Category: 35444-44-1

On June 18, 2020, Conway, Lorna; Riccio, Anna; Santoro, M. Gabriella; Evans, Paul published an article.Related Products of 35444-44-1 The title of the article was Synthesis of the 4-aza cyclopentenone analogue of Δ12,14-15-deoxy-PGJ2 and S-cysteine adducts. And the article contained the following:

The synthesis of a series of 4-aza cross-conjugated cyclopentenones, inspired by the natural prostaglandin Δ12,14-15-deoxy-PGJ2 (5, I) is described. Using the 4-aza cyclopentenone 7 (II), the installation of the α-side chain was performed using N-functionalization, following a Boc-deprotection. The ω-side chain was then installed through a Baylis-Hillman type aldol reaction with trans-2-octenal. This afforded 11 (III), the aza-analog of 5. With this prostaglandin analog in hand, a series of thiol adducts (14-16, IV: R = NHAc, R’ = CO2Me; R = NHAc, R’ = CO2Et; R = NHBoc, R’ = CO2Me, resp.) were prepared Included are activities for compounds 11 and 14-16 in relation to inhibition of the transcription factor NF-κB. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Related Products of 35444-44-1

The Article related to aza cyclopentenone prostaglandin deoxy pgj2 analog synthesis, thiol analog prostaglandin deoxy pgj2 analog synthesis, nf kappa b inhibitor prostaglandin analog thiol adduct and other aspects.Related Products of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 24, 2011, Ano, Yusuke; Tobisu, Mamoru; Chatani, Naoto published an article.Quality Control of Methyl 6-chloro-6-oxohexanoate The title of the article was Palladium-catalyzed direct ethynylation of C(sp3)-H bonds in aliphatic carboxylic acid derivatives. And the article contained the following:

The first catalytic alkynylation of unactivated C(sp3)-H bonds has been accomplished. The method allows for the straightforward introduction of an ethynyl group into aliphatic acid derivatives under palladium catalysis. This new reaction can be applied to the rapid elaboration of complex aliphatic acids, for example, via azide/alkyne cycloaddition The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Quality Control of Methyl 6-chloro-6-oxohexanoate

The Article related to quinolinyltriisopropylsilylpentynamide derivative preparation, quinolinylamide preparation bromoalkyne alkynylation palladium catalyst, acid chloride aminoquinoline amidation and other aspects.Quality Control of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 15, 2014, Xiao, Dong; Zhu, Xiaohong; Yu, Younong; Shao, Ning; Wu, Jie; McCormick, Kevin D.; Dhondi, Pawan; Qin, Jun; Mazzola, Robert; Tang, Haiqun; Rao, Ashwin; Siliphaivanh, Phieng; Qiu, Hongchen; Yang, Xiaoxin; Rivelli, Maria; Garlisi, Charles G.; Eckel, Steve; Mukhopadhyay, Gitali; Correll, Craig; Rindgen, Diane; Aslanian, Robert; Palani, Anandan published an article.Electric Literature of 35444-44-1 The title of the article was Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties. And the article contained the following:

Isoxazoles are frequently used amide isosteres, as shown in the context of discovery of CRTh2 antagonists from amide I to isoxazole II. However, persistent agonism and poor solubility in isoxazole series presented challenges to its further development. Based on the concept of quality by design (QbD), 5,5-disubstituted isoxazolines III (R1, R2 = alkyl, aryl) were introduced. The chirality at 5 position of isoxazolines controlled the switch between two modes of actions, which led to a novel series of pure antagonists. This non-planar motif also conferred a change of shape of these mols., which avoided flat structures and improved their phys. properties. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Electric Literature of 35444-44-1

The Article related to isoxazoline amide isostere crth2 antagonist design, agonism/antagonism switch, amide isostere, crth(2) antagonists, drug-like properties, isoxazolines, quality by design (qbd) and other aspects.Electric Literature of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jinying; Sang, Zitai; Jiang, Youjun; Yang, Chao; He, Linhong published an article in 2019, the title of the article was Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer.Application of 35444-44-1 And the article contains the following content:

Fifty-eight quinazoline-based compounds were designed and synthesized based on the structural optimizations from the lead compound 23bb in an attempt to search for more potent dual HDAC1 and HDAC6 inhibitors. Among them, 32c (HDAC1, IC50 = 31.10 ± 0.37 nM; HDAC6, IC50 = 16.15 ± 0.62 nM) and 32d (HDAC1, IC50 = 37.00 ± 0.24 nM; HDAC6, IC50 = 35.00 ± 0.71 nM) were not only identified as potent dual-acting HDAC1 and HDAC6 inhibitors with over 10-fold selectivity to the other HDACs, but also displayed activities in tubulin acetylation and histone H3 acetylation induction. Importantly, both of them displayed strong antiproliferative activities against various tumor cell lines in vitro with IC50 values <40 nM, especially for hematol. tumors cells (U266 and RPMI8226, IC50 < 1 nM), which were even better than 23bb and SAHA. Furthermore, 32c showed a significant tumor growth inhibition (antitumor rate = 63.98%, p < 0.05) in the resistant MCF-7/ADR xenograft model without any obvious body weight changes and abnormal behaviors. The authors' findings validate that 32c is a potent dual inhibitor of HDAC1/6 that can be an efficacious treatment for breast cancer with Adriamycin resistance. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to quinazoline derivative hdac1 hdac6 inhibitor anticancer agent, design synthesis biol evaluation quinazoline derivative dual hdac1 hdac6, hdac, sar study, cancer, dual inhibitors and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 11, 2017, Ocasio, Cory A.; Sansook, Supojjanee; Jones, Rhiannon; Roberts, Justin M.; Scott, Thomas G.; Tsoureas, Nikolaos; Coxhead, Peter; Guille, Matthew; Tizzard, Graham J.; Coles, Simon J.; Hochegger, Helfrid; Bradner, James E.; Spencer, John published an article.SDS of cas: 35444-44-1 The title of the article was Pojamide: An HDAC3-Selective Ferrocene Analogue with Remarkably Enhanced Redox-Triggered Ferrocenium Activity in Cells. And the article contained the following:

A ferrocene containing ortho-aminoanilide, N1-(2-aminophenyl)-N8-ferrocenyloctanediamide, 2b (Pojamide) displayed nanomolar potency vs. HDAC3. Compared to RGFP966, a potent and selective HDAC3 inhibitor, Pojamide displayed superior activity in HCT116 colorectal cancer cell invasion assays; however, TCH106 and Romidepsin, potent HDAC1 inhibitors, outperformed Pojamide in cellular proliferation and colony formation assays. Together, these data suggest that HDAC 1 and 3 inhibition is desirable to achieve maximum anticancer benefits. Addnl., the authors explored Pojamide-induced redox-pharmacol. Indeed, treating HCT116 cells with Pojamide, SNP (Na nitroprusside) and glutathione (GSH) led to greatly enhanced cytotoxicity and DNA damage attributed to activation to an Fe(III) species. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to pojamide ferrocene analog preparation cellular ferrocenium activity anticancer agent, ferrocenyloctanediamide ferrocene containing ortho aminoanilide preparation anticancer agent and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 9, 2013, Peng, Bo; Geerdink, Danny; Maulide, Nuno published an article.SDS of cas: 35444-44-1 The title of the article was Electrophilic Rearrangements of Chiral Amides: A Traceless Asymmetric α-Allylation. And the article contained the following:

A one-pot protocol for the asym. α-allylation reaction is reported relying on a key efficient asym. Claisen rearrangement, triggered by electrophilic activation of chiral pseudoephedrine amides. Subsequent reduction or hydrolysis of the resulting iminium ions provides highly enantioenriched α-allylic aldehydes or carboxylic acids in a traceless manner. Compared to traditional alternatives which make use of strongly basic conditions, the work presented herein displays unprecedented functional group tolerance. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to chiral pseudoephedrine amide electrophilic claisen rearrangement asym allylation, allylic aldehyde stereoselective preparation, carboxylic acid allylic stereoselective preparation and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bunik, Victoria I.; Artiukhov, Artem V.; Kazantsev, Alexey V.; Aleshin, Vasily A.; Boyko, Alexandra I.; Ksenofontov, Alexander L.; Lukashev, Nikolay V.; Graf, Anastasia V. published an article in 2022, the title of the article was Administration of phosphonate inhibitors of dehydrogenases of 2-oxoglutarate and 2-oxoadipate to rats elicits target-specific metabolic and physiological responses.SDS of cas: 35444-44-1 And the article contains the following content:

In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) and 2-oxoadipate (OADH, encoded by DHTKD1), resp. To assess the selectivity in animals, the effects of SP, AP, and their membrane-penetrating tri-Et esters (TESP and TEAP) on the rat brain metabolism and animal physiol. are compared. Opposite effects of the OGDH and OADH inhibitors on activities of OGDH, malate dehydrogenase, glutamine synthetase, and levels of glutamate, lysine, citrulline, and carnosine are shown to result in distinct physiol. responses. ECG is changed by AP/TEAP, whereas anxiety is increased by SP/TESP. The potential role of the ester moiety in the uncharged precursors of the 2-oxo acid dehydrogenase inhibitors is estimated TMAP is shown to be less efficient than TEAP, in agreement with lower lipophilicity of TMAP vs. TEAP. Non-monotonous metabolic and physiol. impacts of increasing OADH inhibition are revealed. Compared to the non-treated animals, strong inhibition of OADH decreases levels of tryptophan and beta-aminoisobutyrate and activities of malate dehydrogenase and pyruvate dehydrogenase, increasing the R-R interval of ECG. Thus, both metabolic and physiol. actions of the OADH-directed inhibitors AP/TEAP are different from those of the OGDH-directed inhibitors SP/TESP, with the Et ester being more efficient than Me ester. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to phosphonate oxoglutarate oxoadipate dehydrogenase inhibitor, 2-oxoadipate dehydrogenase, 2-oxoglutarate dehydrogenase, dhtkd1, phosphonate analog of 2-oxo acid, regulation of brain metabolism and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 15, 2021, Chai, Xin-Yue; Xu, Hui-Bei; Dong, Lin published an article.SDS of cas: 35444-44-1 The title of the article was Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C-H Activation. And the article contained the following:

An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biol. properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C-H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Addnl., a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to indole preparation, acyl indole bromoalkyne alkynylation carbonylation iridium catalyst, alkynylation, carbonylation, cascade reactions, iridium, multifunctional indole derivatives, multistep c−h activation and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2015, Hu, Peng; Bach, Thorsten published an article.SDS of cas: 35444-44-1 The title of the article was Synthesis of Alkyl-Substituted Pyridines by Directed Pd(II)-Catalyzed C-H Activation of Alkanoic Amides. And the article contained the following:

A general alkylation protocol for substituted iodopyridines was developed, e.g., I, (32 examples, 44-97% yield). The reaction is based on the Pd(II)-catalyzed C-H activation of 8-aminoquinoline-derived alkanoic amides and it employs a catalyst cocktail of Pd(OAc)2 (10 mol%), NaI (30 mol%), and (BuO)2POOH (20 mol%), with Ag2CO3 as base. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to alkyl pyridine aminoquinoline alkanoic amide preparation, infractin preparation, dihydrocanthinone preparation, iodo carboline alkylation, aminoquinoline alkanoic amide iodopyridine alkylation palladium catalyst and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 20, 2012, Uthuppu, Basil; Aamand, Jens; Joergensen, Claus; Kiersgaard, Spire M.; Kostesha, Natalie; Jakobsen, Mogens Havsteen published an article.Recommanded Product: Methyl 6-chloro-6-oxohexanoate The title of the article was Optimization of an immunoassay of 2,6-dichlorobenzamide (BAM) and development of regenerative surfaces by immunosorbent modification with newly synthesized BAM hapten library. And the article contained the following:

Dichlobenil is an extensively used herbicide worldwide which is transformed to the mobile 2,6-dichlorobenzamide (BAM) in soil. BAM has been found in many European groundwater resources that are exploited for drinking water. Currently, immunoassay based monitoring technique (plate based ELISA) is being employed to quant. detect BAM in water samples. As a starting step of developing immunoassay based on-site monitoring systems for pesticide anal., the heterogeneous BAM immunoassay is optimized in terms of surface (polymer) regeneration. We synthesized a small library of BAM haptens which are slightly different in chem. structures, immobilized them on surfaces and compared the affinity constants of the monoclonal antibody HYB 273 towards them. By using ELISA technol., we also checked the regeneration potentials of the haptens, correlated these results to the affinity constants and found that BAM hapten with an intermediate affinity has better regeneration potential. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: Methyl 6-chloro-6-oxohexanoate

The Article related to optimization immunoassay dichlorobenzamide regenerative surface immunosorbent modification synthesized hapten, immunoassay dichlorobenzamide regenerative surface immunosorbent modification synthesized hapten library and other aspects.Recommanded Product: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics