Category: 2272-40-4

Comparison of four methods of predicting newly measured octanol/water coefficients (Log K_ow) for heterocyclic nitrogen compounds and the partition mechanism was written by Li, Li;Wang, Liansheng;Han, Shuokui;Zhang, Zheng. And the article was included in Environmental Toxicology and Chemistry in 1999.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Log K_ow values for 14 heterocyclic nitrogen compounds (by traditional shake-flask method) were reported. Reverse phase-high-performance liquid chromatog. (RP-HPLC) method and three estimation models-linear solvation energy relationship, mol. connectivity indexes (MCIs), and quantum chem. descriptors-were used to study the partition mechanism and to establish the correlations of the models with the measured log K_ow values by stepwise variable regression. Research on the partition mechanism showed that the mol. bulk properties and the hydrogen bond interaction were the most important factors influencing the partition process. Comparison of the quality of the models was made among the four methods. According to the simplicity of the method, the availability of the descriptors, and the closeness of correlation with the measured log K_ow values, the RP-HPLC method was not satisfactory, while the MCIs method introducing the non-disperse force factor was the most satisfactory. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A novel triazine-bearing calix[4]arene: Design, synthesis and gas sensing affinity for volatile organic compounds was written by Halay, Erkan;Acikbas, Yaser;Capan, Rifat;Bozkurt, Selahattin;Erdogan, Matem;Unal, Ridvan. And the article was included in Tetrahedron in 2019.HPLC of Formula: 2272-40-4 The following contents are mentioned in the article:

A novel triazine-calix[4]arene conjugate was designed and synthesized with the aim to study gas sensing against volatile organic compounds (VOCs) such as dichloromethane, chloroform and carbon tetrachloride. This novel compound was fully characterized by spectroscopic techniques such as FTIR, ¹H and ¹³C NMR along with HRMS and BET anal. The triazine based calix[4]arene organic materials were fabricated onto quartz glasses and quartz crystal substrates to form a thin film chem. sensor element by using Langmuir-Blodgett (LB) technique. Quartz Crystal Microbalance, UV-Visible Spectroscopy, Atomic Force Microscopy and SEM techniques were employed to characterize all these LB thin film layers. Fick’s Equations were used for analyzing the swelling process of LB thin film sensor and diffusion coefficient values of organic vapors for swelling were obtained. The initial experiments revealed that new triazine appended calix[4]arene derivative exhibited an effective chem. gas sensor characteristic with a large response to dichloromethane vapor. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4HPLC of Formula: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of Triazine Mimetics As Potent Antileishmanial Agents was written by Chauhan, Kuldeep;Sharma, Moni;Shivahare, Rahul;Debnath, Utsab;Gupta, Suman;Prabhakar, Yenamandra S.;Chauhan, Prem M. S.. And the article was included in ACS Medicinal Chemistry Letters in 2013.Reference of 2272-40-4 The following contents are mentioned in the article:

The World Health Organization has classified the leishmaniasis as a major tropical disease. The discovery of new compounds for leishmaniasis is therefore a pressing concern for the anti-infective research program. We have synthesized 19 compounds of triazine dimers as novel antileishmanial agents. Most of the synthesized derivatives exhibited better activity against intracellular amastigotes (IC₅₀ ranging from 0.77 to 10.32 μM) than the control, pentamidine (IC₅₀ = 13.68 μM), and are not toxic to Vero cells. Compounds 14 and 15 showed significant in vivo inhibition of 74.41% and 62.64%, resp., in L. donovani/hamster model. Moreover, expansion of Th1-type and suppression of Th2-type immune responses proved that compound 14 stimulates mouse macrophages to prevent the progression of leishmania parasite. The mol. docking studies involving PTR1 protein PDB further validated the concepts involved in the design of these compounds Among the investigated analogs, compound 14 has emerged as the potential one to enlarge the scope of the study. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Reference of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12 was written by Sprague, Daniel J.;Getschman, Anthony E.;Fenske, Tyler G.;Volkman, Brian F.;Smith, Brian C.. And the article was included in ACS Medicinal Chemistry Letters in 2021.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function. Pathol., the CXCL12-CXCR4 signaling axis is involved in many cancers and inflammatory diseases and thus has sparked continued interest in the development of therapeutics. Small mols. targeting CXCR4 have had mixed results in clin. trials. Alternatively, small mols. targeting the chemokine instead of the receptor provide a largely unexplored space for therapeutic development. Here we report that trisubstituted 1,3,5-triazines are competent ligands for the sY12-binding pocket of CXCL12. The initial hit was optimized to be more synthetically tractable. Fifty unique triazines were synthesized, and the structure-activity relationship was probed. Using computational modeling, we suggest key structural interactions that are responsible for ligand-chemokine binding. The lipophilic ligand efficiency was improved, resulting in more soluble, drug-like mols. with chem. handles for future development and structural studies. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents was written by Kumar, Ashok;Srivastava, Kumkum;Raja Kumar, S.;Puri, S. K.;Chauhan, Prem M. S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Reference of 2272-40-4 The following contents are mentioned in the article:

There is challenge and urgency to synthesize cost-effective chemotherapeutic agents for treatment of malaria after the widespread development of resistance to chloroquine (CQ). In the present study, we synthesized a new series of hybrid 9-anilinoacridine triazines using the cheap chems. 6,9-dichloro-2-methoxy acridine and cyanuric chloride. The series of new hybrid 9-anilinoacridine triazines were evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of Plasmodium falciparum and their cytotoxicity were determined on VERO cell line. Of the evaluated compounds, two compounds I (R = (CH₂)₃NMe₂, IC₅₀ = 4.21 nM; R = NH₂, IC₅₀ = 4.27 nM) displayed two times higher potency than CQ (IC₅₀ = 8.15 nM). Most of the compounds showed fairly high selectivity index. The compounds II (X = H and F) displayed >96.59% and 98.73% suppression, resp., orally against N-67 strain of Plasmodium yoelii in swiss mice at dose 100 mg/kg for four days. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Reference of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of new s-triazine polymers and their application as nanoparticulate drug delivery systems was written by Khattab, Sherine N.;Abdel Naim, Samar E.;El-Sayed, Mousa;El Bardan, Aly A.;Elzoghby, Ahmed O.;Bekhit, Adnan A.;El-Faham, Ayman. And the article was included in New Journal of Chemistry in 2016.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Herein, we report the synthesis of a library of new s-triazine polyamides containing glycine and thioglycolic acid. The reaction of s-triazine dicarboxylic acid derivatives with ethylenediamine, benzidine, piperazine, or p-phenylenediamine, afforded the target designed s-triazine polyamides. The thermal properties of the polymers were evaluated by different techniques, and the thermodn. parameters of the decomposition processes were evaluated. The feasibility of the synthesized polymers as drug nanodelivery systems was investigated. The nanoparticles were loaded with celecoxib (CXB), an anti-inflammatory drug with a highly promising anti-cancer effect, resulting in high entrapment efficiency levels (62.3-99.8%) with good drug loading in the range 1.58-4.19%. After 48 h, 46.90, 64.20, 57.81, 53.95, and 49.43% of CXB was released from polymeric NPs 26, 43, 44, 45, and 46, resp., demonstrating a sustained drug release profile. Notably, free CXB, and CXB-loaded polymeric NPs CXB-43, CXB-45, and CXB-46 demonstrated considerable reduction in cell viability in a dose-dependent manner. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of semicrystalline poly(guanamine)s based on 2-substituted-4,6-dichloro-1,3,5-triazine with α, ω-alkylene diamines, and the formation of cyclic tetramers was written by Shibasaki, Yuji;Kotaki, Tomohiro;Bito, Takahiro;Sasahara, Rina;Idutsu, Natsuko;Fujimori, Atsuhiro;Miura, Shuntaro;Shidara, Yusaku;Nishimura, Naoya;Oishi, Yoshiyuki. And the article was included in Polymer in 2018.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Polycondensation of various 2-substituted-4,6-dichloro-1,3,5-triazine such as N,N-diphenylamino (DCPT), benzylamino (BnDCT) substituents with α, ω – alkylene diamines including hexamethylene (HMDA), octamethylene (OcDA), decamethylene (DcDA), and dodecamethylene diamine (DdDA) was performed, and the resultant polymers were analyzed. Two-phase polymerization in nitrobenzene/aqueous NaHCO₃ at 100 °C resulted in a high mol. weight (MW) polymer (M_n = 12,400) with a small fraction (26.7 wt%) of low MW oligomer, whose main component was confirmed as a 4-membered cyclic compound Polymers prepared with HMDA were crystalline with poor solubility, whereas those with OcDA, DcDA, and DdDA were all amorphous with high MWs (M_n = 40,000-60,000) and good solubility enough to prepare the self-standing transparent films. The polymers show moderate glass transition temperatures from 76 °C to 159 °C. In differential scanning calorimetry measurements, only poly(BnDCT-HMDA) showed a clear endothermic peak (ΔH = 119 J/g), which corresponds to melting at 220 °C. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and studies on S-triazine-based ligand and its metal complexes was written by Shanmugakala, R.;Tharmaraj, P.;Sheela, C. D.;Anitha, C.. And the article was included in International Journal of Inorganic Chemistry in 2012.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:

Tridentate chelate complexes of ML type (where M = Cu(II), Ni(II), and Co(II)) have been synthesized from triazine-based ligand 4,6-bis(5-mercapto-1,3,4-thiadiazol-amine)2-phenylamino-1,3,5-triazine (BMTDT). Microanal. data, magnetic susceptibility measurements, IR, ¹H NMR, UV-vis, mass, and EPR spectral techniques were used to characterize the structure of chelates. The electronic absorption spectra and magnetic susceptibility measurements suggest that metal complexes show square pyramidal geometry. The electrochem. behavior of copper(II) complex is studied by cyclic voltammetry. All synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation efficiency (SHG) of the ligand and metal complexes has been found to be higher than that of urea and KDP. The antimicrobial activity of the ligand and metal(II) complexes against the species Shigella, Chromobacterium, Staphylococcus aureus, Candida albicans, and Aspergillus niger has been carried out and compared with the standard one. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of Novel Triazine-Based Poly(phenylene sulfide)s with High Refractive Index and Low Birefringence was written by Fu, Mao-Chun;Ueda, Mitsuru;Ando, Shinji;Higashihara, Tomoya. And the article was included in ACS Omega in 2020.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

High-refractive-index (high-n) polymers with a high optical transparency and low birefringence (Δn) have been desired in progressive optoelectronic devices. However, the trade-off between high-n and low-Δn remains a challenge at present. Here, the development of a novel array of high-n, high-sulfur-containing, highly transparent, colorless poly(phenylene sulfide) (PPS) polymers bearing triazine units in the main chains is reported. Six new triazine monomers T1-T6 with various pendant groups via different linkers (-O- and -NH-) could be prepared for developing PPSs with high-n and low Δn values. These PPSs (P1-P6) were obtained by the polycondensation of T1-T6 with com. aromatic dithiol, 4,4′-thiobisbenzenethiol, resp., which showed very high-n values (n_av: 1.6902-1.7169 at 633 nm), high optical transparency (T % > 90% @ 400 nm), and low birefringence (Δn = 0.0015-0.0042). All the PPSs displayed high values (1.6340-1.6654), providing valuable information for the development of high-n triazine-based PPS materials for application not only in the visible region but also in the near-IR region. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisinin-triazine hybrids and hybrid-dimers was written by Cloete, Theunis T.;de Kock, Carmen;Smith, Peter J.;N’Da, David D.. And the article was included in European Journal of Medicinal Chemistry in 2014.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

A series of artemisinin-triazine hybrids and hybrid-dimers were synthesized and their in vitro antimalarial activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) and the chloroquine resistant (CQR) Dd2 strains of Plasmodium falciparum determined, while their toxicity against CHO cells were also established. These compounds were prepared by linking artemisinin and triazine pharmacophores through nucleophilic substitution, using conventional and microwave-assisted methods. These hybrids and hybrid-dimers were all found to be active against all three Plasmodium strains, with the p-anisidino-substituted triazine hybrid-dimer being the most active of all. It showed good antigametocytocidal activity against the NF54 strain, with a 50% inhibitory concentration value in the nanomolar range, while having a potency comparable to that of artesunate against the Dd2 strain. This hybrid-dimer further demonstrated selective toxicity towards the parasitic cells. This dimer hence showed the necessary potential as candidate for further investigation in the search for malaria transmission blocking drugs so desperately needed. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics