Category: 2272-40-4

Design, synthesis, biological evaluation, and molecular docking study on triazine based derivatives as anti-inflammatory agents was written by Asadi, Parvin;Alvani, Mohsen;Hajhashemi, Valiollah;Rostami, Mahboubeh;Khodarahmi, Ghadamali. And the article was included in Journal of Molecular Structure in 2021.Reference of 2272-40-4 The following contents are mentioned in the article:

In an attempt to develop new anti-inflammatory agents, design, synthesis, pharmacol. activities, and docking study of two groups of triazine-based derivatives were reported. Nine compounds I and II [R′ = H, Me, CN, Br; R¹ = R² = H, Cl, methylamino, ethylamino] consisting of triazine, vanillin, and phenylpyrazole were synthesized through the pharmacophore hybridization method. After confirmation of the structure of the synthesized compounds using spectroscopic methods (FT-IR, and NMR spectral data), their anti-inflammatory activity was evaluated using carrageenan-induced paw edema model in male Wistar rats (200-220 g) administered i.p. at doses of 100 and 200 mg/kg. A group of rats received indomethacin (10 mg/kg) as the standard drug. Among compounds II, only compounds II [R¹ = R² = methylamino, ethylamino] showed a significant anti-inflammatory effect (p < 0.01). Also compound II [ R¹ = Cl, R² = methylamino] at a dose of (200 mg/kg) and compounds II at both doses showed significant anti-inflammatory activity and this effect for compound II [R¹ = Cl, R² = methylamino] (200 mg/kg) and both doses of compounds II [ R¹ = Cl, R² = ethylamino; R¹ = R² = H] was comparable with indomethacin. While indomethacin reduced paw edema by 90%, 10b as the most potent tested compound reduced edema by 93%. The synthesized compounds were docked into the binding sites of both cyclooxygenase-1- and 2- isoenzymes (COX-1 and COX-2) to explore their binding mode and possible interactions of these ligands. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Reference of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Excellent performance of aromatic polyguanamines induced by multiple hydrogen bondable tetraazacalix[2]arene[2]-triazine ring in their main chain was written by Sasaki, H.;Kotaki, T.;Fujimori, A.;Tsukamoto, T.;Suzuki, E.;Oishi, Y.;Shibasaki, Y.. And the article was included in RSC Advances in 2020.HPLC of Formula: 2272-40-4 The following contents are mentioned in the article:

A series of poly(guanamine) (c-PG)s containing tetraazacalix[2]arene[2]-triazine (mPDA₂CyC₂) were successfully prepared by solution polycondensation of mPDA₂CyC₂ with various aromatic diamines in an aprotic organic solvent with a lithium chloride additive (5 weight%) at 150°C for 6 h. The number-average mol. weights (Mn)s of these c-PG polymers reached up to 31 500, with a relatively broad mol. weight distribution (Mw/Mn) of 5.3. They showed good solubility in aprotic organic solvents, such as N-methylpyrrolidone and N,N-dimethylacetamide at a concentration of 2 mg mL^-1. The glass transition temperatures (Tg) of the c-PG polymers were in the range 359°C-392°C, approx. 160°C higher than those of counterpart polymers (i.e., with no aza-calixarene-based PG (l-PG)). The coefficients of thermal expansion (CTEs) of the c-PG polymers were 29.7-48.1 ppm K^-1 (at 100°C-150°C), much lower than those of l-PG samples, i.e., 59.1-85.1 ppm K^-1. Transparent and almost colorless c-PG films were successfully prepared by a solution casting method, showing maximum tensile strength (σS), modulus (Eγ), and elongation at break (Eb) values of 151 MPa, 6.3 GPa, and 4.4%, resp., for the c-PG polymer from mPDA₂CyC₂ and 4,4′-oxydianiline monomers. The corresponding l-PG film exhibited σS, Eγ, and Eb values of just 76 MPa, 5.4 GPa, and 1.6%, resp. These outstanding thermal and mech. properties of the c-PG polymers can be attributed to their multiple hydrogen bonding interaction between mPDA₂CyC₂ residues in the polymer backbone. This interaction was identified by IR spectroscopy measurements at the broad absorption band around 3000-3400 cm^-1. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4HPLC of Formula: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, spectroscopic characterization, antimicrobial evaluation and molecular docking study of novel triazine-quinazolinone based hybrids was written by Dinari, Mohammad;Gharahi, Fateme;Asadi, Parvin. And the article was included in Journal of Molecular Structure in 2018.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:

A series of new 1,3,5-triazines incorporating aromatic quinazolinone moiety as potential antimicrobial agents was reported. The first chlorine group of the cyanuric chloride was replaced by aniline and the second one was replaced by various aromatic amines. The prepared monochlorotriazine was allowed to react with hydrazine to give hydrazinyl triazines I (R = Ph, 4-ClC₆H₄, 4-NCC₆H₄, etc.). These hydrazinyl triazines reacted with 2-methyl-4H-benzo[1,3]oxazin-4-one to give novel triazine-quinazolinone based hybrids II. The chem. structure and purity of the hybrid compounds were evaluated by different techniques such as thin layer chromatog., m.p., Fourier-transform IR (FTIR), ¹H and ¹³C NMR spectra and elemental anal. Antimicrobial activity of the hybrid compounds was studied on three Gram-neg. bacteria (Salmonella enteritidis, E. coli, P. aeruginosa) and three Gram-pos. bacteria (S. aureus, Listeria monocytogenes, Bacillus subtilis) as well as Candida albicans as a yeast-like fungus using the serial broth dilution method. Among them, compound I (R = 4-H₂NO₂SC₆H₄) showed higher antimicrobial activity with a min. inhibitory concentration (MIC) value of 16 μg/mL. Furthermore, compounds I (R = 4-H₂NO₂SC₆H₄, 4-ClC₆H₄, 4-NCC₆H₄) showed good activity against several tested strains. In addition, docking simulation was performed to position best antibacterial compounds into the S. aureus dihydrofolate reductase (DHFR) active site to determine the probable binding conformations. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, thermal and optical properties of nanosized polyamides containing N-phenyl- and N-naphthyl-s-triazine rings: Structure-properties correlation was written by Mansour, Elsayed M. E.;Iskander, Abanob A. F.;Hassan, Hammed H. A. M.. And the article was included in Journal of Macromolecular Science in 2017.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

We prepared two series of nanosized polymers containing s-triazine moiety by reactions of newly prepared substituted diacids chlorides derived from 2-anilino-4,6-di-(phenoxy)- and 2-(N-1-naphthylamine)-4,6-di-(phenoxy)-s-triazines with a number of com. diamines. The polymers were carefully characterized by different techniques including IR, UV, fluorescent emission, elemental and thermal analyses and SEM (SEM). The SEM images indicated that most of the polyamides were organized as well defined nano sized spheres, but in certain derivatives small amount of aggregated nanospheres was also observed Structure-property correlations based on a single or more interchange proved to be feasible. The polymers exhibited high thermal behavior and, based on the produced char yields, the limiting oxygen index (LOI) indicated that a dozen polymers were classified as “slow burning polymers” while the other dozen polymers were “self-extinguishing polymers”. Polymers derived from sym. diamine exhibited better thermal stability than those containing asym. diamines. Interestingly, while the naphthyl/phenyl interchange has no influence on the thermal properties in some cases, however, dramatic improvements were noticed in many other cases. Obviously, the pyridine/phenylene interchange has no influence on the thermal properties of the addressed polymers. The polymers exhibited emissions ranging from blue to orange wavelength depending on the nature of the signaling unit. While the introduction of a naphthyl moiety has no significant influence on the electronic properties in some cases, however, the interchange led to either appreciable red-shifted absorptions or disrupt the conjugation and thus blue-shifted absorptions in other analogs. This result enables such polymers as good candidates in different technol. applications. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades was written by Shawish, Ihab;Barakat, Assem;Aldalbahi, Ali;Malebari, Azizah M.;Nafie, Mohamed S.;Bekhit, Adnan A.;Albohy, Amgad;Khan, Alamgir;Ul-Haq, Zaheer;Haukka, Matti;de la Torre, Beatriz G.;Albericio, Fernando;El-Faham, Ayman. And the article was included in ACS Omega in 2022.Computed Properties of C9H6Cl2N4 The following contents are mentioned in the article:

Here, we synthesized a newseries of mono- and bis(dimethylpyrazolyl)-s-triazine derivatives The synthetic methodol. involved the reaction of different mono- and dihydrazinyl-s-triazine derivatives with acetylacetone in the presence of triethylamine to produce the corresponding target products in high yield and purity. The antiproliferative activity of the novel mono- and bis(dimethylpyrazolyl)-s-triazine derivatives was studied against three cancer cell lines, namely, MCF-7, HCT-116, and HepG2. N-(4-Bromophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine 4f, N-(4-chlorophenyl)-4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazin-2-amine 5c, and 4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-methoxyphenyl)-1,3,5-triazin-2-amine 5d showed promising activity against these cancer cells: 4f [(IC₅₀ = 4.53 ± 0.30μM (MCF-7); 0.50 ± 0.080μM (HCT-116); and 3.01 ± 0.49μM (HepG2)]; 5d [(IC₅₀ = 3.66 ± 0.96μM (HCT-116); and 5.42 ± 0.82μM (HepG2)]; and 5c [(IC₅₀ = 2.29 ± 0.92μM (MCF-7)]. Mol. docking studies revealed good binding affinity with the receptor targeting EGFR/PI3K/AKT/mTOR signaling cascades. Compound 4f exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, resp., at a concentration of 10μM. Interestingly, 4f showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, resp.). Hence, the synthetic 1,3,5-triazine derivative 4f exhibited promising antiproliferative activity in HCT-116 cells through apoptosis induction by targeting the EGFR and its downstream pathway. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Computed Properties of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Unraveling the interplay between hydrogen bonding and rotational energy barrier to fine-tune the properties of triazine molecular glasses was written by Laventure, Audrey;De Grandpre, Guillaume;Soldera, Armand;Lebel, Olivier;Pellerin, Christian. And the article was included in Physical Chemistry Chemical Physics in 2016.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Mexylaminotriazine derivatives form mol. glasses with outstanding glass-forming ability (GFA), high resistance to crystallization (glass kinetic stability, GS), and a glass transition temperature (T_g) above room temperature that can be conveniently modulated by selection of the headgroup and ancillary groups. A common feature of all these compounds is their secondary amino linkers, suggesting that they play a critical role in their GFA and GS for reasons that remain unclear because they can simultaneously form hydrogen (H) bonds and lead to a high interconversion energy barrier between different rotamers. To investigate independently and better control the influence of H bonding capability and rotational energy barrier on T_g, GFA and GS, a library of twelve analogous mols. was synthesized with different combinations of NH, NMe and O linkers. Differential scanning calorimetry (DSC) revealed that these compounds form, with a single exception, kinetically stable glasses with T_g values spanning a very broad range from -25 to 94 °C. While variable temperature IR spectroscopy combined to chemometrics reveals that, on average, around 60% of the NH groups are still H-bonded as high as 40 °C above T_g, critical cooling rates obtained by DSC clearly show that mols. without H-bond donating linkers also present an outstanding GFA, meaning that H bonding plays a dominant role in controlling T_g but is not required to prevent crystallization It is a high interconversion energy barrier, provoking a distribution of rotamers, that most efficiently promotes both GFA and resistance to crystallization These new insights pave the way to more efficient glass engineering by extending the possible range of accessible T_g, allowing in particular the preparation of homologous glass-formers with high GS at ambient temperature in either the viscous or vitreous state. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, thermal and optical properties of new nanosized polyamides containing N-phenyl- and O-naphthyl-s-triazine rings; part 2 was written by Iskander, Abanob A. F.;Mansour, Elsayed M. E.;Hassan, Hammed H. A. M.. And the article was included in Journal of Macromolecular Science in 2017.Electric Literature of C9H6Cl2N4 The following contents are mentioned in the article:

We report the chem. and properties of two new series of well-defined nano sized spheres aramides-containing N- and O-naphthyl-s-triazines. The polymers were carefully characterized by different techniques including IR, UV, fluorescent emission, elemental, thermal analyses and SEM (SEM). The polymers were readily soluble in polar aprotic solvents while insoluble neither in water nor halogenated solvents. Thermal analyses data up to 900°C showed high thermal behavior and the polymers were classified either as “slow burning polymers” or “self-extinguishing polymers” based on their calculated the limiting oxygen index. Interestingly, the naphthyl/Ph interchange has dramatic improvement on the thermal properties. Obviously, the pyridine/phenylene interchange has no influence on the thermal properties of the addressed polymers. Thermal stability of the aniline-containing polymers proved to be comparable to their naphthylamine analogs. Polymers containing p-phenylene moieties exhibited better thermal results compared to their analogs containing m-phenylene moieties. Benzidine containing polymers and sulfone containing polymers exhibited better thermal stabilities than their analogs containing either ether or methylene flexible linkages. The kinetic data obtained from the nonisothermal decomposition of the prepared polyamides series were also studied. The polymers exhibited emissions ranging from blue to orange wavelength depending on the nature of the signaling unit. The naphthyl/Ph interchange led to either appreciable red-shifted absorptions in some cases or blue-shifted absorptions in other cases and this behavior may be attributed to the contorted, twisted structural nature of the naphthalene ring. Such attracting properties make these polymers good candidates for applications such as processable high-temperature materials and also as heat-resistant polymeric materials. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Electric Literature of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach was written by Tawfik, Haytham O.;Petreni, Andrea;Supuran, Claudiu T.;El-Hamamsy, Mervat H.. And the article was included in European Journal of Medicinal Chemistry in 2022.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

The hydrophobic and the hydrophilic rims in the active site of human carbonic anhydrase IX (hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously matched to design and synthesize potent and selective inhibitors using a dual-tail approach. Seventeen new compounds, 5a-q, were designed to have the benzenesulfonamide moiety as a zinc binding group. In addition, N-substituted hydrazone and N-Ph fragments were chosen as the hydrophilic and hydrophobic parts, resp. to achieve favorable interactions with the corresponding halves of the active site. All synthesized compounds successfully suppressed the CA IX, with IC50 values in nanomolar range from 13.3 to 259 nM. Compounds, 5h, 5c, 5m, 5e, and 5k were the top-five compounds efficiently inhibited the tumor-related CA IX isoform in the low nanomolar range (KI = 13.3, 22.6, 25.8, 26.9 and 27.2 nM, resp.). The target compounds 5a-q developed remarkable selectivity toward the tumor-associated isoforms (hCA IX and XII) over the off-target isoforms (hCA I and II). Furthermore, they were assessed for their anti-proliferative activity, according to US-NCI protocol, against a panel of fifty-nine cancer cell lines. Compounds 5d, 5k and 5o were passed the criteria for activity and scheduled automatically for evaluation at five concentrations with 10-fold dilutions Compound 5k exhibited significant in vitro anticancer activity with GI50-MID; 8.68 μM compared to compounds 5d and 5o with GI50-MID; 25.76 μM and 34.97 μM resp. The most selective compounds 5h and 5k were further screened for their in vitro cytotoxic activity against SK-MEL-5, HCC-2998 and RXF 393 cancer cell lines under hypoxic conditions. Furthermore, 5k was screened for cell cycle disturbance, apoptosis induction and intracellular reactive oxygen species (ROS) production in SK-MEL-5 cancer cells. Finally, mol. docking studies were performed to gain insights for the plausible binding interactions and affinities for selected compounds within hCA IX active site. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure basis for the inhibitory mechanism of a novel DNase γ-specific inhibitor, DR396 was written by Sunaga, Satoshi;Yoshimori, Atsushi;Shiokawa, Daisuke;Tanuma, Sei-ichi. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Electric Literature of C9H6Cl2N4 The following contents are mentioned in the article:

DNase γ, a member of the DNase I family, has been suggested to cause DNA fragmentation during apoptosis. The authors recently identified 4-(4,6-dichloro-[1,3,5]-triazine-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (DR396) as a novel specific inhibitor for human DNase γ. However, the binding mode (coordinate) of DR396 to DNase γ has not yet been defined. Here, the authors examined the mol. basis for the inhibitory activity of DR396 to DNase γ by structure-based computational docking studies. In the blind-docking study using a human DNase γ homol. model, a unique binding site of DR396 was predicted, which is tentatively named the DNA trapping site because of the binding domain of the unhydrolyzed DNA strand, but not the active site. Targeting the DNA trapping site as a hot spot, new human DNase γ inhibitors were obtained from our diverse chem. library in silico. These inhibitors showed high correlations between their predicted binding-free energies (ΔGs) and observed IC₅₀ values in the DNA trapping site but not the active site. The IC₅₀ of a regioisomer of DR396, 5-(4,6-dichloro-[1,3,5]-triazine-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (DF365), was 73 μM (ΔG = -9.75 kcal/mol), a 20-fold weaker inhibitory ability than that of DR396 (IC₅₀ = 3.2 μM, ΔG = -11.22 kcal/mol). Fluorescein and triazine derivatives, partial structures of DR396, had little inhibitory activity for DNase γ. Docking analyses of the interaction between DR396 and DNase γ revealed that DR396 binds tightly to three subsites (S1, S2, and S3) in the trapping site of DNase γ by forming six hydrogen bonds, whereas DF365 and the partial structures are unable to form hydrogen bonds at all three subsites. These findings suggest that the specificity and potency of the inhibitory activity of DR396 for DNase γ is due to the specific interaction of DR396 with three subsites in the DNA trapping site of DNase γ. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Electric Literature of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and theoretical studies of the photovoltaic properties of novel bifunctional reactive disperse dyes based on aminothiazole derivatives was written by Odey, Joseph O.;Ubana, Emmanuel I.;Eko, Ishegbe J.;Jones, Okama O.. And the article was included in Journal of Molecular Structure in 2022.Formula: C9H6Cl2N4 The following contents are mentioned in the article:

This article comprises synthesis and characterization of two polyfunctional diazo reactive-disperse dyes with aminothiazole moiety for application in dye-sensitized solar cells (DSSC). The characterization techniques employed were Gas chromatog.-mass spectrometry (GC-MS), Fourier-transform IR spectroscopy (FT-IR), UV-visible spectroscopy (UV-vis), and NMR to determine the different functional groups, mol. connectivities and mol. weight of the various fragments of the synthesized dyes. Theor. D. Functional Theory (DFT) and Time-Dependent TD-DFT calculations were performed using B3LYP/6-311+g(d,p). It can be observed that the HOMO energy levels of the resp. dyes have lower values than I^–/I₃^– redox couple level (around -4.80 eV) in the four different phases studied, which is crucial for the regeneration of the oxidized dye mol. and efficient charge separation Furthermore, the HOMO-LUMO energy gaps of DYES F and S are within the range 2.38-5.40 eV, where all LUMO-CB of TiO₂ energy gap values are sufficient for generating enough driving force for effective electron injection. The promising results of Light-harvesting efficiency (LHE) (values ranging from 0.81 to 0.89 except for DYE S in chloroform phase where it has an unusual value of 0.21) and Open-circuit voltage (VOC) values gotten compared with other organic, and natural sensitizers were due to the better interaction between the carboxyl and carbonyl groups of aryl azo mol. joined to the thiazolyl nucleus and the surface of TiO₂ permeable film. DYE S exhibits the lowest band gap (2.374eV), which designates the highest chem. activity of the two dyes. Results from the quantum theory of atoms-in-mols. indicate that DYES F and S exhibit addnl. stability due to their relatively high H-bond interactions as well as certain addnl. intra-at. bonds among the atoms of the investigated compounds The outcome of the Natural bond orbital (NBO) anal. suggests that the strongest charge transfer occurs in DYE S as compared to DYE F. The types and modes of excitations for the first five excited states of the synthesized dyes were observed from the results of the hole-electron excitation anal. First hyperpolarizability values of the dye F and dye S were determined to be 47.24 and 46.90 times the hyperpolarizability value of urea, demonstrating its excellent non-linear optical (NLO) response. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics