Category: 38939-88-7

Peng, Haixia; Chen, Xuxing; Chen, Yanhong; He, Qian; Xie, Yuyuan; Yang, Chunhao published an article in 2011, the title of the article was Solvent-free synthesis of δ-carbolines/carbazoles from 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives using DPPE as a reducing agent.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

A green and efficient preparation of functionalized δ-carbolines/carbazoles via reductive ring closure by 1,2-bis(diphenylphosphino)ethane under solvent-free conditions is described. The starting materials 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives are readily prepared through Suzuki-Miyaura cross-coupling reaction from com. available compounds And the polar byproduct ethane-1,2-diylbis(diphenylphosphine oxide) is easily removed from the relatively polar reaction mixture Various substituted δ-carbolines/carbazoles are obtained in acceptable yields. It is particularly worth mentioning that substrates with electron-withdrawing groups (EWG) also give the desired products in good yield. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to carboline preparation, carbazole preparation, nitro phenyl pyridine preparation, reductive ring closure nitro phenylpyridine nitrobiphenyl dppe, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 15, 2010, Wang, Kai; Zhou, Zhiming; Song, Jinhong; Bi, Lixue; Shen, Ning; Wu, Yukai; Chen, Fuxue; Wen, Hongliang published an article.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene The title of the article was A metal-free aerobic oxidation of nitrotoluenes catalyzed by N,N’,N”-trihydroxyisocyanuric acid (THICA) and a novel approach to the catalyst. And the article contained the following:

A metal-free catalytic system with N,N’,N”-trihydroxyisocyanuric acid (THICA) as the catalyst for the oxidation of nitrotoluenes is introduced, and a novel Pd-free approach for the synthesis of THICA was developed. In a solution of acetic acid, THICA and concentrated nitric acid, nitrotoluenes especially polynitrotoluenes such as 2,4,6-trinitrotoluene (TNT), were converted into the desired carboxylic acids under 0.2 MPa of O2 at 100 °C with yields up to 99%. THICA was synthesized from N-hydroxyphtalimide through a four-step synthesis in a total yield of 46%. A possible mechanism of this catalytic process was proposed where NO2 and nitric acid first induced a radical of THICA, which then abstracts a hydrogen atom from the Me on the aromatic ring to form a benzyl radical. This radical then initiates subsequent reactions. The production of the benzyl radical was supported by ESR measurements. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to nitrotoluene oxidation nitrobenzoic acid trihydroxycyanuric acid catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 1981, Goh, Swee Hock; Kam, Toh Seok published an article.Reference of 2-Chloro-4-methyl-1-nitrobenzene The title of the article was Comparative reactivity of substituted 4-nitrobenzylidene dichlorides with alkali. And the article contained the following:

A comparative study of the reactions of RCHCl2 [R = 3,4- and 2,4-Cl(O2N)C6H3, 4-O2NC6H4, 4,3,5-O2N(Me)2C6H2, 2,4-Me(O2N)C6H3] with aqueous-alc. alkali showed that Cl substitution enhances the electron-transfer radical mechanism, whereas Me substitution favors the solvolysis path. The mechanism of the reaction is discussed. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Reference of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to nitrobenzylidene chloride reactivity alkali, solvolysis nitrobenzylidene chloride, substituent effect reactivity nitrobenzylidene chloride, benzylidene chloride nitro reactivity and other aspects.Reference of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nguyen, Thanh Binh; Ermolenko, Ludmila; Retailleau, Pascal; Al-Mourabit, Ali published an article in 2014, the title of the article was Elemental Sulfur Disproportionation in the Redox Condensation Reaction between o-Halonitrobenzenes and Benzylamines.Formula: C7H6ClNO2 And the article contains the following content:

The disproportionation of elemental sulfur at moderate temperatures is investigated in the redox condensation involving o-halonitrobenzenes 1 and benzylamines 2. As a redox moderator, elemental sulfur plays the dual role of both electron donor and acceptor, generating its lowest and highest oxidation states: S-2 (sulfide equivalent) in benzothiazole 3 and S+6 (sulfate equivalent) in sulfamate 4, and filling the electron gap of the global redox condensation process. Along with this process, a cascade of reactions of reduction of the nitro group of 1, oxidation of the aminomethyl group of 2, metal-free aromatic halogen substitution, and condensation finally led to 2-arylbenzothiazoles 3. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Formula: C7H6ClNO2

The Article related to sulfur disproportionation redox condensation halonitrobenzene benzylamine preparation, benzothiazoles, multicomponent reactions, redox condensation, sulfur, sulfur disproportionation and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 30, 2008, Glatthar, Ralf; Carcache, David published a patent.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene The title of the patent was Preparation of benzimidazoles and related compounds as modulators of metabotropic glutamate receptor-5 for treating gastrointestinal, urinary, and nervous system disorders. And the patent contained the following:

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the Formula I (wherein X1 -X4 each independently represent CR2 or N; R2 is H, halo, OH. etc.; R1 is C1-6alkyl, C1-6halogenalkyl, C3-12cycloalkyl, etc.; B is aryl, nitrogen-containing ring, etc.; C is a 5-12-membered aromatic (un)substituted ring system that may contain hetero atoms) and salts, solvates, hydrates and N-oxides thereof. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting 3-chloro-5-iodo-N-2-propylbenzene-1,2-diamine and 5-chloro-6-(6-methylpyridin-3-ylamino)nicotinoyl chloride, caused 97% inhibition of mGluR5 activity at 0.1 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to benzimidazole derivative preparation therapeutic metabotropic glutamate receptor 5 modulator, benzimidazole derivative mglur5 modulator gastrointestinal urinary nervous system disorder and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 23, 2009, Glatthar, Ralf; Carcache, David published a patent.Computed Properties of 38939-88-7 The title of the patent was Preparation of benzimidazoles and related compounds as modulators of metabotropic glutamate receptor-5 for treating gastrointestinal, urinary, and nervous system disorders. And the patent contained the following:

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the Formula I (wherein X1 -X4 each independently represent CR2 or N; R2 is H, halo, OH. etc.; R1 is C1-6alkyl, C1-6halogenalkyl, C3-12cycloalkyl, etc.; B is aryl, nitrogen-containing ring, etc.; C is a 5-12-membered aromatic (un)substituted ring system that may contain hetero atoms) and salts, solvates, hydrates and N-oxides thereof. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting 3-chloro-5-iodo-N-2-propylbenzene-1,2-diamine and 5-chloro-6-(6-methylpyridin-3-ylamino)nicotinoyl chloride, caused 97% inhibition of mGluR5 activity at 0.1 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Computed Properties of 38939-88-7

The Article related to benzimidazole derivative preparation therapeutic metabotropic glutamate receptor 5 modulator, benzimidazole derivative mglur5 modulator gastrointestinal urinary nervous system disorder and other aspects.Computed Properties of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 6, 2015, Jagadeesh, Rajenahally V.; Natte, Kishore; Junge, Henrik; Beller, Matthias published an article.Formula: C7H6ClNO2 The title of the article was Nitrogen-Doped Graphene-Activated Iron-Oxide-Based Nanocatalysts for Selective Transfer Hydrogenation of Nitroarenes. And the article contained the following:

Nanoscaled iron oxides on carbon were modified with nitrogen-doped graphene (NGr) and found to be excellent catalysts for the chemoselective transfer hydrogenation of nitroarenes to anilines. Under standard reaction conditions, a variety of functionalized and structurally diverse anilines, which serve as key building blocks and central intermediates for fine and bulk chems., were synthesized in good to excellent yields. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Formula: C7H6ClNO2

The Article related to nitroarene nitrogen doped graphene activated iron chemoselective transfer hydrogenation, aniline preparation, nitrogen doped graphene activated iron oxide transfer hydrogenation nanocatalyst and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bujok, Robert; Cmoch, Piotr; Wrobel, Zbigniew; Wojciechowski, Krzysztof published an article in 2017, the title of the article was Transition-metal-free synthesis of 3-(1-pyrrolidinyl)quinolines and 3-(1-pyrrolidinyl)quinoline 1-oxides via a one-pot reaction of 3-(1-pyrrolidinyl)crotonates with nitrobenzenes.Product Details of 38939-88-7 And the article contains the following content:

A carbanion of tert-Bu 3-(1-pyrrolidinyl)crotonate added to nitrobenzenes to form σH-adducts, which in the presence of pivaloyl chloride and triethylamine were converted into 3-(1-pyrrolidinyl)quinolines or 3-(1-pyrrolidinyl)quinoline 1-oxides depending on the nitrobenzene structure. This was the first methodol. in which a quinoline ring was constructed from a substrate bearing a pyrrolidinyl ring. Starting from optically pure enamines, the method allowed synthesis of the corresponding chiral products without racemization. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Product Details of 38939-88-7

The Article related to tert butyl pyrrolidinylcrotonate enantioselective diastereoselective preparation nitrobenzene cyclization, pyrrolidinyl quinolinecarboxylate preparation, quinoline oxide pyrrolidinyl preparation and other aspects.Product Details of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2022, Ouyang, Yao; Xu, Xiu-Hua; Qing, Feng-Ling published an article.Product Details of 38939-88-7 The title of the article was Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen. And the article contained the following:

A conceptually new and operationally simple protocol for the direct C-H trifluoromethoxylation of (hetero)aromatics by the combination of the readily available trifluoromethylating reagent and oxygen under electrochem. reaction conditions was discussed. This reaction proceeded through the initial generation of CF3 radical followed by conversion to CF3O radical, addition to (hetero)aromatics and rearomatization. The utility of this electrochem. trifluoromethoxylation was illustrated by the direct incorporation of CF3O group into a variety of (hetero)aromatics as well as bio-relevant mols. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Product Details of 38939-88-7

The Article related to trifluoromethoxyarene preparation, arene trifluoromethyl pyridylsulfone electrochem trifluoromethoxylation, electrochemistry, oxygen, radical reactions, trifluoromethoxylation, trifluoromethyl groups and other aspects.Product Details of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rodriguez-Aristegui, Sonsoles; Clapham, Kate M.; Barrett, Lauren; Cano, Celine; Desage-El Murr, Marine; Griffin, Roger J.; Hardcastle, Ian R.; Payne, Sara L.; Rennison, Tommy; Richardson, Caroline; Golding, Bernard T. published an article in 2011, the title of the article was Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.Related Products of 38939-88-7 And the article contains the following content:

Amino-substituted biphenyls were obtained by Suzuki cross-coupling of 2,6-dibromoaniline with a phenylboronic acid (substituted with Me, NO2, OH, OMe or Cl) preferably assisted by microwave irradiation Conversion of the amino group into a thiol preceded a base-induced intramol. substitution, also facilitated by microwave heating, to generate the second C-S bond of the target dibenzothiophene, e.g. I (R1 = MeO, R2 = R3 = R4 = H; R1 = R2 = R4 = H, R3 = Cl; R1 = R3 = R4 = H, R2 = OH). The 1-, 2-, 3- or 4-substituted 6-halodibenzothiophenes obtained were subjected to a palladium-mediated coupling with 2-morpholin-4-yl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-chromen-4-one to give the resp. 6-, 7-, 8- or 9-substituted dibenzothiophen-4-ylchromenones, e.g. II (R1 = MeO, R2 = R3 = R4 = H; R1 = R2 = R4 = H, R3 = Cl; R1 = R3 = R4 = H, R2 = OH). These compounds were evaluated as inhibitors of DNA-dependent protein kinase (DNA-PK) and compared to the parent 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholin-4-yl-4H-chromen-4-one. Notably, derivatives bearing hydroxy or methoxy substituents at C-8 or C-9 retained activity, whereas substitution at C-7 lowered activity. Substitution with chloro at C-6 was not detrimental to activity, but a chloro group at C-7 or C-8 reduced potency. The data indicate permissive elaboration of hydroxyl at C-8 or C-9, enabling the possibility of improved pharmaceutical properties, while retaining potency against DNA-PK. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Related Products of 38939-88-7

The Article related to dibenzothiophenylchromenone preparation structure activity relationship dna protein kinase inhibiting, suzuki coupling intramol substitution microwave irradiation dibenzothiophenylchromenone preparation and other aspects.Related Products of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics