Category: 18987-59-2

In 2019,European Journal of Inorganic Chemistry included an article by Dong, Jie; Wang, Baiquan. Electric Literature of C18H24Cl2N2Pd2. The article was titled 《Synthesis and Catalytic Properties of Cyclopalladated Complexes Bearing a Phosphane-Sulfonate Ligand》. The information in the text is summarized as follows:

Reactions of the phosphine-sulfonate ligand with [Pd(OAc)(8-Me-quin-H)]2 or [Pd(dmba)(μ-Cl)]2 (dmba = Me2NCH2C6H5) in MeCN afforded the corresponding C(sp3),N-chelated palladacycle Pd1 and C(sp2),N-chelated palladacycle Pd2 in high yields. Both complexes were fully characterized by 1H and 13C NMR, high-resolution mass spectrometry (HRMS), and elemental anal. The mol. structure of Pd1 was further confirmed by single-crystal x-ray diffraction anal. With Et2AlCl as cocatalyst, these complexes showed moderate catalytic activities for the addition polymerization of norbornene. While with methylaluminoxane (MAO) as cocatalyst, they showed high catalytic activities (up to 5.80 × 107 g of PNB (mol of Pd)-1 h-1) at higher temperatures (above 100°). The C(sp3),N-chelated palladacycle Pd1 exhibited marked higher activities than the C(sp2),N-chelated palladacycle Pd2, whether Et2AlCl or MAO was used as cocatalyst. The experimental part of the paper was very detailed, including the reaction process of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Electric Literature of C18H24Cl2N2Pd2)

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C18H24Cl2N2Pd2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 18987-59-2On March 5, 2021, Al-Jibori, Subhi A.; Al-Janabi, Ahmed S. M.; Al-Sahan, Serwan W. M.; Wagner, Christoph published an article in Journal of Molecular Structure. The article was 《Pd (II)- pyrrolidine dithiocarbamate complexes: Synthesis, spectroscopic studies and molecular structure of [Pd(PyDT)(ppy)]》. The article mentions the following:

Eight palladium(II) pyrrolidine dithiocarbamate complexes were prepared and fully characterized. Reactions of the dimeric cyclopalladated complexes, [Pd(ppy)(μ-Cl)]2 (ppyH= phenylpyridine) or [Pd(N-BAZ)(μ-Cl)]2 (N-BAZH = N,N-dimethylbenzylamine) with two moles equivalent of ammonium pyrrolidine dithiocarbamate NH4(PyDT) afford [Pd(PyDT)(ppy)] and [Pd(κ2-PyDT)(N-BAZ)] in good yield (91 and 71%, resp.). A crystal structure of [Pd(PyDT)(ppy)] reveals that the PyDT ligand is bonded as a bidentate chelate. Reaction of trans-[PdCl2(DMSO)2] with sodium benzisothiazolinate (NaBit), followed by NH4(PyDT) afford Na[Pd(PyDT)(N-Bit)2]. Diphosphine adducts [Pd(PyDT)2{Ph2P(CH2)nPPh2}] {n = 2-4 or (CH2)n = (C5H4)2Fe}, can be prepared in good yield upon addition of the diphosphine to [Pd(PyDT)2]. Reaction of trans-[PdCl2(PPh3)2] with sodium saccharinate (Nasac) followed by NH4(PyDT) afford trans-[Pd(PyDT)(N-sac)(PPh3)2]. The prepared complexes were characterized by elemental anal., IR, 1H, 31P NMR spectroscopic data and conductivity measurements. The experimental process involved the reaction of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Related Products of 18987-59-2)

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Related Products of 18987-59-2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Dinuclear Palladium(II) and Platinum(II) Complexes of a Readily Accessible Bicyclic Diphosphane》 was written by Edgar, Mark; Elsegood, Mark R. J.; Liu, Pingchuan; Miles, Christopher R.; Smith, Martin B.; Wu, Shimeng. Product Details of 18987-59-2 And the article was included in European Journal of Inorganic Chemistry on April 27 ,2022. The article conveys some information:

The one-step synthesis (33% isolated yield) of a novel bicyclic diphosphine I (P-P), from the reaction of [P(CH2OH)4]Cl and H2NC6H4-4-NMe2 in methanol is described. Surprisingly, P-P displays excellent air/solution stability (towards H2O, MeOH) and can also function efficiently as a bridging ligand. Hence reaction of P-P with [Pd(μ-Cl)(η3-allyl)]2 (η3-allyl = C3H5, C4H7) or [Pd(μ-Cl)(κ2-C9H12N)]2 affords the singly-bridged complexes {Pd(Cl)(η3-allyl)}2{μ-P-P} 1a/1b and {Pd(Cl)(κ2-C9H12N)}2{μ-P-P(NMe2)} 1c whereas treatment with [MX2(η4-cod)] (M = Pd, Pt; X = Cl, Br, I, Me; η4-cod = cycloocta-1,5-diene) gave (MX2)2{μ-P-P(NMe2)}2 (2a-2e) in high yields. Protonation of 2a-2d with HBF4·OEt2 gave the corresponding dimethylammonium salts 3a-3d. Single crystal X-ray studies have been undertaken on P-P(NMe2), 1b, 2a, 2b·2CDCl3, 2d, 2e, 3a·12CD3CN and 3b·12CD3CN. The P-P bond lengths in free/coordinated P-P(NMe2) remain similar across all compounds studied here and no M ··· M contacts were observed within the planar M2P4 ring. In 3a/3b the BF4- anion displays a unique secondary interaction with the inorganic six-membered M2P4 core. The experimental process involved the reaction of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Product Details of 18987-59-2)

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Product Details of 18987-59-2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Chao; Gao, Yadong; Bai, Songlin; Jiang, Chao; Qi, Xiangbing published an article in Journal of the American Chemical Society. The title of the article was 《Chemoselective Cross-Coupling of gem-Borazirconocene Alkanes with Aryl Halides》.Synthetic Route of C18H24Cl2N2Pd2 The author mentioned the following in the article:

The direct and chemoselective conversion of the C-metal bond of gem-dimetallic reagents enables rapid and sequential formation of multiple C-C and C-heteroatom bonds, thus representing a powerful method for efficiently increasing structural complexity. Herein, the authors report a visible-light-induced, Ni-catalyzed, chemoselective cross-coupling reaction between gem-borazirconocene alkanes and diverse aryl halides, affording a wide range of alkyl Bpin derivatives in high yields with excellent regioselectivity. This practical method features attractively simple reaction conditions and a broad substrate scope. Addnl., the authors systematically studied a Bpin-directed chain walking process underlying the regioselectivity of alkylzirconocenes, thus uncovering the mechanism of the remote functionalization of internal olefins achieved with the authors’ method. Finally, DFT calculations indicate that the high regioselectivity of this reaction originates from the directing effect of the Bpin group. In the experiment, the researchers used Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Synthetic Route of C18H24Cl2N2Pd2)

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C18H24Cl2N2Pd2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhu, Chenghao; Chu, Haoke; Li, Gen; Ma, Shengming; Zhang, Junliang published their research in Journal of the American Chemical Society on December 11 ,2019. The article was titled 《Pd-Catalyzed Enantioselective Heck Reaction of Aryl Triflates and Alkynes》.Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) The article contains the following contents:

The first palladium-catalyzed asym. Heck reaction between aryl triflates and alkynes to give trisubstituted allenes with high er under mild reaction conditions is described. The key to the success is the discovery and fine-tuning of the different N-substituents of Xu-Phos, which ensure the enantioselectivity and reactivity. Synthetic transformation of the chiral allenes with high chirality transfer was also demonstrated. In the experiment, the researchers used many compounds, for example, Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

da Cunha, Gislaine A.; de Souza, Ronan F. F.; de Farias, Renan L.; Moreira, Mariete B.; Silva, Debora E. S.; Zanetti, Renan D.; Garcia, Daniel M.; Spindola, Daniel G.; Michelin, Luis F. G.; Bincoletto, Claudia; de Souza, Aline A.; Antunes, Alyne A.; Judice, Wagner A. de S.; Leitao, Renan C. F.; Deflon, Victor M.; Mauro, Antonio E.; Netto, Adelino V. G. published their research in Journal of Inorganic Biochemistry on February 29 ,2020. The article was titled 《Cyclopalladated compounds containing 2,6-lutidine: Synthesis, spectral and biological studies》.Product Details of 18987-59-2 The article contains the following contents:

Bridge splitting reactions between [Pd(C2,N-dmba)(μ-X)]2 (dmba = N,N-dimethylbenzylamine; X = Cl, I, N3, NCO) and 2,6-lutidine (lut) in the 1:2 molar ratio at room temperature afforded cyclopalladated compounds of general formulas [Pd(C2,N-dmba)(X)(lut)] {X = Cl- (1), I- (2), NNN- (3), NCO- (4)}, which were characterized by elemental analyses and IR, 1H NMR spectroscopy. The mol. structures of all synthesized palladacycles have been solved by single-crystal x-ray crystallog. The cytotoxicity of the cyclopalladated compounds has been evaluated against a panel of murine {mammary carcinoma (4T1) and melanoma (B16F10-Nex2)} and human {melanoma (A2058, SK-MEL-110 and SK-MEL-5)} tumor cell lines. All complexes were about 10 to 100-fold more active than cisplatin, depending on the tested tumor cell line. For comparison purposes, the cytotoxic effects of 1-4 towards human lung fibroblasts (MRC-5) have also been tested. The late apoptosis-inducing properties of 1-4 compounds in SK-MEL-5 cells were verified 24 h incubation using annexin V-Fluorescein isothiocyanate (FITC)/propidium iodide (PI). The binding properties of the model compound 1 on human serum albumin (HSA) and calf thymus DNA (ct-DNA) have been studied using CD and fluorescence spectroscopy. Docking simulations have been carried out to gain more information about the interaction of the palladacycle and HSA. The ability of compounds 1-4 to inhibit the activity of cathepsin B and L has also been investigated in this work.Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Product Details of 18987-59-2) was used in this study.

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Product Details of 18987-59-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Chao; Gao, Yadong; Bai, Songlin; Jiang, Chao; Qi, Xiangbing published an article in Journal of the American Chemical Society. The title of the article was 《Chemoselective Cross-Coupling of gem-Borazirconocene Alkanes with Aryl Halides》.Synthetic Route of C18H24Cl2N2Pd2 The author mentioned the following in the article:

The direct and chemoselective conversion of the C-metal bond of gem-dimetallic reagents enables rapid and sequential formation of multiple C-C and C-heteroatom bonds, thus representing a powerful method for efficiently increasing structural complexity. Herein, the authors report a visible-light-induced, Ni-catalyzed, chemoselective cross-coupling reaction between gem-borazirconocene alkanes and diverse aryl halides, affording a wide range of alkyl Bpin derivatives in high yields with excellent regioselectivity. This practical method features attractively simple reaction conditions and a broad substrate scope. Addnl., the authors systematically studied a Bpin-directed chain walking process underlying the regioselectivity of alkylzirconocenes, thus uncovering the mechanism of the remote functionalization of internal olefins achieved with the authors’ method. Finally, DFT calculations indicate that the high regioselectivity of this reaction originates from the directing effect of the Bpin group. In the experiment, the researchers used Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Synthetic Route of C18H24Cl2N2Pd2)

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C18H24Cl2N2Pd2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhu, Chenghao; Chu, Haoke; Li, Gen; Ma, Shengming; Zhang, Junliang published their research in Journal of the American Chemical Society on December 11 ,2019. The article was titled 《Pd-Catalyzed Enantioselective Heck Reaction of Aryl Triflates and Alkynes》.Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) The article contains the following contents:

The first palladium-catalyzed asym. Heck reaction between aryl triflates and alkynes to give trisubstituted allenes with high er under mild reaction conditions is described. The key to the success is the discovery and fine-tuning of the different N-substituents of Xu-Phos, which ensure the enantioselectivity and reactivity. Synthetic transformation of the chiral allenes with high chirality transfer was also demonstrated. In the experiment, the researchers used many compounds, for example, Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

da Cunha, Gislaine A.; de Souza, Ronan F. F.; de Farias, Renan L.; Moreira, Mariete B.; Silva, Debora E. S.; Zanetti, Renan D.; Garcia, Daniel M.; Spindola, Daniel G.; Michelin, Luis F. G.; Bincoletto, Claudia; de Souza, Aline A.; Antunes, Alyne A.; Judice, Wagner A. de S.; Leitao, Renan C. F.; Deflon, Victor M.; Mauro, Antonio E.; Netto, Adelino V. G. published their research in Journal of Inorganic Biochemistry on February 29 ,2020. The article was titled 《Cyclopalladated compounds containing 2,6-lutidine: Synthesis, spectral and biological studies》.Product Details of 18987-59-2 The article contains the following contents:

Bridge splitting reactions between [Pd(C2,N-dmba)(μ-X)]2 (dmba = N,N-dimethylbenzylamine; X = Cl, I, N3, NCO) and 2,6-lutidine (lut) in the 1:2 molar ratio at room temperature afforded cyclopalladated compounds of general formulas [Pd(C2,N-dmba)(X)(lut)] {X = Cl- (1), I- (2), NNN- (3), NCO- (4)}, which were characterized by elemental analyses and IR, 1H NMR spectroscopy. The mol. structures of all synthesized palladacycles have been solved by single-crystal x-ray crystallog. The cytotoxicity of the cyclopalladated compounds has been evaluated against a panel of murine {mammary carcinoma (4T1) and melanoma (B16F10-Nex2)} and human {melanoma (A2058, SK-MEL-110 and SK-MEL-5)} tumor cell lines. All complexes were about 10 to 100-fold more active than cisplatin, depending on the tested tumor cell line. For comparison purposes, the cytotoxic effects of 1-4 towards human lung fibroblasts (MRC-5) have also been tested. The late apoptosis-inducing properties of 1-4 compounds in SK-MEL-5 cells were verified 24 h incubation using annexin V-Fluorescein isothiocyanate (FITC)/propidium iodide (PI). The binding properties of the model compound 1 on human serum albumin (HSA) and calf thymus DNA (ct-DNA) have been studied using CD and fluorescence spectroscopy. Docking simulations have been carried out to gain more information about the interaction of the palladacycle and HSA. The ability of compounds 1-4 to inhibit the activity of cathepsin B and L has also been investigated in this work.Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Product Details of 18987-59-2) was used in this study.

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Product Details of 18987-59-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,European Journal of Inorganic Chemistry included an article by Werle, Christophe; Karmazin, Lydia; Bailly, Corinne; Djukic, Jean-Pierre. Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II). The article was titled 《Effect of Enhanced Electron Withdrawal on the Cohesion of Cr-Pd Hemichelates》. The information in the text is summarized as follows:

Bimetallic chromium-palladium and trimetallic dichromium-palladium fluorenyl hemichelates I (4a, M absent, Q = CH2, R = Me, X = H; 4b, M = (CO)3Cr, Q = CH2, R = Me, X = H; 5a, M absent, R2NQ = 4-tert-butyl-2-pyridyl, X = NMe2; 5b, M = (CO)3Cr, R2NQ = 4-tert-butyl-2-pyridyl, X = NMe2) were synthesized and fully characterized. Their mol. structures obtained by X-ray diffraction anal. do not show major differences – in interat. bond lengths within the Pd coordination sphere – when compared to previously reported bimetallic analogs. Theor. investigations were performed using methods of the D. Functional Theory (ZORA-PBE-D3(BJ)/all electron TZP level, EDA, ETS-NOCV and QTAIM-IQA) to analyze the influence of a second Cr(CO)3 moiety in the process of formation of the Cr-Pd hemichelate. Theory shows that despite the extensive charge delocalization in the anion of trans-bistricarbonylchromium(fluorene), the formation of a stable hemichelate is still possible albeit requiring a moderate energy payload to funnel charge d. towards the formation of the benzylic carbon-palladium bond. IQA analyses of hemichelates show the important role of attractive electrostatic interactions in the dominantly noncovalent Cr(CO)3-Pd interactions. In the experiment, the researchers used Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))

Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics