Category: 38939-88-7

On April 1, 2016, Fu, Zhengjiang; Li, Zhaojie; Song, Yuanyuan; Yang, Ruchun; Liu, Yanzhu; Cai, Hu published an article.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene The title of the article was Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions. And the article contained the following:

Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atm. for the first time. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene

The Article related to decarboxylative halogenation cyanation aryl carboxylic acid palladium copper catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 7, 2017, Fu, Zhengjiang; Cai, Hu; Li, Zhaojie; Jiang, Ligao published a patent.SDS of cas: 38939-88-7 The title of the patent was Method for synthesizing aryl halide from aryl carboxylic acid as raw material. And the patent contained the following:

The invention relates to a method for synthesizing aryl halide from aryl carboxylic acid as raw material. The method prepares corresponding aryl halide from an aryl carboxylic acid compound and halide MX through substitution reaction in a solvent and in the presence of oxygen, silver catalyst, copper additive and a bidentate nitrogen ligand, wherein M in MX is alkali metal or alk. earth metal, and X is F, Cl, Br or I. Compared with the conventional aryl halide synthesis method, the method has the obvious advantages such as easily available low-cost reaction raw materials including aryl carboxylic acid and MX, small consumption of metal catalyst, little environmental pollution, good tolerance to multiple functional groups on aromatic ring, and high yield. The method can be widely applied to synthesis of drugs, materials and natural products in the industrial field and academia. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to arylhalide preparation substitution, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 26, 2019, Gupta, Sampa; Ansari, Alisha; Sashidhara, Koneni V. published an article.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene The title of the article was Base promoted peroxide systems for the efficient synthesis of nitroarenes and benzamides. And the article contained the following:

A useful and efficient approach for the synthesis of nitroarenes from several aromatic amines (including heterocycles) using peroxide and base was developed. This oxidative reaction was very easy to handle and afforded the products in good yields. Formation of benzamides from benzylamine was also successfully carried out with this metal-free catalytic system in good to excellent yields. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene

The Article related to aniline hydrogen peroxide oxidation green chem, nitrobenzene preparation, benzylamine tbhb oxidation green chem, benzamide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitro and Nitroso Compounds and other aspects.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 31, 1994, Suzuki, Hitomi; Mori, Tadashi published an article.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene The title of the article was Ozone-mediated nitration of chloro- and bromobenzenes and some methyl derivatives with nitrogen dioxide. High ortho-directing trends of the chlorine and bromine substituents. And the article contained the following:

In the presence of ozone, chloro- and bromobenzenes are nitrated smoothly with nitrogen dioxide at low temperatures, giving a mixture of the corresponding nitro derivatives in nearly quant. yield. The nitration products are generally ortho-rich as compared with those obtained by the conventional procedures based on the use of HNO3 or mixed acid. The ortho:para isomer ratios of the products can be reversed from ortho-rich (o:p = 1.14 and 1.09) to para-predominant (o:p = 0.45 and 0.68) simply by altering the initial concentration of the substrate. This enigmatic phenomenon was interpreted in terms of the equilibrium between the monomer and the dimer forms of the cation radical derived from a halobenzene and the difference in their relative reactivity toward nitrogen dioxide. Similar preference for substitution ortho to the halogen substituent was observed with 4-chloro- and 4-bromotoluenes, which concurrently suffer extensive ipso attack by the present reagent system, giving 4-methyl-2-nitrophenol as a common side product. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to regioselective nitration halobenzene, nitrogen dioxide ozone mediated nitration, solvent effect nitration halobenzene, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitro and Nitroso Compounds and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dennis, W. H. Jr.; Rosenblatt, D. H.; Simcox, J. R. published an article in 1974, the title of the article was Synthesis of nitrotoluenesulfonic acids by oxidative cleavage of disulfides.Reference of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

Oxidation of the disulfides [I and II (r = 4-Me, 5-Me)] gave 85% 5,4,2-Me(O2N)2C6H2SO3H, 11% 4,2-Me(O2N)C6H3SO3K, and 20% 5,2-Me(O2N)C6H3SO3K. I and II were prepared (52-95%) by the reaction of 5,2,4-Cl(O2N)2C6H2Me and x,yCl(O2N)C6H3Me(x = 4, y = 3; x = 3, y = 4), resp. with Na2S2. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Reference of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to toluenesulfonic acid nitro, oxidative cleavage disulfide, Noncondensed Aromatic Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Reference of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 18, 2013, Zhou, Jian published a patent.HPLC of Formula: 38939-88-7 The title of the patent was One-pot serial synthesis method for oxindole. And the patent contained the following:

The title method comprises the steps of: sequentially adding malonate, alkali, first solvent, reducing agent, second solvent, and substituted o-nitro halogenated benzene, performing aromatic nucleophilic substitution, deesterification, and reducing ring-closing reactions in turn, and separating by column chromatog. to obtain oxindole. The byproduct metal salt of the aromatic nucleophilic substitution reaction can be directly used as an accelerator for the deesterification. The method has the advantages of good substrate universality, wide sources of raw materials, low cost, mild reaction condition, simple operation, and no environmental pollution, and is applicable for large-scale industrial production The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).HPLC of Formula: 38939-88-7

The Article related to oxindole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.HPLC of Formula: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 10, 2017, Zhang, Songlin; Yu, Zelong published a patent.Recommanded Product: 38939-88-7 The title of the patent was Process for preparing indole and derivative. And the patent contained the following:

This invention provides a process for the preparation of indole and derivative I and II [wherein R = Me, OMe, CF3, halo, or Ph], which comprises (1) adding catalyst, ligand and base to the reaction tube, performing reaction of mixed solution of β-hydroxy ketone or ester Me2C(OH)CH2COR’ [wherein R’ = Me, Ph, or OEt] and 1-halo-2-nitrobenzenes III [wherein R as defined above; X = Cl, Br, I, or OTf] under the protection of nitrogen in oil-bath pot of 90-120 °C for 3-8 h, cooling to room temperature, extracting, washing, drying, and performing chromatog. to obtain IV, and (2) adding reducing agent system and solvent to the reaction tube, reacting at 60-100 °C for 3-8 h, extracting, washing, drying, and performing chromatog. to obtain the target product indole and derivative thereof. The invention has low cost, high yield, simple process and little pollution. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Recommanded Product: 38939-88-7

The Article related to preparation indole synthesis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pandarus, Valerica; Ciriminna, Rosaria; Beland, Francois; Pagliaro, Mario published an article in 2011, the title of the article was Selective hydrogenation of functionalized nitroarenes under mild conditions.Safety of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

Functionalized anilines are selectively synthesized from the corresponding nitroarenes by simple heterogeneous catalytic hydrogenation carried out under mild conditions over a very low amount (0.5 mol%) of a new sol-gel entrapped Pd(0) catalyst. Only halo-nitroarenes could not be selectively converted. The catalyst is leach-proof and can be reused in many consecutive reaction cycles. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Safety of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to silica palladium nanoparticle catalyst functionalized nitroarene hydrogenation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yong; Lai, Guo-Wei; Nie, Long-Jun; He, Qifang; Lin, Mei-Juan; Chi, Rong; Lu, Dong-Liang; Fan, Xiaolin published an article in 2022, the title of the article was Organocatalytic difluorobenzylation of 1,2-diketones via mild cleavage of carbon-carbon bonds.Name: 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

α-Aryl-α,α-difluoroacetophenones (DFAPs) RCF2C(O)Ph [R = 2,4-di-O2NC6H3, 2-O2NC6H4, 3-Cl-4-O2NC6H3, etc.] were developed as a new class of difluorobenzylation reagents that could be facilely prepared from readily available and cheap starting materials. In situ carbon-carbon bond cleavage of electron-deficient DFAPs gave difluorobenzyl carbanions that underwent base-catalyzed nucleophilic addition to isatins, unsaturated-α-ketoesters and cyclic 1,2-diketones. This organocatalytic difluorobenzylation reaction provided a new and efficient protocol to prepare various valuable building blocks such as I [R1 = H, 5-F, 7-Cl, etc.; R2 = H, Me, Ph, etc.; R3 = 2,4-di-O2NC6H3, 2-O2NC6H4, 3-Cl-4-O2NC6H3, etc.] containing the electron-deficient difluorobenzyl group. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Name: 2-Chloro-4-methyl-1-nitrobenzene

The Article related to difluorobenzylated compound preparation, aryl difluoroacetophenone diketone nucleophilic difluorobenzylation dbu catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Song-Lin; Yu, Ze-Long published an article in 2016, the title of the article was Divergent synthesis of indoles, oxindoles, isocoumarins and isoquinolinones by general Pd-catalyzed retro-aldol/α-arylation.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

Divergent synthesis of indoles I (R = H, 6-CH3, 5-F, etc.; R1 = CH3, C6H5), oxindoles II, isocoumarins e.g., III and isoquinolinones IV (R2 = CH3, C6H5) is described in this report by using a general Pd-catalyzed tandem reaction of β-hydroxy carbonyl compounds R3C(O)CH2C(R4)(OH)CH3 (R3 = CH3, C6H5, OCH3CH2; R4 = CH3, C6H5) with aryl halides bearing an ortho-nitro, -ester or -cyano substituent e.g., Me 2-chloropyridine-3-carboxylate. A key retro-aldol/α-arylation reaction is involved that merges classic Pd cross-coupling chem. with novel Pd-promoted retro-aldol C-C activation to produce α-arylated ketones or esters. Subsequent intramol. condensation of the carbonyl with the ortho-synthon gives target heterocycles I, II, e.g., III and IV. The use of common, com. available and cheap substrates and catalyst system adds addnl. synthetic advantages to the conceptual significance. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to indole oxindole isocoumarin isoquinolinone preparation, aryl halide hydroxy carbonyl retro aldol arylation palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics