349-88-2 Archives - Page 8 of 10 - Chlorides-buliding-blocks

Hang, Zhaojun team published research on Tetrahedron Letters in 2022 | 349-88-2

COA of Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. COA of Formula: C6H4ClFO2S.

Hang, Zhaojun;Tong, Xiaowei;Li, Zuowa;Wang, Zhao-yan;Xue, Weihua research published 《 A practical method for N-cyanation of secondary amines and sulfonamides》, the research content is summarized as follows. Cyanamides are an important class of mols. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1,2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.

COA of Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Han, Shuwen team published research on Bioorganic Chemistry in 2022 | 349-88-2

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Han, Shuwen;Zhou, Wei;Zhuang, Chunlin;Chen, Fener research published 《 Structure-Based design of Marine-derived Meridianin C derivatives as glycogen synthase kinase 3β inhibitors with improved oral bioavailability: From aminopyrimidyl-indoles to the sulfonyl analogues》, the research content is summarized as follows. Glycogen synthase kinase 3β (GSK-3β) has become an attractive target for the treatment of diabetes. Compound I is an indole-based GSK-3β inhibitor designed from the Meridianin C, a marine natural product (MNP) isolated from Aplidium meridianum. However, this compound has a moderate inhibitory activity toward GSK-3β (IC₅₀ = 24.4 μM), moderate glucose uptake (38%), and especially, a low oral bioavailability (F = 11.4%). In the present study, applying the structure-based design strategy, a series of derivatives modified on the indole moiety were synthesized based on the lead compound I, followed by evaluating their cytotoxic activity, antihyperglycemic activity, and kinase inhibitory activity. Among this series, compound 6x with a sulfonyl group displayed the highest glucose uptake (83.5%) in muscle L6 cells, showing much higher inhibitory activity against GSK-3β (IC₅₀ = 5.25 μM). Mol. docking indicated that compound 6x was properly inserted into the ATP-binding binding pocket of GSK-3β with a higher docking score (-8.145 kcal/mol) compared with that of compound I (-6.950 kcal/mol), interpreting the higher kinase inhibitory activity toward GSK-3β. Remarkably, compound 6x showed favorable drug-like properties, including significantly better oral bioavailability (F = 47.4%) and no two-week acute toxicity at a dose of 1g/kg. Our findings suggest that these MNP-derived sulfonyl indole derivatives could be used as lead compounds for the development of anti-hyperglycemic drugs.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Yuting team published research on Organic Chemistry Frontiers in | 349-88-2

Quality Control of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Quality Control of 349-88-2.

Gao, Yuting;Sun, Yang;Fang, Xianfu;Zhao, Guixian;Li, Xufeng;Zhang, Gong;Li, Yangfeng;Li, Yizhou research published 《 Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries》, the research content is summarized as follows. The DNA-encoded chem. library (DEL) technol. is a novel drug discovery tool, benefiting from its large number of compound collections with chem. space coverage. Vinyl sulfone is a privileged functional group, eliciting diverse pharmacol. activities as the covalent warhead. In this report, we incorporated vinyl sulfone into the DEL chem. field by developing a mild and efficient DNA-compatible method starting from simple sodium sulfinates and DNA-conjugated alkenes, affording a broad substrate scope with moderate-to-excellent conversions. Further chem. transformations including the thiol-Michael addition reaction, together with enzymic ligation, were also successfully implemented to demonstrate the feasibility of this DNA-compatible synthesis in DEL construction.

Quality Control of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gong, Bozhen team published research on Organic & Biomolecular Chemistry in 2022 | 349-88-2

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Gong, Bozhen;Zhu, Haibo;Yang, Liu;Wang, Haifeng;Fan, Qiangwen;Xie, Zongbo;Le, Zhanggao research published 《 Base-promoted synthesis of diarylsulfones from sulfonyl hydrazines and diaryliodonium salts》, the research content is summarized as follows. An efficient and concise method for the synthesis of diaryl sulfones ArS(O)₂Ar¹ [Ar = Ph, 4-MeC₆H₄, 4-NCC₆H₄, etc.; Ar¹ = Ph, 4-FC₆H₄, 3-MeC₆H₄, etc.] via metal-free sulfonylation from sulfonyl hydrazines with sym. or unsym. diaryliodonium salts using n-PrOH as the solvent was developed with high selectivity. Using n-PrOH as the solvent, diaryl sulfones are formed even on a gram scale.

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fu, Jiahui team published research on Synthesis in 2022 | 349-88-2

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Fu, Jiahui;Cai, Xingxing;Liu, Yihuo;Li, Jinghua;Cheng, Dongping;Xu, Xiaoliang research published 《 Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-Light-Mediated Cyclization of Acryloylbenzamides with Alkylboronic Acids, Arylsulfonyl Hydrazides and Oxime Esters》, the research content is summarized as follows. An efficient visible-light-mediated tandem reaction of acryloylbenzamides with alkylboronic acids, arylsulfonyl hydrazides and oxime esters was developed. The reaction proceeds via radical addition and cyclization to gave various isoquinoline-1,3(2H,4H)-diones I [R¹ = H, 8-Me, 6-MeO, etc.; R² = Me, Et, Ph, etc.; R³ = cyclohexyl, Ts, 3-cyanopropyl, etc.] in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fang, Yang team published research on European Journal of Organic Chemistry in 2022 | 349-88-2

Quality Control of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Quality Control of 349-88-2.

Fang, Yang;Xu, Dongping;Yu, Yingliang;Tang, Rumeng;Dai, Shuaishuai;Wang, Zhenghua;Zhang, Wu research published 《 Controlled Synthesis of β-Keto Sulfones and Vinyl Sulfones under Electrochemical Oxidation》, the research content is summarized as follows. Selective oxosulfonylation and sulfonylation of alkenes with sulfinates was developed via anodic oxidation in an undivided cell to provide β-keto sulfones I [R¹ = 2-Me, 4-OMe, 3-Cl, etc.; R² = Et, Ph, 2-naphthyl, etc.] and vinyl sulfones II [Ar = Ph, 2-pyridyl, 3-MeC₆H₄, etc.; R³ = Et, Ph, 3-MeC₆H₄, etc.; R⁴ = H, OH] with good to excellent yields in the absence of any transition metal catalyst and oxidants was reported.

Quality Control of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Duan, Wen-Di team published research on Journal of Molecular Structure in 2022 | 349-88-2

SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Duan, Wen-Di;Cao, Jing-Yu;Cai, Chao-Yun;Yang, Zhi-Rong;Cui, Jin-Feng;Lan, Tian;Chen, You-Nan;Wang, Jing;Rao, Yong;Huang, Zhi-Shu;Wang, Bo research published 《 Xanthone sulfonamide derivatives-A novel series of α-glucosidase inhibitors with different inhibitory types》, the research content is summarized as follows. In order to discover highly potent α-glucosidase inhibitors, 20 xanthone-benzenesulfonamide derivatives I (R = H, Me, Br, etc.) and II were designed and synthesized. As expected, most of these derivatives exhibited good to excellent inhibitory activities, the IC₅₀ values of these xanthone sulfonamides varied from 0.4 ± 0.05 to 52.2 ± 2.1μM. Especially, compound I (R = OMe) showed the most potent activity (IC₅₀ = 0.4μM), with 111-fold more potent than the pos. control 1-deoxynojirimycin (DNJ), which is a leap compared to authors previous xanthone compound It was noteworthy that these derivatives can be competitive, noncompetitive or uncompetitive inhibitors, while these inhibitory types differed by the alteration of the substituents on the benzene ring of benzenesulfonamide. To give insight into this interesting effect, further docking study was performed, indicating the flexible conformations introduced by the sulfonamide structure affect the binding site and binding mode of these compounds with the enzyme. Furthermore the uncompetitive inhibitors showed significantly stronger binding interactions with the enzyme-substrate complex than the enzyme. Addnl., the competitive inhibitor I (R = NH₂) (1μM) exhibited a similar glucose-level decreasing and glucose up-take increasing effect compared to DNJ (5μM), the pos. control in HepG2 cells at five-fold lower concentration, revealing that this compound has promising hypoglycemic effect at the cellular level.

SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deng, Rui team published research on Journal of the American Chemical Society in 2022 | 349-88-2

Reference of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Reference of 349-88-2.

Deng, Rui;Wu, Shuquan;Mou, Chengli;Liu, Jianjian;Zheng, Pengcheng;Zhang, Xinglong;Chi, Yonggui Robin research published 《 Carbene-Catalyzed Enantioselective Sulfonylation of Enone Aryl Aldehydes: A New Mode of Breslow Intermediate Oxidation》, the research content is summarized as follows. A carbene-catalyzed sulfonylation reaction between enone aryl aldehydes and sulfonyl chlorides is disclosed. The reaction effectively installs sulfone moieties in a highly enantioselective manner to afford sulfone-containing bicyclic lactones. The sulfonyl chloride behaves both as an oxidant and a nucleophilic substrate (via its reduced form) in this N-heterocyclic carbene (NHC)-catalyzed process. The NHC catalyst provides both activation and stereoselectivity control on a very remote site of enone aryl aldehyde substrates. Water plays an important role in modulating catalyst deactivation and reactivation routes that involve reactions between NHC and sulfonyl chloride. Exptl. studies and DFT calculations suggest that an unprecedented intermediate and a new oxidation mode of the NHC-derived Breslow intermediate are involved in the new asym. sulfonylation reaction.

Reference of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Das, Sumit team published research on Chemical Communications (Cambridge, United Kingdom) in 2022 | 349-88-2

SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Das, Sumit;Roy, Shantonu;Bhowmik, Arup;Sarkar, Writhabrata;Mondal, Imtiaj;Mishra, Aniket;Saha, Shubhra Jyoti;Karmakar, Sudip;Deb, Indubhusan research published 《 A radical-radical cross-coupling reaction of xanthene with sulfonyl hydrazides: facile access to xanthen-9-sulfone derivatives》, the research content is summarized as follows. A straightforward strategy for direct incorporation of sulfonyl units into a xanthene moiety for accessing xanthen-9-sulfone derivatives I (R = n-Bu, Cl, Ph, etc.; R¹ = H, Me, F, Br, etc.; R² = H, OMe; R³ = H; R²R³ = -CH=CH-CH=CH-) in good to excellent yields has been established via metal-free radical-radical cross-coupling reaction of xanthenes II and sulfonyl hydrazides RS(O)₂NHNH₂. Using easily accessible starting materials, this methodol. proceeds efficiently with a high degree of functional group compatibility and with a wide scope of both xanthenes II and sulfonyl hydrazides under operationally simple reaction conditions. Mechanistic investigations revealed that sulfonyl radicals could be generated from sulfonyl hydrazides in the presence of TBHP under an oxygen atm.

SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dai, Linlin team published research on ChemMedChem in 2022 | 349-88-2

SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. SDS of cas: 349-88-2.

Dai, Linlin;Wang, Luyao;Tan, Cheng;Cai, Jun;Shen, Hongsheng;Zhang, Ting;Zhi, Shuang;Yang, Zibo;Hu, Yunhui;Zhao, Xiumei;Li, Dongdong research published 《 Sophoridine Derivatives Induce Apoptosis and Autophagy to Suppress the Growth of Triple-Negative Breast Cancer through Inhibition of mTOR Signaling》, the research content is summarized as follows. In order to improve the antitumor potency and therapeutic margins of natural product sophoridine, its novel nitrogen mustard carbamate derivatives were designed and synthesized. In screening their in vitro activity, we found all the tested compounds were more potent against the highly aggressive triple-neg. breast cancer cell line MDA-MB-231. Cellular functional assays showed that representative compounds could induce G1-phase arrest and trigger apoptosis, evidenced by the alteration of Bax, Bcl-2, caspase-3 and PARP levels. Furthermore, these compounds significantly enhanced the autophagic flux with increased expression of LC3-II and Beclin-1, as well as decreased level of p62, which may attribute to simultaneously inhibition of the phosphorylation of p70S6K, 4E-BP1 and AKT, the key substrates of the mTOR signaling pathway. In vivo, two compounds revealed potent antitumor activity in mice bearing MDA-MB-231. Altogether, our work describes novel leads to yield more potent chemotherapeutics against triple-neg. breast cancers, possibly mesenchymal stem-like subtype.

SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics