Category: 2272-40-4

Design and development of novel thiazolidin-4-one-1,3,5-triazine derivatives as neuro-protective agent against cerebral ischemia-reperfusion injury in mice via attenuation of NF-kB was written by Lu, Min;Qi, Yujun;Han, Yu;Yi, Qiong;Xu, Lei;Sun, Wenlin;Ni, Guihua;Ni, Xiaoyu;Xu, Changsong. And the article was included in Chemical Biology & Drug Design in 2020.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:

The present study enumerates the discovery and development of novel thiazolidin-4-one-1,3,5-triazine as neuro-protective agent against cerebral ischemia-reperfusion injury in mice. These compounds showed significant inhibition of NF-kB transcriptional activity in LPS-stimulated RAW264.7 cells, displaying compound 8k as most potent inhibitor among the tested derivative The compound 8k was further studied in in vivo middle cerebral artery occlusion (MCAO) mice model for neuro-protective action. Results suggest that compound 8k causes attenuation of inflammation (TNF-α, IL-β, and IL-6), oxidative stress (SOD, GSH, and MDA), and apoptosis (Bcl-2, Bax, and cleaved caspase-3) in MCAO mice in concentration-dependent manner. Collectively, our results documented that compound 8k pre-treatment protects cerebral I/R. This novel lead scaffold may be helpful for investigation of new neuro-protective agent by inactivation of NF-kB. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery was written by Ekins, Sean;Reynolds, Robert C.;Kim, Hiyun;Koo, Mi-Sun;Ekonomidis, Marilyn;Talaue, Meliza;Paget, Steve D.;Woolhiser, Lisa K.;Lenaerts, Anne J.;Bunin, Barry A.;Connell, Nancy;Freundlich, Joel S.. And the article was included in Chemistry & Biology (Oxford, United Kingdom) in 2013.Product Details of 2272-40-4 The following contents are mentioned in the article:

Identification of unique leads represents a significant challenge in drug discovery. This hurdle is magnified in neglected diseases such as tuberculosis. We have leveraged public high-throughput screening (HTS) data to exptl. validate a virtual screening approach employing Bayesian models built with bioactivity information (single-event model) as well as bioactivity and cytotoxicity information (dual-event model). We virtually screened a com. library and exptl. confirmed actives with hit rates exceeding typical HTS results by one to two orders of magnitude. This initial dual-event Bayesian model identified compounds with antitubercular whole-cell activity and low mammalian cell cytotoxicity from a published set of antimalarials. The most potent hit exhibits the in vitro activity and in vitro/in vivo safety profile of a drug lead. These Bayesian models offer significant economies in time and cost to drug discovery. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Product Details of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives was written by Salado, Irene G.;Baan, Adrienn;Verdeyen, Tomas;Matheeussen, An;Caljon, Guy;Van der Veken, Pieter;Kiekens, Filip;Maes, Louis;Augustyns, Koen. And the article was included in European Journal of Medicinal Chemistry in 2018.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Human African trypanosomiasis is causing thousands of deaths every year in the rural areas of sub-saharan Africa. There is a high unmet medical need since the approved drugs are poorly efficacious, show considerable toxicity and are not easy to administer. This work describes the optimization of the pharmacokinetic properties of a previously published family of triazine lead compounds One compound (35 (UAMC-03011)) with potent anti-trypanosomal activity and no cytotoxicity was selected for further study because of its good microsomal stability and high selectivity for Trypanosoma brucei over a panel including Trypanosoma cruzi, Leishmania infantum, and Plasmodium falciparum. In vivo pharmacokinetic parameters were determined and the compound was studied in an acute in vivo mouse disease model. One of the important learnings of this study was that the rate of trypanocidal activity is an important parameter during the lead optimization process. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new way to improve the light-fastness of azo reactive dyes through the introduction of benzene sulfonamide derivatives into the triazine ring was written by Wei, Xiong;Wei, Ma;Zhang, Shufen. And the article was included in RSC Advances in 2019.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Herein, a new kind of hetero-bifunctional reactive dyes with high light-fastness was designed and synthesized by introducing benzene sulfonamide and its derivatives into the triazine ring. Benzene sulfonamide or its derivatives and 2-amino-5-naphthol-7-sulfonic acid (J-acid) were condensed with cyanuric chloride to synthesize coupling components, which were then coupled with the diazo salt of 4-(β-sulfatoethylsulfonyl)aniline. The dyes were characterized by IR spectroscopy and MS. The color fastness test proved that the light-fastness of the dyes could be improved by 1 grade via the introduction of benzene sulfonamide derivatives into the triazine ring when compared with the case of the control dyes. Fluorescence spectra demonstrated that after the introduction of benzene sulfonamide derivatives, the dye mol. could return to the ground state from the excited state and emit fluorescence; in addition, the introduced benzene sulfonamide derivatives helped to deteriorate the adverse effect of UV light on the dye. Moreover, the dyeing results showed that the dyes containing the sulfonamide groups had equal dyeing properties when compared with that of the control dyes. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new small molecule that directly inhibits the DNA binding of NF-κB was written by Kobayashi, Takanobu;Yoshimori, Atsushi;Kino, Katsuhito;Komori, Rie;Miyazawa, Hiroshi;Tanuma, Sei-ich. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Application of 2272-40-4 The following contents are mentioned in the article:

Nuclear factor-κB (NF-κB) has been considered as a good target for the treatment of many diseases. Although a lot of NF-κB inhibitors have already been reported, many of them have several common problems. Thus, we attempted to identify novel NF-κB inhibitors to be unique lead compounds for creating new pharmaceuticals. In the present study, we screened our chem. library for compounds that directly inhibit the DNA binding of NF-κB by using fluorescence correlation spectroscopy (FCS). Consequently, we identified a promising compound, 4,6-dichloro-N-phenyl-1,3,5-triazin-2-amine, referred to as NI241. It mediated a dose-dependent inhibition of the DNA binding of NF-κB p50. Its analogs also showed dose-dependent inhibition and their inhibitory effects were altered by the substituents on the N-Ph group. Furthermore, we predicted the binding mode of NI241 with p50 in silico. In this model, NI241 forms three hydrogen bonds with Tyr60, His144, and Asp242 on p50, which are important amino acid residues for the interaction with DNA. These results suggest that NI241 with structural novelty may serve as a useful scaffold for the creation of new NF-κB inhibitors by rational optimization. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optoelectronic and charge transport properties of D-n-A type 1,3,5-triazine derivatives: A combined experimental and DFT study was written by V. M., Vidya;Pola, Someshwar;Chetti, Prabhakar. And the article was included in Spectrochimica Acta in 2021.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

The synthesis of five D-n-A type star-shaped octupolar mols. is presented in the current work. The exploration of the potential applicability of mols. under study in organic optoelectronics as electron or hole transporting materials is carried out by DFT methods. All the mols. have a 1,3,5-triazine core, which acts as an electron acceptor (A). Ph ring and pyridine ring act as electron donors (D) in AZ and PZ series of mols. resp. The donor and acceptor core are connected by -NH bridge (n). The crystal structure of a mol. in the PZ series is elucidated. Thermogravimetric studies are carried out to confirm the thermal stability of mols. The frontier MOs of mols. are characterized with the help of cyclic voltammetry. With the assistance of DFT methodologies, the whole research presented in this work focuses on the electronic excitations, reorganization energies, electron affinity, ionization potential and features of frontier MOs of mols. The investigation of the variation of optoelectronic properties of mols. with changing patterns of nucleophilic substitution on 1,3,5-triazine core and presence of a hetero (nitrogen) atom in the donor part of the mol. is also accomplished. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of moisture content on the characterization of products from the pyrolysis of sewage sludge was written by Xiong, Sijiang;Zhuo, Jiankun;Zhang, Beiping;Yao, Qiang. And the article was included in Journal of Analytical and Applied Pyrolysis in 2013.SDS of cas: 2272-40-4 The following contents are mentioned in the article:

Sewage sludge samples with moisture contents of 0%, 31%, 47% and 80% were pyrolyzed at 1000 °C in a tubular furnace to evaluate the effect of moisture content on the pyrolysis process. The evaporation of water accelerated the evolution of porosity in the solid char and hence contributed to the devolatilization of sewage sludge, leading to an increase in the gas fraction and a decrease in the solid fraction. The steam-rich atm. generated by the high moisture content of sewage sludge favored the steam reforming reactions of volatile compounds and the steam gasification of solid char, enhancing the production of hydrogen rich fuel gas. A saturation value was also observed for the steam involved in the gasification and reforming reactions. GC-MS anal. showed that the increase of moisture content not only promoted the reduction of the species in the tar, but also improved the production of light aromatics, as a result, the toxic effect of tar decreased considerably. The decrease in the peak areas of organic functional groups of solid char demonstrated that the participation of steam promoted the ejection of volatile matters of sewage sludge during the pyrolysis process. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Influence of side chain monomers on the synthesis and properties of piperazine based triazine charring agent was written by Zhang, Qi;Qiu, Yanyan;Zhou, Fulong;Liu, Junhong;Tang, Linsheng. And the article was included in Gaofenzi Cailiao Kexue Yu Gongcheng in 2020.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

The influence of side chain monomers on the synthesis and properties of piperazine based triazine charring agent was studied. The results show that side chain monomers have a great influence on the synthesis of the charring agent. The stronger the hydrophilicity of side chain monomers is, the more the water-solubility of the charring agent is and the lower the yield is. The weak nucleophilicity of aromatic amines results in higher chlorine content and lower yield of charring agents. Side chain monomers also have significant effects on the thermal stability and flame retardancy of the charring agents. The charring agent with ethanolamine has the best thermal stability, followed by the charring agent with morpholine or aniline, butylamine, diethanolamine and ammonia; the more hydroxyl groups the side chain monomers have, the better the flame retardant effect of the corresponding charring agent is. The side chain monomers without hydroxyl groups result in the poor flame retardant effect of the corresponding charring agent, and the charring agent with ammonia has the worst flame retardant effect. The side chain monomers have little effect on the mech. properties of the flame retardant PP. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Simple and efficient synthetic routes to bioactive s-triazinyl dithiocarbamate derivatives was written by Desai, R. M.;Dodiya, D. K.;Trivedi, A. R.;Shah, V. H.. And the article was included in Medicinal Chemistry Research in 2008.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Series of 2,4-diarylamino-6-[N-(3′-methylphenyl)dithiocarbamoyl]-s-triazines I (R = Ph, 4-ClC₆H₄, 2-MeOC₆H₄, etc.) and 2,4-bis[N-(3′-methylphenyl)dithiocarbamoyl]-6-arylamino-s-triazines II were synthesized by two different synthetic routes. In the first route (A), 2,4,6-trichloro-s-triazine (III) was condensed with N-(3-methylphenyl)ammoniumdithiocarbamate to afford compounds IV [X = Cl, SC(:S)NHC₆H₄-Me-3], which on reaction with different aryl amines afforded compounds I or II. In the second route (B), condensation of III with different aryl amines yielded compounds V (Y = Cl, NHR). On further treatment with N-(3-methylphenyl)ammoniumdithiocarbamate these afforded compounds I or II. The newly synthesized compounds I and II were characterized by elemental analyses, IR (IR), and ¹H NMR (NMR) spectroscopic investigation. All the products were evaluated for their antibacterial and antifungal activity. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and comparative thermal degradation kinetics of s-Triazine based polymers was written by Osman, Sameh M.;Alasmary, Fatmah A.;Kenawy, El-Refaie;Aly, El-Saied A.;Khattab, Sherine N.;El-Faham, Ayman. And the article was included in Journal of Polymer Research in 2021.SDS of cas: 2272-40-4 The following contents are mentioned in the article:

A series of copolymers based on s-triazine and ethylene diamine moiety were synthesized; the prepared copolymers were characterized by FT-IR, TGA, DSC, and GPC. The thermogravimetric anal. of and the thermal stability of the copolymers were used to investigate their non-isothermal behavior. The comparative kinetic study was done using Kissinger method as a model-free; in addition, iso-conversional methods of Kissinger-Akahira-Sunose (KAS), Flynn-Wall-Ozawa (FWO) and Friedman (FR) are reported. The activation energy data extracted by the KAS, FWO and FR fit well with each other (as they are showing the same trend). Generally, the activation parameters were highly dependent on the copolymer’s mol. structure. In addition, the substituent on the triazine core has a great impact, where the activation parameters increased in the presence of an electron-donating group such as a methoxy group (OCH₃) on the aniline moiety. In contrast, it has decreased in the presence of the unsubstituted and p-bromo derivative (week deactivating group). On the other hand, the methoxy group attached to the aniline moiety gave the highest ash formation and the highest limiting oxygen index (LOI) value (29.45). This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics