Category: 35444-44-1

Kachbi Khelfallah, S.; Monteil, M.; Deschamp, J.; Gager, O.; Migianu-Griffoni, E.; Lecouvey, M. published an article in 2015, the title of the article was Synthesis of novel polymerizable molecules bearing bisphosphonate.Application In Synthesis of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

In recent years, bisphosphonate chem. has undergone an exponential growth due to the potential applications of these compounds in medicine and nanobiomaterial research. In this paper authors describe the synthesis methods of different families of methacrylic monomers bearing a bisphosphonate with varying lengths of the chain, PEG linkers and more or less hydrolyzable functions such as ester, carbamate or amide. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application In Synthesis of Methyl 6-chloro-6-oxohexanoate

The Article related to methacrylic monomer bisphosphonate nanobiomaterial ester carbamate amide, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Application In Synthesis of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2021, Leite, Irena; Andrianov, Victor; Zelencova-Gopejenko, Diana; Loza, Einars; Kazhoka-Lapsa, Iveta; Domracheva, Ilona; Stoyak, Marta; Chlopicki, Stefan; Kalvins, Ivars published an article.Reference of Methyl 6-chloro-6-oxohexanoate The title of the article was Aziridine-2-carboxylic acid derivatives and its open-ring isomers as a novel PDIA1 inhibitors. And the article contained the following:

Acyl derivatives of aziridine-2-carboxylic acid have been synthesized and tested as PDIA1 inhibitors. Calculations of charge value and distribution in aziridine ring system and some alkylating agents were performed. For the first time was found that acyl derivatives of aziridine-2-carboxylic acid are weak to moderately active PDIA1 inhibitors. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Reference of Methyl 6-chloro-6-oxohexanoate

The Article related to aziridine carboxylic acid preparation pdia1 inhibitor, Heterocyclic Compounds (One Hetero Atom): Ethylene Sulfides and Other 3-Membered Rings and other aspects.Reference of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 5, 2018, Chen, Hui; Guo, Liangliang; Yu, Shouyun published an article.Formula: C7H11ClO3 The title of the article was Primary, Secondary, and Tertiary γ-C(sp3)-H Vinylation of Amides via Organic Photoredox-Catalyzed Hydrogen Atom Transfer. And the article contained the following:

An efficient strategy for primary, secondary and tertiary aliphatic γ-C(sp3)-H vinylation of amides with alkenylboronic acids is reported. These reactions are catalyzed by visible-light organic photoredox agents. Regioselective γ-C(sp3)-H vinylation of amides is controlled by a 1,5-hydrogen atom transfer of an amidyl radical generated in situ. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Formula: C7H11ClO3

The Article related to aliphatic amide alkenylboronic acid vinylation photoredox hydrogen atom transfer, unsaturated amide stereoselective preparation, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 18, 2015, Zhou, Xin; Yu, Changjiang; Feng, Zeya; Yu, Yang; Wang, Jun; Hao, Erhong; Wei, Yun; Mu, Xiaolong; Jiao, Lijuan published an article.Name: Methyl 6-chloro-6-oxohexanoate The title of the article was Highly Regioselective α-Chlorination of the BODIPY Chromophore with Copper(II) Chloride. And the article contained the following:

A general and efficient method for α-chlorination of 4,4′-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) was developed using CuCl2 as chlorination reagent. The reaction is characterized by complete 3/5-positions of BODIPY regioselectivity. This unusual highly regioselective α-halogenation of BODIPY is in sharp contrast to previously reported halogenation methods which preferred to occur first at the 2,6-positions of BODIPY. This approach provides a straightforward, facile, and economical route to 3- and/or 5-chloroBODIPYs with various meso-groups (H, alkyl, and aryl) and their derivatives The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Name: Methyl 6-chloro-6-oxohexanoate

The Article related to regioselective chlorination bodipy copper chloride, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Name: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Min; Hao, Erhong; Xu, Yajun; Zhang, Shengzhou; Zhu, Hongnian; Wang, Qi; Yu, Changjiang; Jiao, Lijuan published an article in 2012, the title of the article was One-pot efficient synthesis of pyrrolylBODIPY dyes from pyrrole and acyl chloride.Quality Control of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

A facile one-pot synthesis of pyrrolylBODIPY dyes from acid chloride and excess pyrrole was developed through oxidative nucleophilic substitution of in situ formed dipyrromethene with pyrrole. Fluorescence imaging of living cells by using selected dyes was successfully demonstrated. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Quality Control of Methyl 6-chloro-6-oxohexanoate

The Article related to pyrrolylbodipy dye pyrrole acyl chloride synthesis fluorescent imaging, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Quality Control of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Patel, Hiren; Chuckowree, Irina; Coxhead, Peter; Guille, Matthew; Wang, Minghua; Zuckermann, Alexandra; Williams, Robin S. B.; Librizzi, Mariangela; Paranal, Ronald M.; Bradner, James E.; Spencer, John published an article in 2014, the title of the article was Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors.Reference of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

Fragments based on the VEGFR2i Semaxanib (SU5416, vascular endothelial growth factor receptor-2 inhibitor) and the HDACi (histone deacetylase inhibitor) SAHA (suberanilohydroxamic acid) have been merged to form a range of low mol. weight dual action hybrids. Vindication of this approach is provided by SAR, docking studies, in vitro cancer cell line and biochem. enzyme inhibition data as well as in vivo Xenopus data for the lead mol. I. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Reference of Methyl 6-chloro-6-oxohexanoate

The Article related to oxoindoline zinc binding group hybrid preparation anticancer docking, kinase histone deacetylase inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2011, Zhang, Bao-hua; Shi, Lan-xiang published an article.COA of Formula: C7H11ClO3 The title of the article was New synthesis technology of N-[2-(3,4-dimethoxyphenyl)ethyl]-N’-(2-phenylethyl)-1,6-hexanediamide. And the article contained the following:

One new synthesis technol. of N-[2(3,4-dimethoxyphenyl)ethyl]-N’-(2-phenylethyl)-1,6-hexanediamide was designed through chlorination, condensation, hydrolysis, chlorination and condensation reaction with hexanedioic acid monomethyl ester as raw material. The technol. has the advantages of simple operation, easy separation and easy purification, while the yield of the compound is up to 75.2% and it is applicable to large-scale industrial production The structure of the final product is characteried by 1H NMR. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3

The Article related to dimethoxyphenylethyl phenylethyl hexanediamide chlorination condensation hydrolysis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.COA of Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lau, Garrett C.; Sather, Nicholas A.; Sai, Hiroaki; Waring, Elizabeth M.; Deiss-Yehiely, Elad; Barreda, Leonel; Beeman, Emily A.; Palmer, Liam C.; Stupp, Samuel I. published an article in 2018, the title of the article was Oriented Multiwalled Organic-Co(OH)2 Nanotubes for Energy Storage.Category: chlorides-buliding-blocks And the article contains the following content:

In energy storage materials, large surface areas and oriented structures are key architecture design features for improving performance through enhanced electrolyte access and efficient electron conduction pathways. Layered hydroxides provide a tunable materials platform with opportunities for achieving such nanostructures via bottom-up syntheses. These nanostructures, however, can degrade in the presence of the alk. electrolytes required for their redox-based energy storage. A layered Co(OH)2-organic hybrid material that forms a hierarchical structure consisting of micrometer-long, 30 nm diameter tubes with concentric curved layers of Co(OH)2 and 1-pyrenebutyric acid is reported. The nanotubular structure offers high surface area as well as macroscopic orientation perpendicular to the substrate for efficient electron transfer. Using a comparison with flat films of the same composition, it is demonstrated that the superior performance of the nanotubular films is the result of a large accessible surface area for redox activity. It is found that the organic mols. used to template nanotubular growth also impart stability to the hybrid when present in the alk. environments necessary for redox function. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Category: chlorides-buliding-blocks

The Article related to oriented multiwalled organic cobalt hydroxide nanotube energy storage, Electrochemical, Radiational, and Thermal Energy Technology: Energy Handling, Transport, and Storage and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 13, 2012, Shukla, Krupa; Ferraris, Dana V.; Thomas, Ajit G.; Stathis, Marigo; Duvall, Bridget; Delahanty, Greg; Alt, Jesse; Rais, Rana; Rojas, Camilo; Gao, Ping; Xiang, Yan; Dang, Chi V.; Slusher, Barbara S.; Tsukamoto, Takashi published an article.Electric Literature of 35444-44-1 The title of the article was Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors. And the article contained the following:

Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) that has served as a mol. probe to determine the therapeutic potential of GLS inhibition. In an attempt to identify more potent GLS inhibitors with improved drug-like mol. properties, a series of BPTES analogs were synthesized and evaluated. The structure-activity relationship (SAR) studies revealed that some truncated analogs retained the potency of BPTES, presenting an opportunity to improve its aqueous solubility The analog I exhibited similar potency and better solubility relative to BPTES and attenuated the growth of P493 human lymphoma B cells in vitro as well as in a mouse xenograft model. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Electric Literature of 35444-44-1

The Article related to sulfide thiadiazolylethyl phenylacetamido analog preparation glutaminase inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 15, 2014, Yin, Kai-Hao; Hsieh, Yi-Han; Sulake, Rohidas S.; Wang, Su-Pei; Chao, Jui-I.; Chen, Chinpiao published an article.SDS of cas: 35444-44-1 The title of the article was Optimization of gefitinib analogues with potent anticancer activity. And the article contained the following:

The interactions of gefitinib (Iressa) in epidermal growth factor receptor (EGFR) are hydrogen bonding and van der Waals forces through quinazoline and aniline rings. However the morpholino group of gefitinib is poorly ordered due to its weak electron d. A series of novel piperazino analogs of gefitinib where morpholino groups substituted with various piperazino groups were designed and synthesized. Most of them indicated significant anti-cancer activities against human cancer cell lines. In particular, three compounds alkyl 4-(4-(3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)propyl)piperazin-1-yl)-4-oxobutanoate (alkyl = decyl, undecyl, dodecyl) showed excellent potency against cancer cells. Convergent synthetic approach has been developed for the synthesis of gefitinib intermediate which can lead to gefitinib as well as numerous analogs. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to piperazino analog gefitinib anticancer activity, quinazolinyloxypropylpiperazinylbutanoate preparation anticancer activity, a549, anti-cancer, egfr, gefitinib, iressa, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics