Category: 2272-40-4

Synthesis of highly refractive and highly fluorescent rigid cyanuryl polyimines with polycyclic aromatic hydrocarbon pendants was written by Kotaki, T.;Nishimura, N.;Ozawa, M.;Fujimori, A.;Muraoka, H.;Ogawa, S.;Korenaga, T.;Suzuki, E.;Oishi, Y.;Shibasaki, Y.. And the article was included in Polymer Chemistry in 2016.Reference of 2272-40-4 The following contents are mentioned in the article:

A series of rigid cyanuryl polyimines, polyguanamines (PGs) bearing polycyclic aromatic hydrocarbon pendants were successfully synthesized from 2-substituted 4,6-dichloro-1,3,5-triazine and aromatic diamine monomers used in conventional solution polymerization In addition, their thermal and optical properties were also investigated. All polymers showed high thermostabilities (T_g âˆ?320 °C, T_d5 (N₂) âˆ?466 °C, residue at 800 °C under nitrogen âˆ?9.0%) and adequate solubilities in polar organic solvents. Films prepared by the solvent-cast method showed good transparencies, which mainly depended on the diamine structure as opposed to the dichloride moiety. The refractive indexes at the D-line (589 nm) of the PG films were unexpectedly high, between 1.677 and 1.800, compared to those of common organic optical polymeric resins. The incorporated melamine moieties afforded effective dense packing with the polycyclic aromatic hydrocarbon groups filling the free spaces between rigid polymer chains, resulting in unusually high refractive indexes. The PG polymer solution in N-methylpyrrolidone showed strong blue fluorescence (371-471 nm) with a quantum yield of up to 98%. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Reference of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and structure-activity relationship study of triazine-based inhibitors of the DNA binding of NF-κB was written by Fujii, Shinya;Kobayashi, Takanobu;Nakatsu, Aki;Miyazawa, Hiroshi;Kagechika, Hiroyuki. And the article was included in Chemical & Pharmaceutical Bulletin in 2014.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Nuclear transcription factor nuclear factor-κ B (NF-κB) has diverse pathophysiol. functions, and NF-κB inhibitors are considered to be candidates for multiple therapeutic applications. The previously reported novel triazine-based NF-κB inhibitor, 2-anilino-4,6-dichloro-1,3,5-triazine (NI241), directly inhibits DNA binding of NF-κB. Here, the synthesis of a series of triazine derivatives I (R¹ = Cl, BuO, NHMe, NMe₂; R² = MeO, OC₆H₅, N-pyrrolidino, etc.) II (R³ = H, Me, Et, etc.; R⁴ = C₆H₅, 2-MeOC₆H₄, 3-MeOC₆H₄, etc.) and evaluation of their structure-activity relationships for NF-κB inhibition are reported. The 2-amino-4,6-dichloro-1,3,5-triazine substructure is essential for the inhibitory activity of the lead compound NI241, and modification of NI241 by introduction of an m-methoxy substituent on the Ph ring afforded the more potent derivative The structure-activity relationships identified in this study suggested a possible mechanism of irreversible NF-κB inhibition by NI241, and should be helpful in the design of other NF-κB inhibitors. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structural investigations of three triazines: Solution-state NMR studies of internal rotation and structural information from solid-state NMR, plus a full structure determination from powder X-ray diffraction in one case was written by Birkett, Helen E.;Cherryman, Julian C.;Chippendale, A. Margaret;Evans, John S. O.;Harris, Robin K.;James, Mark;King, Ian J.;McPherson, Graham J.. And the article was included in Magnetic Resonance in Chemistry in 2003.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Three model 2,4,6-tris(amino)-1,3,5-triazines, structurally related to a dyestuff mol. previously studied by NMR, were synthesized in order to enable the effects of rotamer exchange on the NMR spectra to be investigated in more detail. Two of the compounds are novel. Internal rotation of the triazine ring substituents was studied by variable-temperature solution-state ¹H, ¹³C and ¹⁵N NMR spectroscopy. All the expected rotamers were detected for each mol. Rotamer exchange rates varied from slow to fast over the temperature range -40 to 90°C, as observed for the dyestuff mol. itself. Solid-state ¹³C and ¹⁵N NMR provided information about the structures of the solid mols. A full crystal structure determination from high-resolution powder x-ray diffraction was achieved for one of the mols. using simulated annealing techniques. Ab initio MO and ¹⁵N NMR chem. shift calculations, based on energy-minimized structures derived from the x-ray structure determination, enabled the effect of intermol. hydrogen bonding on the ¹⁵N NMR chem. shifts to be studied. The results compared favorably with the exptl. solid-state ¹⁵N NMR shifts. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice was written by Singh, Palwinder;Kaur, Sukhmeet;Kumari, Priya;Kaur, Baljit;Kaur, Manpreet;Singh, Gurjit;Bhatti, Rajbir;Bhatti, Manpreet. And the article was included in Journal of Medicinal Chemistry in 2018.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:

Here, the authors report analgesic and anti-inflammatory activity of a series of compounds obtained by appending 4-aminophenylmorpholin-3-one and acyclic, cyclic, or heterocyclic moieties on 1,3,5-triazine. The structures of compounds 4b (4-(4-(4-chloro-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)morpholin-3-one) and 6b (4-(4-(4-chloro-6-(4-chlorophenylamino)-1,3,5-triazin-2-ylamino)phenyl)morpholin-3-one) are optimized for the best inhibition of COX-2 with IC₅₀ values of 0.06 and 0.08 μM, resp., and selectivity over COX-1 of 166 and >125, resp. At the dose of 5 mg kg^-1, these compounds significantly reduced acetic acid induced writhings, and their ED₅₀ values were found to be 2.2 and 1.9 mg kg^-1, resp. Besides the cell-based and animal-based experiments showing the modes of action of these compounds targeting COX-2, the interaction behavior of 4b with COX-2 was also characterized, with physicochem. experiments including ITC, NMR, UV-vis, and mol.-modeling studies. Characteristically, these compounds interact with R120, Y355, and W385, the residues responsible for holding the substrate and mediating the process of electron transfer during the metabolic phase of the enzyme. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New scaffolds of inhibitors targeting the DNA binding of NF-κB was written by Kobayashi, Takanobu;Tanuma, Sei-ich;Kino, Katsuhito;Miyazawa, Hiroshi. And the article was included in Integrative Molecular Medicine in 2016.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Nuclear factor-kappa B (NF-κB) has numerous pathophysiol. functions and is therefore considered a suitable target in the search for drugs to treat many diseases, including cancers and inflammatory diseases. We previously reported a novel triazine-based NF-κB inhibitor, 4,6-dichloro-N-phenyl-1,3,5-triazin-2-amine (NI241), which directly inhibits binding of NF-κB to DNA. We predicted the mode of binding between NI241 and p50 (a member of NF-κB family) using in silico docking simulations. Here, we searched for new NF-κB inhibitors using structure-based virtual screening (SBVS), a computational method widely used to identify candidate compounds in drug discovery. In the present study, we performed SBVS with the docking simulation program Glide and selected 33 compounds from our virtual chem. library. Subsequently, we investigated the NF-κB inhibitory effects of these compounds using electrophoretic mobility shift assays. We identified two compounds that inhibited the DNA binding of p50. Although these compounds were less effective than NI241 as NF-κB inhibitors, they have new scaffold structures and provide clues that will aid future efforts to identify novel compounds that specifically inhibit the binding of NF-κB to DNA. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The modification of wool with reactive hydrophobes was written by Lewis, D. M.;Pailthorpe, M. T.. And the article was included in Journal of the Society of Dyers and Colourists in 1984.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

Of 7 reactive hydrophobic compounds synthesized and applied as aqueous dispersions to wool by pad-dry-steam or exhaustion procedures, 2 imparted significant disperse dye affinity to the wool, namely 6-anilino-2,4-dichloro-s-triazine (I) [2272-40-4] and 6-(1-naphthylamino)-2,4-dichloro-s-triazine (II) [30369-88-1]. For I a weight gain of 12.7% was achieved by exhaustion and 11% by padding. The ISO2 washfastness rating for the dyes examined increased from <1 to 4 and there was a slight improvement in lightfastness. With II a weight gain of 8.9% was achieved with the standard exhaustion recipe. While washfastness rating were satisfactory, II had an adverse effect on lightfastness of the dyes. I-treated wool had an affinity for disperse dyes equivalent to that of benzoylated wool of similar weight gain; however, the application of I caused significantly less yellowing than the benzoylation process. Thus, 100% wool and 60:40 wool-polyester blends were dyed satisfactory with disperse dyes in the presence of I to achieve good washfastness ratings. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of a series of reactive ionic, nonionic, and hydrophobic compounds as antistatic agents for wool was written by Lewis, D. M.;Pailthorpe, M. T.. And the article was included in Textile Research Journal in 1984.Application of 2272-40-4 The following contents are mentioned in the article:

The antistatic effectiveness was determined for >30 compounds having as reactant groups mono- and dichlorotriazine, epoxy, γ-chlorohydrin, β-sulfato ethyl sulfone, aceto-s-thiosulfate, and chloroacetyl; as ionic groups sulfonate, sulfate, sulfamate, carboxylate, phosphonate, and quaternary ammonium groups; as the nonionic groups polyethylene glycols. The addition of bulky hydrophobic groups to wool caused a reduction in natural moisture regain of the wool which caused the elec. resistance of wool to increase. The inclusion of anionic groups in wool, fixed by covalent bonds, did not caused a significant decrease in the elec. resistance of wool, even at high add on levels. Cationic groups had significant effect on elec. resistance of wool, especially at 65% relative humidity; however the cationically treated wool was not antistatic at 25% relative humidity. The addition of polyethylene glycol had significant effect on the elec. resistance, especially for poly(ethylene glycol) [25322-68-3] of mol. weight 600. Combination of this compound with cationic compounds either in mixture or chem. combined, were especially effective in reducing the elec. resistance of wool at 65% and 25% relative humidity. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, Spectra, and Theoretical Investigations of 1,3,5-Triazine Compounds as Ultraviolet Rays Absorber Based on Time-Dependent Density Functional Calculations and three-Dimensional Quantitative Structure-Property Relationship was written by Wang, Xueding;Xu, Yilian;Yang, Lu;Lu, Xiang;Zou, Hao;Yang, Weiqing;Zhang, Yuanyuan;Li, Zicheng;Ma, Menglin. And the article was included in Journal of Fluorescence in 2018.Electric Literature of C9H6Cl2N4 The following contents are mentioned in the article:

A series of 1,3,5-triazines I (R¹ = H, p-Cl, m-F, etc.; R² = H, p-CH₃) were synthesized and their UV absorption properties were tested. The computational chem. methods were used to construct quant. structure-property relationship (QSPR), which was used to computer aided design of new 1,3,5-triazines UV rays absorber compounds The exptl. UV absorption data are in good agreement with those predicted data using the time-dependent d. functional theory (TD-DFT) [B3LYP/6-311 + G(d,p)]. A suitable forecasting model (R > 0.8, P < 0.0001) was revealed. Predictive three-dimensional quant. structure-property relationship (3D-QSPR) model was established using multifit mol. alignment rule of Sybyl program, which conclusion is consistent with the TD-DFT calculation The exceptional photostability mechanism of such UV rays absorber compounds was studied and confirmed as principally banked upon their ability to underwent excited-state deactivation via an ultrafast excited-state proton transfer (ESIPT). The intramol. hydrogen bond (IMHB) of 1,3,5-triazine compounds is the basis for the excited state proton transfer, which was explored by IR spectroscopy, UV spectra, structural and energetic aspects of different conformers and frontier MOs anal. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Electric Literature of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Association of hard segments in gas separation through polyurethane membranes with aromatic bulky chain extenders was written by Fakhar, Afsaneh;Sadeghi, Morteza;Dinari, Mohammad;Lammertink, Rob. And the article was included in Journal of Membrane Science in 2019.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Poly(urethane-urea) (PUU) membranes based on contributing hard segments in gas separation were prepared using 2 novel bulky chain extenders, polytetramethylene glycol, isophorone and hexamethylene diisocyanate. The chain extenders were synthesized by cyanuric chloride, aniline/naphthylamine and hydrazine. According to FTIR, AFM and DSC, bulkier PUU membranes showed more phase separation and lower glass transition temperature consistent with higher fractional free volume, which were correlated with single (CO₂, CH₄, O₂ and N₂) and mixed (CO₂:N₂ and CO₂:CH₄) gas permeation results. The main findings indicate these polyurethanes serve efficiently designed mol. structures favoring bulky hard segments contribution in gas separation The bulky PUU membranes afford simultaneous increased permeability and selectivity, while maintaining high tensile properties. Enhanced O₂/N₂ diffusivity selectivity by bulkier PUU and CO₂ sorption/desorption study by Ellipsometry confirmed hard segments’ association, too. The bulkiest membrane provided 126% and 54% improvement for single CO₂ permeability and CO₂/N₂ selectivity compared to linear one. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and bioactivities of multiheterocyclic molecules based on s-triazine was written by Liu, Yaning;Sun, Xiaona;Gao, Ran;Li, Chuanyin;Wang, Jing;Li, Yizheng;Zhang, Chenglu. And the article was included in Youji Huaxue in 2017.Related Products of 2272-40-4 The following contents are mentioned in the article:

S-triazine derivatives have good significant biol. activities. It has been an important method to develop novel drugs by introduction of other heterocyclic rings onto s-triazine. Twenty-one novel target mols. were designed and synthesized by combination of 1,2,4-triazole, triazole[3,4-b]thiadiazole and 1,2,4-triazine unit with s-triazine resp. The structures of the target mols. were characterized by IR, ¹H NMR and HRMS. In order to study the effect of different substituents on the efficacy activities, first, 8 target mols. containing double 1,2,4-triazole unit were synthesized by the condensation of four different mono-substituted s-triazines with intermediates containing n-pentyl and benzyl, resp. Meanwhile, 4 target mols. were synthesized by the modification of the amino group. Nine target mols. were also afforded by the reaction of seven disubstituted s-triazines with the intermediates. The inhibitory activities of the 21 target mols. against Cdc25B were evaluated. The results showed that 13 target mols. exhibited good inhibitory activities against Cdc25B. The IC₅₀ values were between (3.99±0.80) and (0.44±0.07) μg/mL, wherein the IC₅₀ of 5 target mols. were lower than comparison reference Na₃VO₄, which were expected to be potential anticancer drugs. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics