Category: 3386-33-2

Electric Literature of 3386-33-2,Some common heterocyclic compound, 3386-33-2, name is 1-Chlorooctadecane, molecular formula is C18H37Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

After dropping 173.4 g (0.6 mol) of 1-chlorooctadecane thereinto within about 15 minutes, the mixture was allowed to stand overnight under stirring at room temperature. Then the reaction mixture was washed with 500 ml of isopropyl ether and thus crystals of acryloyloxyethyl-N,N-dimethyloctadecylammonium chloride were obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chlorooctadecane, its application will become more common.

Reference:
Patent; Hisamitsu Pharmaceutical Co, Inc.; US5665348; (1997); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 3386-33-2, name is 1-Chlorooctadecane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3386-33-2, Computed Properties of C18H37Cl

EXAMPLE 25 (4-(6,7-bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester To a solution of (4-(6,7-dihydroxy-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester as obtained in Reference Example 6 (50 mg) in chloroform (1 ml), triethylamine (0.258 ml), stearyl chloride (0.25 ml) and dimethylaminopyridine (1 mg) were added, followed by stirring at room temperature for 24 hours. After addition of water, the reaction mixture was extracted with ethyl acetate. The extract was washed with a 5% aqueous solution of citric acid, a saturated aqueous solution of sodium hydrogen carbonate and saturated saline, and dried over anhydrous sodium sulfate, and the solvent was distilled off. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to yield the title compound (75 mg, yield 76%) as a wax-like substance. IRupsilonmaxKBr cm-1:3430, 1750, 1710, 1640 1 H-NMR (CDCl3)delta:0.88 (6H, t, J=6.6 Hz), 1.04-1.30 (56H, m), 1.42 (9H, s), 1.49 (9H, s), 1.52-3.15 (18H, m), 4.15 (1H, dd, J=6.8, 12.2 Hz), 4.47 (1H, dd, J=3.2, 12.2 Hz), 4.59-4.73 (1H, m), 5.07-5.24 (1H, m), 6.99 (1H, d, J=7.6 Hz 7.65 (2H, d, J=8.8 Hz), 7.81 (2H, d, J=8.8 Hz), 8.08 (1H, bs)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chlorooctadecane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US5506267; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3386-33-2, name is 1-Chlorooctadecane, A new synthetic method of this compound is introduced below., Quality Control of 1-Chlorooctadecane

REFERENCE EXAMPLE 30 Preparation of (1R,2R)-2-(Stearoylamino)cyclohexanol (1R,2R)-2-Aminocyclohexanol (1.15 g) and 3.02 g of stearyl chloride were reacted in the same manner as in Reference Example 20 to obtain 3.0 g of the objective compound (yield: 100%). Property: Oily. Mass Spectrometric Analysis: Molecular formula: C24 H47 NO2, Calculated: 381.3606, Found: 381.3611. NMR(delta, CDCl3): 0.88 (3H,t,J=7Hz), 1.11-1.41 (32H,m), 1.57-1.78 (4H,m), 1.89-2.11 (2H,m), 2.22 (2H,t,J=7Hz), 3.31 (1H,ddd,J=11Hz,11Hz, 5Hz), 3.58-3.70 (1H,m), 5.42-5.51 (1H,m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Fujirebio Inc.; US5120738; (1992); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

3386-33-2, Adding a certain compound to certain chemical reactions, such as: 3386-33-2, name is 1-Chlorooctadecane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3386-33-2.

Diallylphenol (3.48 gm, 0.02 mol) was diluted in dimethyl sulfoxide (50 ml) and sodium hydroxide (0.8 gm, 0.02 mol) added to the solution followed by 1-chlorooctadecane (5.78 gm, 0.02 mol) and heated at 80 C. for 2 hrs. After cooling and diluting with water, the reaction mixture was extracted with hexane, dried over MgSO4 filtered and evaporated to give the desired product. MS m/z 426. (M+ calcd for C30H50O=426). H NMR (300 MHz, CDCl3) d 0.80 (t ,3, CH3), 1.25 (s, 32, CH2).1.75-1.80 (m, 2, CH2), 3.30-3.40 (d, 4, CH2), 3.70-3.80 (t, 2, OCH2), 5.05-5.21(m, 2, CH2 vinyl), 5.95-6.10 (m, 2,CH2 vinyl), 7.00-7.20(m, 3, aromatic). Oxidation with MCPBA as described in Example 1 gave 2,6-di(epoxypropyl)phenyl octadecyl ether. MS m/z 458 (M+ calcd for C30H50O3=458). H NMR (300 MHz, CDCl3) d 0.80 (t, 3, CH3), 1.25 (s, 30, CH2), 2.60-2.70 (m, 2, CH2 epoxypropyl), 2.75-3.10 (m, 6, CH2 epoxypropyl), 3.20-3.30 (m, 2, epoxypropyl CH), 3.55-3.75 (t, 2, CH2), 7.10-7.25 (m, 1, aromatic), 7.40-7.60 (m, 2, aromatic).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chlorooctadecane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pews, R. Garth; US2005/90673; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics