Category: 2272-40-4

Nucleophilic aromatic substitution in heterocycles: alcoholysis and hydrolysis of 2-anilino-4,6-dichloro-1,3,5-triazines was written by Renfrew, A. Hunter M.;Taylor, John A.;Whitmore, James M. J.;Williams, Andrew. And the article was included in Journal of the Chemical Society in 1994.Recommanded Product: 2272-40-4 The following contents are mentioned in the article:

Kinetics are reported for the alk. hydrolysis and alcoholysis of the title compounds A rate law and linear Hammett and Broensted relations are obtained. The data are consistent with a mechanism involving addition of the hydroxide ion to the neutral triazine. The polar substituent effects on the hydroxide ion reactivity indicate that there is substantial charge accumulation in the triazine nucleus in the transition state of the addition step. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis was written by Gustafson, Gary R.;Baldino, Carmen M.;O’donnell, Mary-Margaret E.;Sheldon, Adrian;Tarsa, Robert J.;Verni, Christopher J.;Coffen, David L.. And the article was included in Tetrahedron in 1998.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all, have been produced in 50μmol quantities using automated parallel solution phase synthesis. The use of this technol. in a search for protease inhibitors, glycopeptide surrogates and other bioactive compound classes will also be discussed. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of new 1,3,5-triazine scaffolds with potent activity against Mycobacterium tuberculosis H37Rv was written by Sunduru, Naresh;Gupta, Leena;Chaturvedi, Vinita;Dwivedi, Richa;Sinha, Sudhir;Chauhan, Prem M. S.. And the article was included in European Journal of Medicinal Chemistry in 2010.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

A series of eighty one 2,4,6-trisubstituted-1,3,5-triazines were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds from this series exhibited good to moderate activity with an MIC in the range 1.56-3.12 μg/mL and most of them were found to be nontoxic against VERO cells and mouse bone marrow derived macrophages. This is for the first time that 2,4,6-trisubstituted-1,3,5-triazines were identified as a potent inhibitors of M. tuberculosis H37Rv. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines was written by Zhou, Yuefen;Sun, Zhongxiang;Froelich, Jamie M.;Hermann, Thomas;Wall, Daniel. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

Structure-activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole cell antibacterial activity was achieved by linking addnl. aromatic moieties at the triazine C-4 position. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reaction of cyanuric chloride and its derivatives with polyamide fibers in non-aqueous medium was written by Hanna, H. L.;Abd El-Thalouth, I.;Hebeish, A.. And the article was included in Angewandte Makromolekulare Chemie in 1978.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Cyanuric chloride [108-77-0] did not react with polyamide fibers in non-aqueous medium but became phys. adhered to the fiber. Increasing the concentration of cyanuric chloride caused a substantial increase in the amount of extra N content of the fiber. Greater adsorption occurred in xylene than in tetrachloroethylene but a 1:3 mixture of tetrachloroethylene and xylene gave the best results. Chem. reaction was achieved by use of 2-anilino-4,6-dichloro-1,3,5-triazine [2272-40-4] and disperse dyes containing chlorotriazine rings. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids as potential antimalarial agents was written by Manohar, Sunny;Khan, Shabane I.;Rawat, Diwan S.. And the article was included in Chemical Biology & Drug Design in 2011.Related Products of 2272-40-4 The following contents are mentioned in the article:

The authors report the synthesis of a series of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids and evaluation of their antimalarial activity against D6 and W2 strains of Plasmodium falciparum. To study the structure-activity relationship of substituted 4-aminoquinoline-based hybrids, 34 structurally diverse compounds were synthesized and tested against D6 and W2 strains of P. falciparum. Some of the compounds showed promising antimalarial activity without toxicity against Vero cells. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient, “green” approach to aryl amination of cyanuric chloride using acetic acid as solvent was written by Kolmakov, Kirill A.. And the article was included in Journal of Heterocyclic Chemistry in 2008.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Acetic acid is an inexpensive and environmentally friendly solvent for facile, clean and high-yielding aryl amination of cyanuric chloride with aromatic amines, including nitroanilines. Aryl amination in acetic acid medium and isolation protocol are greatly simplified as compared to previously reported procedures. Under proper conditions, it is possible to attach the same or different aniline residues in a controlled way to obtain in excellent yields sym. and unsym. 1,3,5-triazine derivatives, e.g. I and II, resp. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optically active S-triazine: preparation of α-(2-anilino-4-amino-S-triazin-6-ylamino)-β-thiolpropionic acid was written by Watanabe, Nobuo;Mitsumoto, Isao;Kato, Tadashi;Usami, Takashi. And the article was included in Tokyo Kogyo Koto Senmon Gakko Kenkyu Hokokusho in 1979.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

The title triazine derivative I [R = NH₂, R¹ = NHCH(CH₂SH)CO₂H] was prepared by amination of cyanuric chloride with aniline in acetone at 0-5° to give 96.7% I (R = R¹ = Cl)(II), amination of II with L-(-)-cysteine in acetone at 40-50° to give 86.2% I [R = Cl, R¹ = NHCH(CH₂SH)CO₂H], followed by amination with NH₄OH 2 h at 80-90°(in 83.3% yield). This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Utilization of cyanuric chloride in the synthesis of some novel chalcones and their derivatives was written by Kapadia, Kishor;Solankee, Pankit;Prajapati, Yogesh;Patel, Hiral;Solankee, Sejal;Solankee, Anjani. And the article was included in Organic Chemistry: An Indian Journal in 2007.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Base catalyzed condensation of 2,4-bis-(phenylamino)-6-(4′-acetyl phenylamino)-5-triazine with different aromatic aldehydes yield chalcones. These chalcones on cyclization with hydrazine hydrate in presence of glacial acetic acid and malononitrile in presence of ammonium acetate give the corresponding acetylpyrazolines, e.g., I, and cyanopyridines, e.g., II, resp. The constitutions of newly synthesized compounds have been established on the basis of their elemental anal., IR and ¹H NMR spectral data. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Targeting the hydrophobic region of Hsp90’s ATP binding pocket with novel 1,3,5-triazines was written by Lee, Taeho;Seo, Young Ho. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Application of 2272-40-4 The following contents are mentioned in the article:

Heat shock protein 90 (Hsp90) is a mol. chaperone that plays an important role in regulating the maturation and stabilization of many oncogenic proteins. In an attempt to discover a new class of Hsp90 inhibitors, a series of 1,3,5-triazine compounds were rationally designed, synthesized, and their biol. activities were evaluated. Compound 3b was found to degrade Hsp90’s client proteins of Her2, Met and Akt and to induce the expression level of Hsp70. The binding mode of 3b in the ATP-binding site of Hsp90 was predicted by the mol. docking. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics