Category: 3696-23-9

Seelam, Mohan published the artcileAn efficient methodology for the synthesis of thioureas from amine mediated by a cobalt source, HPLC of Formula: 3696-23-9, the publication is Tetrahedron Letters (2016), 57(48), 5297-5300, database is CAplus.

The cheap, readily available and air stable cobalt catalyst was used as the desulfurization agent for the conversion of aniline to thioureas in one pot three step reaction under mild reaction conditions. The reactions are rapid and facile and accomplished at room temperature

Tetrahedron Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C17H20ClN3, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Karan published the artcileSynthesis, characterization and antimicrobial study of some novel fluorine based 2-aminothiazoles, Synthetic Route of 3696-23-9, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2014), 6(10), 429-433, 5 pp., database is CAplus.

The synthesis of some novel fluorine based 2-aminothiazoles I (R = 4-Cl, 4-CH₃, 4-NO₂, etc.; R¹ = 2,4-F₂C₆H₃, 3-O₂NC₆H₄, 4-H₃COC₆H₄, etc.), II (R² = Cl, CH₃, OCH₃) have been described by using hypervalent iodine [I(III)] mediated approach. The synthesized compounds I and II were screened for their anti-microbial activity. The results revealed that compounds I (R = 4-OCH₃, R¹ = 2,4-F₂C₆H₃; R = 2,4-Cl₂, R¹ = 2,4-F₂C₆H₃; R² = Cl; R² = CH₃; R² = OCH₃; R = 2,4-F₂, R¹ = 3-O₂NC₆H₄; R = 2,4-F₂, R² = C₆H₅) showed moderate to good antibacterial activity as compared with the standard drug chloramphenicol.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H8BFO2, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Pengfei published the artcileMultipathways for the Synthesis of Fused Bicyclic 2-Aminothiazolyl Compounds Tuned by Ring Size, Product Details of C7H7ClN2S, the publication is Synlett (2014), 25(19), 2797-2801, database is CAplus.

A new methodol. for the synthesis of fused bicyclic 2-aminothiazolyl compounds was developed, using cyclocondensation of aromatic thioureas with α,β-epoxy cycloketones in alc. under microwave irradiation without any catalyst. The product distribution is related to the ring size of α,β-epoxy cycloketones. Mechanistic studies suggest that the reactions share analogous bicyclic dihydroxy intermediates but undergo different further reactions to give diverse products.

Synlett published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dabholkar, Vijay V. published the artcileMicrowave assisted synthesis of 5H-2(substituted)phenylimino-5-phenyloxazole-4-ones, Category: chlorides-buliding-blocks, the publication is Heterocyclic Letters (2015), 5(3), 419-423, database is CAplus.

A series of 5H-2(substituted)phenylimino-5-phenyloxazole-4-ones and 5H-2(substituted)phenylimino-5-phenylthiazole-4-ones was synthesized by interaction of ethyl-2-bromo-2-phenylethanoate with urea and thiourea under microwave condition resp. The technique consumes less time and gaves excellent yields. These compounds were also synthesized by conventional method. Structure of compounds were elucidated on the basis of spectral and laboratorial techniques. Further, the compound were scanned for their biol. activities.

Heterocyclic Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sarmah, N. K. published the artcileSynthesis and antimicrobial evaluation of a novel series of some s-triazine moiety, Related Products of chlorides-buliding-blocks, the publication is Journal of Applicable Chemistry (Lumami, India) (2014), 3(5), 1936-1944, 9 pp., database is CAplus.

Some new 2-[N-(3,4,5-trimethoxybenzylidino)(benzoylhydrazinoyl)-amino-4-yl]-4-(4-cyclohexylamino)-6-(arylthioureido)-1,3,5-triazines I (R = 2-OMe, 2-Me, 2-Cl, etc.) were synthesized and evaluated for their in vitro antimicrobial activity against gram pos. and gram neg. strains using micro dilution procedure. Synthesized compounds proved to be effective with MIC (mg ml^-1), among them I (R = 4-OMe, 2-O₂N, 2,4-di-O₂N, R = 2-Cl-4-O₂N) showed excellent activity against a panel of microorganisms.

Journal of Applicable Chemistry (Lumami, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bagherzadeh, Nastaran published the artcileGreen and efficient synthesis of thioureas, ureas, primary O-thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2021), 45(26), 11852-11858, database is CAplus.

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(II) chloride [ChCl][SnCl₂]₂ with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nandi, Sudipta published the artcileUrea transporter and its specific and nonspecific inhibitors: State of the art and pharmacological perspective, Application of 1-(4-Chlorophenyl)thiourea, the publication is European Journal of Pharmacology (2021), 174508, database is CAplus and MEDLINE.

Hypertension is a major concern for a wide array of patients. The traditional drugs are commonly referred as ′water pills′ and these mols. have been successful in alleviating hypertension. However, this comes at the high expense of precious electrolytes in our body. To dissipate this major adverse effect, the urea transporter inhibitors play especially important roles in maintaining the fluid balance by maintaining the concentration of urea in the inner medullary collecting duct. The purpose of this communication is to provide insights into the structural feature of these target proteins and inhibition of both urea transporter types A (UT-A) and B (UT-B) selectively and non-selectively with a special focus on the UT-A inhibitors as they are the primary target for diuresis. It was observed that a wide class of drugs such as thiourea analogs, 2,7-disubstituted fluorenones can inhibit both the protein non-selectively whereas 8-hydroxyquinoline, aminothiazolone, 1,3,5-triazine, triazolothienopyrimidine, thienoquinoline, arylthiazole, γ-sultambenzosulfonamide and 1,2,4-triazoloquinoxaline classes of compounds inhibit UT-A. The goal of this study is to highlight the important aspects that may be useful to understanding the perspectives of urea transporter inhibitors in rational drug discovery.

European Journal of Pharmacology published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharma, Prabodh Chander published the artcileDesign, Synthesis and Molecular Docking Studies of Some Thiazole Clubbed Heterocyclic Compounds as Possible Anti-infective Agents, HPLC of Formula: 3696-23-9, the publication is Letters in Organic Chemistry (2018), 15(8), 716-726, database is CAplus.

{[(Chlorophenyl)thiazolyl]arylpyrazolylmethylene}(arylimino)thiazolidinones I (R = 4-ClC₆H₄, 2-ClC₆H₄, Ph, 3-Cl-2-FC₆H₃, 4-FC₆H₄, 2,4-Cl₂C₆H₃, 2-ClC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄; R¹ = H, F, Cl, Br) were prepared and tested as antibacterial, antifungal, antimalarial, and antihelminthic agents. Potential binding modes of selected compounds with 14α-sterol demethylase and DNA gyrase subunit A were determined using mol. docking calculations The tested compounds exhibited moderate to significant antimicrobial activities. I (R = 4-O₂NC₆H₄; R¹ = Br) showed significant antimalarial activity with an IC₅₀ value of 0.59 μg/mL [as compared to chloroquine (IC₅₀ = 0.020 μg/mL) and quinine (IC₅₀ = 0.268 μg/mL)]. I (R = 2,4-Cl₂C₆H₃; R¹ = Cl) showed antihelminthic activity in earthworms with a mean time to paralysis of 19.2 ± 0.9 min and mean time to death of 31.7 ± 2.5 min.

Letters in Organic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C15H14O3, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Madhura, V. published the artcileA new route for the synthesis of 4-arylacetamido-2-aminothiazoles and their biological evaluation, Related Products of chlorides-buliding-blocks, the publication is Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences (2015), 70(7), 483-489, database is CAplus.

A series of 2-(2-amino-1,3-thiazol-4-yl)-N-phenylacetamides I [R = H, C₆H₅, 4-MeC₆H₄, etc.; R¹ = H, 2-Me, 3-Cl, 4-Cl] was synthesized in high yields via a single step reaction of ω-bromoacetoacetanilides and thiourea/phenyl thioureas. These synthesized thiazoles I were evaluated for their in vitro antibacterial, antifungal and antioxidant activities. In vitro antimicrobial evaluation of these compounds indicated their specificity towards Gram-pos. species such as S. aureus and E. faecalis. Among the tested compounds, thiazole derivatives I [R = 4-MeC₆H₄, R¹ = H; R = 3-ClC₆H₄, R¹ = H] exhibited the lowest min. inhibitory concentration values against S. aureus and E. faecalis whereas thiazole I [R = 4-MeC₆H₄; R¹ = 4-Cl] showed maximum antioxidant activity. The other compounds exhibited promising antimicrobial and moderate antioxidant activity.

Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pragathi, Yazala Jyothsna published the artcileIodine promoted synthesis and construction of aromatic thioureas from amines, Synthetic Route of 3696-23-9, the publication is European Journal of Biomedical and Pharmaceutical Sciences (2018), 5(7), 1-3, database is CAplus.

A new facile methodol. for the synthesis of thioureas by desulfurization and addition reaction of the required amines, carbon disulfide and ammonia solution in the presence of DMF solvent using iodine at room temperature The structures of the synthesized compounds were confirmed by IR, and ¹H-NMR methods. The synthetic benefits were operational simplicity, mild reaction conditions, short reaction times, high purity and yield of the products. Considering the com. importance of thioureas, it should be emphasized that implementation of the optimal synthesis of thiourea determined good intermediate for the synthesis heterocyclic compounds having good biol. activity from amines using iodine as a reagent.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics