Category: 1878-65-5

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. SDS of cas: 1878-65-5.

Nguyen, Thanh Binh;Retailleau, Pascal research published 《 Sulfur-Promoted Decarboxylative Sulfurative Hexamerization of Phenylacetic Acids: Direct Approach to Hexabenzylidyne Tetrasulfides》, the research content is summarized as follows. During our experiments aimed at understanding the reaction pathways by which arylacetic acids were oxidatively decarboxylated and condensed with different nucleophiles in the presence of elemental sulfur, these acids have been treated with sulfur powder in DMSO (DMSO) and N-methylpiperidine in the absence of nucleophiles, producing a remarkable sym. sulfurated hexamer consisting of six benzylidyne moieties and four sulfur atoms.

SDS of cas: 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Name: 3-Chlorophenylacetic acid.

Nguyen, Khang X.;Nguyen, Duyen K.;Pham, Phuc H.;Le, Ha V.;Nguyen, Tung T.;Phan, Nam T. S. research published 《 Sulfur-Mediated Decarboxylative Coupling of 2-Nitrobenzyl Alcohols and Arylacetic Acids》, the research content is summarized as follows. A new method for the synthesis of substituted quinazolines by the condensation of 2-nitrobenzyl alcs. with arylacetic acids. The transformation requires the use of urea as a nitrogen source, elemental sulfur as a promoter, DABCO as a base and DMSO as a solvent. Functionalities such as chloro, fluoro, trifluoromethyl, thienyl and indolyl groups were all compatible with the reaction conditions. Because this method uses stable simple substrates to obtain the N,N-heterocycles in the absence of transition metals, it offers a potential pathway for preparing complex structures under mild conditions.

Name: 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. HPLC of Formula: 1878-65-5.

Neumann, William L.;Sandoval, Karin E.;Mobayen, Shirin;Minaeian, Mahsa;Kukielski, Stephen G.;Srabony, Khush N.;Frare, Rafael;Slater, Olivia;Farr, Susan A.;Niehoff, Michael L.;Hospital, Audrey;Kontoyianni, Maria;Crider, A. Michael;Witt, Ken A. research published 《 Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer′s disease treatment》, the research content is summarized as follows. Somatostatin receptor-4 (SST₄) is highly expressed in brain regions affiliated with learning and memory. SST₄ agonist treatment may act to mitigate Alzheimer′s disease (AD) pathol. An integrated approach to SST₄ agonist lead optimization is presented herein. High affinity and selective agonists with biol. efficacy were identified through iterative cycles of a structure-based design strategy encompassing computational methods, chem., and preclin. pharmacol. 1,2,4-Triazole derivatives of our previously reported hit (4) showed enhanced SST₄ binding affinity, activity, and selectivity. Thirty-five compounds showed low nanomolar range SST₄ binding affinity, 12 having a K_i < 1 nM. These compounds showed >500-fold affinity for SST₄ as compared to SST_2A. SST₄ activities were consistent with the resp. SST₄ binding affinities (EC₅₀ < 10 nM for 34 compounds). Compound 208 (SST₄K_i = 0.7 nM; EC₅₀ = 2.5 nM; >600-fold selectivity over SST_2A) display a favorable physiochem. profile, and was advanced to learning and memory behavior evaluations in the senescence accelerated mouse-prone 8 model of AD-related cognitive decline. Chronic administration enhanced learning with i.p. dosing (1 mg kg^-1) compared to vehicle. Chronic administration enhanced memory with both i.p. (0.01, 0.1, 1 mg kg^-1) and oral (0.01, 10 mg kg^-1) dosing compared to vehicle. This study identified a novel series of SST₄ agonists with high affinity, selectivity, and biol. activity that may be useful in the treatment of AD.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., HPLC of Formula: 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Recommanded Product: 3-Chlorophenylacetic acid.

Mondal, Biswajit;Ghosh, Prasanjit;Kundu, MrinalKanti;Das, Sajal research published 《 8-Aminoimidazo[1,2-a]pyridine (AIP) directed Pd(II) catalysis: site-selective ortho-C(sp²)-H arylation in aqueous medium》, the research content is summarized as follows. Herein the first example of a palladium(II) catalyzed regioselective ortho-C(sp²)-H arylation in aqueous medium (a sustainable solvent) utilizing 8-AIP (8-aminoimidazo[1,2-a]pyridine) as a promising and removable bidentate directing group/auxilliary has been demonstrated. This newly developed protocol features a broad substrate scope with excellent functional group tolerance and enables an expeditious route to a library of unsym. amides in good to excellent yields with exclusive site-selectivity.

Recommanded Product: 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Application In Synthesis of 1878-65-5.

Mohammadifarani, Ahmad;Mousavi, Hosna Sadat Zamani;Hosseini, Amin;Aliabadi, Alireza research published 《 Synthesis and cytotoxicity evaluation of N-(5-mercapto-4H-1,2,4-triazol3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects》, the research content is summarized as follows. Discovery of new anticancer drugs is one of the urgent issues in the medicinal chem. researches. Incidence of severe side effects and acquired resistance to the current medications are the logical reasons for the development of novel antineoplastic agents. Herein, a new series of 4H-1,2,4-triazole derivatives was synthesized and subsequently their cytotoxicity was assessed using dimethylthiazol diphenyltetrazolium bromide assay. Furthermore, activity of caspase 3, mitochondrial membrane potential (MMP), and generation of reactive oxygen species (ROS) were investigated. All synthesized derivatives (3a-3o) were tested against Hela (cervical cancer), A549 (lung carcinoma), and U87 (glioblastoma), and the obtained data were compared with doxorubicin. Among the chlorinated derivatives, compound 3c with para positioning of the chlorine on the Ph residue possessed higher cytotoxicity (IC50 = s3.2 ± 0.6 μM) than compounds 3a and 3b, which positioned chlorine at ortho and meta position, resp. Chlorine as electron-withdrawing moiety caused enhancement in cytotoxicity. Fortunately, most of the tested compounds showed remarkable cytotoxic activity toward applied cells, especially Hela. Activation of caspase 3, MMP reduction, and ROS generation were also observed for the studied compounds

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Application In Synthesis of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Product Details of C8H7ClO2.

Mitra, Trisha;Kundu, Mrinalkanti;Roy, Brindaban research published 《 Additive Free, Pd-Catalyzed 3-Amino-1-Methyl-1H-Pyridin-2-one Directed C(sp²)-H Arylation and Methylation In Water》, the research content is summarized as follows. The studies on Pd(II)-catalyzed coupling reaction between Me, aryl, heteroaryl iodides and sp² carbons both at β- and γ-positions using 3-amino-1-methyl-1H-pyridin-2-one (AMP) as an efficient, built-in bidentate N,O-directing group (DG) towards the synthesis of pyridone derivatives has been reported. Effect of temperature, solvent, reagent equivalence and substrate has been investigated for this DG mediated late stage functionalization reactions along with crystal structure of a selected analog. Moreover, this DG has been successfully applied for ortho selective C(sp²)-H activation in aqueous medium in high yields to demonstrate the practicability of this present methodol.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Product Details of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Application of C8H7ClO2.

Mirabile, Salvatore;Vittorio, Serena;Paola Germano, Maria;Adornato, Ilenia;Ielo, Laura;Rapisarda, Antonio;Gitto, Rosaria;Pintus, Francesca;Fais, Antonella;De Luca, Laura research published 《 Evaluation of 4-(4-Fluorobenzyl)piperazin-1-yl]-Based Compounds as Competitive Tyrosinase Inhibitors Endowed with Antimelanogenic Effects》, the research content is summarized as follows. There is a considerable attention for the development of inhibitors of tyrosinase (TYR) as therapeutic strategy for the treatment of hyperpigmentation disorders in humans. Continuing in our efforts to identify TYR inhibitors, we describe the design, synthesis and pharmacophore exploration of new small mols. structurally characterized by the presence of the 4-fluorobenzylpiperazine moiety as key pharmacophoric feature for the inhibition of TYR from Agaricus bisporus (AbTYR). Our investigations resulted in the discovery of the competitive inhibitor [4-(4-fluorobenzyl)piperazin-1-yl]-(3-chloro-2-nitro-phenyl)methanone 26 (I, IC₅₀=0.18μM) that proved to be ∼100-fold more active than reference compound kojic acid (IC₅₀=17.76μM). Notably, compound 26 exerted antimelanogenic effect on B16F10 cells in absence of cytotoxicity. Docking anal. suggested its binding mode into AbTYR and into modelled human TYR.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Application of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Recommanded Product: 3-Chlorophenylacetic acid.

Miao, Wei-Hang;Gao, Wen-Xia;Huang, Xiao-Bo;Liu, Miao-Chang;Zhou, Yun-Bing;Wu, Hua-Yue research published 《 Cascade Ring-Opening Dual Halogenation of Cyclopropenones with Saturated Oxygen Heterocycles》, the research content is summarized as follows. A CuX₂– or I₂-promoted ring-opening dual halogenation of cyclopropenones with saturated oxygen heterocycles, providing an efficient method for the synthesis of 3-haloacrylates. The ring-opening reaction enabled the construction of two C-X (X = Cl, Br, I) bonds and a C-O bond as well as the cleavage of two C-O bonds and a C-C bond in a single step. This protocol features high at. economy, excellent substrate scope, and the ability for gram-scale reaction.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Recommanded Product: 3-Chlorophenylacetic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Computed Properties of 1878-65-5.

Ma, Jiajia;Chen, Shuming;Bellotti, Peter;Wagener, Tobias;Daniliuc, Constantin;Houk, Kendall N.;Glorius, Frank research published 《 Facile access to fused 2D/3D rings via intermolecular cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinolines with alkenes》, the research content is summarized as follows. Two types of energy-transfer-mediated cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinoline derivatives with alkenes, which provide a straightforward avenue to 2D/3D pyridine-fused 6-5-4-3- and 6-4-6-membered ring systems are reported. Notably, this energy-transfer-mediated strategy features excellent diastereoselectivity that bypasses the general reactivity and selectivity issues of photochem. [2+2] cycloaddition of various other aromatics Tuning the aza-arene substitutions enabled selective diversion of the iridium photocatalyzed energy transfer manifold towards either cyclopropanation or cyclobutane-rearrangement products. D. functional theory calculations revealed a cascade energy transfer scenario to be operative.

Computed Properties of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Application of C8H7ClO2.

Ma, Ben;Sun, Rongxia;Yang, Jingya research published 《 Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source》, the research content is summarized as follows. Herein, a cobalt-catalyzed α-hydroxymethylation of amides RCH₂C(O)NR¹R² [R = Ph, 3-methoxyphenyl, thiophen-2-yl, etc.; R¹ = Me, Et, Ph; R² = Me, 2-fluorophenyl, 3-methylphenyl, etc.; R¹R² = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-] and 1-(2,3-dihydro-1H-indol-1-yl)-2-phenylethan-1-one with methanol under mild conditions was reported. Using CoCl₂.6H₂O as an inexpensive and efficient catalyst, some important bioactive β-hydroxyamides RCHCH₂(OH)C(O)NR¹R² and 3-hydroxy-1-(indolin-1-yl)-2-phenylpropan-1-one were obtained in moderate to excellent yields. The developed method features a wide substrate scope and good functional group tolerance. In addition, anticholinergic tropicamide was easily synthesized in this way.

Application of C8H7ClO2, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics