Category: 3696-23-9

Khayyat, Ahdab N. published the artcileDesign, Synthesis, and Antipoliferative Activities of Novel Substituted Imidazole-Thione Linked Benzotriazole Derivatives, Application In Synthesis of 3696-23-9, the publication is Molecules (2021), 26(19), 5983, database is CAplus and MEDLINE.

A new series of benzotriazole moiety bearing substituted imidazol-2-thiones I [R = H, 4-Me, 2-F, etc.] at N1 was designed, synthesized and evaluated for in vitro anticancer activity against the different cancer cell lines MCF-7(breast cancer), HL-60 (Human promyelocytic leukemia), and HCT-116 (colon cancer). Most of the benzotriazole analogs exhibited promising antiproliferative activity against tested cancer cell lines. Among all the synthesized compounds, I [R = 2,4-di-Cl] showed potent activity against the cancer cell lines such as MCF-7, HL-60 and HCT-116 with IC₅₀ 3.57, 0.40 and 2.63μM, resp. Compound I [R = 2,4-di-Cl] was taken up for elaborate biol. studies and the HL-60 cells in the cell cycle were arrested in G2/M phase. Compound I [R = 2,4-di-Cl] showed remarkable inhibition of tubulin polymerization with the colchicine binding site of tubulin. In addition, compound I [R = 2,4-di-Cl] promoted apoptosis by regulating the expression of pro-apoptotic protein BAX and anti-apoptotic proteins Bcl-2. These results provide guidance for further rational development of potent tubulin polymerization inhibitors for the treatment of cancer.

Molecules published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sahoo, Prangya Rani published the artcileOxidation of phenylthioureas by cetyltrimethylammonium permanganate: a kinetic study, Formula: C7H7ClN2S, the publication is Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry (2014), 53A(2), 174-178, database is CAplus.

Phenylthioureas have been subjected to oxidation in acetonitrile medium in neutral condition to investigate the oxidation behavior of cetyltrimethylammonium permanganate on multifunctional groups. The oxidation product in each reaction is found to be the corresponding phenylurea. The rate of reaction is dependent on [CTAP], [phenylthiourea], [surfactant] and reaction temperature A Michaelis-Menten type kinetics is observed with respect to the substrate. A reaction mechanism involving the formation of a cyclic intermediate in the slow step is proposed for the oxidation reaction.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagarajaiah, Honnappa published the artcileMechanochemical solid-state synthesis of 2-aminothiazoles, quinoxalines and benzoylbenzofurans from ketones by one-pot sequential acid- and base-mediated reactions, Computed Properties of 3696-23-9, the publication is Organic & Biomolecular Chemistry (2016), 14(17), 4129-4135, database is CAplus and MEDLINE.

Mechanochem. solid-state synthesis of 2-aminothiazoles, 2-hydrazinylthiazoles, quinoxalines and benzoylbenzofurans via one-pot sequential α-chlorination of ketones followed by base-mediated condensations with thiourea/thiosemicarbazides, o-phenylenediamine and salicylaldehyde resp. under ball-milling conditions was described. Chlorination of ketones proceeded with atom-economical trichloroisocyanuric acid reagent in the presence of p-TSA under ball-milling conditions to give α-chloroketones which was then further used without isolation. The viability of one-pot sequential acid- and base-mediated reactions in the solid state under ball-milling conditions was thus demonstrated.

Organic & Biomolecular Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wadhawa, Gurumeet C. published the artcileOne-pot synthesis of 2-substituted-4-methylthiazole-5-carboxylates from ethyl acetoacetate and thiourea by using oxone and iodobenzene, HPLC of Formula: 3696-23-9, the publication is Materials Today: Proceedings (2022), 58(Part_2), 749-752, database is CAplus.

A present report expressed that oxone and iodobenzene reaction system was useful for the synthesis of several 2-substituted-4-methylthiazole-5-carboxylates I [R = H, Me, Ph, etc.] from com. available starting materials. Et acetoacetate and thiourea in an efficient way instead of the traditional two-step reaction was used for the synthesis of desired product. Advantages of this simple method contained greener and cleaner conditions, shorter reaction time and excellent yield of products. A simple one-pot protocol had been developed for the synthesis of 2-substituted-4-methylthiazole-5-carboxylates derivatives from readily available starting materials.

Materials Today: Proceedings published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C14H23N, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Agrawal, V. L. published the artcileSynthesis and properties of 3-substituted benzothiazolyl 1-phenyl amino methanamides with Cu(II) complex compound, Product Details of C7H7ClN2S, the publication is International Journal of Chemical Sciences (2014), 12(4), 1677-1680, database is CAplus.

Several complexes of Cu(II) are formed by refluxing purified Cu palmitate with 3-substituted benzothiazolyl 1-Ph amino methanamide, RC₇H₄NS-NHC(O)NHPh (R = H, 4-Me, 6-Me, 4-Cl, 6-NO₂), in the ratio 1:1.7 using EtOH as a solvent for four hrs. Resultant solution was filtered hot and complexes were recrystallized using petroleum ether solvent. Granular solid complexes of different colors like light blue, green gray and blackish were obtained in sufficient yield.

International Journal of Chemical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Djud, Mateja published the artcileSynthesis of monosubstituted thioureas by vapour digestion and mechanochemical amination of thiocarbamoyl benzotriazoles, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Green Chemistry (2016), 18(9), 2666-2674, database is CAplus.

Thiocarbamoyl benzotriazoles, as safe and easy-to-handle isothiocyanate equivalent, were quant. converted to N-monosubstituted thioureas by vapor digestion synthesis under an ammonia atm. This simple, but timely process provided a synthetic platform that enabled the “slow” amination reaction to be successfully transformed into a rapid one aided by mechanochem. milling. The ammonium chloride/sodium carbonate equimolar mixture allowed in situ formation of ammonia under ball-milling conditions. This novel and green approach yielded aromatic and aliphatic primary thioureas in near-quant. isolated yields with workup entirely based on using only water. In addition, the mol. and crystal structures of selected polyaromatic primary thioureas were determined from the synchrotron powder diffraction data.

Green Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Yuncan published the artcileSynthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas, Formula: C7H7ClN2S, the publication is Chinese Chemical Letters (2021), 32(8), 2555-2558, database is CAplus.

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, provided a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.

Chinese Chemical Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Woodring, Jennifer L. published the artcileDisrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein, Formula: C7H7ClN2S, the publication is Journal of Medicinal Chemistry (2020), 63(1), 205-215, database is CAplus and MEDLINE.

Antiviral drug resistance in influenza infections has been a major threat to public health. To develop a broad-spectrum inhibitor of influenza to combat the problem of drug resistance, we previously identified the highly conserved E339…R416 salt bridge of the nucleoprotein trimer as a target and compound 1 as an inhibitor disrupting the salt bridge with an EC₅₀ = 2.7μM against influenza A (A/WSN/1933). We have further modified this compound via a structure-based approach and performed antiviral activity screening to identify compounds 29 and 30 with EC₅₀ values of 110 and 120 nM, resp., and without measurable host cell cytotoxicity. Compared to the clin. used neuraminidase inhibitors, these two compounds showed better activity profiles against drug-resistant influenza A strains, as well as influenza B, and improved survival of influenza-infected mice.

Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C4H6BrFO2, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Diao, Peng-Cheng published the artcileDiscovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity, Formula: C7H7ClN2S, the publication is European Journal of Medicinal Chemistry (2019), 196-207, database is CAplus and MEDLINE.

To develop novel CDK2 inhibitors as anticancer agents, a series of novel pyrimidine-based benzothiazole derivatives I (R = 4-(S(O)₂NH₂), 4-(piperidin-1-yl), 3-F, etc.) and II (R¹ = H, F, Cl, Me, MeO; R² = H, Me, F; R³ = Me, NH₂) was designed and synthesized. Initial biol. evaluation demonstrated that some of target compounds displayed potent antitumor activity in vitro against five cancer cell lines. Especially, the analog II (R¹ = F; R² = H; R³ = NH₂) exhibited approx. potency with AZD5438 toward four cells including HeLa, HCT116, PC-3, and MDA-MB-231 with IC₅₀ values of 0.45, 0.70, 0.92, 1.80 μM, resp. More interestingly, the most highly active compound II (R¹ = F; R² = H; R³ = NH₂) in this study also possessed promising CDK2/cyclin A2 inhibitory activities with IC₅₀ values of 15.4 nM, which was almost 3-fold potent than pos. control AZD5438, and mol. docking studies revealed that the analog bound efficiently with the CDK2 binding site. Further studies indicated that compound II (R¹ = F; R² = H; R³ = NH₂) could induce cell cycle arrest and apoptosis in a concentration-dependent manner. These observations suggest that pyrimidine-benzothiazole hybrids represent a new class of CDK2 inhibitors and well worth further investigation aiming to generate potential anticancer agents.

European Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vashi, D. M. published the artcileSynthesis and characterizations of substituted 1, 3, 5-triazine -2, 4, 6-triamines as biological potent agents, Application In Synthesis of 3696-23-9, the publication is Journal of Applicable Chemistry (Lumami, India) (2016), 5(4), 871-876, database is CAplus.

Some novel 1, 3, 5-triazine-2, 4, 6- triamines have been synthesized and characterized by elemental analyses, IR and NMR. The products have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria.

Journal of Applicable Chemistry (Lumami, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C4H4N2O2, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics