Category: 2272-40-4

Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates was written by Manohar, Sunny;Khan, Shabana I.;Rawat, Diwan S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 2272-40-4 The following contents are mentioned in the article:

A series of 4-aminoquinoline-triazine conjugates I [X = (CH₂)_n, n = 2 – 4, 6, 8; X = CH₂CHMe; R¹ = Et₂N, PhNH, 2-MeC₆H₄NH, 4-morpholinyl, 1-piperidinyl; R² = Cl, c-C₆H₁₁NH, PhNH, 3,5-(MeO)₂C₆H₃NH, etc.] with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum. Compounds I [X = (CH₂)₃, (CH₂)₈; R¹ = 4-morpholinyl; R² = 3,5-(MeO)₂C₆H₃NH], I (X = CH₂CH₂; R¹ = R² = PhNH) and I [X = CH₂CH₂; R¹ = 2-(7-chloroquinolin-4-ylamino)ethylamino; R² = Cl] exhibited promising antimalarial activity against both strains of P. falciparum. Cytotoxicity of these compounds was tested against three cell lines. Several compounds did not show any cytotoxicity up to a high concentration (48 μM), others exhibited mild toxicities but selective index for antimalarial activity was high for most of these conjugates. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4HPLC of Formula: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, and Molecular Structure Investigations of a New s-Triazine Derivatives Incorporating Pyrazole/Piperidine/Aniline Moieties was written by Shawish, Ihab;Soliman, Saied M.;Haukka, Matti;Dalbahi, Ali;Barakat, Assem;El-Faham, Ayman. And the article was included in Crystals in 2021.Related Products of 2272-40-4 The following contents are mentioned in the article:

In this work, authors synthesized two new s-triazine incorporates pyrazole/piperidine/aniline moieties I (R = H, 4-Br). Mol. structure investigations in the light of X-ray crystallog. combined with Hirshfeld and DFT calculations were presented. Intermol. interactions controlling the mol. packing of 4-(3,5-dimethyl-1H-pyrazol-1-yl)-N-phenyl-6-(piperidin-1-yl)-1,3,5-triazin-2-amine and N-(4-bromophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)-1,3,5-triazin-2-amine were analyzed using Hirshfeld calculations The most dominant interactions are the H…H, N…H and H…C contacts in both compounds The N…H and H…C interactions in I (R = H) and the N…H, Br…H and H…H interactions in I (R = 4-Br) are the most important. In addition, DFT calculations were used to compute the mol. structures of I (R = H, 4-Br); then, their electronic properties, as well as the ¹H- and ¹³C-NMR spectra, were predicted. Both compounds are polar where I (R = H) (1.018 Debye) has lower dipole moment than I (R = 4-Br) (4.249 Debye). The NMR chem. shifts were calculated and very good correlations between the calculated and exptl. data were obtained (R² = 0.938-0.997). This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

1,3,5-Triazine-based polymer: synthesis, characterization and application for immobilization of silver nanoparticles was written by Osman, Sameh M.;Khattab, Sherine N.;Aly, El-Saied A.;Kenawy, El-Refaie;El-Faham, Ayman. And the article was included in Journal of Polymer Research in 2017.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Six s-triazine-based polymers were prepared through the nucleophilic reaction of 2,4-dichloro-6-substituted s-triazine derivatives with 1,4-diaminobutane employing conventional heating and microwave irradiation The prepared polymers were characterized by using Fourier-transform IR spectroscopy (FTIR), thermogravimetric anal. (TGA), differential scanning calorimetry (DSC) and gel permeation chromatog. (GPC). The microwave irradiation provides the target polymers in less reaction time with higher yields and purities; the results from the TGA revealed that microwave technique enhanced the thermal behavior of the prepared polymers. The effect of substituent on the thermal stability of polymers has the main factor, where incorporation of the aromatic ring on the triazine core in the prepared polymers increased their thermal stability. As a model for immobilization of silver nanoparticles (AgNPs), p-methoxy-s-triazine-1,4-butadiamine (BDPMA) copolymer was used as an example in the presence and absence of hydrazine hydrate. AgNPs were characterized by zeta potential, scanning electron microscope (SEM), X-ray powder diffraction anal. (XRD) and transmission electron microscope (TEM). Best results in term of particle size was obtained by using BDPMA in the absence of hydrazine hydrate, where the particle size of AgNPs was less than 20 nm as observed from TEM. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of New S-Triazine Bishydrazino and Bishydrazido-Based Polymers and Their Application in Flame-Retardant Polypropylene Composites was written by Aldalbahi, Ali;AlOtaibi, Bander S.;Thamer, Badr M.;El-Faham, Ayman. And the article was included in Polymers (Basel, Switzerland) in 2022.SDS of cas: 2272-40-4 The following contents are mentioned in the article:

In this study six new s-triazine bishydrazino and bishydrazido-based polymers were synthesized via condensation of bishydrazino s-triazine derivatives with terephthaldehyde or via nucleophilic substitution of dichloro-s-triazine derivatives with terephthalic acid hydrazide. The synthesized polymers were characterized by different techniques. The new polymers displayed good thermal behavior with great values in terms of limited oxygen indexed (LOI) 27.50%, 30.12% for polymers 5b,c (bishydrazino-s-triazine based polymers) and 27.23%, 29.86%, 30.85% for polymers 7a-c (bishydrazido-s-triazine based polymers) at 800°C. Based on the LOI values, these polymers could be classified as flame retardant and self-extinguishing materials. The thermal results also revealed that the type of substituent groups on the triazine core has a considerable impact on their thermal behavior. Accordingly, the prepared polymers were mixed with ammonium polyphosphate (APP) in different proportions to form an intumescent flame-retardant (IFRs) system and were introduced into polypropylene (PP) to improve the flame-retardancy of the composites. The best results were obtained with a mass ratio of APP: 5a-c or 7a-c of 2:1, according to the vertical burning study (UL-94). In addition, the presence of 25% “weight ratio” of IFR in the composite showed great impact and passed UL-94 V-0 and V-1 tests. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel deep-cavity calix[4]arene derivatives with large s-triazine conjugate systems: synthesis and complexation for dyes was written by Yang, Fafu;Liu, Weiwei;Xie, Jianwei;Bai, Xiaoyan;Guo, Hongyu. And the article was included in Journal of Inclusion Phenomena and Macrocyclic Chemistry in 2013.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Two novel deep-cavity calix[4]arenes 3 and 4 with large s-triazine π-conjugate systems were designed and synthesized in high yields by reacting calix[4]arene with mono phenyl-substituted cyanuric chloride or further substitution with aniline. The liquid-liquid extraction experiment showed that they possessed excellent extraction abilities towards one cationic and three anionic dyes (Orange I, methylene blue, neutral red, brilliant green). The highest extraction percentage of compound 4 was 88.8 % for brilliant green. The complexation UV-visible spectra of compounds 3 and 4 with the four dyes indicated the existences of complexation action between hosts and guests with 1:1 ratio of complexation in DMSO solution The association constants suggested that the larger π-conjugate system of compound 4 possessed the stronger complexation abilities than that of compound 3. The association constant of compound 4 with BG was as high as 8.1 × 10⁶ M^-1. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of reactive dyes by the introduction of Phenyl Urea derivatives into the triazine ring and their application on different fibers was written by Patel, Manoj J.;Tandel, R. C.. And the article was included in Materials Today: Proceedings in 2021.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:

Reactive dyes are most popular class of dyeing for cotton. Currently bifunctional reactive dyes is mostly used in textiles industries. Bifunctional reactive dyes have good fastness properties, wide color gamut, flexible application procedure. Novel bifunctional reactive dyes synthesized into the triazine ring by introducing Ph Urea and its derivatives Derivatives of Ph Urea and (j-acid) 2-amino-5-naphthol-7-sulfonic acid were condensed with 2, 4, 6-Trichloro-1, 3, 5-triazin synthesized coupling component.4-(β-sulfatoethysulfonyl) anilin was used as a diazo component. IR spectroscopy, Visible absorption spectra and ¹H NMR were used for characterization. All dyes has been examined on silk, wool and cotton. Fastness properties and exhaustion and fixation value of all synthesized dyes were evaluated. In this study it was observed that all synthesis dyes showed high exhaustion and fixation, good Wash fastness to color, good migration and leveling dyeing. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, and application of a protein A mimetic was written by Li, Rongxiu;Dowd, Victor;Stewart, David J.;Burton, Stephen J.;Lowe, Christopher R.. And the article was included in Nature Biotechnology in 1998.Electric Literature of C9H6Cl2N4 The following contents are mentioned in the article:

Low-mol.-weight synthetic mols. that mimic the activity of native biol. macromols. have therapeutic potential, utility in large-scale production of biopharmaceuticals, and the capacity to act as probes to study mol. recognition events. The authors have developed a nonpeptidyl mimic for Staphylococcus aureus Protein A (SpA). The specific recognition and complexation elements between the B domain (Fb) of SpA and the Fc fragment of IgG were identified from the x-ray crystallog. structure. Computer-aided mol. modeling was used to design a series of biomimetic mols. around the Phe 132-Tyr133 dipeptide involved in its binding to IgG. One of the ligands binds IgG competitively with SpA in solution and when immobilized on agarose beds, with an affinity constant of 10⁵-10⁶ M^-1. The immobilized artificial Protein A was used to purify IgG from human plasma and murine IgG from ascites fluid, and to remove bovine IgG from fetal calf serum. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Electric Literature of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Study of the properties of some triazine-containing polycarbonates was written by Smirnova, O. V.;Kutepov, D. F.;Bolmosova, V. P.;Atrushkevich, A. A.. And the article was included in Trudy Instituta – Moskovskii Khimiko-Tekhnologicheskii Institut imeni D. I. Mendeleeva in 1980.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

I (R = Ph, NPh₂, NHPh, or piperidino; m = 5-30; 2m + n = 100) showed higher alkali resistance and O index and lower thermal stability in comparison with Diflon  [24936-68-3] (I, m = 0). The thermal degradation of I was presumed to proceed via homolytic cleavage of the C-N bonds of the triazine rings, based on high (>167.6 kJ/mol) activation energies of liberation of CO₂, CO, and CH₄ gases from I and model compounds The thermal degradation of I began at 300-310, 290, and 265-290° for m = 0, 5, and 30, resp., while thermal stability of I (m = 30) decreased in the order: R = Ph, NPh₂, NHPh, and piperidino. The alkali resistance of I increased with decreasing NaOH solution concentration and exposure period and with increasing m. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Differential dyeing cotton. 1. Preparation and evaluation of differential dyeing cotton yarn was written by Clipson, Jacqueline A.;Roberts, George A. F.. And the article was included in Journal of the Society of Dyers and Colourists in 1989.Product Details of 2272-40-4 The following contents are mentioned in the article:

The synthesis and evaluation of a series of colorless reactive cationic compounds based on the s-triazine nucleus, together with an anionic analog, and the results of a preliminary investigation of their effects on the subsequent dyeing behavior of cotton yarns pretreated with these reagents are reported. Yarns pretreated with cationic reagents showed better uptake of acid and direct dyes than did untreated yarn, and since the degree of differential uptake depended on the level of pretreatment, which could be readily controlled, fabrics exhibiting a variety of tone-on-tone effects were produced. Treatment with an anionic reagent gave cotton dyeable with basic dyes. Combinations of anionic- and cationic-treated yarns were cross dyed in a single-bath 1-step process with very little cross staining. Pretreated cotton was converted to rayon or cellulose acetate fibers with retention of the modified dyeing properties, thus providing roots to differential-dyeing rayon and acetate fibers. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Product Details of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Arylamino-1,3,5-triazines Functionalized with Alkylatin 2-chloroethylamine Fragments and Studies of their Cytotoxicity on the Breast Cancer MCF-7 Cell Line was written by Fraczyk, Justyna;Kolesinska, Beata;Swiontek, Monika;Lipinski, Wojciech;Drozdowska, Danuta;Kaminski, Zbigniew Jerzy. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2016.Computed Properties of C9H6Cl2N4 The following contents are mentioned in the article:

Dual action alkyl(aryl)amino-1,3,5-triazines functionalized with nitrogen mustards were obtained by treating 2-alkyl(aryl) amino-4-chloro-6-methoxy-1,3,5-triazines with amines or amino acid Me esters, followed by reactions with 1,4-diazabicyclo[2.2.2]octane (DABCO) and rearrangement with an opening diazabicyclic fragment, leading to the formation of 2-chloroethylamino moiety. In vitro antitumor activity was tested in the standard human breast cancer MCF-7 and MDA-MB-231 cell lines using flow cytometry, based on the detection of apoptosis through qual. anal. of morphol. changes, DNA fragmentation, DNA loss and membrane changes. For all the compounds studied, induced apoptosis was substantially stronger than necrosis at concentrations of both 5 μM and 50 μM, and in some cases there was no increase in necrotic cell death for the estrogen dependent MCF-7 cell line. The most active compounds were derivatives of triazine substituted with phenylamine (IC50 = 12.30 μM) and/or p-tolylamine fragments (IC50 = 7.40 μM). This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Computed Properties of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics