Category: 3900-89-8

Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Name: (2-Chlorophenyl)boronic acid.

Shi, Zhaojiang;Lu, Hao-Kuan;Li, Nan;Yuan, Yaofeng;Li, Zhen;Ye, Ke-Yin research published 《 Electrochemical oxidative dearomatization of 2-arylthiophenes》, the research content is summarized as follows. A green and sustainable electrochem. oxidative dearomatization of 2-arylthiophenes was reported. The variation of substitution patterns afforded easy access to both C2/C3 and C2/C5 difunctionalized dearomative dihydrothiophenes such as I [R = Ph, 3-FC₆H₄, 2-pyridyl, etc.; R¹ = OAc, OC(O)Et]. The synthetic utility of the resulting dihydrothiophenes was further demonstrated by the concise synthesis of a pyridazinone analog with interesting vasodilator activity.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Name: (2-Chlorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Recommanded Product: (2-Chlorophenyl)boronic acid.

Singh, Gurpreet;Singh, Manpreet;Kumar, Sourav;Kumar, Manoj;Bhalla, Vandana research published 《 ′Lighted′ Assemblies of a PBI Derivative: Activation of Aerial Oxygen via Combined Charge and Energy Transfer Processes for Photocatalytic Oxidative Hydroxylation of Boronic Acids》, the research content is summarized as follows. The donor-acceptor ′lighted′ assemblies of PBI-TPY have been developed, which exhibit strong absorption in the visible region, have high photostability, excellent electron transportation ability and high potential to activate aerial oxygen to generate reactive oxygen species, such as singlet oxygen, superoxide anion radical and hydroxide ions. Empowered by excellent photosensitizing properties, assemblies of PBI-TPY exhibit high photocatalytic efficiency in visible light mediated oxidative hydroxylation of aromatic/aliphatic boronic acids through combined charge/energy transfer processes in the presence of weak electron donor (NEt₃) and air as the ′oxidant′ in mixed aqueous media. The work being presented in this manuscript also reveales the potential of PBI-TPY assemblies for gram-scale preparation of phenol and recyclability of upto six catalytic cycles in the oxidative hydroxylation reaction.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Recommanded Product: (2-Chlorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Recommanded Product: (2-Chlorophenyl)boronic acid.

Sajith, Ayyiliath M.;Narasimhamurthy, Kereyagalahally H.;Shanmugam, Muthu K.;Rangappa, Shobith;Chandra Nayak, S.;Chinnathambi, Arunachalam;Awad Alahmadi, Tahani;Ali Alharbi, Sulaiman;Haridas, K. R.;Reddy, E. K.;Savitha, B.;Mohan, Chakrabhavi Dhananjaya;Rangappa, Kanchugarakoppal S. research published 《 Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells》, the research content is summarized as follows. Signal transducer and activator of transcription 3 (STAT3) is a tumorigenic transcription factor that is persistently activated in various human cancers including hepatocellular carcinoma (HCC). Therefore, STAT3 is considered as a prominent target to counteract the uncontrolled proliferation of cancer cells. In the present report, pyrimidine-2,4-diones (N-methyluracil derivatives) (I [R =3-isopropoxyphenyl]-I [R =2-chlorophenyl]) were synthesized in an ionic liquid (BMIm PF₆) medium employing a ligand-free Suzuki-Miyaura cross-coupling process. Among the I compound I [R = naphthalen-1-yl] showed good cytotoxicity towards both the tested cell lines and did not display a toxic effect against normal hepatocytes (LO2). MNK8 significantly increased the Sub-G1 cell count in both cell lines and the cytotoxic effect of I [R = naphthalen-1-yl] was found to be mediated through the suppression of constitutive phosphorylation of STAT3^Y705. It also decreased the DNA interaction ability of nuclear STAT3 in HCC cells. I [R = naphthalen-1-yl] downregulated the levels of apoptosis-related proteins (such as Bcl-2, cyclin D1, survivin) and increased cleaved caspase-3 inferring the apoptogenic effect of I [R = naphthalen-1-yl]. It also reduced the CXCL12-triggered cell migration and invasion in in vitro assay systems. Overall, I [R = naphthalen-1-yl] has been demonstrated as a new inhibitor of STAT3 signaling cascade in HCC cells.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Recommanded Product: (2-Chlorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Formula: C6H6BClO2.

Saranya, Salim;Radhika, Sankaran;Anilkumar, Gopinathan research published 《 Ligand- and Base-Free Cu-Catalyzed C-N Coupling of Aminoquinolines with Boronic Acids》, the research content is summarized as follows. A ligand- and base-free Cu-catalyzed protocol for the synthesis of N-arylquinolin-8-amine and N-arylquinolin-3-amine derivatives has been developed. A wide range of N-aryl heterocycles were synthesized in moderate to good yields under the mild condition of 10 mol% Cu(OAc)₂ in 3 mL methanol at room temperature in presence of air.

Formula: C6H6BClO2, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. HPLC of Formula: 3900-89-8.

Seal, Jonathan T.;Atkinson, Stephen J.;Bamborough, Paul;Bassil, Anna;Chung, Chun-wa;Foley, James;Gordon, Laurie;Grandi, Paola;Gray, James R. J.;Harrison, Lee A.;Kruger, Ryan G.;Matteo, Jeanne J.;McCabe, Michael T.;Messenger, Cassie;Mitchell, Darren;Phillipou, Alex;Preston, Alex;Prinjha, Rab K.;Rianjongdee, Francesco;Rioja, Inmaculada;Taylor, Simon;Wall, Ian D.;Watson, Robert J.;Woolven, James M.;Wyce, Anastasia;Zhang, Xi-Ping;Demont, Emmanuel H. research published 《 Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors》, the research content is summarized as follows. The profound efficacy of pan-BET inhibitors is well documented, but these epigenetic agents have shown pharmacol.-driven toxicity in oncol. clin. trials. The opportunity to identify inhibitors with an improved safety profile by selective targeting of a subset of the eight bromodomains of the BET family has triggered extensive medicinal chem. efforts. In this article, we disclose the identification of potent and selective drug-like pan-BD2 inhibitors such as pyrazole 23 (GSK809) and furan 24 (GSK743) that were derived from the pyrrole fragment 6. We transpose the key learnings from a previous pyridone series (GSK620 2 as a representative example) to this novel class of inhibitors, which are characterized by significantly improved solubility relative to our previous research.

HPLC of Formula: 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Formula: C6H6BClO2.

Qiu, Jian;Wang, Cece;Zhou, Lu;Lou, Yixian;Yang, Kai;Song, Qiuling research published 《 Ni-Catalyzed Radical-Promoted Defluoroalkylborylation of Trifluoromethyl Alkenes To Access gem-Difluorohomoallylic Boronates》, the research content is summarized as follows. Gem-Difluoroalkenyl boronates are attractive synthons for constructing diverse gem-difluoroalkenes and organoboron compounds However, the strategies for the construction of gem-difluorohomoallyl boronates has scarcely been described. Herein, authors develop an efficient protocol for the construction of gem-difluorohomoallylic boronates through a Ni-catalyzed radical-promoted defluoroalkylborylation of α-trifluoromethyl alkenes with α-haloboronates under mild conditions. This reaction features a broad substrate scope with good functional group tolerance and diverse transformations.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Formula: C6H6BClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Safety of (2-Chlorophenyl)boronic acid.

Redon, Sebastien;Remusat, Vincent;Vanelle, Patrice research published 《 Green Synthesis of Diaryl Selenides from Arylboronic Acids and Arylseleninic Acids》, the research content is summarized as follows. A new method of deborylative selanylation using arylboronic acids and arylseleninic acids gave diaryl selenoethers and diarylselenoxide. The present approach required only equimolar arylseleninic acid and led selectively to selenoethers or selenoxides depending on the solvent. The method was metal-free, base- or oxidant-free, efficient, and environmentally friendly.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Safety of (2-Chlorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Application of C6H6BClO2.

Pfaffenrot, Bent;Kloevekorn, Philip;Juchum, Michael;Selig, Roland;Albrecht, Wolfgang;Zender, Lars;Laufer, Stefan A. research published 《 Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) – A promising target for liver regeneration》, the research content is summarized as follows. Currently, the therapeutic options for treatment of liver failure are very limited. As mitogen-activated protein kinase kinase 4 (MKK4) has recently been identified by in vivo RNAi experiments to be a major regulator in hepatocyte regeneration, authors pursued the development of a small mol. targeting this protein kinase. Starting from the approved BRAFV600E inhibitor vemurafenib, that showed a high off-target affinity to MKK4 in an initial screening, authors followed a scaffold-hopping approach, changing the core heterocycle from 1H-pyrrolo[2,3-b]pyridine to 1H-pyrazolo[2,3-b]pyridine I. Affinity to MKK4 could be conserved while the selectivity against off-target protein kinases was slightly improved. Further modifications led to II and III showing high affinity to MKK4 in the low nanomolar range and excellent selectivity profile from mandatory multiparameter-optimization for the essential anti-targets (MKK7, JNK1) and off-targets (BRAF, MAP4K5, ZAK) in the MKK4 pathway. Herein authors report the first selective MKK4 inhibitors in this class.

3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Application of C6H6BClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Quality Control of 3900-89-8.

Orritt, Kyle M.;Feng, Lipeng;Newell, Juliette F.;Sutton, Jack N.;Grossman, Scott;Germe, Thomas;Abbott, Lauren R.;Jackson, Holly L.;Bury, Benjamin K. L.;Maxwell, Anthony;McPhillie, Martin J.;Fishwick, Colin W. G. research published 《 De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region》, the research content is summarized as follows. By 2050, it is predicted that antimicrobial resistance will be responsible for 10 million global deaths annually, more deaths than cancer, costing the world economy $100 trillion. Clearly, strategies to address this problem are essential as bacterial evolution is rendering our current antibiotics ineffective. The discovery of an allosteric binding site on the established antibacterial target DNA gyrase offers a new medicinal chem. strategy. As this site is distinct from the fluoroquinolone binding site, resistance is not yet documented. Using in silico mol. design methods, we have designed and synthesized a novel series of biphenyl-based inhibitors inspired by a published thiophene-based allosteric inhibitor. This series was evaluated in vitro against Escherichia coli DNA gyrase and E. coli topoisomerase IV with the most potent compounds exhibiting IC₅₀ values towards the low micromolar range for DNA gyrase and only ∼2-fold less active against topoisomerase IV. The structure-activity relationships reported herein suggest insights to further exploit this allosteric site, offering a pathway to overcome developing fluoroquinolone resistance.

Quality Control of 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Application In Synthesis of 3900-89-8.

Ou, Yifeng;Yang, Tianbao;Tang, Niu;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua research published 《 Photo-Induced N-N Coupling of o-Nitrobenzyl Alcohols and Indolines To Give N-Aryl-1-amino Indoles》, the research content is summarized as follows. A novel method to synthesize N-aryl-1-amino indoles I [R = H, Me, Ph, etc.; R¹ = H, 6-Me, 5-Cl, etc.; R² = H, 4-F, 5-Br, etc.] was established by the photoinduced N-N coupling reaction. This protocol was operated by treatment of o-nitrobenzyl alcs. and indolines in the presence of TEAI and acetic acid with a 24 W UV light-emitting diode (LED) (385-405 nm) irradiation The products bearing an aldehyde group can be further transformed to fluorescent probes based on Rhodamine derivative, which shows a high specificity and sensitivity for Fe³⁺.

Application In Synthesis of 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics