Category: 2272-40-4

Synthesis and biological potency of anilino-triazine insecticides was written by Johnson, Timothy C.;Brown, Annette V.;Bryan, Kristy K.;Guenthenspberger, Katherine K.;Hunter, Ricky;Martin, Timothy P.;Niyaz, Noormohamed;Tisdell, Gene F.;Trullinger, Tony. And the article was included in Pest Management Science in 2017.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

BACKGROUND : An insecticide screening effort identified N-(4-bromophenyl)-4,6-bis(2,2,2-trifluoroethoxy)-1,3,5-triazine-2-amine as having weak potency against two lepidopteran species, Helicoverpa zea and Spodoptera exigua. A structure-activity relationship study about the trifluoroethoxy substituents and the aniline of this compound was carried out in an effort to improve insecticidal potency. RESULTS : Initially, a series of analogs bearing various substituents on the aniline were prepared, and the insecticidal potency was evaluated against H. zea and S. exigua in greenhouse diet feeding assays. The results showed that electron-withdrawing substituents, such as Cl, Br and CF₃, were preferred over electron-donating substituents, such as methoxy, and that potency was significantly better when the substituent was in the para-position. Addnl. investigations showed that bis(anilino)trifluoroethoxytriazines were more potent. Replacement of the remaining trifluoroethyl group in the bis(anilino)triazine series with an alkyl amine lead to compounds of equal or superior efficacy. CONCLUSION : The work presented showed that electron-withdrawing substituents in the para-position of the aniline ring of the initial hit delivered the best levels of insecticidal potency against the two insect species tested. Further investigations showed that potency could be improved by replacing one of the two trifluoroethoxy groups with addnl. 4-substituted aniline. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation and characterization of oligomeric char forming agent and its effect on the thermal degradation and flame retardant properties of LDPE with ammonium polyphosphate was written by Feng, Caimin;Liang, Minyi;Jiang, Jiali;Huang, Jianguang;Liu, Hongbo. And the article was included in Journal of Analytical and Applied Pyrolysis in 2016.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

An efficient oligomeric charring agent (CNCA-DA) containing a triazine and benzene rings was synthesized and characterized by the NMR spectroscopy (¹³C solid-state NMR), elemental anal. (EA) and thermal gravimetric anal. (TGA). The synergistic effects between ammonium polyphosphate (APP) and CNCA-DA on the flame retardancy, thermal degradation and flame retardant mechanism of low d. polyethylene (LDPE) were investigated. The thermogravimetric anal. (TGA) and thermogravimetric analyzer coupled to a mass spectrometer (TGA/MS) results indicated that IFR could reduce the thermal degradation rate at main stage of degradation and side chain fragmentation was probably the dominant mechanism of thermal degradation The cone calorimeter test (CCT) results demonstrated that IFR clearly changed the decomposition behavior of LDPE and formed an intumescent char layer on the surface of the composites, subsequently resulting in the efficient reduction of the flammability parameters, such as the heat release rate (HRR), total heat release (THR), smoke production rate (SPR), total smoke production (TSP), mass loss (ML), CO production (COP) and CO₂ production (CO₂P). The Fourier-transform IR spectroscopy (FTIR), laser Raman spectroscopy anal. (LRS) anal. results revealed that an appropriate graphitization degree and network structure of the residue char were formed to improve the strength and shield properties of the char layer to obtain better flame retardant properties of the composite. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Probabilistic neural networks modeling of the 48-h LC50 acute toxicity endpoint to Daphnia magna was written by Niculescu, S. P.;Lewis, M. A.;Tigner, J.. And the article was included in SAR and QSAR in Environmental Research in 2008.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Two modeling experiments based on the maximum likelihood estimation paradigm and targeting prediction of the Daphnia magna 48-h LC50 acute toxicity endpoint for both organic and inorganic compounds are reported. The resulting models computational algorithms are implemented as basic probabilistic neural networks with Gaussian kernel (statistical corrections included). The first experiment uses strictly D. magna information for 971 structures as training/learning data and the resulting model targets practical applications. The second experiment uses the same training/learning information plus addnl. data on another 29 compounds whose endpoint information is originating from D. pulex and Ceriodaphnia dubia. It only targets investigation of the effect of mixing strictly D. magna 48-h LC50 modeling information with small amounts of similar information estimated from related species, and this is done as part of the validation process. A complementary 81 compounds dataset (involving only strictly D. magna information) is used to perform external testing. On this external test set, the Gaussian character of the distribution of the residuals is confirmed for both models. This allows the use of traditional statistical methodol. to implement computation of confidence intervals for the unknown measured values based on the models predictions. Examples are provided for the model targeting practical applications. For the same model, a comparison with other existing models targeting the same endpoint is performed. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pharmacological and Molecular docking studies of new copper (II) complexes of N²-Phenyl-N⁴,N⁶-di(thiazol-2-yl)-1,3,5-triazine-2,4,6-triamine was written by Vathanaruba, M.;Raja, S. Johnson;Princess, R.;Tharmaraj, P.. And the article was included in Journal of Molecular Structure in 2022.Related Products of 2272-40-4 The following contents are mentioned in the article:

Cu(II) complexes of tri substituted 1,3,5 triazine based ligand (PDTTA) N²-Phenyl-N⁴,N⁶-di(thiazol-2-yl)-1,3,5-triazine-2,4,6-triamine were synthesized. The structural features of the ligand and its metal complexes were characterized by micro anal. data, magnetic susceptibility measurements, molar conductance, IR, UV-Visible, ¹HNMR, Mass and EPR spectral techniques. The nonelectrolytic behavior of the complexes was confirmed from their conductance data. The electrochem. behavior of the complexes was studied by cyclic voltammetry. The free ligand and its metal complexes were screened for their in vitro biol. activity against bacteria Staphylococcus aureus and Escherichia coli and the fungi Candida albicans and Aspergillus niger by well diffusion method. The free ligand and the Cu(II) complexes were screened for in vivo anticonvulsant activity by maximal electroshock method and showed significant activity. Carrageenan induced rat paw edema is the most widely used primary test to screen inflammation which measures the ability of the compounds to reduce local edema induced in the rat paw by carrageenan. The ligand and Cu[(PDTTA)(ac)₂] are identified as a new lead structure, demonstrated antiinflammatory properties in preliminary studies in mice. Mol. docking study was conducted to study the mol. mechanism of antiinflammatory activity. Cu[(PDTTA)(ac)₂] is potent inhibitor of PDE4 enzyme which is involved in the inflammation process. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of tetraazacalix[2]arene[2]triazine-containing poly(dimethylsiloxane) with elastic property induced by pinning effect of the calixarene ring was written by Shibata, Ryota;Ishihara, Tsutomu;Tsukamoto, Tadashi;Oishi, Yoshiyuki;Fujimori, Atsuhiro;Shibasaki, Yuji. And the article was included in European Polymer Journal in 2022.Product Details of 2272-40-4 The following contents are mentioned in the article:

Tetraazacalix[2]arene[2]triazine dichloride was polymerized with telechelic poly(dimethylsiloxane)s having NH₂ terminals (PDMS_x; d.p. x = 8, 18, 38) via solution polycondensation to give the corresponding azacalixarene-containing polymers (ACAT-PDMS_x) in good yield. The fraction of the hard ACAT moiety (fHS) of the ACAT-PDMS polymers was calculated to be 33.0%, 20.4%, and 11.6% for x of 8, 18, and 38, resp. The number-average mol. weight (Mn) of the polymers ranged from 20 to 32 kDa, and freestanding tough films were successfully fabricated via solvent cast method. As a control sample, a polymer not containing azacalixarene (AnDCT-PDMS) with Mn and fHS values of 21 kDa and 19.8%, resp., was prepared via the solution polymerization of 2-anilino-4,6-dichloro-1,3,5-triazine (AnDCT) with PDMS8. Although the fHS values of AnDCT-PDMS₈ and ACAT-PDMS₁₈ were similar, the film obtained from the former polymer was much softer and sticky at room temperature than that from the latter. The glass transition temperature of the ACAT-PDMS_x films ranged from 77°C to 105°C according to thermomech. and dynamic mech. analyses. Wide-angle X-ray diffraction and polarized optical microscopy studies indicated that the azacalixarene units were first locally aggregated via multiple hydrogen bonds within the ACAT-PDMSx films and then were well dispersed in the film on heating. The ACAT-PDMS polymer showed no cytotoxicity to HeLa and IMR-90 cells in the exptl. concentration of below 100μg/mL. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Product Details of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemical treatments designed to modify the affinity of wool for dyes was written by Bell, V. A.;Lewis, D. M.;Pailthorpe, M. T.. And the article was included in Journal of the Society of Dyers and Colourists in 1984.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

The dyeing properties of wool were modified by treating it with a series of reactive hydrophobic, anionic, and cationic compounds The extent of fixation of these compounds was 10-13 weight% for sulfamic acid, Sandospace R (QNHZSO₃Na; Z = arylene, Q = 2,4-dichloro-s-triazin-6-yl) [4156-21-2], MP 1 (2,4-HO(QNH)C₆H₃CO₂Na) [91869-47-5], KP 1 (3-QNHC₆H₄PO₃Na₂) [91869-46-4], ANEX (QNHPh) [2272-40-4], and benzoylation, and 6-8 weight% for BNEX (4-QNHC₆H₄Bu) [90850-60-5], NAPEX (1-C₁₀H₇NHQ) [30369-88-1], Sandospace DP  [92047-56-8], and Glytac A (glycidyltrimethylammonium chloride) [3033-77-0]. Dyeing properties were examined with a series of anionic, cationic, and reactive dyes. The hydrophobic mechanism of dyeing appeared to predominate over the ionic mechanism, except for those dyes which were highly ionized. The monosulfonated dye C.I. Acid Red 88 was more strongly absorbed by hydrophobic wool (benzoylated or ANEX-treated) and had an improved wash fastness rating on the treated wool. C.I. Reactive Red 116 was effectively resisted by the hydrophobic anionic treatments since these compounds eliminated nucleophilic sites normally available for reaction with reactive dyes. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Self-Assembly through Hydrogen Bonding: Peripheral Crowding – A New Strategy for the Preparation of Stable Supramolecular Aggregates Based on Parallel, Connected CA₃·M₃ Rosettes was written by Mathias, John P.;Simanek, Eric E.;Whitesides, George M.. And the article was included in Journal of the American Chemical Society in 1994.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The self-assembly of two new types of stable hydrogen-bonded supramol. aggregates – bisrosettes – that are based on parallel, connected CA₃·M₃ rosettes is reported. The minimization of intermol. steric hindrance (peripheral crowding within the aggregate) is proposed as the structural feature responsible for selecting the cyclic CA₃·M₃ rosette over competing linear hydrogen-bonded networks available to the precursors. One series of aggregates – 3bis(M)₂:6(CA) – is composed of 3 equiv of a bulky bismelamine [bis(M)₂] and 6 equiv of a bulky isocyanurate (CA). The second series of aggregates rosette – 3bis(CA)₂:6(M) – is composed of 3 equiv of a bisisocyanurate [bis(CA)₂] and 6 equiv of a melamine (M) bearing two bulky substituents. The nine particles in these aggregates are stabilized by 36 hydrogen bonds in two connected CA₃·M₃ rosettes. Each aggregate has been characterized by ¹H NMR spectroscopy, gel permeation chromatog., and vapor pressure osmometry. Correlations between the size of the substituents and the preorganization of the precursors and the stability of the aggregates derived from them are discussed. Observations from ¹H NMR spectroscopy and gel permeation chromatog. indicate that aggregates comprising two connected CA₃·M₃ rosettes are more stable than those stabilized by a single CA₃·M₃ rosette, for similar extents of peripheral crowding in the rosettes. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of novel triazine charring agent and its effect in intumescent flame-retardant polypropylene was written by Feng, Caimin;Zhang, Yi;Liu, Siwei;Chi, Zhenguo;Xu, Jiarui. And the article was included in Journal of Applied Polymer Science in 2012.Application of 2272-40-4 The following contents are mentioned in the article:

A novel charring agent (CNCA-DA) containing triazine and benzene ring, using cyanuric chloride, aniline, and ethylenediamine as raw materials, was synthesized and characterized. The effects of CNCA-DA on flame retardancy, thermal degradation, and flammability properties of polypropylene (PP) were investigated by limited oxygen index (LOI), vertical burning test (UL-94), thermogravimetric anal. (TGA), and cone calorimeter test (CCT). The TGA results showed that CNCA-DA had a good char forming ability, and a high initial temperature of thermal degradation; the char residue of CNCA-DA reached 18.5% at 800°; Ammonium polyphosphate (APP) could improve the char residue of APP/CNCA-DA system, the char residue reached 31.6% at 800°. The results from LOI and UL-94 showed that the intumescent flame retardant (IFR) containing CNCA-DA and APP was very effective in flame retardancy of PP. When the mass ratio of APP and CNCA-DA was 2 : 1, and the IFR loading was 30%, the IFR showed the best effect; the LOI value reached 35.6%. It was also found that when the IFR loading was only 20%, the flame retardancy of PP/IFR can still pass V-0 rating in UL-94 tests, and its LOI value reached 27.1%. The CCT results demonstrated that IFR could clearly change the decomposition behavior of PP and form a char layer on the surface of the composites, consequently resulting in efficient reduction of the flammability parameters, such as heat release rate (HRR), total heat release (THR), smoke production rate (SPR), total smoke production (TSP), and mass loss (ML). © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ultra-low-modulus positive-type photosensitive polyimides (4). Improvement of adhesion strength with copper foil was written by Ishii, Junichi;Morita, Keisuke;Hasegawa, Masatoshi. And the article was included in Journal of Photopolymer Science and Technology in 2009.Reference of 2272-40-4 The following contents are mentioned in the article:

Amide- and triazine-containing diamines were incorporated by copolymerization into a siloxane-containing ultra-low-modulus polyimide (PI) as a novel cover layer material to solve some serious problems in the plating process such as interpenetration of an acidic plating solution into the interface between the S-side of electro-deposited copper foil and the cover layer. Our previous approach, a phys. roughness modification of the S-side was effective to inhibit the interpenetration of the plating solution This result suggests that the Cu/cover layer adhesion strength can be an important factor in the present case. The present work describes our chem. approach to increase the adhesion strength by using some heterocyclic monomers expected as adhesion promoters. The modified siloxane-containing PI possessed significant film toughness in spite of their low inherent viscosities. Unfortunately, the use of the amide- and triazine-containing diamines with minor contents (5-20 mol %) did not enhance the peel strength, however, the initial peel strength was almost maintained at 5 mol% without curling in the copper clad laminates (CCL), although the value significantly decreased at higher contents (10-20 mol%) with a prompt increase in the tensile modulus of the PI films and concomitant CCL curling. The results suggest that the decreased peel strength is closely related to the increased modulus of the PIs. Other properties (thermal and elec. properties, resistance to plating solutions, and photosensitivity etc.) of the modified siloxane-containing PIs will be also discussed in this work. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Reference of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and spectral studies on metal complexes of s-triazine based ligand and non linear optical properties was written by Shanmugakala, R.;Tharmaraj, P.;Sheela, C. D.. And the article was included in Journal of Molecular Structure in 2014.Product Details of 2272-40-4 The following contents are mentioned in the article:

A series of transition metal complexes of type [ML] (1–3) and [ML₂]Cl₂ (4–6) (M = Cu(II), Ni(II), Co(II)) synthesized from 2-phenylamino-4,6-dichloro-s-triazine and 3,5-di-Me pyrazole; their characteristics were studied by elemental analyses, magnetic susceptibility, molar conductance, IR, UV-visible, Mass, NMR and ESR spectra. The electrochem. behavior of copper(II) complexes the authors have studied, by using cyclic voltammetry. The ESR spectra of copper(II) complexes are recorded at 300 K and 77 K and their salient features are appropriately reported. Spectral datas, the authors found, show that the ligand acts as a neutral tridentate, and coordinates through the triazine ring nitrogen and pyrazolyl ring nitrogen atoms to the metal ion. Evident from the authors’ findings, the metal(II) complexes of [ML] type exhibit square pyramidal geometry, and that of [ML₂]Cl₂ exhibit octahedral geometry. The in vitro antimicrobial activities of the ligand and its complexes are evaluated against Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Proteus vulgaris, Cryptococcus neoformans, Pseudomonas aeruginosa, Salmonella typhi, Serratia marcescens, Shigella flexneri, Vibrio cholera, Vibris parahaemolyticus, Aspergillus niger, Candida albicans and Penicillium oxalicum by well-diffusion method. The second harmonic generation efficiency of the ligand and its complexes are determined and compared with urea and KDP. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Product Details of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics