Category: 38939-88-7

On March 15, 2016, Ji, Haitao; Yu, Binxun; Zhang, Min; Guo, Wenxing published a patent.SDS of cas: 38939-88-7 The title of the patent was Substituted 1h-indazol-1-ol analogs as inhibitors of beta catenin/tcf protein-protein interactions. And the patent contained the following:

In one aspect, the invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analogs, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g. various tumors and cancers, associated with β-catenin/Tcf protein-protein interaction dysfunction using the compounds and compositions This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to substituted indazole preparation beta catenin tcf protein interaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 29, 1980, Bird, C. W.; Latif, M. published an article.Synthetic Route of 38939-88-7 The title of the article was A new synthesis of 3H-phenoxazin-3-ones. And the article contained the following:

Nine 3H-phenoxazin-3-ones I (R = H, Me, CO2Me; R1 = H, Me; R2 = H, Me, Cl, CO2Me, OH), potential intermediates in actinomycin synthesis, were prepared by cyclization of the novel nitro ethers II. Thus, II (R = R1 = R2 = H) was treated with Zn dust and NH4Cl in aqueous MeOCH2CH2OMe, and the solution aerated to give 67% I (R = R1 = R2 = H). The aeration is required to reconvert the alc. product of the reduction to I. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Synthetic Route of 38939-88-7

The Article related to reductive cyclization nitrophenyl hydroxyphenyl ether, actinomycin potential synthon phenoxazinone, phenoxazinone, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines and other aspects.Synthetic Route of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 13, 2022, Yang, Chao; Shen, Zhengjia; Yao, Lijuan published a patent.Related Products of 38939-88-7 The title of the patent was Method for preparing aniline derivative using 3,3,4,4-tetramethylborane and tetrabutylammonium bromide. And the patent contained the following:

The invention relates to a method for preparing aniline derivative that has advantages of simple operation, no pollution, safety and environmental protection and low cost. The method includes the following steps: (1) mixing the nitro compound, boron reagent, electrolyte and organic solvent evenly to obtain mixed solution; (2) putting two electrodes into the mixed solution, turning on the power supply, and carry out an electrocatalytic reaction at room temperature and in an air atm. with stirring to obtain reaction mixture; (3) distilling the reaction mixture under reduced pressure to remove the solvent, and adding silica gel to stir to obtain crude product; and (4) purifying the crude product by silica gel column chromatog. to obtain aniline derivative The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Related Products of 38939-88-7

The Article related to butylammonium bromide methylborane aniline derivative, Electrochemistry: Other Industrial Electrochemical Processes and other aspects.Related Products of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rubio-Presa, Ruben; Fernandez-Rodriguez, Manuel A.; Pedrosa, Maria R.; Arnaiz, Francisco J.; Sanz, Roberto published an article in 2017, the title of the article was Molybdenum-Catalyzed Deoxygenation of Heteroaromatic N-Oxides and Hydroxides using Pinacol as Reducing Agent.COA of Formula: C7H6ClNO2 And the article contains the following content:

A molybdenum-catalyzed deoxygenation of pyridine N-oxides and N-hydroxybenzotriazoles, as well as other azole N-oxides, has been developed using pinacol as an environmentally friendly oxo-acceptor. The only byproducts are acetone and water making the process a convenient alternative to established protocols in terms of waste generation. The reaction is highly chemoselective and a variety of functional groups are tolerated. The processes are usually very clean allowing the isolation of the pure deoxygenated products after a simple extraction in most cases. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).COA of Formula: C7H6ClNO2

The Article related to heteroaromatic oxide hydroxide deoxygenation chemoselective molybdenum catalyst green chem, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.COA of Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 15, 2013, Ji, Haitao; Yu, Binxun; Zhang, Min; Guo, Wenxing published a patent.COA of Formula: C7H6ClNO2 The title of the patent was Preparation of substituted 1H-indazol-1-ol analogs as inhibitors of beta-catenin/Tcf protein-protein interactions. And the patent contained the following:

The invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analogs of formula I, synthetic methods for making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders, e.g. various tumors and cancers, associated with β-catenin/Tcf protein-protein interaction dysfunction using the compounds and compositions Compounds of formula I wherein A1 is N, NH and CR2a; A2 is N, CO, CS and CR2b; A3 is NOH and O; L is CH2, CH2CH2, CH2CH2CH2, OCH2, NHCH2, etc.; B1 is N, O and S; B2 is N, CO, CS, and SO; R11, R1b and R1c are independently H, halo, OH, NH2, C1-3 alkyl, etc.; R2a and R2b are independently H, halo, OH, NH2, C1-3 haloalkyl, etc.; and pharmaceutically acceptable salts, esters, hydrates, solvates, or polymorphs thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their inhibitory activity of β-catenin/Tcf protein-protein interaction. From the assay, it was determined that compound II exhibited Ki value of 1304 ± 2.03 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).COA of Formula: C7H6ClNO2

The Article related to substituted indazole preparation beta catenin tcf protein interaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.COA of Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Mao; Buchwald, Stephen L. published an article in 2013, the title of the article was Continuous-flow synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines in a C-N bond formation/hydrogenation/diazotization/cyclization sequence.Product Details of 38939-88-7 And the article contains the following content:

We have developed an efficient and regiospecific synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines by a C-N bond formation/hydrogenation/diazotization/cyclization sequence under continuous-flow conditions. Two approaches beginning either with an SnAr reaction or Pd catalysis were developed to prepare unsym. substituted benzotriazoles with a range of substituents. Of particular note is that benzotriazoles that bear various N-substituted groups, including alkyl, aryl, and heteroaryl, can all be efficiently and regiospecifically accessed with the described method. This protocol represents a successful example of a continuous-flow method with consecutive multiphase processes. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Product Details of 38939-88-7

The Article related to benzotriazoles regioselective synthesis continuous flow, chloronitrobenzene amine tandem reaction cn coupling hydrogenation diazotization cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Product Details of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 25, 2011, Simoneau, Bruno; Deroy, Patrick; Fader, Lee; Faucher, Anne-Marie; Gagnon, Alexandre; Grand-Maitre, Chantal; Kawai, Steven; Landry, Serge; Mercier, Jean-Francois; Rancourt, Jean published a patent.Electric Literature of 38939-88-7 The title of the patent was 1-Phenyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione derivatives as HIV replication inhibitors and their preparation and use for the treatment of HIV infection. And the patent contained the following:

The invention relates to benzodiazepinedione derivatives of formula I, which are HIV replication inhibitors and which are useful in the treatment of HIV infection. Compounds of formula I wherein X is C=O; Y is substituted CHPh, substituted benzo-fused spirocycle, substituted NPh, etc.; XY taken together to form (un)substituted 5-membered heteroaryl; each R1 is independently C1-6 alkyl, C1-6 haloalkyl, halo and C3-7 cycloalkyl; R2 is H, C1-6 alkyl, C1-6 alkyl-C3-7 cycloalkyl and C3-7 cycloalkyl; R3 is (un)substituted Ph and thiophene; m is 1 to 3; are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their HIV replication inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values in the range 0.38 – 047 μM and an EC50 value of 2.6 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Electric Literature of 38939-88-7

The Article related to benzodiazepinedione preparation replication inhibitor treatment hiv infection, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Electric Literature of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 15, 2008, Grewal, Gurmit; Hennessy, Edward; Kamhi, Victor; Li, Danyang; Lyne, Paul; Oza, Vibha; Saeh, Jamel Carlos; Su, Qibin; Yang, Bin published a patent.SDS of cas: 38939-88-7 The title of the patent was Preparation of heterocyclic sulfonamide compounds as Edg-1 antagonists useful in the treatment of cancer. And the patent contained the following:

The invention relates to chem. compounds of formula I (wherein ring A is carbocyclyl or heterocyclyl; n = 0-5; R1 is halo, nitro, cyano, etc.; R2 is C1-6alkyl, carbocyclyl, etc.; R3 is H, C1-6alkyl, etc.; or alternatively, R2 and R3 together may form part of C3-6carbocyclic ring; R4 is C1-6alkyl or carbocyclyl; Ring D is a 5-7 membered ring; R5 is a substituent on carbon and is halo, nitro, cyano, etc.; m is 0-5) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chem. compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man. Example compound II, prepared by reacting the appropriate sulfonyl chloride with [1-[1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]ethyl]amine, caused 100% inhibition of Edg-1 receptor activity at 3.70 μM in an in vitro cell based receptor activation assay. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to preparation heterocyclic sulfonamide edg1 receptor antagonist treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2019, Yan, Jingbo; Li, Song; Zhong, Wu; Xiao, Junhai; Wang, Gang published a patent.Electric Literature of 38939-88-7 The title of the patent was Preparing method and application of Quetiapine analog. And the patent contained the following:

The title Quetiapine analog is shown in formula (I), wherein, m, n and p are independently integers of 0, 1, 2, 3 and 4; R1 and R2 are independently selected from H, halogen, nitro, cyano, hydroxy, etc.; R3 is 3-10-membered cycloalkyl, 3-membered heterocycloalkyl, etc.; R4 is H, cyano, C1-6 alkyl, etc.; R5 is H, C1-6 alkyl, C1-6 alkoxy, etc. The invented Quetiapine analog shows higher bioactivity than Quetiapine. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Electric Literature of 38939-88-7

The Article related to quetiapine antidepressant anxiolytic analgesic preparation, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Electric Literature of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 1, 1980, Gupta, R. R.; Ojha, K. G.; Kalwania, G. S.; Kumar, M. published an article.SDS of cas: 38939-88-7 The title of the article was A convenient and single step synthesis of substituted 4H[1,4]-benzothiazines. And the article contained the following:

Benzothiazines I (R = H, Cl, OMe; R1 = H, Me; R2 = H, Cl, Br, Me, OMe, OEt; R3 = Me, Ph, OEt; R4 = Me, Ph) were obtained in 45-75% yield by condensing 2-aminobenzenethiols with R4COCH2COR3. Some of the aminobenzenethiols were prepared from anilines. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to benzothiazine, aminobenzenethiol active methylene cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines (Including Cephalosporins) and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics