, you can check out my other related articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4144-22-3, is researched, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2Journal, Tetrahedron Letters called Synthesis of rotaxanes consisting of crown ether wheel and sec-ammonium axle under basic condition, Author is Nakazono, Kazuko; Oku, Tomoya; Takata, Toshikazu, the main research direction is rotaxane preparation crown ether wheel sec ammonium axle.Reference of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.

A novel synthetic method of [2]rotaxane by end-capping of pseudorotaxane via conjugate addition of thiol to N-substituted maleimide C=C bond under basic condition was developed. Several [2]rotaxanes were obtained in good yields.

Compound(4144-22-3)Reference of 1-(tert-Butyl)-1H-pyrrole-2,5-dione received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione), if you are interested, you can check out my other related articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bhattacharyya, Jayanta; Weitzhandler, Isaac; Ho, Shihan Bryan; McDaniel, Jonathan R.; Li, Xinghai; Tang, Lei; Liu, Jinyao; Dewhirst, Mark; Chilkoti, Ashutosh researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Category: chlorides-buliding-blocks.They published the article 《Encapsulating a Hydrophilic Chemotherapeutic into Rod-Like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves Its Efficacy》 about this compound( cas:4144-22-3 ) in Advanced Functional Materials. Keywords: peptide gemcitabine conjugate antitumor tumor maleimide derivative; asymmetric triblock polypeptide; colon cancer; gemcitabine; hydrophilic drug delivery; nanoparticle. We’ll tell you more about this compound (cas:4144-22-3).

Encapsulating hydrophilic chemotherapeutics into the core of polymeric nanoparticles can improve their therapeutic efficacy by increasing their plasma half-life, tumor accumulation, and intracellular uptake, and by protecting them from premature degradation To achieve these goals, a recombinant asym. triblock polypeptide (ATBP) that self-assembles into rod-shaped nanoparticles, and which can be used to conjugate diverse hydrophilic mols., including chemotherapeutics, into their core is designed. These ATBPs consist of three segments: a biodegradable elastin-like polypeptide, a hydrophobic tyrosine-rich segment, and a short cysteine-rich segment, that spontaneously self-assemble into rod-shaped micelles. Covalent conjugation of a structurally diverse set of hydrophilic small mols., including a hydrophilic chemotherapeutic-gemcitabine-to the cysteine residues also leads to formation of nanoparticles over a range of ATBP concentrations Gemcitabine-loaded ATBP nanoparticles have significantly better tumor regression compared to free drug in a murine cancer model. This simple strategy of encapsulation of hydrophilic small mols. by conjugation to an ATBP can be used to effectively deliver a range of water-soluble drugs and imaging agents in vivo.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Reference of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.Butler, Richard N.; Coyne, Anthony G.; McArdle, Patrick; Cunningham, Desmond; Burke, Luke A. published the article 《Regioselectivity and endo/exo selectivity in the cycloadditions of the phthalazinium dicyanomethanide 1,3-dipole with unsymmetrical alkene and alkyne dipolarophiles. Unexpected reversals of regiochemistry: a combined experimental and DFT theoretical study》 about this compound( cas:4144-22-3 ) in Journal of the Chemical Society, Perkin Transactions 1. Keywords: dipolar cycloaddition phthalazinium dicyanomethanide alkene alkyne regiochem stereochem. Let’s learn more about this compound (cas:4144-22-3).

In the reactions of phthalazinium dicyanomethanide 1,3-dipole with electron-poor monosubstituted alkene and alkyne dipolarophiles the dicyanomethanide terminus bonds to the unsubstituted carbon giving 1-substituted pyrrolo[2,1-a]phthalazines. With electron-rich dipolarophiles the regiochem. is reversed and the products are 2-substituted pyrrolo[2,1-a]phthalazines. An unexpected reversal of regiochem. occurred with Me methacrylate, due to a steric effect of the C-Me group, and the main product was 2-exo-methyl-2-endo-methoxycarbonyl-3,3-dicyano-1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine, I. endo Cycloadditions were strongly favored with alkene dipolarophiles containing π bonds in substituents on the alkene unit. With N-substituted maleimides endo products were formed exclusively even when the N-substituent was tBu or adamantyl. Only with alkoxyvinyl ethers were exo-cycloadducts encountered. The mechanisms are discussed in conjunction with DFT calculations An X-ray crystal structure is reported on endo-N-tert-butyl-3,3-dicyano-1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine-1,2-dicarboximide, II.

From this literature《Regioselectivity and endo/exo selectivity in the cycloadditions of the phthalazinium dicyanomethanide 1,3-dipole with unsymmetrical alkene and alkyne dipolarophiles. Unexpected reversals of regiochemistry: a combined experimental and DFT theoretical study》,we know some information about this compound(4144-22-3)Reference of 1-(tert-Butyl)-1H-pyrrole-2,5-dione, but this is not all information, there are many literatures related to this compound(4144-22-3).

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Computed Properties of C8H11NO2.Li, Xin-Ran; Chen, Si-Qi; Fan, Juan; Li, Chao-Jun; Wang, Xue; Liu, Zhong-Wen; Shi, Xian-Ying published the article 《Controllable Tandem [3+2] Cyclization of Aromatic Aldehydes with Maleimides: Rhodium(III)-Catalyzed Divergent Synthesis of Indane-Fused Pyrrolidine-2,5-dione》 about this compound( cas:4144-22-3 ) in Organic Letters. Keywords: indane fused pyrrolidinedione diastereoselective synthesis tandem cyclization aldehyde maleimide. Let’s learn more about this compound (cas:4144-22-3).

Controllable rhodium(III)-catalyzed tandem [3+2] cyclization of aromatic aldehydes with maleimides is developed for the divergent synthesis of stereoselective indane-fused pyrrolidine-2,5-dione. Switchable access to different products could be achieved by employing different additives and varying the reaction time. This atom-economic transformation proceeds efficiently via the C-H bond activation directed by weakly coordinating aldehydes and is characterized by exclusive stereoselectivity, air atm., and being free of nitrogen-based transient directing groups.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kita, Yuichi; Kishino, Kazuo published an article about the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3,SMILESS:O=C(C=C1)N(C(C)(C)C)C1=O ).Safety of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4144-22-3) through the article.

An industrial process for the production of maleimides is based on a reaction model which was revealed by analyzing the reactions occurring in the dehydration of maleamic acid. A re-usable catalyst was developed which has high performance without corrosion problems.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hwang, Joon Young; Ji, A. Young; Lee, Sang Hyeok; Kang, Eun Joo published the article 《Redox-Selective Iron Catalysis for α-Amino C-H Bond Functionalization via Aerobic Oxidation》. Keywords: redox selective iron catalyst aerobic oxidation.They researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Synthetic Route of C8H11NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4144-22-3) here.

Single-electron oxidation and α-deprotonation of tertiary anilines using Fe(phen)3(PF6)3 afford α-aminoalkyl radicals, which can be coupled with electrophilic partners to afford various tetrahydroquinolines. Mechanistically, the Fe(phen)n2+/3+ catalytic cycle is maintained by O2 or a TBHP oxidant, and the presence of the oxygen bound iron complex, Fe(III)-OO(H), was elucidated by ESR and electrospray ionization mass spectrometry. This redox-selective nonheme iron catalyst behaves similarly to bioinspired heme iron catalysts.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics