Category: 3900-89-8

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Reference of 3900-89-8.

Ito, Sora;Fujimoto, Hayato;Tobisu, Mamoru research published �Non-stabilized Vinyl Anion Equivalents from Styrenes by N-Heterocyclic Carbene Catalysis and Its Use in Catalytic Nucleophilic Aromatic Substitution� the research content is summarized as follows. A protocol for the catalytic nucleophilic activation of unactivated styrenes was reported, which enables the generation of a non-stabilized alkenyl anion equivalent as a transient intermediate. In the reaction, N-heterocyclic carbenes add across styrenes to generate ylide intermediates, which could then be used in intramol. nucleophilic aromatic substitution reactions of aryl fluorides, chlorides and Me ethers. The method allowed for straightforward access to complex polyaromatic compounds

Reference of 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Safety of (2-Chlorophenyl)boronic acid.

He, Chang;Wang, Zijuan;Chen, Yitong;Zhang, Guolin;Yu, Yongping research published 《 Palladium(II)-Catalyzed C(sp)-C(sp²) Coupling: A Direct Approach to Multi-Substituted Pyrrolo[1,2-a]pyrazines》, the research content is summarized as follows. A direct synthesis of multi-substituted pyrrolo[1,2-a]pyrazines via palladium(II)-catalyzed C(sp)-C(sp²) cascade coupling and intramol. cyclization in the presence of ligand was developed. This reaction originates from phenylboronic acids and readily synthesized 2-carbonyl- or 2-formylpyrroloacetonitriles, and affords products in good to excellent yields for a diversity of substrates. Addnl., a possible mechanism for the transformation is proposed.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Safety of (2-Chlorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. COA of Formula: C6H6BClO2.

He, Zhangxu;Jiao, Haomiao;An, Qi;Zhang, Xin;Dan, Zengyangzong;Xu, Jiale;Liu, Hongmin;Ma, Liying;Zhao, Wen research published 《 Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis》, the research content is summarized as follows. Bromodomain containing protein 4 (BRD4), as an epigenetic reader, can specifically bind to the acetyl lysine residues of histones and has emerged as an attractive therapeutic target for various diseases, including cancer, cardiac remodeling and heart failure. Herein, we described the discovery of hit 5 bearing 4-phenylquinazoline skeleton through a high-throughput virtual screen using 2,003,400 compound library (enamine). Then, structure-activity relationship (SAR) study was performed and 47 new 4-phenylquinazoline derivatives toward BRD4 were further designed, synthesized and evaluated, using HTRF assay set up in our laboratory Eventually, we identified compound C-34, which possessed better pharmacokinetic and physicochem. properties as well as lower cytotoxicity against NRCF and NRCM cells, compared to the pos. control JQ1. Using computer-based mol. docking and cellular thermal shift assay, we further verified that C-34 could target BRD4 at mol. and cellular levels. Furthermore, treatment with C-34 effectively alleviated fibroblast activation in vitro and cardiac fibrosis in vivo, which was correlated with the decreased expression of BRD4 downstream target c-MYC as well as the depressed TGF-β1/Smad2/3 signaling pathway. Taken together, our findings indicate that novel BRD4 inhibitor C-34 tethering a 4-phenylquinazoline scaffold can serve as a lead compound for further development to treat fibrotic cardiovascular disease.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., COA of Formula: C6H6BClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Synthetic Route of 3900-89-8.

Grenz, David C.;Rose, Daniel;Wossner, Jan S.;Wilbuer, Jennifer;Adler, Florin;Hermann, Mathias;Chan, Chin-Yiu;Adachi, Chihaya;Esser, Birgit research published 《 Spiroconjugated Tetraaminospirenes as Donors in Color-Tunable Charge-Transfer Emitters with Donor-Acceptor Structure》, the research content is summarized as follows. Charge-transfer emitters are attractive due to their color tunability and potentially high photoluminescence quantum yields (PLQYs). Herein, the authors present tetraaminospirenes as donor moieties, which, in combination with a variety of acceptors, furnished 12 charge-transfer emitters with a range of emission colors and PLQYs of up to 99%. The spatial separation of their frontier MOs was obtained through careful structural design, and two donor-acceptor structures were confirmed by X-ray crystallog. A range of photophys. measurements supported by DFT calculations shed light on the optoelectronic properties of this new family of spiro-NN-donor-acceptor dyes.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Synthetic Route of 3900-89-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Quality Control of 3900-89-8.

Guo, Yuying;Chen, Jiabao;Ren, Dan;Du, Bo;Wu, Lei;Zhang, Yuanyuan;Wang, Zhouyu;Qian, Shan research published 《 Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection》, the research content is summarized as follows. Plant pathogenic fungi decrease the quality and productivity of plant production The botanical fungicides have better biocompatibility and rapid biodegradation, little or no cross resistance, and the structural diversity, and thus are beneficial to deal with plant fungal diseases. Osthole has been widely used as the com. botanical fungicide against powdery mildew in China. In this article, a series of osthole derivatives were synthesized, which resp. contain different substituents on the benzene ring, at the C8-position and pyrone ring. All the target compounds were evaluated in vitro for their antifungal activity against resistant phytopathogenic fungi. Colletotrichum fragariae, Strawberry Botrytis cinerea, Kiwifruit Botrytis cinerea, Kiwifruit brown Rots, which are common in fruit fungal diseases. The compound 7-hydroxy-8-methyl-4-(trifuoromethyl)-2H-chromen-2-one (I) was identified as the most promising candidate with the EC₅₀ values at 38.7μg/mL against Colletotrichum Fragariae, 14.5μg/mL against Strawberry Botrytis Cinerea and 24.3μg/mL against Kiwifruit Botrytis Cinerea, resp., whereas the antifungal activity against resistant phytopathogenic fungi. of osthole is too low to be used (EC₅₀ > 400 ppm). The results of mycelial relative conductivity determination, PI uptake and fluorescence spectroscopy indicated that the cell membrane of fungi is the key action site of I. Besides, I has the potent inhibitory activity against both of plant and human pathogenic bacteria. Our studies showed that C₄ was worthy for further attention as a promising botanical fungicide candidate in crop protection.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Quality Control of 3900-89-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: (2-Chlorophenyl)boronic acid.

Hager, Joanna;Kang, Seongsoo;Chmielewski, Piotr J.;Lis, Tadeusz;Kim, Dongho;Stepien, Marcin research published 《 Acenaphthylene-fused ullazines: fluorescent π-extended monopyrroles with tunable electronic gaps》, the research content is summarized as follows. π-Extended dibenzoullazines, e.g., I (R = 2,6-idisopropylphenyl, 2,9-di-tert-Bu, etc.) containing an acenaphthylene subunit were designed and synthesized. Two different synthetic strategies were employed: route A, based on Pd-catalyzed cyclodehydrohalogenation of α,α-disubstituted N-arylpyrroles, and route B, using a dipolar 1,3-cycloaddition reaction of azomethine ylides (PAMYs) to functionalized acenaphthylenes. Mols. of the resulting ullazines were almost flat, leading to strong π-π interactions in the solid state. The new ullazines were highly fluorescent (with a quantum yield of up to 0.89 for the naphthalimide-fused system), and showed moderate solvatochromism with no fluorescence quenching in polar solvents. Stepwise two-electron oxidation of the ullazines was possible, yielding reversibly the corresponding ullazine radical cations and dications. Edge expansion of the ullazine core with methylene bridges was addnl. shown to produce an ullazine analog containing two seven-membered rings in its structure, which was characterized by axial chirality and could be resolved into enantiomers.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Recommanded Product: (2-Chlorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Application In Synthesis of 3900-89-8.

Haut, Franz-Lucas;Feichtinger, Niklas J.;Plangger, Immanuel;Wein, Lukas A.;Mueller, Mira;Streit, Tim-Niclas;Wurst, Klaus;Podewitz, Maren;Magauer, Thomas research published 《 Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines》, the research content is summarized as follows. Authors present a modular, synthetic entry to polysubstituted pyrroles employing readily available 2,5-dihydrothiophenes. Ring-opening of the heterocycle provides access to a panel of 1,3-dienes which underwent pyrrole formation in the presence of inexpensive chloramine-T trihydrate. The transformation is conducted in an open flask and proceeds at ambient temperatures (23°) in nondry solvents. A careful adjustment of the electronics and sterics of the 1,3-diene precursor allows for the isolation of key intermediates. DFT studies identified a reaction mechanism that features a 6π-electrocyclization of a sulfilimine intermediate followed by spontaneous ring-contraction to reveal the pyrrole skeleton.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Application In Synthesis of 3900-89-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: (2-Chlorophenyl)boronic acid.

Gao, Ya;Qin, Wei;Tian, Ming-Qing;Zhao, Xuefei;Hu, Xu-Hong research published 《 Defluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base》, the research content is summarized as follows. Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols.

Recommanded Product: (2-Chlorophenyl)boronic acid, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Formula: C6H6BClO2.

Fan, Chi-Hang;Xu, Tianyue;Ke, Zhihai;Yeung, Ying-Yeung research published 《 Autocatalytic aerobic ipso-hydroxylation of arylboronic acid with Hantzsch ester and Hantzsch pyridine》, the research content is summarized as follows. Hantzsch esters were very useful hydrogen and electron donors that was applied in many reactions. After the reactions, aromatic Hantzsch pyridines are generated as the byproducts and their roles were commonly ignored. Herein, the use of Hantzsch pyridine as a promoter to activate Hantzsch ester in the generation of the hydrogen peroxy radical, which is useful for the ipso-hydroxylation of arylboronic acids to give phenols was reported. The reaction does not require an external catalyst or light. The conditions were mild and highly compatible with different functional groups.

Formula: C6H6BClO2, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Computed Properties of 3900-89-8.

Fan, Lingling;Luo, Zhongfu;Yang, Changfei;Guo, Bing;Miao, Jing;Chen, Yang;Tang, Lei;Li, Yong research published 《 Design and synthesis of small molecular 2-aminobenzoxazoles as potential antifungal agents against phytopathogenic fungi》, the research content is summarized as follows. In order to discover novel antifungal agents, three series of simple 2-aminobenzoxazole derivatives I (R = H, NO₂, Ph, 2-benzothienyl, etc.; R¹ = NH₂, acetamidyl, benzenesulfonamido, etc.) were designed, synthesized and evaluated for their antifungal activities against eight phytopathogenic fungi. The in vitro antifungal results showed that most of the target compounds exhibited excellent and broad-spectrum antifungal activities to all the tested fungi. Particularly, the six compounds I (R = Ph, 2-fluorophenyl, 4-fluorophenyl, 3-chlorophenyl, 3,5-dimethylphenyl, 3-thienyl; R¹ = NH₂) displayed the most potent antifungal activity, with EC₅₀ value of 1.48-16.6μg/mL, which were much superior to the pos. control hymexazol. The in vivo study further confirmed that compounds I (R = Ph, 4-fluorophenyl, 3-chlorophenyl, 3,5-dimethylphenyl; R¹ = NH₂) displayed good preventative effect against Botrytis cinerea at the concentration of 100μg/mL. The structure-activity relationships research provides significant reference for the further structural optimization of 2-aminobenzoxazole as potential fungicides.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Computed Properties of 3900-89-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics