Category: 35444-44-1

Wang, Haiyang; Guo, Chang published an article in 2019, the title of the article was Enantioselective γ-Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine.Name: Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

Chiral phosphines were found to catalyze the enantioselective asym. γ-addition of heteroaromatic compounds to allenoates in good yields with high enantiomeric ratios and regioselectivity in the presence of (S)-BINOL. Both pyrazole and imidazole could be employed in this process. The synthetic value of these γ-addition products was demonstrated by the preparation of biol. relevant mols. and structural scaffolds. Remarkably, the synthetic utility of this strategy was demonstrated through a two-step synthesis of a Janus kinase (JAK) inhibitor. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Name: Methyl 6-chloro-6-oxohexanoate

The Article related to heterocycle substituted alkenoate enantioselective preparation, heteroaromatic compound allenoate enantioselective addition chiral phosphine catalyst, allenoates, asymmetric catalysis, heterocycles, phosphines, γ-addition and other aspects.Name: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 20, 2020, Plaza, Manuel; Jandl, Christian; Bach, Thorsten published an article.COA of Formula: C7H11ClO3 The title of the article was Photochemical Deracemization of Allenes and Subsequent Chirality Transfer. And the article contained the following:

Trisubstituted allenes with a 3-(1′-alkenylidene)-pyrrolidin-2-one motif were successfully deracemized (13 examples, 86-98% ee) employing visible light (λ=420 nm) and a chiral triplet sensitizer as the catalyst (2.5 mol %). The photocatalyst likely operates by selective recognition of one allene enantiomer via hydrogen bonds and by a triplet-sensitized racemization process. Even a tetrasubstituted allene (45% ee) and a seven-membered 3-(1′-alkenylidene)-azepan-2-one (62% ee) could be enantiomerically enriched under the chosen conditions. It was shown that the axial chirality of the allenes can be converted into point chirality by a Diels-Alder (94-97% ee) or a bromination reaction (91% ee). Ring opening of the five-membered pyrrolidin-2-one was achieved without significantly compromising the integrity of the chirality axis (92% ee). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3

The Article related to allene deracemization chiral resolution chiral triplet sensitizer enantioselectivity light, chiral trisubstituted allene preparation, allenes, chiral resolution, enantioselectivity, hydrogen bonds, photochemistry, sensitizers and other aspects.COA of Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 15, 2020, Liu, Jian; Zhou, Jingxian; He, Fengjun; Gao, Liang; Wen, Yu; Gao, Lina; Wang, Ping; Kang, Di; Hu, Lihong published an article.Application of 35444-44-1 The title of the article was Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening. And the article contained the following:

Based on fragment-based virtual screening and bioisosterism strategies, novel indazoles I [R = C6H5, 4-C5H4N, 3-C4H3S etc.; X = C; Y = (CH2)3, (CH2)4, (CH2)6, etc.] and pyrazolo[3,4-b] pyridine derivatives I [R = 3-MeO-C6H4, 4-MeO-C6H4; X = N; Y = (CH2)6] as HDACs inhibitors were synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] showed better anti-proliferative activities against HCT-116 and HeLa cells than pos. control SAHA. The western blot anal. results indicated that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the mol. docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to arylindazolyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, phenylpyrazolopyridinyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, antitumor activity, fragment-based drug design, hdac, hdac inhibitors, indazole scaffold and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jerhaoui, Soufyan; Djukic, Jean-Pierre; Wencel-Delord, Joanna; Colobert, Francoise published an article in 2017, the title of the article was Stereoselective Sulfinyl Aniline-Promoted Pd-Catalyzed C-H Arylation and Acetoxylation of Aliphatic Amides.Related Products of 35444-44-1 And the article contains the following content:

Stereoselective functionalization of aliphatic C-H bonds presents a great challenge. Following this target, we disclose herein an original strategy towards direct arylation of aliphatic chains at β-methylene position based on a use of amide-sulfoxide bicoordinating directing group. Although moderate to high chiral induction (up to 9:1 d.r.) is achieved, diastereomerically pure compounds may be afforded by simple separation of diastereomeric products by silica gel chromatog. Accordingly, this reaction allows preparation of a large scope of high-value scaffolds in synthetically useful yields while recyclable character of our chiral auxiliary brings an addnl. benefit. A potential of this methodol. to build up original mols. by sequential diarylation and expedient (two step) synthesis of a biol. active compound are further disclosed. Finally a first example of stereoselective direct acetoxylation of aliphatic chains is reported. Thus, e.g., treatment of valeric acid derivative I with 4-iodonitrobenzene in presence of Pd(OAc)2 and AgOAc in PhMe/HFIP afforded arylated product II (85% conversion, 3:2 d.r.). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Related Products of 35444-44-1

The Article related to stereoselective palladium catalyzed arylation acetoxylation aliphatic amide, sulfinyl aniline directing group chiral auxiliary stereoselective arylation acetoxylation, c−h activation, aliphatic substrates, bixoordinating dg, direct arylation, sulfoxide and other aspects.Related Products of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 15, 2020, Liu, Jian; Zhou, Jingxian; He, Fengjun; Gao, Liang; Wen, Yu; Gao, Lina; Wang, Ping; Kang, Di; Hu, Lihong published an article.Application of 35444-44-1 The title of the article was Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening. And the article contained the following:

Based on fragment-based virtual screening and bioisosterism strategies, novel indazoles I [R = C6H5, 4-C5H4N, 3-C4H3S etc.; X = C; Y = (CH2)3, (CH2)4, (CH2)6, etc.] and pyrazolo[3,4-b] pyridine derivatives I [R = 3-MeO-C6H4, 4-MeO-C6H4; X = N; Y = (CH2)6] as HDACs inhibitors were synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] showed better anti-proliferative activities against HCT-116 and HeLa cells than pos. control SAHA. The western blot anal. results indicated that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the mol. docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to arylindazolyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, phenylpyrazolopyridinyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, antitumor activity, fragment-based drug design, hdac, hdac inhibitors, indazole scaffold and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2018, Sakhautdinov, I. M.; Mukhamet’yanova, A. F. published an article.Product Details of 35444-44-1 The title of the article was Cycloaddition of Bromo(chloro)methyl Ketones and Allenoates of Adipic Acid Monoesters to Fullerene C60. And the article contained the following:

Chloro- and bromoketones XCH2CO(CH2)4CO2R (R = Me, Et; X = Cl, Br) and allenoates MeO2CCH:C:CH(CH2)3CO2R (R = Me, Et) were prepared from monomethyl and monoethyl adipates and subjected to Bingel cyclopropanation and phosphine-catalyzed cycloaddition reactions, resp., with fullerene-C60 to yield cyclopropa- and cyclopentenofullerenes. The use of chloroketones in the Bingel reaction gave higher product yields than the use of bromoketones; the cycloaddition of allenoates to C60 gave products in higher yields than the Bingel cycloadditions The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Product Details of 35444-44-1

The Article related to chlorooxoheptanoate bromooxoheptanoate preparation bingel cyclopropanation reaction c60, octadienoate preparation phosphine catalyzed cycloaddition c60, cyclopropafullerene cyclopentenofullerene preparation, bingel cyclopropanation chlorooxoheptanoate bromooxoheptanoate c60, cycloaddition octadienoate c60 and other aspects.Product Details of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Chang-Liang; Fuerstner, Alois published an article in 2013, the title of the article was Formal Ring-Opening/Cross-Coupling Reactions of 2-Pyrones: Iron-Catalyzed Entry into Stereodefined Dienyl Carboxylates.COA of Formula: C7H11ClO3 And the article contains the following content:

In the presence of Fe(acac)3, α-pyrones such as 4,6-dimethyl-2-pyrone underwent stereoselective and chemoselective ring opening reactions with MeMgBr in Et2O at -60° to give (2Z)-2,4-pentadienoic acids such as (Z)-Me2C:CHCMe:CHCO2H in 68-94% yields and in 7:1->20:1 diastereoselectivities; if the reactions were warmed to ambient temperature during reaction, (E)-alkadienoic acids were isolated stereoselectively. The method was used to prepare the dodecadienamide natural product granulatamide B and a fragment of the marine natural product pateamine A. The structure of (Z)-Me2C:CHCMe:CHCO2H was determined by X-ray crystallog. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3

The Article related to alkadienoic acid stereoselective preparation, pateamine a fragment stereoselective preparation, granulatamide b stereoselective preparation, alpha pyrone stereoselective ring opening iron catalyst methyl grignard, methylhexadienoic acid mol crystal structure, cross-coupling, dienes, heterocycles, iron, natural products and other aspects.COA of Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 8, 2011, LaMarche, Matthew J.; Leeds, Jennifer A.; Amaral, Kerri; Brewer, Jason T.; Bushell, Simon M.; Dewhurst, Janetta M.; Dzink-Fox, JoAnne; Gangl, Eric; Goldovitz, Julie; Jain, Akash; Mullin, Steve; Neckermann, Georg; Osborn, Colin; Palestrant, Deborah; Patane, Michael A.; Rann, Elin M.; Sachdeva, Meena; Shao, Jian; Tiamfook, Stacey; Whitehead, Lewis; Yu, Donghui published an article.HPLC of Formula: 35444-44-1 The title of the article was Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: Identification of the cycloalkylcarboxylic acids. And the article contained the following:

4-Aminothiazolyl analogs of the antibiotic natural product GE2270 A were designed, synthesized, and optimized for their activity against Gram pos. bacterial infections. Optimization efforts focused on improving the physicochem. properties (e.g., aqueous solubility and chem. stability) of the 4-aminothiazolyl natural product template while improving the in vitro and in vivo antibacterial activity. Structure-activity relationships were defined, and the solubility and efficacy profiles were improved over those of previous analogs and GE2270 A. These studies identified novel, potent, soluble, and efficacious elongation factor-Tu inhibitors, which bear cycloalkylcarboxylic acid side chains, and culminated in the selection of development candidates amide (I) (R1 = C:O) and urethane I (R1 = OC:O). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).HPLC of Formula: 35444-44-1

The Article related to antibiotic natural product ge2270a aminothiazolyl analog synthesis structure activity, macrocyclic peptidomimetic antibacterial structure activity solubility stability pharmacokinetic, elongation factor tu inhibitor aminothiazolyl ge2270a analog cycloalkylcarboxylic acid, ge2270a acylation azidation curtius rearrangement and other aspects.HPLC of Formula: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yamazoe, Sayumi; Liu, Qingyang; McQuade, Lindsey E.; Deiters, Alexander; Chen, James K. published an article in 2014, the title of the article was Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides.SDS of cas: 35444-44-1 And the article contains the following content:

Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-selective illumination have been used to sequentially inactivate organismal gene function. The efficacy of these reverse-genetic chem. probes has been demonstrated in zebrafish embryos, and these reagents have been employed to examine the mechanisms of mesoderm patterning. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to wavelength selective caged morpholino oligonucleotide preparation gene targeting zebrafish, mesoderm patterning gene targeting wavelength selective caged morpholino oligonucleotide, nb deacm mn bifunctional linker caged morpholino oligonucleotide, antisense agents, cage compounds, developmental biology, gene expression, oligonucleotides and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2018, Sakhautdinov, I. M.; Mukhamet’yanova, A. F. published an article.Product Details of 35444-44-1 The title of the article was Cycloaddition of Bromo(chloro)methyl Ketones and Allenoates of Adipic Acid Monoesters to Fullerene C60. And the article contained the following:

Chloro- and bromoketones XCH2CO(CH2)4CO2R (R = Me, Et; X = Cl, Br) and allenoates MeO2CCH:C:CH(CH2)3CO2R (R = Me, Et) were prepared from monomethyl and monoethyl adipates and subjected to Bingel cyclopropanation and phosphine-catalyzed cycloaddition reactions, resp., with fullerene-C60 to yield cyclopropa- and cyclopentenofullerenes. The use of chloroketones in the Bingel reaction gave higher product yields than the use of bromoketones; the cycloaddition of allenoates to C60 gave products in higher yields than the Bingel cycloadditions The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Product Details of 35444-44-1

The Article related to chlorooxoheptanoate bromooxoheptanoate preparation bingel cyclopropanation reaction c60, octadienoate preparation phosphine catalyzed cycloaddition c60, cyclopropafullerene cyclopentenofullerene preparation, bingel cyclopropanation chlorooxoheptanoate bromooxoheptanoate c60, cycloaddition octadienoate c60 and other aspects.Product Details of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics