Category: 3696-23-9

Bala, Renu published the artcilePhthaloyl Dichloride-DMF Mediated Synthesis of Benzothiazole-based 4-Formylpyrazole Derivatives: Studies on Their Antimicrobial and Antioxidant Activities, Product Details of C7H7ClN2S, the publication is Journal of Heterocyclic Chemistry (2018), 55(11), 2507-2515, database is CAplus.

Benzothiazole-based pyrazole derivatives were prepared by a mol. hybridization approach with an aim to influence the biol. activity significantly. Efficient conversion of hydrazones I (R = H, OMe, Cl, etc.; R’ = H, F; R” = H, Me, Br, Cl) derived from their corresponding Me ketones to 4-formylpyrazoles II was carried out at 60° in dioxane, using the Vilsmeier-Haack reagent isolated from phthaloyl dichloride and N,N-dimethylformamide. The newly synthesized compounds II and hydrazones I were screened in vitro for their antimicrobial activities using the broth macrodilution method. The compounds I were also screened for their antioxidant activities using the DPPH radical scavenging assay. Some of the synthesized compounds showed significant antibacterial and antifungal activities as evident from their min. inhibitory concentrations Compound II (R = R’ = H; R” = Br) showed remarkable antioxidant activity.

Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Rahul published the artcileSynthesis and exploration of configurational dynamics in equilibrating E/Z 2-aryliminothiazolidin-4-ones using NMR and estimation of thermodynamic parameters, Safety of 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2022), 46(11), 5012-5025, database is CAplus.

In the present study, 2-aryliminothiazolidin-4-ones I [R¹ = H, OMe, NMe₂, NO₂; R² = H, Me, MeO, Cl, NO₂] were utilized as dynamic chem. systems, whose different states were modulated in a reversible fashion through specific chem. stimuli. The in-depth NMR investigation revealed that the magnitude of rotational energy barrier ΔG^{â€?/sup> was affected markedly by (1) the solvent polarity; (2) the electronic nature of the ring system present on the exocyclic CQN bond and (3) the temperature of the system. The derivatives of I exist in two isomeric forms at room temperature in DMSO-d₆: (2E,5Z,7E) (2Z,5Z,7E). The stereodynamics of the synthesized derivatives I were investigated using variable temperature dynamic 1H-NMR (VT DNMR). The ΔGâ€?/sup> values (â‰?5 kcal mol-1) estimated for the dynamic process depicted a significant barrier between two forms in solution at ambient temperature To go a step further, line shape anal. were also performed to get a clear understanding of the equilibration mechanism.}

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C17H16O2, Safety of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Srikrishna, Devulapally published the artcilePEG-600 mediated one-pot reaction of 3-acetyl-2H-chromen-2-one with heterylthiols and phenylthioureas using tetrabutylammonium tribromide as an efficient green reagent, Application of 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2017), 41(12), 5168-5175, database is CAplus.

A simple method for the one-pot reaction of 3-acetyl-2H-chromen-2-one with different heterylthiols and phenylthioureas under green conditions using tetrabutylammonium tribromide (TBATB) as an efficient reagent has been described. 3-Acetyl-2H-chromen-2-one was reacted with TBATB in acetic acid to give 3-(2-bromoacetyl)-2H-chromen-2-one. Poly(ethylene glycol) 600 (PEG-600) was found to be the effective solvent for this reaction. Thus, a one-pot reaction of equimolar amounts of 3-acetyl-2H-chromen-2-one, TBATB and heterylthiols or phenylthioureas, resulted in the formation of heterylthioacetylcoumarins I (X = NH, O, S) or coumarinylthiazoles II (Ar = C₆H₅, 4-FC₆H₄, 2-Cl-4-FC₆H₃, etc.), resp. The effect of the solvent on these reactions was studied. The merits of this preparation are the mild reaction conditions, easy workup, good yields and use of PEG-600 as a green reaction medium.

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C9H9NO, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagaraju, Tumula published the artcilePhI(OAc)₂-Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5-a]pyridines via Oxidative N-S and N-N Bond Formation, HPLC of Formula: 3696-23-9, the publication is Synthesis (2019), 51(19), 3600-3610, database is CAplus.

An effective and expeditious approach for the construction of biol. important 5-guanidino-1,2,4-thiadiazoles I [R¹ = n-Pr, Ph, 3-ClC₆H₄, etc.; R² = Ph, 2-MeOC₆H₄, 4-ClC₆H₄, etc.] and 1,2,4-triazolo[1,5- a]pyridine derivatives II [R³ = H, 7-Me, 7-Cl; R⁴ = Ph, 2-thienyl, 3-O₂NC₆H₄, etc.] were developed with high efficiency and excellent regioselectivity. This new protocol involved the phenyliodine(III) diacetate-mediated oxidative cyclization of thioureas/2-aminopyridines and imidates via N-S and N-N bond formation at ambient temp to afford target compounds I and II resp.

Synthesis published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prevost, Julien R. C. published the artcileConvenient one-pot formation of highly functionalized 5-bromo-2-aminothiazoles, potential endocannabinoid hydrolase MAGL inhibitors, Product Details of C7H7ClN2S, the publication is Tetrahedron Letters (2018), 59(49), 4315-4319, database is CAplus.

Highly functionalized 5-bromo-2-amino-1,3-thiazoles bearing various substituents could be easily prepared by a rapid and efficient one-pot method, using simple starting materials and mild conditions while avoiding the use of metal catalysts or inconvenient reagents such as elemental halogens. These useful products can serve as starting materials for other reactions or as pharmacol. interesting compounds In our work we have shown that the resulting 5-bromothiazole compounds could lead to monoacylglycerol lipase (MAGL) inhibition in the μM range.

Tetrahedron Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Balinge, Kamlesh Rudreshwar published the artcileFacile access to polymer supported zinc-salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium, Application In Synthesis of 3696-23-9, the publication is Research on Chemical Intermediates (2018), 44(3), 2075-2097, database is CAplus.

The synthesis of polymer supported zinc-salen complex (PS-Zn-salen) is described. The mononuclear zinc(II)-salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform IR spectrophotometry (FT-IR), thermogravimetric anal., SEM, surface area and pore size distribution by Brunauer-Emmett-Teller. The synthesized PS-Zn-salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, resp. In spite of conventional heterogeneous catalysts, current PS-Zn-salen complex shows thermal stability up to 280 °C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn-salen is negligible, which was confirmed by AAS and hot filtration test.

Research on Chemical Intermediates published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sareen, V. published the artcileSynthesis of some new 2-(4-nitroanilino)-4-(4-carboxyanilino)-6-(substituted thioureido)-1,3,5-triazines, Quality Control of 3696-23-9, the publication is Heterocyclic Letters (2014), 4(1), 115-118, 4 pp., database is CAplus.

Some new 2-(4-nitroanilino)-4-(4-carboxyanilino)-6-(substituted thioureido)-1,3,5-triazines I (R = C₆H₅, 4-FC₆H₄, 4-ClC₆H₄, etc.) have been prepared by reacting 2,4,6-trichloro-1,3,5-triazine with nucleophilic reagents, 4-nitroaniline, 4-carboxyaniline and different substituted thioureas.

Heterocyclic Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Quality Control of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Attimarad, Mahesh Veerabhadra published the artcileMicrowave assisted synthesis, pharmacological activities, and molecular docking studies of ethyl 2-[2-substituted-4-(thiophenyl) thiazolyl] acetates, Application In Synthesis of 3696-23-9, the publication is Iranian Journal of Pharmaceutical Research (2017), 16(4), 1379-1395, database is CAplus.

Two series of Et 2-[2-anilino-4-(2-thienyl)thiazol-5-yl]acetates I [R = 3-MeC₆H₄, 4-MeOC₆H₄, 4-BrC₆H₄, etc.] and Et 2-[2-(2-benzylidenehydrazino)-4-(2-thienyl)thiazol-5-yl]acetates II [R¹ = 2-HOC₆H₄, 4-ClC₆H₄, 4-Me₂NC₆H₄] were synthesized and screened for their anti-inflammatory, analgesic and antioxidant activities. In-vivo test results showed that the compounds I [R¹ = 4-FC₆H₄, 4-ClC₆H₄, 3-Cl-4-FC₆H₃, 2,4-Cl₂C₆H₃, 4-BrC₆H₄] exhibited good anti-inflammatory and analgesic activities, similar to that of indomethacin and aspirin, resp. Compounds II showed better anti-oxidant activity than compounds I when compared to ascorbic acid. Further, a mol. docking study was performed to predict the possible binding modes on cyclooxygenase-1 (COX-1) and COX-2 for compounds I and II. Good correlation was observed between the anti-inflammatory activity of the compounds I and II and the results of the binding modes in COX-2.

Iranian Journal of Pharmaceutical Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nadaf, Afra Quasar A. published the artcileSynthesis, characterization, crystal structure and hirshfeld surface analysis of alkyl substituted N,4-diphenyl thiazole-2-amine., Computed Properties of 3696-23-9, the publication is Chemical Data Collections (2019), 100297, database is CAplus.

The present work describes the synthesis of alkyl substituted N,4-di-Ph thiazole-2-amines (I) and (II) through a three step pathway. Further, the structures were confirmed by single crystal X-ray diffraction studies which revealed that compound I crystallizes in triclinic system with P-1 space group whereas compound II crystallizes as monoclinic with P2₁/c space group. The asym. unit consists of only one mol. in both the structures. The study of torsional angles of compound I and compound II indicated that S1 and C4 are cis to each other whereas N2 and C4 are trans. A detailed anal. of intermol. hydrogen bonding interactions has been performed. Also their C-H···π and π···π stacking interactions have been explored using Hirshfeld surface anal. and their 2D fingerprint plots. The most significant contributions in both the compounds are due to H···H interactions which also account for their stability.

Chemical Data Collections published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kumar, Gupta Girish published the artcileIsolation of 4-hydroxythiazoline. A solid phase study in Hantzsch thiazole reaction, Computed Properties of 3696-23-9, the publication is Research Journal of Chemistry and Environment (2014), 18(2), 38-44, database is CAplus.

A simple, efficient and rapid practical procedure for the preparation of various thiazole derivatives was developed. The present protocol offered the solid phase reaction of various α-bromo ketones with a wide variety of thioamides/thioureas in the presence of Na₂CO₃ at room temperature (within 3-5 min). More specifically, it also provided an excellent synthetic route to 2-(pyrazol-1-yl)thiazole derivatives that can not be prepared easily using solvent or acidic conditions mediated Hantzsch thiazole reaction due to the exclusive formation of thiocyanatoketones. Increase in amount of solid catalyst led to the formation of 4-hydroxythiazole, a cyclic intermediate which is formed in Hantzsch thiazole reaction. In conclusion, reaction could be stopped either at intermediate state or was directed towards thiazole formation by changing the amount of base.

Research Journal of Chemistry and Environment published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics