1878-65-5 Archives - Page 5 of 10 - Chlorides-buliding-blocks

Reed, Brian team published research in ACS Chemical Neuroscience in 2022 | 1878-65-5

Product Details of C8H7ClO2, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Product Details of C8H7ClO2.

Reed, Brian;Miller, Michael;Michino, Mayako;Butelman, Eduardo R.;Ben-Ezra, Ariel;Pikus, Philip;Morochnik, Michelle;Kim, Yuli;Ripka, Amy;Vacca, Joseph;Kreek, Mary Jeanne research published 《 Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold》, the research content is summarized as follows. The kappa agonist structure-activity relationship around the novel, pyrrolidinyl substituted pyranopiperazine scaffold was developed. More specifically, the dichloroPhenylAcetamide-Pyrrolidinyl-PyranoPiperazine (PAPPP) core A was the focus of our work. The modulation of kappa receptor potency/G-protein activation and arrestin recruitment with respect to changes of the piperazine R group in A was demonstrated. Reduced β₂-arrestin recruitment and differential G-protein bias were observed for select analogs. To better understand the subtlety in receptor signaling, analogs were profiled as the resolved enantiomers. To determine in vivo target engagement, a subset of compounds was tested in mice for stimulation of serum prolactin, a neuroendocrine biomarker of KOR-agonist effects. Addnl. in vivo characterization included measurement of potential unwanted effects of kappa receptor activation such as sedation. These studies demonstrate a novel kappa receptor agonist scaffold with potential for G-protein signaling bias to probe in vivo pharmacol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reddy, Palagulla Maheswar team published research in Journal of Catalysis in 2021 | 1878-65-5

Formula: C8H7ClO2, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Formula: C8H7ClO2.

Reddy, Palagulla Maheswar;Ramachandran, Kuppan;Anbarasan, Pazhamalai research published 《 Palladium-catalyzed diastereoselective synthesis of 2,2,3-trisubstituted dihydrobenzofurans via intramolecular trapping of O-ylides with activated alkenes》, the research content is summarized as follows. An efficient palladium catalyzed diastereoselective synthesis of 2,2,3-trisubstituted dihydrobenzofurans was accomplished in good yield as a single diastereomer. The transformation involved in-situ generation of oxonium ylide from 2-hydroxyphenyl substituted enone and diazo compound followed by intramol. trapping via Michael addition Successful integration of the developed method with intramol. aldol condensation afforded potent dibenzofuran derivatives in good yield.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rahman, Taskia team published research in Catalysis Letters in 2020 | 1878-65-5

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Formula: C8H7ClO2.

Rahman, Taskia;Borah, Geetika;Gogoi, Pradip K. research published 《 Spinel Structured Copper Ferrite Nano Catalyst with Magnetic Recyclability for Oxidative Decarboxylation of Phenyl Acetic Acids》, the research content is summarized as follows. A simple, efficient and environmentally benign method has been discussed for the synthesis of aldehydes and ketones by the oxidative decarboxylation of phenylacetic acid under ligand free condition using simple, efficient, preparatively easy, magnetically recoverable and low cost spinel CuFe₂O₄ nanoparticles. The catalyst was characterized using powder-XRD, FTIR, FE-SEM, EDX, VSM and HRTEM. The recyclability was examined and the results showed that the catalyst remained almost equally active up to five consecutive cycles. Spinel Structured Copper Ferrite is a very efficient nano catalyst for Oxidative decarboxylation of Ph acetic acids and can be reused up to five cycles without significant loss in catalytic activity.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quintano, Mateus team published research in Chemical Physics Letters in 2022 | 1878-65-5

Name: 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Quintano, Mateus;Kraka, Elfi research published 《 Theoretical insights into the linear relationship between pK_a values and vibrational frequencies》, the research content is summarized as follows. A linear relationship between pK_a values and vibrational frequencies has been derived in this work for hydrogen halides based on a statistical thermodn. ansatz and successfully tested for a set of 24 aliphatic carboxylic acids, with predicted pK_a values differing from measured values by less than 0.3 pK_a units. Our work opens the door to reliably predicting pK_a values for families of compounds often difficult to measure and paves the way for a natural extension of the derived relationship referring to local vibrational mode theory to treat systems with more delocalized A-H stretching vibrations, such as nitroacetic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qi, Dan team published research in Green Chemistry in 2022 | 1878-65-5

Synthetic Route of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Synthetic Route of 1878-65-5.

Qi, Dan;Bai, Jinrui;Zhang, Haoxiang;Li, Bin;Song, Zhuoheng;Ma, Na;Guo, Lin;Song, Lijuan;Xia, Wujiong research published 《 Photoinduced synthesis of functionalized oxetanes via diradical-mediated ring contraction》, the research content is summarized as follows. A versatile photochem. ring contraction was reported for the synthesis of oxetanes under catalyst-free conditions. The reaction was enabled by the use of 2,5-dihydrofurans and diazo compounds under visible light irradiation, delivering functionalized 3-vinyloxetanes as major products. The outstanding features of this protocol included mild reaction conditions, operational simplicity and scalability, as well as excellent functional-group tolerance. DFT calculations indicated that the reaction may proceed through the formation of an oxonium ylide intermediate followed by a diradical-mediated rearrangement and cyclization.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pham, Hang T. team published research in Synlett in 2020 | 1878-65-5

Pham, Hang T.;Ho, Tuan H.;Do, Duy Q.;Nguyen, Kim L. H.;Nguyen, Tung T.;Phan, Nam T. S. research published 《 Synthesis of 2-Arylbenzothiazol-5-amines from N,N-Dialkyl-3-nitroanilines》, the research content is summarized as follows. A simple method for coupling of N, N-dialkyl-3-nitroarenes, I (R¹ = Me₂N, morpholinyl, 4-Me-piperazinyl,etc.) elemental sulfur, and activated sp³ C-H bonds in 2-methylazaarenes or arylacetic acids to afford derivatives of 2-arylbenzothiazol-5-amines II (R² = Ph, 4-MeC₆H₄, 2-pyridinyl, 2-thiphenyl, etc. ) is described. Only DABCO base was required, and many heterocycles such as imidazoles, oxazoles, quinolines, and thiophenes were compatible with the reaction conditions. Authors’ approach offers a simple route to useful substituted thiazol-5-amines from com. available nitroarenes.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pham, Phuc H. team published research in RSC Advances in 2020 | 1878-65-5

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Application In Synthesis of 1878-65-5

Pham, Phuc H.;Nguyen, Khang X.;Pham, Hoai T. B.;Tran, Thien T.;Nguyen, Tung T.;Phan, Nam T. S. research published 《 Functionalization of C-H bonds in acetophenone oximes with arylacetic acids and elemental sulfur》, the research content is summarized as follows. Fused thieno[3,2-d]thiazoles were synthesized via a coupling of acetophenone ketoximes, arylacetic acids, and elemental sulfur in the presence of Li2CO3 base. Functionalities including chloro, bromo, fluoro, trifluoromethyl, and pyridyl groups were compatible with reaction conditions. High yields and excellent regioselectivities were obtained even if meta-substituted ketoxime acetates were used. Et esters of heteroarylacetic acids were competent substrates, which is very rare in the literature. This method would offer a convenient protocol to afford polyheterocyclic structures from simple substrates.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Mengqi team published research in Advanced Synthesis & Catalysis in 2022 | 1878-65-5

Safety of 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Peng, Mengqi;Li, Hengzhao;Qin, Zixuan;Li, Junyu;Sun, Yanhao;Zhang, Xiaoxu;Jiang, Ling;Do, Hainam;An, Jie research published 《 Pentafluorophenyl Group as Activating Group: Synthesis of α-Deuterio Carboxylic Acid Derivatives via Et₃N Catalyzed H/D Exchange》, the research content is summarized as follows. Discovered that highly regioselective H/D exchange was achieved on the α-position of the pentafluorophenyl (Pfp) ester using Et₃N as the catalyst and D₂O as the deuterium source. Computational and exptl. results showed that the Pfp group can significantly increase the acidity of the α-hydrogen of the ester. This mild reaction condition tolerated a variety of functional groups. 90%∼98% yields and 91%∼98% deuterium incorporations were obtained with all the tested Pfp esters. Taking advantage of the high reactivity of Pfp esters, a series of valuable α-deuterio carboxylic acid derivatives, including herbicide, drugs and drug intermediates, was synthesized using α-deuterio Pfp esters as precursors.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Patil, Bhausaheb N. team published research in Tetrahedron Letters in 2019 | 1878-65-5

Application In Synthesis of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Patil, Bhausaheb N.;Lade, Jatin J.;Karpe, Aniket S.;Pownthurai, B.;Vadagaonkar, Kamlesh S.;Mohanasrinivasan, V.;Chaskar, Atul C. research published 《 Transition metal-catalyzed C-H functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides》, the research content is summarized as follows. Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides I [R = Ph, 4-FC₆H₄, 3-ClC₆H₄, etc.] and II [R¹ = Ph, 2-furyl, 2-thienyl, etc.] was developed via C-H functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonamide. This functional group tolerant approach furnished benzothiadiazine 1,1-dioxide derivatives in good to excellent yields. Broad substrate scope, inexpensive catalyst and high product yields were notable features of this protocol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Park, So Hee team published research in Archives of Pharmacal Research in 2019 | 1878-65-5

Park, So Hee;Choi, Dubok;Cho, Hoon research published 《 Effect of thiazolidinedione phenylacetate derivatives on wound-healing activity》, the research content is summarized as follows. The aim of this work was to evaluate the synthesis and structure-activity relationship of 4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl 2-phenylacetate derivatives as potential wound-healing agents. The IC₅₀ values of the lead compounds ranged from 0.01 to 0.05 μM. These compounds also increased the levels of extracellular prostaglandin E₂ (PGE₂) in A549 cells. Among the synthesized compounds, compounds 66, 67, 69, and 86 increased PGE₂ levels 3- to 4-fold of those achieved with the neg. control. Introduction of a halogen at the intermediate Ph ring, compounds 66, 67, 69, and 86 resulted in higher IC₅₀ values, which indicated lower cytotoxicity than that observed upon the introduction of other substituents at the same position. In particular, cells exposed to compound 69 showed significantly improved wound healing, and the wound closure rate achieved was approx. 3.2-fold higher than that of the control. Therefore, compound 69 can be used for tissue regeneration and treatment of diverse diseases caused by PGE₂ deficiency. Overall, our findings suggested that compound 69 might be a novel candidate for skin wound therapy.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics