Category: 2272-40-4

Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents was written by Kumar, G. Jagadeesh;Kumar, S. Naveen;Thummuri, Dinesh;Adari, Lavanya Bindu Sree;Naidu, V. G. M.;Srinivas, Kolupula;Rao, V. Jayathirtha. And the article was included in Medicinal Chemistry Research in 2015.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Two new series of s-triazine derivatives appended with benzimidazole and benzothiazole derivatives are synthesized, and structure-activity relationships on anticancer activity of these compounds is probed. In vitro inhibitory activity against the growth of six cancer cell lines, viz., MCF-7, MDAMB-231, PC-3, DU-145, HT-29, and HGC-27 was evaluated for the synthesized analogs. Among the two series of compounds, derivatives containing the benzimidazole scaffold were found to be relatively potent over benzothiazole analogs. In accordance with our previous observation, within benzimidazole derivatives, trisubstituted s-triazine derivatives were found to be more potent over disubstituted derivatives irresp. of cell lines. Structure-activity relationships provided useful insights into these classes of compounds and paved the way to design of novel analogs with more potency. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anomeric O-alkylation. Part 16. Synthesis of hetaryl glycosides and their glycosyl donor properties was written by Huchel, Ursula;Schmidt, Christoph;Schmidt, Richard R.. And the article was included in European Journal of Organic Chemistry in 1998.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Anomeric O-hetarylation of tetra-O-benzyl- and tetra-O-acetylglucose can be directly performed with electron-deficient heteroaromatic/heterocyclic systems, which contain imide halide moieties. The reactions were carried out in the presence of a base and led, through an exchange of the halide by the glucopyranosyloxy moiety. β-Products were obtained predominantly or exclusively. Systems bearing >1 imide halide moiety, such as cyanuric fluoride or 5-chloro-2,4,6-trifluoropyrimidine, can be employed for successive anomeric O-hetarylations. Investigation of the glycosyl donor properties of O-glucosyl heteroaromatic imidates with 6-O-and 4-O-unprotected glucose derivatives as acceptors and comparison of the results obtained with data for the corresponding β-trichloroacetimidates, reveals that 2,3,5,6-tetrafluoropyridin-4-yl glucopyranosides exhibit similar properties. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel 1,2-3,4-Bridged and 1,3-Bridged Calix[4]arene Based on Large s-triazine Conjugate Systems: Synthesis and Complexation for Dyes was written by Bai, Xiaoyan;Yang, Fafu;Xie, Jianwei;Guo, Hongyu. And the article was included in Journal of Macromolecular Science in 2013.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Two novel 1,2-3,4-bridged and 1,3-bridged calix[4]arenes and based on large s-triazine conjugate systems were designed and synthesized in high yields. The liquid-liquid extraction experiment showed that they possessed excellent extraction abilities towards one cationic and three anionic dyes [Orange I (OI), Methylene blue (MB), Neutral red (NR), Brilliant green (BG)]. The highest extraction percentage of compound was 91.2% for BG. The complexation UV-visible spectra of compounds and with four dyes indicated the existence of complexation action between hosts and guests with 1:1 ratio of complexation in DMSO solution The association constants suggested that the 1,2-3,4-bridging structure was more favorable for producing excellent complexation abilities than 1,3-bridging structure. The association constant of compound with BG was ≤4.5 × 10⁶ M^-1. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Photoinduced addition of the fungicide anilazine to cyclohexene and methyl oleate as model compounds of plant cuticle constituents was written by Breithaupt, D. E.;Schwack, W.. And the article was included in Chemosphere in 2000.Application of 2272-40-4 The following contents are mentioned in the article:

Photoreactions, initiated by sunlight irradiation, between organochlorine pesticides and olefinic compounds of plant cuticles have been postulated. Concerning the formation of bound residues, which so far have not been detectable by common anal. techniques, photoaddn. reactions are of main interest. In order to study the photochem. behavior of chlorinated fungicides, anilazine was irradiated in cyclohexene and Me oleate as model compounds for olefinic plant cuticle constituents. Anilazine extensively reacted with the cis-double bond of both model compounds via radical mechanisms. In addition to a dechlorinated photoproduct several addition products were formed showing plausible reaction pathways for the formation of bound residues in plant cuticles. Photoproducts were isolated by preparative HPLC and analyzed by HPLC, MS, ¹H-, and ¹³C-NMR. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

QSAR study on environmental properties and biological activities of nitrogen-containing heterocyclic compound was written by Yu, Xun-Min;Zhang, Xu. And the article was included in Anquan Yu Huanjing Xuebao in 2003.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

The present article intends to introduce a new method of calculating the values of 13 mols. for nitrogen-containing heterocyclic compounds The author has found that ^mx^y (m = 0, 1, 2, 3) is highly correlated with the environment properties lgSW, lgKow and biol. activities -lgEC₅₀ of nitrogen-containing heterocyclic for such compounds Thus it can be concluded that this index bears excellent structure selectivity and relativity when the results from index were compared with that of other ones. Repeated testing practice shows that the new method proves to be easy in calculation, clear in phys. meaning and convenient in applications. Furthermore,-lgEC₅₀=a₂‘+b₂⁰χ^Y+b₃¹χ^Y model is performed to validate the model robustness with Jackknifed method. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Soluble maleimide prepolymers containing 1,3,5-triazine groups as composite resin matrices: synthesis, characterization, and evaluation was written by Dolui, Swapan K.. And the article was included in Angewandte Makromolekulare Chemie in 1991.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Low-mol.-weight amine-terminated monomaleimide prepolymers containing 1,3,5-triazine groups as well as ether linkages were prepared by reacting benzophenonetetracarboxylic dianhydride, diamines containing 1,3,5-triazine groups, and maleic anhydride. These reactive prepolymers were soluble in low-boiling solvents such as CHCl₃, THF, etc. They were characterized by elemental anal., IR and NMR spectroscopy, vapor pressure osmometry, and viscosity. On heating at 180-190°, these prepolymers underwent simultaneous chain extension by Michael addition reaction and crosslinking by mutual reaction between their amine-terminated and maleimide-terminated ends. The cured polymers were thermostable, and the thermal behavior was studied by TG, DTA, and isothermal aging. Laminates fabricated using these prepolymers and carbon fiber reinforcement were evaluated by flexural strength and interlaminar shear strength. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new kind of H-acid monoazo-anthraquinone reactive dyes with surprising color was written by Shan, Bin;Tong, Xing;Xiong, Wei;Qiu, Wenzhu;Tang, Bingtao;Lu, Rongwen;Ma, Wei;Luo, Yi;Zhang, Shufen. And the article was included in Dyes and Pigments in 2015.Computed Properties of C9H6Cl2N4 The following contents are mentioned in the article:

A new kind of reactive dyes containing both monoazo and anthraquinone chromophores was obtained by using 1,4-bis((4-aminophenyl)amino)anthrancene- 9,10-dione as diazo component and 1-amino-8-naphthol-3,6-disulfonicacid (H-acid) derivatives as coupling components. The dyes were characterized by UV-Vis, IR, MS, ¹H NMR and ¹³C NMR. The maximum absorption wavelengths of the dyes were all about 590 nm, which indicated that they were a kind of blue dyes. ¹H NMR and ¹³C NMR results revealed that there were two kinds of tautomerisms in dye structure and a new conjugated system formed between the anthraquinone ring and the Ph azo linkage. D. functional theory (DFT) calculations also proved the formation of the new larger conjugated system from which the blue color was generated. The fixations of the dyes on cotton were over 88% and the light fastness reached 5 grade. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Computed Properties of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and studies of some chalcones and their derivatives was written by Patel, Ghanshyam;Solankee, Anjani. And the article was included in Acta Ciencia Indica, Chemistry in 2012.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

Chalcones, 2-phenylamino-(4′-chlorophenylamino)-6-[4′-{3″-(phenyl/substituted phenyl)-2″-propenon-1″-yl}phenylamino]-s-triazine I [R = C₆H₅, 3-BrC₆H₄, 4-FC₆H₄, 3-PhOC₆H₄, 3-MeOC₆H₄] have been prepared from ketones on treatment with different aldehydes. These chalcones I on cyclization with malononitrile in the presence of ammonium acetate give cyanopyridines II. Chalcones I on treatment with hydrazine hydrate in the presence of glacial acetic acid provide acetyl pyrazolines III. Chalcones on treatment with guanidine hydrochloride in the presence of alkali afford aminopyrimidines IV. The characterization of newly synthesized compounds have been confirmed on the basis of IR, ¹H NMR spectral data and phys. data. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and antimicrobial activity of benzothiazoles and 1,3-oxazine based derivatives of s-triazine was written by Patel, T. V.;Malik, G. M.. And the article was included in Journal of Ultra Chemistry in 2018.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Some new substituted 1,3,5-triazine derivatives I [R = H, 4-COMe, 2-O₂N-4-Cl, etc.] were synthesized by reacting with N²-(4-(benzo[d]thiazol-2-yl)phenyl)-6-chloro-N⁴-phenyl-1,3,5-triazine-2,4-diamines, which in-turn prepared from 4,6-dichloro-N-phenyl-1,3,5-triazin-2-amines (prepared from cyanuric chloride and primary amines) with 4(beno[d]thiazol-2-yl)aniline and 6-(4-methoxypheny1)-4-phenyl-2H-1,3-oxazin-2-amine and evaluated for their in-vitro antimicrobial activity against Gram pos. and Gram neg. strains using a micro dilution procedure. Synthesized compoundsI proved to be effective with MIC (μg/mL), among them I [R = 4-Br, 4-Me, 2-OMe, 2-O₂N-4-Cl, 4-COMe] showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, ¹H- NMR, ¹³CNMR and mass Anal. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and anticancer activity of some new s-triazine derivatives was written by Jagadeesh Kumar, G.;Sriramkumar Bomma, H. V. S.;Srihari, E.;Shrivastava, Shweta;Naidu, V. G. M.;Srinivas, Kolupula;Jayathirtha Rao, V.. And the article was included in Medicinal Chemistry Research in 2013.Related Products of 2272-40-4 The following contents are mentioned in the article:

New s-triazines I (R = C₆H₅NH, 4-OMeC₆H₄NH, 4-FC₆H₄NH, C₆H₅CH₂NH; R¹ = Cl, morpholinyl) were synthesized for the structure-activity relationship studies as potent anticancer agents. The prepared analogs were evaluated for their in vitro inhibitory activity against the growth of PA-1 (Ovarian cancer), A549 (Lung cancer), MCF-7 (Breast cancer), and HT-29 (Colon cancer). Tri-substituted s-triazine derivatives with morpholino group on s-triazine scaffold exhibited potent anticancer activities compared to di-substituted s-triazine derivatives These compounds also showed relatively selective PA-1 and HT-29 cancer cell inhibition over other cancer cell lines. Structure-activity relationships provided useful insights in these classes of compounds and paved the way to design novel analogs with more potency. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics